LIN9

Functionⁱ

Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.2 Publications

GO - Molecular functionⁱ

DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
DNA biosynthetic process Source: UniProtKB-KW
regulation of cell cycle Source: Reactome
reproduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription, DNA-templated Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, DNA synthesis

Biological process

Cell cycle, DNA synthesis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1538133 G0 and Early G1 R-HSA-156711 Polo-like kinase mediated events R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
SIGNORⁱ	Q5TKA1

Reactomeⁱ

R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133 G0 and Early G1
R-HSA-156711 Polo-like kinase mediated events
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry

SIGNORⁱ

Q5TKA1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein lin-9 homolog Short name: HuLin-9 Short name: hLin-9 Alternative name(s): Beta subunit-associated regulator of apoptosis TUDOR gene similar protein Type I interferon receptor beta chain-associated protein pRB-associated protein
Gene namesⁱ	Name:LIN9 Synonyms:BARA, TGS
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000183814.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30830 LIN9
MIMⁱ	609375 gene
neXtProtⁱ	NX_Q5TKA1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	286826
Open Targets More...OpenTargetsⁱ	ENSG00000183814
PharmGKBⁱ	PA134970771

Polymorphism and mutation databases

BioMutaⁱ	LIN9
DMDMⁱ	74708186

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000249546	2 – 542	Protein lin-9 homologAdd BLAST		541

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Cross-linkⁱ	21	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	65	PhosphoserineCombined sources	1
Modified residueⁱ	95	PhosphoserineBy similarity	1
Modified residueⁱ	96	PhosphothreonineCombined sources	1
Modified residueⁱ	304	PhosphothreonineCombined sources	1
Modified residueⁱ	309	PhosphoserineCombined sources	1
Modified residueⁱ	321	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q5TKA1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5TKA1
PaxDbⁱ	Q5TKA1
PeptideAtlas More...PeptideAtlasⁱ	Q5TKA1
PRIDEⁱ	Q5TKA1
ProteomicsDBⁱ	65201 65202 [Q5TKA1-2] 65203 [Q5TKA1-3]

PTM databases

iPTMnetⁱ	Q5TKA1
PhosphoSitePlusⁱ	Q5TKA1

Expressionⁱ

Tissue specificityⁱ

Expressed in thymus and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000183814 Expressed in 158 organ(s), highest expression level in heart
CleanExⁱ	HS_LIN9
ExpressionAtlasⁱ	Q5TKA1 baseline and differential
Genevisibleⁱ	Q5TKA1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030241

HPAⁱ

HPA030241

Interactionⁱ

Subunit structureⁱ

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RB1.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
E2F4	Q16254	3	EBI-1389424,EBI-448943
MYBL2	P10244	7	EBI-1389424,EBI-1389468

Protein-protein interaction databases

BioGridⁱ	130420, 34 interactors
CORUMⁱ	Q5TKA1
IntActⁱ	Q5TKA1, 17 interactors
Molecular INTeraction database More...MINTⁱ	Q5TKA1
STRINGⁱ	9606.ENSP00000329102

Structureⁱ

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 296	Sufficient for interaction with RB11 PublicationAdd BLAST		295

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	354 – 413	Sequence analysisAdd BLAST		60

Sequence similaritiesⁱ

Belongs to the lin-9 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG1019 Eukaryota ENOG410YA1T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003188
HOGENOMⁱ	HOG000007517
HOVERGENⁱ	HBG057743
InParanoidⁱ	Q5TKA1
KEGG Orthology (KO) More...KOⁱ	K21773
PhylomeDBⁱ	Q5TKA1
TreeFamⁱ	TF314315

Family and domain databases

InterProⁱ	View protein in InterPro IPR033471 DIRP IPR010561 LIN-9/ALY1
PANTHERⁱ	PTHR21689 PTHR21689, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06584 DIRP, 1 hit
SMARTⁱ	View protein in SMART SM01135 DIRP, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q5TKA1-1) [UniParc]FASTA Add to basket

