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Entry version 131 (12 Aug 2020)
Sequence version 2 (05 Jul 2005)
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Protein

Histone acetyltransferase KAT6A

Gene

Kat6a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2 (By similarity). Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei678Proton donor/acceptorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei682Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri199 – 258PHD-type 1PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri255 – 306PHD-type 2PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri535 – 560C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Acyltransferase, Chromatin regulator, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-3214847, HATs acetylate histones
R-RNO-6804758, Regulation of TP53 Activity through Acetylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone acetyltransferase KAT6A (EC:2.3.1.48By similarity)
Alternative name(s):
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3
Short name:
MYST-3
Monocytic leukemia zinc finger homolog
Monocytic leukemia zinc finger protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kat6a
Synonyms:Moz, Myst3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
1304892, Kat6a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000515741 – 1998Histone acetyltransferase KAT6AAdd BLAST1998

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei172N6-acetyllysineBy similarity1
Modified residuei350N6-acetyllysineBy similarity1
Modified residuei355N6-acetyllysineBy similarity1
Modified residuei369Phosphothreonine; by PKB/AKT1By similarity1
Modified residuei419PhosphoserineBy similarity1
Modified residuei471PhosphoserineBy similarity1
Modified residuei602N6-acetyllysine; by autocatalysisBy similarity1
Modified residuei785PhosphoserineBy similarity1
Modified residuei815N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki835Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei900PhosphotyrosineCombined sources1
Modified residuei940PhosphoserineBy similarity1
Modified residuei953PhosphoserineBy similarity1
Modified residuei1006N6-acetyllysineBy similarity1
Modified residuei1088PhosphoserineBy similarity1
Modified residuei1089PhosphoserineBy similarity1
Modified residuei1114PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autoacetylated. Autoacetylation at Lys-602 is required for proper function.By similarity
Phosphorylation at Thr-369 by PKB/AKT1 inhibits its interaction with PML and negatively regulates its acetylation activity towards p53/TP53.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TKR9

PRoteomics IDEntifications database

More...
PRIDEi
Q5TKR9

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q5TKR9

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TKR9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TKR9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.

Interacts with RUNX1; phosphorylation of RUNX1 enhances the interaction.

Interacts with RUNX2.

Interacts with p53/TP53.

Interacts with PML and this interaction positively regulates its acetylation activity towards p53/TP53.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000037279

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5TKR9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini95 – 171H15PROSITE-ProRule annotationAdd BLAST77
Domaini502 – 776MYST-type HATPROSITE-ProRule annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 144Required for activation of RUNX1-1By similarityAdd BLAST144
Regioni52 – 166Required for nuclear localizationBy similarityAdd BLAST115
Regioni144 – 662Interaction with PMLBy similarityAdd BLAST519
Regioni312 – 662Interaction with RUNX1-1By similarityAdd BLAST351
Regioni486 – 776CatalyticBy similarityAdd BLAST291
Regioni505 – 808Mediates interaction with BRPF1, required for histone H3 acetyltransferase activityBy similarityAdd BLAST304
Regioni643 – 647Acetyl-CoA bindingBy similarity5
Regioni652 – 658Acetyl-CoA bindingBy similarity7
Regioni1510 – 1735Interaction with PMLBy similarityAdd BLAST226
Regioni1510 – 1635Interaction with RUNX1-2By similarityAdd BLAST126
Regioni1907 – 1942Required for activation of RUNX1-2By similarityAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi988 – 994Poly-Glu7
Compositional biasi1018 – 1025Poly-Arg8
Compositional biasi1028 – 1106Glu-richAdd BLAST79
Compositional biasi1107 – 1113Poly-Glu7
Compositional biasi1141 – 1168Lys-richAdd BLAST28
Compositional biasi1231 – 1237Poly-Glu7
Compositional biasi1262 – 1270Poly-Glu9
Compositional biasi1463 – 1583Ser-richAdd BLAST121
Compositional biasi1586 – 1590Poly-Ser5
Compositional biasi1593 – 1691Gln-richAdd BLAST99
Compositional biasi1665 – 1672Poly-Pro8
Compositional biasi1676 – 1680Poly-Pro5
Compositional biasi1684 – 1690Poly-Pro7
Compositional biasi1884 – 1964Met-richAdd BLAST81

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri199 – 258PHD-type 1PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri255 – 306PHD-type 2PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri535 – 560C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2747, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TKR9

KEGG Orthology (KO)

More...
KOi
K11305

Database of Orthologous Groups

More...
OrthoDBi
629545at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TKR9

