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Protein

Lymphotoxin-alpha

Gene

LTA

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotoxin-alpha
Short name:
LT-alpha
Alternative name(s):
TNF-beta
Tumor necrosis factor ligand superfamily member 1
Gene namesi
Name:LTA
Synonyms:TNFB, TNFSF1
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34By similarityAdd BLAST34
ChainiPRO_000003446535 – 205Lymphotoxin-alphaAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41O-linked (GalNAc...) threonineBy similarity1
Glycosylationi96N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000008843
ExpressionAtlasiQ5TM20 baseline

Interactioni

Subunit structurei

Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000011590

Structurei

3D structure databases

ProteinModelPortaliQ5TM20
SMRiQ5TM20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWT9 Eukaryota
ENOG410YQC4 LUCA
GeneTreeiENSGT00530000062992
HOGENOMiHOG000048729
HOVERGENiHBG012516
InParanoidiQ5TM20
KOiK05468
OMAiQYPFHVP
OrthoDBiEOG091G0HIG
TreeFamiTF332169

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002960 TNF_beta
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01236 TNFBETA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5TM20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPERLFLS RVRGTPLHLL LLGLLLVLLP GAQGLPGVGL TPSAAQTARQ
60 70 80 90 100
HPKMHLAHST LKPAAHLIGD PSKQNSLLWR ANTDRAFLQD GFSLSNNSLL
110 120 130 140 150
VPTSGIYFVY SQVVFSGKAY SPKATPTPLY LAHEVQLFSS QYPFHVPLLS
160 170 180 190 200
SQKMVYPGLQ EPWLHSMYHG AAFQLTQGDQ LSTHTDGIPH LVLSPSTVFF

GAFAL
Length:205
Mass (Da):22,360
Last modified:December 21, 2004 - v1
Checksum:i5EE2A7FCE556548A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB128049 Genomic DNA Translation: BAD69725.1
RefSeqiNP_001040613.1, NM_001047148.1
XP_014991411.1, XM_015135925.1
XP_014991412.1, XM_015135926.1
UniGeneiMmu.10857

Genome annotation databases

EnsembliENSMMUT00000012357; ENSMMUP00000011590; ENSMMUG00000008843
GeneIDi715425
KEGGimcc:715425

Similar proteinsi

Entry informationi

Entry nameiTNFB_MACMU
AccessioniPrimary (citable) accession number: Q5TM20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 21, 2004
Last modified: June 7, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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