Also known as: Lin9-L, Long form

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELDQLPDE SSSAKALVSL KEGSLSNTWN EKYSSLQKTP VWKGRNTSSA 
        60         70         80         90        100
VEMPFRNSKR SRLFSDEDDR QINTRSPKRN QRVAMVPQKF TATMSTPDKK 
       110        120        130        140        150
ASQKIGFRLR NLLKLPKAHK WCIYEWFYSN IDKPLFEGDN DFCVCLKESF 
       160        170        180        190        200
PNLKTRKLTR VEWGKIRRLM GKPRRCSSAF FEEERSALKQ KRQKIRLLQQ 
       210        220        230        240        250
RKVADVSQFK DLPDEIPLPL VIGTKVTARL RGVHDGLFTG QIDAVDTLNA 
       260        270        280        290        300
TYRVTFDRTG LGTHTIPDYE VLSNEPHETM PIAAFGQKQR PSRFFMTPPR 
       310        320        330        340        350
LHYTPPLQSP IIDNDPLLGQ SPWRSKISGS DTETLGGFPV EFLIQVTRLS 
       360        370        380        390        400
KILMIKKEHI KKLREMNTEA EKLKSYSMPI SIEFQRRYAT IVLELEQLNK 
       410        420        430        440        450
DLNKVLHKVQ QYCYELAPDQ GLQPADQPTD MRRRCEEEAQ EIVRHANSST 
       460        470        480        490        500
GQPCVENENL TDLISRLTAI LLQIKCLAEG GDLNSFEFKS LTDSLNDIKS 
       510        520        530        540 
TIDASNISCF QNNVEIHVAH IQSGLSQMGN LHAFAANNTN RD

Length:542

Mass (Da):61,946

Last modified:December 21, 2004 - v1

Checksum:ⁱ1107865E6FF33037

GO

Isoform 2 (identifier: Q5TKA1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MHRGGQPLKKRRGSFKM

« Hide

        10         20         30         40         50
MHRGGQPLKK RRGSFKMAEL DQLPDESSSA KALVSLKEGS LSNTWNEKYS 
        60         70         80         90        100
SLQKTPVWKG RNTSSAVEMP FRNSKRSRLF SDEDDRQINT RSPKRNQRVA 
       110        120        130        140        150
MVPQKFTATM STPDKKASQK IGFRLRNLLK LPKAHKWCIY EWFYSNIDKP 
       160        170        180        190        200
LFEGDNDFCV CLKESFPNLK TRKLTRVEWG KIRRLMGKPR RCSSAFFEEE 
       210        220        230        240        250
RSALKQKRQK IRLLQQRKVA DVSQFKDLPD EIPLPLVIGT KVTARLRGVH 
       260        270        280        290        300
DGLFTGQIDA VDTLNATYRV TFDRTGLGTH TIPDYEVLSN EPHETMPIAA 
       310        320        330        340        350
FGQKQRPSRF FMTPPRLHYT PPLQSPIIDN DPLLGQSPWR SKISGSDTET 
       360        370        380        390        400
LGGFPVEFLI QVTRLSKILM IKKEHIKKLR EMNTEAEKLK SYSMPISIEF 
       410        420        430        440        450
QRRYATIVLE LEQLNKDLNK VLHKVQQYCY ELAPDQGLQP ADQPTDMRRR 
       460        470        480        490        500
CEEEAQEIVR HANSSTGQPC VENENLTDLI SRLTAILLQI KCLAEGGDLN 
       510        520        530        540        550
SFEFKSLTDS LNDIKSTIDA SNISCFQNNV EIHVAHIQSG LSQMGNLHAF 

AANNTNRD

Show »

Length:558

Mass (Da):63,811

Checksum:ⁱ90ECE86266AF02CE

GO

Isoform 3 (identifier: Q5TKA1-3) [UniParc]FASTA Add to basket

Also known as: Lin9-S, Short form

The sequence of this isoform differs from the canonical sequence as follows:
54-88: Missing.

« Hide

        10         20         30         40         50
MAELDQLPDE SSSAKALVSL KEGSLSNTWN EKYSSLQKTP VWKGRNTSSA 
        60         70         80         90        100
VEMKFTATMS TPDKKASQKI GFRLRNLLKL PKAHKWCIYE WFYSNIDKPL 
       110        120        130        140        150
FEGDNDFCVC LKESFPNLKT RKLTRVEWGK IRRLMGKPRR CSSAFFEEER 
       160        170        180        190        200
SALKQKRQKI RLLQQRKVAD VSQFKDLPDE IPLPLVIGTK VTARLRGVHD 
       210        220        230        240        250
GLFTGQIDAV DTLNATYRVT FDRTGLGTHT IPDYEVLSNE PHETMPIAAF 
       260        270        280        290        300
GQKQRPSRFF MTPPRLHYTP PLQSPIIDND PLLGQSPWRS KISGSDTETL 
       310        320        330        340        350
GGFPVEFLIQ VTRLSKILMI KKEHIKKLRE MNTEAEKLKS YSMPISIEFQ 
       360        370        380        390        400
RRYATIVLEL EQLNKDLNKV LHKVQQYCYE LAPDQGLQPA DQPTDMRRRC 
       410        420        430        440        450
EEEAQEIVRH ANSSTGQPCV ENENLTDLIS RLTAILLQIK CLAEGGDLNS 
       460        470        480        490        500
FEFKSLTDSL NDIKSTIDAS NISCFQNNVE IHVAHIQSGL SQMGNLHAFA 

