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Entry version 103 (23 Feb 2022)
Sequence version 1 (21 Dec 2004)
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Protein

Vacuolar cation/proton exchanger 1b

Gene

CAX1b

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Vacuolar cation/proton exchanger (CAX). Translocates Ca2+ and other metal ions into vacuoles using the proton gradient formed by H+-ATPase and H+-pyrophosphatase.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Calcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar cation/proton exchanger 1b
Alternative name(s):
Ca(2+)/H(+) exchanger 1b
OsCAX1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAX1b
Ordered Locus Names:Os05g0594200, LOC_Os05g51610
ORF Names:OsJ_19769Imported, OSJNBa0030I14.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryza sativa subsp. japonica (Rice)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39947 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007752 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5
  • UP000059680 Componenti: Chromosome 5
  • UP000000763 Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 67CytoplasmicSequence analysisAdd BLAST67
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei68 – 85HelicalSequence analysisAdd BLAST18
Topological domaini86 – 91ExtracellularSequence analysis6
Transmembranei92 – 109HelicalSequence analysisAdd BLAST18
Topological domaini110 – 126CytoplasmicSequence analysisAdd BLAST17
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 160ExtracellularSequence analysisAdd BLAST13
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 194CytoplasmicSequence analysisAdd BLAST13
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 232ExtracellularSequence analysisAdd BLAST17
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 283CytoplasmicSequence analysisAdd BLAST30
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Topological domaini305 – 327ExtracellularSequence analysisAdd BLAST23
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Topological domaini349 – 364CytoplasmicSequence analysisAdd BLAST16
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386 – 388ExtracellularSequence analysis3
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Topological domaini410 – 414CytoplasmicSequence analysis5
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 453ExtracellularSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002094981 – 453Vacuolar cation/proton exchanger 1bAdd BLAST453

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TKG3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in embryo and roots.1 Publication

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TKG3, OS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4530.OS05T0594200-01

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5TKG3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni136 – 171Cation selectionSequence analysisAdd BLAST36
Regioni335 – 370Cation selectionSequence analysisAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1397, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008721_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TKG3

Identification of Orthologs from Complete Genome Data

More...
OMAi
WHVSRAF

Database of Orthologous Groups

More...
OrthoDBi
727723at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1420.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004713, CaH_exchang
IPR004798, CAX-like
IPR004837, NaCa_Exmemb
IPR044880, NCX_ion-bd_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR31503, PTHR31503, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01699, Na_Ca_ex, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00378, cax, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5TKG3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVSRMMMES NTMAKEMAVR HHLLPGSPRR RTAHNLSSSS LRKSSDASLL
60 70 80 90 100
HKVPCAALRS LLANLNDVLL TTRLFLLFPA VLLAIAATYL HFGQVWVFVL
110 120 130 140 150
SLIGLVPLAE RLSFLTEQIA FYTGPTVGGL LNATFGNVTE VIIALLALRE
160 170 180 190 200
GKIEVVKCSL LGSILSNLLL VLGTSLFLAG IANLRAHQPY DTKQAHVNTA
210 220 230 240 250
LLMLAVLCHS LPLMLRYAVT SGDHAIVSGD AALHLSRACS ILMLIAYLAY
260 270 280 290 300
LFFQLNTHRQ LFEPQQVEDD DDDDLVIAQD DEPVLGFSSA MIWLALMTLL
310 320 330 340 350
TALLSGYVVS TIEAASESWE LSVSFISIIL LPIVGNAAEH AGAVIFALKN
360 370 380 390 400
KMDITLGVSL GSATQISMFV VPVSVIVAWT MGIPMDLDFN LLETGSLFLA
410 420 430 440 450
ILVTAFTLQE GESHYLKGLI LVLCYAVISV CFFVIRRRSA GGTDGVHHLD

VIV
Length:453
Mass (Da):49,109
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF2F0492165156CA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB112770 mRNA Translation: BAD83660.1
AC136217 Genomic DNA Translation: AAV59377.1
AP008211 Genomic DNA Translation: BAF18420.1
AP014961 Genomic DNA Translation: BAS95656.1
CM000142 Genomic DNA Translation: EEE64909.1
AK069021 mRNA Translation: BAG91219.1

NCBI Reference Sequences

More...
RefSeqi
XP_015637691.1, XM_015782205.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
Os05t0594200-01; Os05t0594200-01; Os05g0594200

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4339806

Gramene; a comparative resource for plants

More...
Gramenei
Os05t0594200-01; Os05t0594200-01; Os05g0594200

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
osa:4339806

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB112770 mRNA Translation: BAD83660.1
AC136217 Genomic DNA Translation: AAV59377.1
AP008211 Genomic DNA Translation: BAF18420.1
AP014961 Genomic DNA Translation: BAS95656.1
CM000142 Genomic DNA Translation: EEE64909.1
AK069021 mRNA Translation: BAG91219.1
RefSeqiXP_015637691.1, XM_015782205.1

3D structure databases

SMRiQ5TKG3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4530.OS05T0594200-01

Proteomic databases

PaxDbiQ5TKG3

Genome annotation databases

EnsemblPlantsiOs05t0594200-01; Os05t0594200-01; Os05g0594200
GeneIDi4339806
GrameneiOs05t0594200-01; Os05t0594200-01; Os05g0594200
KEGGiosa:4339806

Phylogenomic databases

eggNOGiKOG1397, Eukaryota
HOGENOMiCLU_008721_2_0_1
InParanoidiQ5TKG3
OMAiWHVSRAF
OrthoDBi727723at2759

Gene expression databases

GenevisibleiQ5TKG3, OS

Family and domain databases

Gene3Di1.20.1420.30, 1 hit
InterProiView protein in InterPro
IPR004713, CaH_exchang
IPR004798, CAX-like
IPR004837, NaCa_Exmemb
IPR044880, NCX_ion-bd_dom_sf
PANTHERiPTHR31503, PTHR31503, 1 hit
PfamiView protein in Pfam
PF01699, Na_Ca_ex, 2 hits
TIGRFAMsiTIGR00378, cax, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAX1B_ORYSJ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TKG3
Secondary accession number(s): Q0DFF3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 21, 2004
Last modified: February 23, 2022
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families
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