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Protein

Protein zyg-11 homolog

Gene

zyg11

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex zyg11-cul2-elongin BC.By similarity

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein zyg-11 homolog
Gene namesi
Name:zyg11
ORF Names:si:ch211-11m18.3, zgc:136612
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-041014-17 zyg11

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050891 – 746Protein zyg-11 homologAdd BLAST746

Proteomic databases

PaxDbiQ5TYQ1

Expressioni

Gene expression databases

BgeeiENSDARG00000007737 Expressed in 25 organ(s), highest expression level in pharyngeal gill
ExpressionAtlasiQ5TYQ1 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094887

Structurei

3D structure databases

ProteinModelPortaliQ5TYQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati185 – 209LRR 1Add BLAST25
Repeati216 – 241LRR 2Add BLAST26
Repeati265 – 289LRR 3Add BLAST25

Sequence similaritiesi

Belongs to the zyg-11 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG3665 Eukaryota
ENOG410XPSX LUCA
GeneTreeiENSGT00530000063187
HOGENOMiHOG000004816
HOVERGENiHBG108780
InParanoidiQ5TYQ1
KOiK10350
OMAiHVCSKNA
OrthoDBiEOG091G031E
PhylomeDBiQ5TYQ1
TreeFamiTF313007

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR032675 LRR_dom_sf
SMARTiView protein in SMART
SM00185 ARM, 3 hits
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q5TYQ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIHLSQTMDK SSLPSLSDLC MSLVSSRLEL FCEMRDDGSL SFREPLVFPQ
60 70 80 90 100
ELADQLLCKM ATDGVLNDST VGIFRNCQQF RLRHACIRTA RISAEAFHRA
110 120 130 140 150
LCPHRLVELD ASRVNADLTI ADILRGLSSN KSLQESLQRL VLNGLTMSSL
160 170 180 190 200
EEPSRRCFSA MQGLRALSVS NVDFYDWGLA DVCLLPRLES LDISNTSVSN
210 220 230 240 250
LTPLLGLRSR LRYLTMHQLK RLEMTTAQLL AVLSQLEVLQ HLDISDDKQF
260 270 280 290 300
TSDVARQLLE TPGILPQLVS LDVSGRKQVT DAAVKAFVEA RPGMTFVGLL
310 320 330 340 350
ATDAGFSEFL SGEGSLKVTG EANETQICEA LRRYSEREGF VREALFHLFS
360 370 380 390 400
LTHAIEKPRP DILKLVALGM KNHPTTLNVQ LAASACVFNL TKQELAFGIP
410 420 430 440 450
VRLLGNVTQQ LLEAMKTFPN HQQLQKNCLL SLCSDRILQE VPFNRFEAAK
460 470 480 490 500
LVMQWLCNHE DQNMQRMAVA IISILAAKLS TEQTAQLGAE LFIVKQLLHI
510 520 530 540 550
VRQKTCQSTV DATLKFTLSA LWNLTDESPT TCRHFIENQG LELFIKVLES
560 570 580 590 600
FPSESSIQQK VLGLLNNIAE VSELHGELMV QSFLDHIRTL LHSPEVEVSY
610 620 630 640 650
FAAGILAHLT SRGEKVWTLE LTLRNTLLQQ LHSAILKWPT PECEMVAYRS
660 670 680 690 700
FNPFFPLLEC FQTPGVQLWA AWAMQHVCSK NAGRYCSMLL EEGGLQHLEA
710 720 730 740
ITSHPKTHSD VRRLTESILD GLQRHRARTG YTAIPKTQAH REKCNP
Length:746
Mass (Da):83,666
Last modified:December 7, 2004 - v1
Checksum:iD3C612B65A555FCB
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q0V968Q0V968_DANRE
Protein zyg-11 homolog
zyg11 si:ch211-11m18.3
237Annotation score:
A0A2R8PXN5A0A2R8PXN5_DANRE
Protein zyg-11 homolog
zyg11
742Annotation score:
A0A2R8RKW2A0A2R8RKW2_DANRE
Protein zyg-11 homolog
zyg11
770Annotation score:
R4GDW6R4GDW6_DANRE
Protein zyg-11 homolog
zyg11
154Annotation score:

Sequence cautioni

The sequence CAH68868 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX942844 Genomic DNA Translation: CAH68868.1 Sequence problems.
BX942844 Genomic DNA Translation: CAH68869.1
BC115195 mRNA Translation: AAI15196.1
RefSeqiNP_001035422.1, NM_001040332.2
UniGeneiDr.14207

Genome annotation databases

EnsembliENSDART00000104112; ENSDARP00000094887; ENSDARG00000007737
GeneIDi555349
KEGGidre:555349

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX942844 Genomic DNA Translation: CAH68868.1 Sequence problems.
BX942844 Genomic DNA Translation: CAH68869.1
BC115195 mRNA Translation: AAI15196.1
RefSeqiNP_001035422.1, NM_001040332.2
UniGeneiDr.14207

3D structure databases

ProteinModelPortaliQ5TYQ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094887

Proteomic databases

PaxDbiQ5TYQ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000104112; ENSDARP00000094887; ENSDARG00000007737
GeneIDi555349
KEGGidre:555349

Organism-specific databases

CTDi555349
ZFINiZDB-GENE-041014-17 zyg11

Phylogenomic databases

eggNOGiKOG3665 Eukaryota
ENOG410XPSX LUCA
GeneTreeiENSGT00530000063187
HOGENOMiHOG000004816
HOVERGENiHBG108780
InParanoidiQ5TYQ1
KOiK10350
OMAiHVCSKNA
OrthoDBiEOG091G031E
PhylomeDBiQ5TYQ1
TreeFamiTF313007

Miscellaneous databases

PROiPR:Q5TYQ1

Gene expression databases

BgeeiENSDARG00000007737 Expressed in 25 organ(s), highest expression level in pharyngeal gill
ExpressionAtlasiQ5TYQ1 baseline and differential

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR032675 LRR_dom_sf
SMARTiView protein in SMART
SM00185 ARM, 3 hits
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZYG11_DANRE
AccessioniPrimary (citable) accession number: Q5TYQ1
Secondary accession number(s): Q5TYQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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