UniProtKB - Q5TKA1 (LIN9_HUMAN)
Protein lin-9 homolog
LIN9
Functioni
GO - Molecular functioni
- DNA binding Source: GO_Central
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- DNA biosynthetic process Source: UniProtKB-KW
- regulation of cell cycle Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- reproduction Source: GO_Central
- transcription, DNA-templated Source: InterPro
Keywordsi
Biological process | Cell cycle, DNA synthesis |
Enzyme and pathway databases
PathwayCommonsi | Q5TKA1 |
Reactomei | R-HSA-1362277, Transcription of E2F targets under negative control by DREAM complex R-HSA-1362300, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1538133, G0 and Early G1 R-HSA-156711, Polo-like kinase mediated events R-HSA-69202, Cyclin E associated events during G1/S transition R-HSA-69205, G1/S-Specific Transcription R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry |
SIGNORi | Q5TKA1 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein lin-9 homologShort name: HuLin-9 Short name: hLin-9 Alternative name(s): Beta subunit-associated regulator of apoptosis TUDOR gene similar protein Type I interferon receptor beta chain-associated protein pRB-associated protein |
Gene namesi | Name:LIN9 Synonyms:BARA, TGS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30830, LIN9 |
MIMi | 609375, gene |
neXtProti | NX_Q5TKA1 |
VEuPathDBi | HostDB:ENSG00000183814.15 |
Subcellular locationi
Nucleus
- nucleoplasm 2 Publications
Note: Found in perinucleolar structures. Associated with chromatin.
Nucleus
- nucleoplasm Source: HPA
Other locations
- transcription repressor complex Source: InterPro
Keywords - Cellular componenti
NucleusPathology & Biotechi
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 286826 |
OpenTargetsi | ENSG00000183814 |
PharmGKBi | PA134970771 |
Miscellaneous databases
Pharosi | Q5TKA1, Tbio |
Genetic variation databases
BioMutai | LIN9 |
DMDMi | 74708186 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000249546 | 2 – 542 | Protein lin-9 homologAdd BLAST | 541 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Cross-linki | 21 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 65 | PhosphoserineCombined sources | 1 | |
Modified residuei | 95 | PhosphoserineBy similarity | 1 | |
Modified residuei | 96 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 304 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 309 | PhosphoserineCombined sources | 1 | |
Modified residuei | 321 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q5TKA1 |
jPOSTi | Q5TKA1 |
MassIVEi | Q5TKA1 |
MaxQBi | Q5TKA1 |
PaxDbi | Q5TKA1 |
PeptideAtlasi | Q5TKA1 |
PRIDEi | Q5TKA1 |
ProteomicsDBi | 65201 [Q5TKA1-1] 65202 [Q5TKA1-2] 65203 [Q5TKA1-3] |
PTM databases
iPTMneti | Q5TKA1 |
PhosphoSitePlusi | Q5TKA1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000183814, Expressed in heart and 178 other tissues |
ExpressionAtlasi | Q5TKA1, baseline and differential |
Genevisiblei | Q5TKA1, HS |
Organism-specific databases
HPAi | ENSG00000183814, Low tissue specificity |
Interactioni
Subunit structurei
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.
Interacts with RB1.
