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UniProtKB - Q5TIA1 (MEI1_HUMAN)

Protein

Meiosis inhibitor protein 1

Gene

MEI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity).By similarity

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Meiosis inhibitor protein 1
Alternative name(s):
Meiosis defective protein 1
Gene namesi
Name:MEI1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000167077.12
HGNCiHGNC:28613 MEI1
MIMi608797 gene
neXtProtiNX_Q5TIA1

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi150365
OpenTargetsiENSG00000167077
PharmGKBiPA162395678

Polymorphism and mutation databases

BioMutaiMEI1
DMDMi205815070

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003472641 – 1274Meiosis inhibitor protein 1Add BLAST1274

Proteomic databases

PaxDbiQ5TIA1
PeptideAtlasiQ5TIA1
PRIDEiQ5TIA1
ProteomicsDBi65181
65182 [Q5TIA1-2]
65183 [Q5TIA1-3]
65184 [Q5TIA1-4]
65185 [Q5TIA1-5]
65186 [Q5TIA1-6]
65187 [Q5TIA1-7]

PTM databases

iPTMnetiQ5TIA1
PhosphoSitePlusiQ5TIA1

Expressioni

Tissue specificityi

Expressed predominantly in testis. Weakly expressed in spleen and thymus.1 Publication

Gene expression databases

BgeeiENSG00000167077 Expressed in 122 organ(s), highest expression level in right testis
CleanExiHS_MEI1
ExpressionAtlasiQ5TIA1 baseline and differential
GenevisibleiQ5TIA1 HS

Organism-specific databases

HPAiHPA049240

Interactioni

Protein-protein interaction databases

BioGridi127286, 5 interactors
STRINGi9606.ENSP00000384115

Structurei

3D structure databases

ProteinModelPortaliQ5TIA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IDYP Eukaryota
ENOG410Y5J6 LUCA
GeneTreeiENSGT00390000002077
HOVERGENiHBG108129
InParanoidiQ5TIA1
OMAiVYPNEGV
OrthoDBiEOG091G00RU
PhylomeDBiQ5TIA1
TreeFamiTF336500

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 2 hits

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q5TIA1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVRQAATAG TPGPRREEEA ALLFERAHYR HDPRWLLPVT PRLCLACALE 
        60         70         80         90        100
LLPDPGVSLV RKKHMLSCFQ DALVRHTSLV TQLVSQDQRV CIHFISVLFG 
       110        120        130        140        150
LLCSMEDGSV TDLCIEVLIQ ITTQLKLEQT IRCLLDECHK ELCNMPSMRG 
       160        170        180        190        200
SLATLTLLGK LVDAIPALAD ELVMEHGNLM EHLLRGLVYP SEGIQASVCY 
       210        220        230        240        250
LYGKLYSSPV AAEMLSGHFR EKLFPLFLSI LDGAQTKELQ INCLGLLRQL 
       260        270        280        290        300
LKYDLFVSMI MNQDGLGESA KNIEGSSGNT SLPLVLKKLL LSRDETLQVA 
       310        320        330        340        350
SAHCITAVLV HSPAKHASAF IHADIPEFLF EHLSSSSEVL VWSSCNCLTL 
       360        370        380        390        400
LVEEPLFFSK CHTVYGIEAV VRSLQGSLKM NNIELHKQGL LLFAEILTRQ 
       410        420        430        440        450
PEEIKLFTSS AMCRDAGRAL QEAVSSPVLE VAAEALKATS AFLRKDHQST 
       460        470        480        490        500
PPVQYGELQA LLEAMLNRCA EFSQTLLSRR PLGHASSRDS EKAILQRGKF 
       510        520        530        540        550
LLSTLEGFRS ACRLAIEFQS EPSAQENPFT APSAKKEDTL EAFSEFLLSA 
       560        570        580        590        600
CDSLCIPMVM RHLEQTTHPA LMEVFLSILH NLFVIVPHMK EKFSKKLASS 
       610        620        630        640        650
SFIRLTLELK ARFCSGLSHS ALNQVCSNFL YYMCLNLLSA PEKTGPPSKE 
       660        670        680        690        700
ELSAVSELLQ HGLPQISSRS PESLAFLSDR QYMEGAARQR QYCILLLFYL 
       710        720        730        740        750
AYIHEDRFVS EAELFEAVQS FLLSLQDQGE RPPLVVFKAS IYLLAICQDK 
       760        770        780        790        800
DNTLRETMVS AIRKFLEGIP DLQLVYTHHP LLLRFFLLYP ELMSRYGHRV 
       810        820        830        840        850
LELWFFWEES SYEELDDVTS AGQPALPASL VVLFQLLRSI PSILLILLDL 
       860        870        880        890        900
IYSSPVDTAH KVLISLRTFL RRNEDIQVGG LIRGHFLLIL QRLLVEHGAS 
       910        920        930        940        950
PSGASGNLPL LLSLLSLMQL RNVSEQELDS VAMKLLHQVS KLCGKCSPTD 
       960        970        980        990       1000
VDILQPSFNF LYWSLHQTTP SSQKRAAAVL LSSTGLMELL EKMLALTLAK 
      1010       1020       1030       1040       1050
ADSPRTALLC SAWLLTASFS AQQHKGSLQV HQTLSVEMDQ VLKALSFPKK 
      1060       1070       1080       1090       1100
KAALLSAAIL CFLRTALRQS FSSALVALVP SGAQPLPATK DTVLAPLRMS 
      1110       1120       1130       1140       1150
QVRSLVIGLQ NLLVQKDPLL SQACVGCLEA LLDYLDARSP DIALHVASQP 
      1160       1170       1180       1190       1200
WNRFLLFTLL DAGENSFLRP EILRLMTLFM RYRSSSVLSH EEVGDVLQGV 
      1210       1220       1230       1240       1250
ALADLSTLSN TTLQALHGFF QQLQSMGHLA DHSMAQTLQA SLEGLPPSTS 
      1260       1270 
SGQPPLQDML CLGGVAVSLS HIRN
Note: No experimental confirmation available.Curated
Length:1,274
Mass (Da):141,161
Last modified:April 8, 2008 - v2
Checksum:i3F339400DD50B11E
GO
Isoform 21 Publication (identifier: Q5TIA1-2) [UniParc]FASTAAdd to basket
Also known as: Long1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-632: Missing.

Show »
Length:642
Mass (Da):71,012
Checksum:i7CC67F82BCCB6677
GO
Isoform 31 Publication (identifier: Q5TIA1-3) [UniParc]FASTAAdd to basket
Also known as: Short1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-632: Missing.
     904-938: Missing.

Show »
Length:607
Mass (Da):67,167
Checksum:i65F6318FF6D997EC
GO
Isoform 41 Publication (identifier: Q5TIA1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     561-569: RHLEQTTHP → VGSPEPRAT
     570-1274: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:569
Mass (Da):62,758
Checksum:i33FEE854AC0C1B16
GO
Isoform 51 Publication (identifier: Q5TIA1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-757: Missing.
     1193-1222: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:487
Mass (Da):53,736
Checksum:iE2FBC0BCCF47D825
GO
Isoform 61 Publication (identifier: Q5TIA1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-1274: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:444
Mass (Da):49,015
Checksum:i9FAFEDC4D6CC5CF1
GO
Isoform 72 Publications (identifier: Q5TIA1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-992: Missing.
     1179-1222: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:238
Mass (Da):25,555
Checksum:i4A13904D7038F278
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GZT0F5GZT0_HUMAN
Meiosis inhibitor protein 1
MEI1
506Annotation score:
H0Y787H0Y787_HUMAN
Meiosis inhibitor protein 1
MEI1
63Annotation score:

Sequence cautioni

The sequence AAH25400 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH35720 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti367I → T in AAH35720 (PubMed:15489334).Curated1

Polymorphismi

Genetic variation in MEI1 may predispose European American but not Israeli men to azoospermia by meiotic arrest.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046037657E → Q. Corresponds to variant dbSNP:rs17002655Ensembl.1
Natural variantiVAR_046038853S → T. Corresponds to variant dbSNP:rs17002665Ensembl.1
Natural variantiVAR_0511841049K → E. Corresponds to variant dbSNP:rs12484839Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0528831 – 992Missing in isoform 7. 2 PublicationsAdd BLAST992
Alternative sequenceiVSP_0528841 – 757Missing in isoform 5. 1 PublicationAdd BLAST757
Alternative sequenceiVSP_0528851 – 632Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST632
Alternative sequenceiVSP_052886445 – 1274Missing in isoform 6. 1 PublicationAdd BLAST830
Alternative sequenceiVSP_052887561 – 569RHLEQTTHP → VGSPEPRAT in isoform 4. 1 Publication9
Alternative sequenceiVSP_052888570 – 1274Missing in isoform 4. 1 PublicationAdd BLAST705
Alternative sequenceiVSP_052889904 – 938Missing in isoform 3. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_0528901179 – 1222Missing in isoform 7. 2 PublicationsAdd BLAST44
Alternative sequenceiVSP_0528911193 – 1222Missing in isoform 5. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY952376 mRNA Translation: AAY27427.1
AY952377 mRNA Translation: AAY27428.1
AK094461 mRNA Translation: BAC04361.1
AK301435 mRNA Translation: BAH13481.1
AL021453 Genomic DNA No translation available.
AL023879 Genomic DNA No translation available.
Z83840 Genomic DNA No translation available.
BC025400 mRNA Translation: AAH25400.1 Different initiation.
BC032248 mRNA Translation: AAH32248.1
BC035720 mRNA Translation: AAH35720.1 Different initiation.
CCDSiCCDS46718.1 [Q5TIA1-1]
RefSeqiNP_689726.3, NM_152513.3 [Q5TIA1-1]
UniGeneiHs.116419

Genome annotation databases

EnsembliENST00000401548; ENSP00000384115; ENSG00000167077 [Q5TIA1-1]
ENST00000403492; ENSP00000385298; ENSG00000167077 [Q5TIA1-7]
GeneIDi150365
KEGGihsa:150365
UCSCiuc003baz.2 human [Q5TIA1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY952376 mRNA Translation: AAY27427.1
AY952377 mRNA Translation: AAY27428.1
AK094461 mRNA Translation: BAC04361.1
AK301435 mRNA Translation: BAH13481.1
AL021453 Genomic DNA No translation available.
AL023879 Genomic DNA No translation available.
Z83840 Genomic DNA No translation available.
BC025400 mRNA Translation: AAH25400.1 Different initiation.
BC032248 mRNA Translation: AAH32248.1
BC035720 mRNA Translation: AAH35720.1 Different initiation.
CCDSiCCDS46718.1 [Q5TIA1-1]
RefSeqiNP_689726.3, NM_152513.3 [Q5TIA1-1]
UniGeneiHs.116419

3D structure databases

ProteinModelPortaliQ5TIA1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127286, 5 interactors
STRINGi9606.ENSP00000384115

PTM databases

iPTMnetiQ5TIA1
PhosphoSitePlusiQ5TIA1

Polymorphism and mutation databases

BioMutaiMEI1
DMDMi205815070

Proteomic databases

PaxDbiQ5TIA1
PeptideAtlasiQ5TIA1
PRIDEiQ5TIA1
ProteomicsDBi65181
65182 [Q5TIA1-2]
65183 [Q5TIA1-3]
65184 [Q5TIA1-4]
65185 [Q5TIA1-5]
65186 [Q5TIA1-6]
65187 [Q5TIA1-7]

Protocols and materials databases

DNASUi150365
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401548; ENSP00000384115; ENSG00000167077 [Q5TIA1-1]
ENST00000403492; ENSP00000385298; ENSG00000167077 [Q5TIA1-7]
GeneIDi150365
KEGGihsa:150365
UCSCiuc003baz.2 human [Q5TIA1-1]

Organism-specific databases

CTDi150365
DisGeNETi150365
EuPathDBiHostDB:ENSG00000167077.12
GeneCardsiMEI1
H-InvDBiHIX0016529
HGNCiHGNC:28613 MEI1
HPAiHPA049240
MIMi608797 gene
neXtProtiNX_Q5TIA1
OpenTargetsiENSG00000167077
PharmGKBiPA162395678
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDYP Eukaryota
ENOG410Y5J6 LUCA
GeneTreeiENSGT00390000002077
HOVERGENiHBG108129
InParanoidiQ5TIA1
OMAiVYPNEGV
OrthoDBiEOG091G00RU
PhylomeDBiQ5TIA1
TreeFamiTF336500

Miscellaneous databases

ChiTaRSiMEI1 human
GenomeRNAii150365
PROiPR:Q5TIA1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167077 Expressed in 122 organ(s), highest expression level in right testis
CleanExiHS_MEI1
ExpressionAtlasiQ5TIA1 baseline and differential
GenevisibleiQ5TIA1 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMEI1_HUMAN
AccessioniPrimary (citable) accession number: Q5TIA1
Secondary accession number(s): B7Z745
, Q1XAP1, Q1XAP2, Q8IYJ5, Q8N5K5, Q8N9H3, Q8TC68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 8, 2008
Last modified: October 10, 2018
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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