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UniProtKB - Q5TIA1 (MEI1_HUMAN)

Entry version 103 (25 May 2022)
Sequence version 2 (08 Apr 2008)
Previous versions | rss
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Protein

Meiosis inhibitor protein 1

Gene

MEI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • meiosis I Source: GO_Central
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processMeiosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5TIA1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q5TIA1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Meiosis inhibitor protein 1
Alternative name(s):
Meiosis defective protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEI1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28613, MEI1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608797, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5TIA1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000167077

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hydatidiform mole, recurrent, 3 (HYDM3)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by excessive trophoblast development that produces a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0826051151 – 1274Missing in HYDM3; the variant leads to a normally spliced transcript and two abnormal isoforms. 1 PublicationAdd BLAST124
Susceptibility to azoospermia may be associated with MEI1 variations.2 Publications

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		150365

MalaCards human disease database

More...MalaCardsi		MEI1
MIMi618431, phenotype

Open Targets

More...OpenTargetsi		ENSG00000167077

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		254688, Complete hydatidiform mole

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162395678

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5TIA1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MEI1

Domain mapping of disease mutations (DMDM)

More...DMDMi		205815070

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003472641 – 1274Meiosis inhibitor protein 1Add BLAST1274

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5TIA1

PeptideAtlas

More...PeptideAtlasi		Q5TIA1

PRoteomics IDEntifications database

More...PRIDEi		Q5TIA1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65181 [Q5TIA1-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5TIA1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5TIA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in testis. Weakly expressed in spleen and thymus. Expressed in the ovaries, Fallopian tubes and uterus (PubMed:30388401).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000167077, Expressed in muscle tissue and 143 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5TIA1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5TIA1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000167077, Tissue enhanced (lymphoid tissue, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127286, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q5TIA1, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000384115

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5TIA1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q5TIA1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5TIA1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QV5Z, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002077

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006759_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5TIA1

Identification of Orthologs from Complete Genome Data

More...OMAi		GLLCNVE

Database of Orthologous Groups

More...OrthoDBi		67575at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5TIA1

TreeFam database of animal gene trees

More...TreeFami		TF336500

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q5TIA1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVRQAATAG TPGPRREEEA ALLFERAHYR HDPRWLLPVT PRLCLACALE 
        60         70         80         90        100
LLPDPGVSLV RKKHMLSCFQ DALVRHTSLV TQLVSQDQRV CIHFISVLFG 
       110        120        130        140        150
LLCSMEDGSV TDLCIEVLIQ ITTQLKLEQT IRCLLDECHK ELCNMPSMRG 
       160        170        180        190        200
SLATLTLLGK LVDAIPALAD ELVMEHGNLM EHLLRGLVYP SEGIQASVCY 
       210        220        230        240        250
LYGKLYSSPV AAEMLSGHFR EKLFPLFLSI LDGAQTKELQ INCLGLLRQL 
       260        270        280        290        300
LKYDLFVSMI MNQDGLGESA KNIEGSSGNT SLPLVLKKLL LSRDETLQVA 
       310        320        330        340        350
SAHCITAVLV HSPAKHASAF IHADIPEFLF EHLSSSSEVL VWSSCNCLTL 
       360        370        380        390        400
LVEEPLFFSK CHTVYGIEAV VRSLQGSLKM NNIELHKQGL LLFAEILTRQ 
       410        420        430        440        450
PEEIKLFTSS AMCRDAGRAL QEAVSSPVLE VAAEALKATS AFLRKDHQST 
       460        470        480        490        500
PPVQYGELQA LLEAMLNRCA EFSQTLLSRR PLGHASSRDS EKAILQRGKF 
       510        520        530        540        550
LLSTLEGFRS ACRLAIEFQS EPSAQENPFT APSAKKEDTL EAFSEFLLSA 
       560        570        580        590        600
CDSLCIPMVM RHLEQTTHPA LMEVFLSILH NLFVIVPHMK EKFSKKLASS 
       610        620        630        640        650
SFIRLTLELK ARFCSGLSHS ALNQVCSNFL YYMCLNLLSA PEKTGPPSKE 
       660        670        680        690        700
ELSAVSELLQ HGLPQISSRS PESLAFLSDR QYMEGAARQR QYCILLLFYL 
       710        720        730        740        750
AYIHEDRFVS EAELFEAVQS FLLSLQDQGE RPPLVVFKAS IYLLAICQDK 
       760        770        780        790        800
DNTLRETMVS AIRKFLEGIP DLQLVYTHHP LLLRFFLLYP ELMSRYGHRV 
       810        820        830        840        850
LELWFFWEES SYEELDDVTS AGQPALPASL VVLFQLLRSI PSILLILLDL 
       860        870        880        890        900
IYSSPVDTAH KVLISLRTFL RRNEDIQVGG LIRGHFLLIL QRLLVEHGAS 
       910        920        930        940        950
PSGASGNLPL LLSLLSLMQL RNVSEQELDS VAMKLLHQVS KLCGKCSPTD 
       960        970        980        990       1000
VDILQPSFNF LYWSLHQTTP SSQKRAAAVL LSSTGLMELL EKMLALTLAK 
      1010       1020       1030       1040       1050
ADSPRTALLC SAWLLTASFS AQQHKGSLQV HQTLSVEMDQ VLKALSFPKK 
      1060       1070       1080       1090       1100
KAALLSAAIL CFLRTALRQS FSSALVALVP SGAQPLPATK DTVLAPLRMS 
      1110       1120       1130       1140       1150
QVRSLVIGLQ NLLVQKDPLL SQACVGCLEA LLDYLDARSP DIALHVASQP 
      1160       1170       1180       1190       1200
WNRFLLFTLL DAGENSFLRP EILRLMTLFM RYRSSSVLSH EEVGDVLQGV 
      1210       1220       1230       1240       1250
ALADLSTLSN TTLQALHGFF QQLQSMGHLA DHSMAQTLQA SLEGLPPSTS 
      1260       1270 
SGQPPLQDML CLGGVAVSLS HIRN
Length:1,274
Mass (Da):141,161
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F339400DD50B11E
GO
Isoform 21 Publication (identifier: Q5TIA1-2) [UniParc]FASTAAdd to basket
Also known as: Long1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-632: Missing.

