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UniProtKB - Q5TKG3 (CAX1B_ORYSJ)
Protein
Vacuolar cation/proton exchanger 1b
Gene
CAX1b
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
Vacuolar cation/proton exchanger (CAX). Translocates Ca2+ and other metal ions into vacuoles using the proton gradient formed by H+-ATPase and H+-pyrophosphatase.
1 PublicationGO - Molecular functioni
- calcium:proton antiporter activity Source: GO_Central
GO - Biological processi
- calcium ion transmembrane transport Source: GO_Central
- cellular calcium ion homeostasis Source: GO_Central
Keywordsi
Biological process | Antiport, Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar cation/proton exchanger 1bAlternative name(s): Ca(2+)/H(+) exchanger 1b OsCAX1b |
Gene namesi | Name:CAX1b Ordered Locus Names:Os05g0594200, LOC_Os05g51610 ORF Names:OsJ_19769Imported, OSJNBa0030I14.3 |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Subcellular locationi
Vacuole
- Vacuole membrane Curated; Multi-pass membrane protein Curated
Note: Tonoplast.
Vacuole
- plant-type vacuole membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 67 | CytoplasmicSequence analysisAdd BLAST | 67 | |
Transmembranei | 68 – 85 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 86 – 91 | ExtracellularSequence analysis | 6 | |
Transmembranei | 92 – 109 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 110 – 126 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 127 – 147 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 148 – 160 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 161 – 181 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 182 – 194 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 195 – 215 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 216 – 232 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 233 – 253 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 254 – 283 | CytoplasmicSequence analysisAdd BLAST | 30 | |
Transmembranei | 284 – 304 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 305 – 327 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 328 – 348 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 349 – 364 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 365 – 385 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 386 – 388 | ExtracellularSequence analysis | 3 | |
Transmembranei | 389 – 409 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 410 – 414 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 415 – 435 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 436 – 453 | ExtracellularSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Membrane, VacuolePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209498 | 1 – 453 | Vacuolar cation/proton exchanger 1bAdd BLAST | 453 |
Proteomic databases
PaxDbi | Q5TKG3 |
Expressioni
Tissue specificityi
Expressed in embryo and roots.1 Publication
Gene expression databases
Genevisiblei | Q5TKG3, OS |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 136 – 171 | Cation selectionSequence analysisAdd BLAST | 36 | |
Regioni | 335 – 370 | Cation selectionSequence analysisAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. Cation/proton exchanger (CAX) subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1397, Eukaryota |
HOGENOMi | CLU_008721_2_0_1 |
InParanoidi | Q5TKG3 |
OMAi | WHVSRAF |
OrthoDBi | 727723at2759 |
Family and domain databases
Gene3Di | 1.20.1420.30, 1 hit |
InterProi | View protein in InterPro IPR004713, CaH_exchang IPR004798, CAX-like IPR004837, NaCa_Exmemb IPR044880, NCX_ion-bd_dom_sf |
PANTHERi | PTHR31503, PTHR31503, 1 hit |
Pfami | View protein in Pfam PF01699, Na_Ca_ex, 2 hits |
TIGRFAMsi | TIGR00378, cax, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5TKG3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVSRMMMES NTMAKEMAVR HHLLPGSPRR RTAHNLSSSS LRKSSDASLL
60 70 80 90 100
HKVPCAALRS LLANLNDVLL TTRLFLLFPA VLLAIAATYL HFGQVWVFVL
110 120 130 140 150
SLIGLVPLAE RLSFLTEQIA FYTGPTVGGL LNATFGNVTE VIIALLALRE
160 170 180 190 200
GKIEVVKCSL LGSILSNLLL VLGTSLFLAG IANLRAHQPY DTKQAHVNTA
210 220 230 240 250
LLMLAVLCHS LPLMLRYAVT SGDHAIVSGD AALHLSRACS ILMLIAYLAY
260 270 280 290 300
LFFQLNTHRQ LFEPQQVEDD DDDDLVIAQD DEPVLGFSSA MIWLALMTLL
310 320 330 340 350
TALLSGYVVS TIEAASESWE LSVSFISIIL LPIVGNAAEH AGAVIFALKN
360 370 380 390 400
KMDITLGVSL GSATQISMFV VPVSVIVAWT MGIPMDLDFN LLETGSLFLA
410 420 430 440 450
ILVTAFTLQE GESHYLKGLI LVLCYAVISV CFFVIRRRSA GGTDGVHHLD
VIV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB112770 mRNA Translation: BAD83660.1 AC136217 Genomic DNA Translation: AAV59377.1 AP008211 Genomic DNA Translation: BAF18420.1 AP014961 Genomic DNA Translation: BAS95656.1 CM000142 Genomic DNA Translation: EEE64909.1 AK069021 mRNA Translation: BAG91219.1 |
RefSeqi | XP_015637691.1, XM_015782205.1 |
Genome annotation databases
EnsemblPlantsi | Os05t0594200-01; Os05t0594200-01; Os05g0594200 |
GeneIDi | 4339806 |
Gramenei | Os05t0594200-01; Os05t0594200-01; Os05g0594200 |
KEGGi | osa:4339806 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB112770 mRNA Translation: BAD83660.1 AC136217 Genomic DNA Translation: AAV59377.1 AP008211 Genomic DNA Translation: BAF18420.1 AP014961 Genomic DNA Translation: BAS95656.1 CM000142 Genomic DNA Translation: EEE64909.1 AK069021 mRNA Translation: BAG91219.1 |
RefSeqi | XP_015637691.1, XM_015782205.1 |
3D structure databases
SMRi | Q5TKG3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4530.OS05T0594200-01 |
Proteomic databases
PaxDbi | Q5TKG3 |
Genome annotation databases
EnsemblPlantsi | Os05t0594200-01; Os05t0594200-01; Os05g0594200 |
GeneIDi | 4339806 |
Gramenei | Os05t0594200-01; Os05t0594200-01; Os05g0594200 |
KEGGi | osa:4339806 |
Phylogenomic databases
eggNOGi | KOG1397, Eukaryota |
HOGENOMi | CLU_008721_2_0_1 |
InParanoidi | Q5TKG3 |
OMAi | WHVSRAF |
OrthoDBi | 727723at2759 |
Gene expression databases
Genevisiblei | Q5TKG3, OS |
Family and domain databases
Gene3Di | 1.20.1420.30, 1 hit |
InterProi | View protein in InterPro IPR004713, CaH_exchang IPR004798, CAX-like IPR004837, NaCa_Exmemb IPR044880, NCX_ion-bd_dom_sf |
PANTHERi | PTHR31503, PTHR31503, 1 hit |
Pfami | View protein in Pfam PF01699, Na_Ca_ex, 2 hits |
TIGRFAMsi | TIGR00378, cax, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CAX1B_ORYSJ | |
Accessioni | Q5TKG3Primary (citable) accession number: Q5TKG3 Secondary accession number(s): Q0DFF3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 23, 2022 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations - SIMILARITY comments
Index of protein domains and families