3 PublicationsBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 130420, 40 interactors |
CORUMi | Q5TKA1 |
IntActi | Q5TKA1, 29 interactors |
MINTi | Q5TKA1 |
STRINGi | 9606.ENSP00000329102 |
Miscellaneous databases
RNActi | Q5TKA1, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q5TKA1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 296 | Sufficient for interaction with RB11 PublicationAdd BLAST | 295 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 354 – 413 | Sequence analysisAdd BLAST | 60 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1019, Eukaryota |
GeneTreei | ENSGT00390000003188 |
InParanoidi | Q5TKA1 |
OrthoDBi | 622946at2759 |
PhylomeDBi | Q5TKA1 |
TreeFami | TF314315 |
Family and domain databases
InterProi | View protein in InterPro IPR033471, DIRP IPR010561, LIN-9/ALY1 |
PANTHERi | PTHR21689, PTHR21689, 1 hit |
Pfami | View protein in Pfam PF06584, DIRP, 1 hit |
SMARTi | View protein in SMART SM01135, DIRP, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAELDQLPDE SSSAKALVSL KEGSLSNTWN EKYSSLQKTP VWKGRNTSSA
60 70 80 90 100
VEMPFRNSKR SRLFSDEDDR QINTRSPKRN QRVAMVPQKF TATMSTPDKK
110 120 130 140 150
ASQKIGFRLR NLLKLPKAHK WCIYEWFYSN IDKPLFEGDN DFCVCLKESF
160 170 180 190 200
PNLKTRKLTR VEWGKIRRLM GKPRRCSSAF FEEERSALKQ KRQKIRLLQQ
210 220 230 240 250
RKVADVSQFK DLPDEIPLPL VIGTKVTARL RGVHDGLFTG QIDAVDTLNA
260 270 280 290 300
TYRVTFDRTG LGTHTIPDYE VLSNEPHETM PIAAFGQKQR PSRFFMTPPR
310 320 330 340 350
LHYTPPLQSP IIDNDPLLGQ SPWRSKISGS DTETLGGFPV EFLIQVTRLS
360 370 380 390 400
KILMIKKEHI KKLREMNTEA EKLKSYSMPI SIEFQRRYAT IVLELEQLNK
410 420 430 440 450
DLNKVLHKVQ QYCYELAPDQ GLQPADQPTD MRRRCEEEAQ EIVRHANSST
460 470 480 490 500
GQPCVENENL TDLISRLTAI LLQIKCLAEG GDLNSFEFKS LTDSLNDIKS
510 520 530 540
TIDASNISCF QNNVEIHVAH IQSGLSQMGN LHAFAANNTN RD
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y322 | H0Y322_HUMAN | Protein lin-9 homolog | LIN9 | 613 | Annotation score: | ||
C9J5J4 | C9J5J4_HUMAN | Protein lin-9 homolog | LIN9 | 489 | Annotation score: | ||
H7C4T7 | H7C4T7_HUMAN | Protein lin-9 homolog | LIN9 | 518 | Annotation score: | ||
B1B047 | B1B047_HUMAN | Protein lin-9 homolog | LIN9 | 71 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 436 | E → V in AAH43444 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 508 | S → R in AAV41873 (PubMed:15538385).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020509 | 1 | M → MHRGGQPLKKRRGSFKM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_020510 | 54 – 88 | Missing in isoform 3. 2 PublicationsAdd BLAST | 35 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY786184 mRNA Translation: AAV41873.1 AF190323 mRNA Translation: AAQ13710.1 AF190324 mRNA Translation: AAQ13711.1 AK126177 mRNA Translation: BAC86475.1 BX537869 mRNA Translation: CAD97871.1 Different initiation. BC043444 mRNA Translation: AAH43444.1 Different initiation. BC045625 mRNA Translation: AAH45625.1 |
CCDSi | CCDS1553.1 [Q5TKA1-2] |
RefSeqi | NP_001257338.1, NM_001270409.1 NP_001257339.1, NM_001270410.1 NP_775106.2, NM_173083.3 [Q5TKA1-2] |
Genome annotation databases
Ensembli | ENST00000328205; ENSP00000329102; ENSG00000183814 [Q5TKA1-2] |
GeneIDi | 286826 |
KEGGi | hsa:286826 |