TreeFam database of animal gene trees

More...
TreeFami
TF106483

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR002717, HAT_MYST-type
IPR005818, Histone_H1/H5_H15
IPR031280, KAT6A
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
IPR040706, Zf-MYST
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR10615:SF26, PTHR10615:SF26, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01853, MOZ_SAS, 1 hit
PF00628, PHD, 1 hit
PF17772, zf-MYST, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00526, H15, 1 hit
SM00249, PHD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit
SSF55729, SSF55729, 1 hit
SSF57903, SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51504, H15, 1 hit
PS51726, MYST_HAT, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5TKR9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKLANPLYT QWILEAIKKV KKQKQRPSEE RICNAVSSSH GLDRKTVLEQ
60 70 80 90 100
LELSVKDGTI LKVSNKGLNS YKDPDNPGRI ALPKPRNHGK LDNKQSVDWN
110 120 130 140 150
KLLKRAFEGL AESGGSTLKS IERFLKSQKD VSAACGGTAA SGFHQQLRLA
160 170 180 190 200
IKRAVGHGRL LKDGPLYRLN TKAANAEGKE GCESLSCLPP VSLLPHEKDK
210 220 230 240 250
PVAEPIPICS FCLGTKEQNR EKKPEDLISC ADCGNSGHPS CLKFSPELTV
260 270 280 290 300
RVRALRWQCI ECKTCSSCRD QGKNADNMLF CDSCDRGFHM ECCDPPLTRM
310 320 330 340 350
PKGMWICQIC RPRKKGRKLL QKKAAQIKRR YANPIGRPKN RLKKQSTVSK
360 370 380 390 400
GPFSKVRTGP GRGRKRKITV SSQSASSSEE GYLERIDGLD FCRDSSAPLK
410 420 430 440 450
FNKKTKGLID GLTKFFTPSP DGRKARGEAV DYSELRIRKK GNRKSSTSHW
460 470 480 490 500
PTDNQDGWES KQESEERLFG SQEIMTERDM ELFRDIQEQA LQKVGVTGPP
510 520 530 540 550
DPQVRCPSVI EFGKYEIHTW YSSPYPQEYS RLPKLYLCEF CLKYMKSRTI
560 570 580 590 600
LQQHMKKCGW FHPPANEIYR KNNISVFEVD GNVSTIYCQN LCLLAKLFLD
610 620 630 640 650
HKTLYYDVEP FLFYVLTQND VKGCHLVGYF SKEKHCQQKY NVSCIMILPQ
660 670 680 690 700
YQRKGYGRFL IDFSYLLSKR EGQAGSPEKP LSDLGRLSYM AYWKSVILEC
710 720 730 740 750
LYHQNDKQIS IKKLSKLTGV CPQDITSTLH HLRMLDFRSD QFVIIRREKL
760 770 780 790 800
IQDHMAKLQL NLRPVDVDPE CLRWTPVIVS NSVVSEEEDE EADDGEKEEP
810 820 830 840 850
QGQERELETR ERVGKSVSRE NKDQDSSSLI ESEKKPEVKE LASSSRLSKQ
860 870 880 890 900
ALVRDSLPAN SQPPRRGRCG RKNRKTQERF GDKDSKMLVG ETLSTSQEQY
910 920 930 940 950
GECEEKSAAS RERYTEVGEQ PAAPQAQADG NPDIPKGRFS ESADLWRGQL
960 970 980 990 1000
KKSPETLKCR LPEGNDRLPC CYTDGDRAVF RGFSESSEEE EEPESPRSNS
1010 1020 1030 1040 1050
PPVLTKPTLK RKKPILHRRR RVRKRKHHNS SVVTETISET TEVLDEPFED
1060 1070 1080 1090 1100
SDSERPMPRL EPTFEIEEEE EEEDENELFP RGYFHCLSSQ DILRCQASSK
1110 1120 1130 1140 1150
RTASKDEEEE EEESDDADDT PVLKPVSLLR KCDVNSASLE PDTSTPMKKK
1160 1170 1180 1190 1200
KGWPKGKSRK PIHWKKRPGR KPGFKLNQDI IAVSTQECIV EPIVPIKPGR
1210 1220 1230 1240 1250
KPRTQESEEL VEVKEGLVEE RKEEMHTEAD EEAEEEEDAA SSDIRAMSPL
1260 1270 1280 1290 1300
DSSNSPDADP KEPEAEEEEE KPLDDPRQSE EEPQELEEQE QEEEDEVTAE
1310 1320 1330 1340 1350
ANQNEDHDAD DEDDGHLDSL KTKEPEGQPA REDGTEEPGT QESFLDASIQ
1360 1370 1380 1390 1400
DSRENAKDKD ETEADSEEEQ PSHEASVGSE TMPGSEEDHE EDSNTKEELI
1410 1420 1430 1440 1450
ELKEEEEIPH SELDLETVQA VQSLTQEESS EHEGAYQDCE ETLAACQTLQ
1460 1470 1480 1490 1500
SYTHTDEDPQ MSMVEDCHAS EHNSPISSIP SHPSQSVRSV SSPSMPALES
1510 1520 1530 1540 1550
GYTQISPEQG SLSAPSMQNM ETSPMMDVPS VSDHSQQVVD SGFSDLGSIE
1560 1570 1580 1590 1600
STTENYENPS SYDSTMGSSI CGNNSSQSSC SYGGLSSSSS LTQNSCVVTQ
1610 1620 1630 1640 1650
QMASMGNSCS MLQQNSVQPA TNCNIKSPQT CVVERPPSNQ QPPPPPPPPP
1660 1670 1680 1690 1700
PPQQPQPQPQ QQAAPQPPPP QPQQQPPPPP QQQPQPPPPP QQQPPLSQCS
1710 1720 1730 1740 1750
MNNSFTAAPM IMEIPESGGT GNISIYERIP GDFGAGSYSQ PSATFSLAKL
1760 1770 1780 1790 1800
QQLTNTIMDP HAMPYSHSPA VTSYATSVSL SNTGLAQLAP SHPLAGTPQA
1810 1820 1830 1840 1850
QATMTPPPNL APTTMNLTSP LLQCNMSATN IGIPHTQRLQ GQMPVKGHIS
1860 1870 1880 1890 1900
IRSKSAPLPS ATAHQQQLYG RSPPAVAMQA GPRALAVQRG MNMGVNLMPT
1910 1920 1930 1940 1950
PAYNVNSMNM NTLNAMNSYR MTQPMMNSSY HSNPAYMNQT AQYPMQMQMG
1960 1970 1980 1990
MMGSQAYTQQ PMQPNPHGNM MYTGPSHHSY MNAAGVPKQS LNGPYMRR
Length:1,998
Mass (Da):223,331
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37092EED5475855D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MY12A0A0A0MY12_RAT
Histone acetyltransferase
Kat6a
1,998Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K1C6A0A0G2K1C6_RAT
Histone acetyltransferase
Kat6a
1,699Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AABR03100194 Genomic DNA No translation available.
AB195309 mRNA Translation: BAD72833.1