Show »
Length:642
Mass (Da):71,012
Checksum:i7CC67F82BCCB6677
GO
Isoform 31 Publication (identifier: Q5TIA1-3) [UniParc]FASTAAdd to basket
Also known as: Short1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-632: Missing.
     904-938: Missing.

Show »
Length:607
Mass (Da):67,167
Checksum:i65F6318FF6D997EC
GO
Isoform 41 Publication (identifier: Q5TIA1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     561-569: RHLEQTTHP → VGSPEPRAT
     570-1274: Missing.

Show »
Length:569
Mass (Da):62,758
Checksum:i33FEE854AC0C1B16
GO
Isoform 51 Publication (identifier: Q5TIA1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-757: Missing.
     1193-1222: Missing.

Show »
Length:487
Mass (Da):53,736
Checksum:iE2FBC0BCCF47D825
GO
Isoform 61 Publication (identifier: Q5TIA1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-1274: Missing.

Show »
Length:444
Mass (Da):49,015
Checksum:i9FAFEDC4D6CC5CF1
GO
Isoform 72 Publications (identifier: Q5TIA1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-992: Missing.
     1179-1222: Missing.

Show »
Length:238
Mass (Da):25,555
Checksum:i4A13904D7038F278
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y787H0Y787_HUMAN
Meiosis inhibitor protein 1
MEI1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZT0F5GZT0_HUMAN
Meiosis inhibitor protein 1
MEI1
506Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH25400 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH35720 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti367I → T in AAH35720 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081145408T → R Found in patients with non-obstructive azoospermia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs533817526Ensembl.1
Natural variantiVAR_046037657E → Q. Corresponds to variant dbSNP:rs17002655EnsemblClinVar.1
Natural variantiVAR_046038853S → T. Corresponds to variant dbSNP:rs17002665Ensembl.1
Natural variantiVAR_0511841049K → E. Corresponds to variant dbSNP:rs12484839Ensembl.1
Natural variantiVAR_0826051151 – 1274Missing in HYDM3; the variant leads to a normally spliced transcript and two abnormal isoforms. 1 PublicationAdd BLAST124

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0528831 – 992Missing in isoform 7. 2 PublicationsAdd BLAST992
Alternative sequenceiVSP_0528841 – 757Missing in isoform 5. 1 PublicationAdd BLAST757
Alternative sequenceiVSP_0528851 – 632Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST632
Alternative sequenceiVSP_052886445 – 1274Missing in isoform 6. 1 PublicationAdd BLAST830
Alternative sequenceiVSP_052887561 – 569RHLEQTTHP → VGSPEPRAT in isoform 4. 1 Publication9
Alternative sequenceiVSP_052888570 – 1274Missing in isoform 4. 1 PublicationAdd BLAST705
Alternative sequenceiVSP_052889904 – 938Missing in isoform 3. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_0528901179 – 1222Missing in isoform 7. 2 PublicationsAdd BLAST44
Alternative sequenceiVSP_0528911193 – 1222Missing in isoform 5. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY952376 mRNA Translation: AAY27427.1
AY952377 mRNA Translation: AAY27428.1
AK094461 mRNA Translation: BAC04361.1
AK301435 mRNA Translation: BAH13481.1
AL021453 Genomic DNA No translation available.
AL023879 Genomic DNA No translation available.
Z83840 Genomic DNA No translation available.
BC025400 mRNA Translation: AAH25400.1 Different initiation.
BC032248 mRNA Translation: AAH32248.1
BC035720 mRNA Translation: AAH35720.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46718.1 [Q5TIA1-1]