UCSCi | uc001hqa.4, human [Q5TKA1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY786184 mRNA Translation: AAV41873.1 AF190323 mRNA Translation: AAQ13710.1 AF190324 mRNA Translation: AAQ13711.1 AK126177 mRNA Translation: BAC86475.1 BX537869 mRNA Translation: CAD97871.1 Different initiation. BC043444 mRNA Translation: AAH43444.1 Different initiation. BC045625 mRNA Translation: AAH45625.1 |
CCDSi | CCDS1553.1 [Q5TKA1-2] |
RefSeqi | NP_001257338.1, NM_001270409.1 NP_001257339.1, NM_001270410.1 NP_775106.2, NM_173083.3 [Q5TKA1-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6C48 | X-ray | 2.32 | A/D | 333-450 | [»] | |
SMRi | Q5TKA1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 130420, 40 interactors |
CORUMi | Q5TKA1 |
IntActi | Q5TKA1, 29 interactors |
MINTi | Q5TKA1 |
STRINGi | 9606.ENSP00000329102 |
PTM databases
iPTMneti | Q5TKA1 |
PhosphoSitePlusi | Q5TKA1 |
Genetic variation databases
BioMutai | LIN9 |
DMDMi | 74708186 |
Proteomic databases
EPDi | Q5TKA1 |
jPOSTi | Q5TKA1 |
MassIVEi | Q5TKA1 |
MaxQBi | Q5TKA1 |
PaxDbi | Q5TKA1 |
PeptideAtlasi | Q5TKA1 |
PRIDEi | Q5TKA1 |
ProteomicsDBi | 65201 [Q5TKA1-1] 65202 [Q5TKA1-2] 65203 [Q5TKA1-3] |
Protocols and materials databases
Antibodypediai | 34650, 138 antibodies |
Genome annotation databases
Ensembli | ENST00000328205; ENSP00000329102; ENSG00000183814 [Q5TKA1-2] |
GeneIDi | 286826 |
KEGGi | hsa:286826 |
UCSCi | uc001hqa.4, human [Q5TKA1-1] |
Organism-specific databases
CTDi | 286826 |
DisGeNETi | 286826 |
GeneCardsi | LIN9 |
HGNCi | HGNC:30830, LIN9 |
HPAi | ENSG00000183814, Low tissue specificity |
MIMi | 609375, gene |
neXtProti | NX_Q5TKA1 |
OpenTargetsi | ENSG00000183814 |
PharmGKBi | PA134970771 |
VEuPathDBi | HostDB:ENSG00000183814.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1019, Eukaryota |
GeneTreei | ENSGT00390000003188 |
InParanoidi | Q5TKA1 |
OrthoDBi | 622946at2759 |
PhylomeDBi | Q5TKA1 |
TreeFami | TF314315 |
Enzyme and pathway databases
PathwayCommonsi | Q5TKA1 |
Reactomei | R-HSA-1362277, Transcription of E2F targets under negative control by DREAM complex R-HSA-1362300, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1538133, G0 and Early G1 R-HSA-156711, Polo-like kinase mediated events R-HSA-69202, Cyclin E associated events during G1/S transition R-HSA-69205, G1/S-Specific Transcription R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry |
SIGNORi | Q5TKA1 |
Miscellaneous databases
BioGRID-ORCSi | 286826, 309 hits in 884 CRISPR screens |
ChiTaRSi | LIN9, human |
GeneWikii | LIN9 |
GenomeRNAii | 286826 |
Pharosi | Q5TKA1, Tbio |
PROi | PR:Q5TKA1 |
RNActi | Q5TKA1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183814, Expressed in heart and 178 other tissues |
ExpressionAtlasi | Q5TKA1, baseline and differential |
Genevisiblei | Q5TKA1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033471, DIRP IPR010561, LIN-9/ALY1 |
PANTHERi | PTHR21689, PTHR21689, 1 hit |
Pfami | View protein in Pfam PF06584, DIRP, 1 hit |
SMARTi | View protein in SMART SM01135, DIRP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LIN9_HUMAN | |
Accessioni | Q5TKA1Primary (citable) accession number: Q5TKA1 Secondary accession number(s): Q5U5L8 Q7Z3J1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2006 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 10, 2021 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM