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UniProtKB - Q5TKS0 (FABF_STAAU)
Protein
3-oxoacyl-[acyl-carrier-protein] synthase 2
Gene
fabF
Organism
Staphylococcus aureus
Status
Functioni
Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.
By similarityCatalytic activityi
- (9Z)-hexadecenoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]By similarityEC:2.3.1.179By similarity
: fatty acid biosynthesis Pathwayi
This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 158 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.179By similarity)Alternative name(s): 3-oxoacyl-[acyl-carrier-protein] synthase II Beta-ketoacyl-ACP synthase II Short name: KAS II |
Gene namesi | Name:fabF |
Organismi | Staphylococcus aureus |
Taxonomic identifieri | 1280 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180319 | ‹1 – ›403 | 3-oxoacyl-[acyl-carrier-protein] synthase 2Add BLAST | ›403 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR017568, 3-oxoacyl-ACP_synth-2 IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
PIRSFi | PIRSF000447, KAS_II, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR03150, fabF, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q5TKS0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
VITGMGALSP IGNDVKTTWE NALKGVNGID KITRIDTEPY SVHLAGELKN
60 70 80 90 100
FNIEDHIDKK EARRMDRFTQ YAIVAAREAV KDAQLDINEN TADRIGVWIG
110 120 130 140 150
SGIGGMETFE IAHKQLMDKG PRRVSPFFVP MLIPDMATGQ VSIDLGAKGP
160 170 180 190 200
NGATVTACAT GTNSIGEAFK IVQRGDADAM ITGGTEAPIT HMAIAGFSAS
210 220 230 240 250
RALSTNDDIE TACRPFQEGR DGFVMGEGAG ILVIESLESA QARGANIYAE
260 270 280 290 300
IVGYGTTGDA YHITAPAPEG EGGSRAMQAA MDDAGIEPKD VQYLNAHGTS
310 320 330 340 350
TPVGDLNEVK AIKNTFGEAA KHLKVSSTKS MTGHLLGATG GIEAIFSALS
360 370 380 390 400
IKDSKIAPTI HAVTPDPECD LDIVPNEAQD LDITYAMSNS LGFGGHNAVL
VFK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 | ||
Non-terminal residuei | 403 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB195291 Genomic DNA Translation: BAD72839.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB195291 Genomic DNA Translation: BAD72839.1 |
3D structure databases
AlphaFoldDBi | Q5TKS0 |
SMRi | Q5TKS0 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q5TKS0 |
ChEMBLi | CHEMBL5341 |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR017568, 3-oxoacyl-ACP_synth-2 IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
PIRSFi | PIRSF000447, KAS_II, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR03150, fabF, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FABF_STAAU | |
Accessioni | Q5TKS0Primary (citable) accession number: Q5TKS0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | December 21, 2004 | |
Last modified: | May 25, 2022 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families