NCBI Reference Sequences

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RefSeqi
NP_001094040.1, NM_001100570.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
306571

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:306571

UCSC genome browser

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UCSCi
RGD:1304892, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03100194 Genomic DNA No translation available.
AB195309 mRNA Translation: BAD72833.1
RefSeqiNP_001094040.1, NM_001100570.2

3D structure databases

SMRiQ5TKR9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037279

PTM databases

CarbonylDBiQ5TKR9
iPTMnetiQ5TKR9
PhosphoSitePlusiQ5TKR9

Proteomic databases

PaxDbiQ5TKR9
PRIDEiQ5TKR9

Genome annotation databases

GeneIDi306571
KEGGirno:306571
UCSCiRGD:1304892, rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7994
RGDi1304892, Kat6a

Phylogenomic databases

eggNOGiKOG2747, Eukaryota
InParanoidiQ5TKR9
KOiK11305
OrthoDBi629545at2759
PhylomeDBiQ5TKR9
TreeFamiTF106483

Enzyme and pathway databases

ReactomeiR-RNO-3214847, HATs acetylate histones
R-RNO-6804758, Regulation of TP53 Activity through Acetylation

Miscellaneous databases

Protein Ontology

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PROi
PR:Q5TKR9

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR002717, HAT_MYST-type
IPR005818, Histone_H1/H5_H15
IPR031280, KAT6A
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
IPR040706, Zf-MYST
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR10615:SF26, PTHR10615:SF26, 1 hit
PfamiView protein in Pfam
PF01853, MOZ_SAS, 1 hit
PF00628, PHD, 1 hit
PF17772, zf-MYST, 1 hit
SMARTiView protein in SMART
SM00526, H15, 1 hit
SM00249, PHD, 2 hits
SUPFAMiSSF46785, SSF46785, 1 hit
SSF55729, SSF55729, 1 hit
SSF57903, SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS51504, H15, 1 hit
PS51726, MYST_HAT, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAT6A_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TKR9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: August 12, 2020
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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