NCBI Reference Sequences

More...RefSeqi		NP_689726.3, NM_152513.3 [Q5TIA1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000401548.8; ENSP00000384115.3; ENSG00000167077.13
ENST00000403492.5; ENSP00000385298.1; ENSG00000167077.13 [Q5TIA1-7]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		150365

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:150365

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000401548.8; ENSP00000384115.3; NM_152513.4; NP_689726.3

UCSC genome browser

More...UCSCi		uc003baz.2, human [Q5TIA1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY952376 mRNA Translation: AAY27427.1
AY952377 mRNA Translation: AAY27428.1
AK094461 mRNA Translation: BAC04361.1
AK301435 mRNA Translation: BAH13481.1
AL021453 Genomic DNA No translation available.
AL023879 Genomic DNA No translation available.
Z83840 Genomic DNA No translation available.
BC025400 mRNA Translation: AAH25400.1 Different initiation.
BC032248 mRNA Translation: AAH32248.1
BC035720 mRNA Translation: AAH35720.1 Different initiation.
CCDSiCCDS46718.1 [Q5TIA1-1]
RefSeqiNP_689726.3, NM_152513.3 [Q5TIA1-1]

3D structure databases

AlphaFoldDBiQ5TIA1
SMRiQ5TIA1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127286, 8 interactors
IntActiQ5TIA1, 1 interactor
STRINGi9606.ENSP00000384115

PTM databases

iPTMnetiQ5TIA1
PhosphoSitePlusiQ5TIA1

Genetic variation databases

BioMutaiMEI1
DMDMi205815070

Proteomic databases

PaxDbiQ5TIA1
PeptideAtlasiQ5TIA1
PRIDEiQ5TIA1
ProteomicsDBi65181 [Q5TIA1-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27052, 78 antibodies from 15 providers

The DNASU plasmid repository

More...DNASUi		150365

Genome annotation databases

EnsembliENST00000401548.8; ENSP00000384115.3; ENSG00000167077.13
ENST00000403492.5; ENSP00000385298.1; ENSG00000167077.13 [Q5TIA1-7]
GeneIDi150365
KEGGihsa:150365
MANE-SelectiENST00000401548.8; ENSP00000384115.3; NM_152513.4; NP_689726.3
UCSCiuc003baz.2, human [Q5TIA1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		150365
DisGeNETi150365

GeneCards: human genes, protein and diseases

More...GeneCardsi		MEI1
HGNCiHGNC:28613, MEI1
HPAiENSG00000167077, Tissue enhanced (lymphoid tissue, testis)
MalaCardsiMEI1
MIMi608797, gene
618431, phenotype
neXtProtiNX_Q5TIA1
OpenTargetsiENSG00000167077
Orphaneti254688, Complete hydatidiform mole
PharmGKBiPA162395678
VEuPathDBiHostDB:ENSG00000167077

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QV5Z, Eukaryota
GeneTreeiENSGT00390000002077
HOGENOMiCLU_006759_0_0_1
InParanoidiQ5TIA1
OMAiGLLCNVE
OrthoDBi67575at2759
PhylomeDBiQ5TIA1
TreeFamiTF336500

Enzyme and pathway databases

PathwayCommonsiQ5TIA1
SignaLinkiQ5TIA1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		150365, 9 hits in 1070 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MEI1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		150365
PharosiQ5TIA1, Tbio

Protein Ontology

More...PROi		PR:Q5TIA1
RNActiQ5TIA1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000167077, Expressed in muscle tissue and 143 other tissues
ExpressionAtlasiQ5TIA1, baseline and differential
GenevisibleiQ5TIA1, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEI1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TIA1
Secondary accession number(s): B7Z745
, Q1XAP1, Q1XAP2, Q8IYJ5, Q8N5K5, Q8N9H3, Q8TC68
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 8, 2008
Last modified: May 25, 2022
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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