ANNTNRD

Show »

Length:507

Mass (Da):57,733

Checksum:ⁱB657E9DD7A2882F0

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y322	H0Y322_HUMAN	Protein lin-9 homolog Protein lin-9 homolog	LIN9	613	Annotation score:
C9J5J4	C9J5J4_HUMAN	Protein lin-9 homolog Protein lin-9 homolog	LIN9	489	Annotation score:
H7C4T7	H7C4T7_HUMAN	Protein lin-9 homolog Protein lin-9 homolog	LIN9	518	Annotation score:
B1B047	B1B047_HUMAN	Protein lin-9 homolog Protein lin-9 homolog	LIN9	71	Annotation score:

Sequence cautionⁱ

The sequence AAH43444 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAD97871 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	436	E → V in AAH43444 (PubMed:15489334).Curated		1
Sequence conflictⁱ	508	S → R in AAV41873 (PubMed:15538385).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_020509	1	M → MHRGGQPLKKRRGSFKM in isoform 2. 1 Publication		1
Alternative sequenceⁱVSP_020510	54 – 88	Missing in isoform 3. 2 PublicationsAdd BLAST		35

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY786184 mRNA Translation: AAV41873.1 AF190323 mRNA Translation: AAQ13710.1 AF190324 mRNA Translation: AAQ13711.1 AK126177 mRNA Translation: BAC86475.1 BX537869 mRNA Translation: CAD97871.1 Different initiation. BC043444 mRNA Translation: AAH43444.1 Different initiation. BC045625 mRNA Translation: AAH45625.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1553.1 [Q5TKA1-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001257338.1, NM_001270409.1 NP_001257339.1, NM_001270410.1 NP_775106.2, NM_173083.3 [Q5TKA1-2]
UniGeneⁱ	Hs.120817

Genome annotation databases

Ensemblⁱ	ENST00000328205; ENSP00000329102; ENSG00000183814 [Q5TKA1-2]
GeneIDⁱ	286826
KEGGⁱ	hsa:286826
UCSC genome browser More...UCSCⁱ	uc001hqa.4 human [Q5TKA1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5TKA1	LIN9 isoform 2		PANTR		558	UniRef100_Q5TKA1
protein lin-9 homolog		Yangtze finless porpoise		165
Protein lin-9 homolog (Fragment)		HUMAN		71
LIN9 isoform 5 (Fragment)		PONAB		71
Uncharacterized protein		PANPA		558
+6
Q5TKA1-3	Uncharacterized protein		PANPA		523	UniRef100_A0A2R9A8K6
Protein lin-9 homolog (Fragment)		HUMAN		518
LIN9 isoform 1 (Fragment)		PANTR		518
UPI0008F54F90		GORGO		455
UPI000D098EB3		PANTR		748

Protein	Similar proteins		Species	Score	Length	Source
Q5TKA1	LIN9 isoform 2		PANTR		558	UniRef90_Q5TKA1
protein lin-9 homolog		Yangtze finless porpoise		165
Protein lin-9 homolog (Fragment)		HUMAN		71
LIN9 isoform 5 (Fragment)		PONAB		71
Uncharacterized protein		PANPA		558
+9
Q5TKA1-3	Uncharacterized protein		PANPA		523	UniRef90_A0A2R9A8K6
Protein lin-9 homolog (Fragment)		HUMAN		518
LIN9 isoform 1 (Fragment)		PANTR		518
UPI0008F54F90		GORGO		455
UPI000D098EB3		PANTR		748

Protein	Similar proteins		Species	Score	Length	Source
Q5TKA1	Protein lin-9 homolog		MACFA		542	UniRef50_Q5TKA1
LIN9 isoform 2		PANTR		558
protein lin-9 homolog		Yangtze finless porpoise		165
Protein lin-9 homolog (Fragment)		HUMAN		71
LIN9 isoform 5 (Fragment)		PONAB		71
+46

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY786184 mRNA Translation: AAV41873.1 AF190323 mRNA Translation: AAQ13710.1 AF190324 mRNA Translation: AAQ13711.1 AK126177 mRNA Translation: BAC86475.1 BX537869 mRNA Translation: CAD97871.1 Different initiation. BC043444 mRNA Translation: AAH43444.1 Different initiation. BC045625 mRNA Translation: AAH45625.1
CCDSⁱ	CCDS1553.1 [Q5TKA1-2]
RefSeqⁱ	NP_001257338.1, NM_001270409.1 NP_001257339.1, NM_001270410.1 NP_775106.2, NM_173083.3 [Q5TKA1-2]
UniGeneⁱ	Hs.120817

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6C48	X-ray	2.32	A/D	333-450	[»]
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	130420, 34 interactors
CORUMⁱ	Q5TKA1
IntActⁱ	Q5TKA1, 17 interactors
MINTⁱ	Q5TKA1
STRINGⁱ	9606.ENSP00000329102

PTM databases

iPTMnetⁱ	Q5TKA1
PhosphoSitePlusⁱ	Q5TKA1

Polymorphism and mutation databases

BioMutaⁱ	LIN9
DMDMⁱ	74708186

Proteomic databases

EPDⁱ	Q5TKA1
MaxQBⁱ	Q5TKA1
PaxDbⁱ	Q5TKA1
PeptideAtlasⁱ	Q5TKA1
PRIDEⁱ	Q5TKA1
ProteomicsDBⁱ	65201 65202 [Q5TKA1-2] 65203 [Q5TKA1-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000328205; ENSP00000329102; ENSG00000183814 [Q5TKA1-2]
GeneIDⁱ	286826
KEGGⁱ	hsa:286826
UCSCⁱ	uc001hqa.4 human [Q5TKA1-1]

Organism-specific databases

CTDⁱ	286826
DisGeNETⁱ	286826
EuPathDBⁱ	HostDB:ENSG00000183814.15
GeneCardsⁱ	LIN9
HGNCⁱ	HGNC:30830 LIN9
HPAⁱ	HPA030241
MIMⁱ	609375 gene
neXtProtⁱ	NX_Q5TKA1
OpenTargetsⁱ	ENSG00000183814
PharmGKBⁱ	PA134970771
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1019 Eukaryota ENOG410YA1T LUCA
GeneTreeⁱ	ENSGT00390000003188
HOGENOMⁱ	HOG000007517
HOVERGENⁱ	HBG057743
InParanoidⁱ	Q5TKA1
KOⁱ	K21773
PhylomeDBⁱ	Q5TKA1
TreeFamⁱ	TF314315

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1538133 G0 and Early G1 R-HSA-156711 Polo-like kinase mediated events R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
SIGNORⁱ	Q5TKA1

Reactomeⁱ

R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133 G0 and Early G1
R-HSA-156711 Polo-like kinase mediated events
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry

SIGNORⁱ

Q5TKA1

Miscellaneous databases

ChiTaRSⁱ	LIN9 human
GeneWikiⁱ	LIN9
GenomeRNAiⁱ	286826
Protein Ontology More...PROⁱ	PR:Q5TKA1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000183814 Expressed in 158 organ(s), highest expression level in heart
CleanExⁱ	HS_LIN9
ExpressionAtlasⁱ	Q5TKA1 baseline and differential
Genevisibleⁱ	Q5TKA1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR033471 DIRP IPR010561 LIN-9/ALY1
PANTHERⁱ	PTHR21689 PTHR21689, 1 hit
Pfamⁱ	View protein in Pfam PF06584 DIRP, 1 hit
SMARTⁱ	View protein in SMART SM01135 DIRP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LIN9_HUMAN
Accessionⁱ	Q5TKA1Primary (citable) accession number: Q5TKA1 Secondary accession number(s): Q5U5L8 , Q5U7E1, Q6PI55, Q6ZTV4, Q7Z3J1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
	Last sequence update:	December 21, 2004
	Last modified:	November 7, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q5TKA1 (LIN9_HUMAN)

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Protein lin-9 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