UniProtKB - Q5TI25 (NBPFE_HUMAN)
Protein
Neuroblastoma breakpoint family member 14
Gene
NBPF14
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.
Names & Taxonomyi
Protein namesi | Recommended name: Neuroblastoma breakpoint family member 14 |
Gene namesi | Name:NBPF14 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25232 NBPF14 |
MIMi | 614003 gene |
neXtProti | NX_Q5TI25 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 25832 |
PharmGKBi | PA142671273 |
Miscellaneous databases
Pharosi | Q5TI25 |
Polymorphism and mutation databases
BioMutai | NBPF14 |
DMDMi | 152123242 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288048 | 1 – 921 | Neuroblastoma breakpoint family member 14Add BLAST | 921 |
Proteomic databases
EPDi | Q5TI25 |
jPOSTi | Q5TI25 |
MassIVEi | Q5TI25 |
MaxQBi | Q5TI25 |
PaxDbi | Q5TI25 |
PeptideAtlasi | Q5TI25 |
PRIDEi | Q5TI25 |
ProteomicsDBi | 65171 |
PTM databases
iPTMneti | Q5TI25 |
PhosphoSitePlusi | Q5TI25 |
Expressioni
Tissue specificityi
Expressed in spleen and fetal liver.1 Publication
Organism-specific databases
HPAi | HPA042595 HPA043105 HPA043692 HPA044023 HPA046971 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 96 – 188 | NBPF 1PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 189 – 260 | NBPF 2PROSITE-ProRule annotationAdd BLAST | 72 | |
Domaini | 261 – 352 | NBPF 3PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 355 – 410 | NBPF 4PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 411 – 503 | NBPF 5PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 504 – 596 | NBPF 6PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 599 – 671 | NBPF 7PROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 674 – 729 | NBPF 8PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 730 – 822 | NBPF 9PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 823 – 921 | NBPF 10PROSITE-ProRule annotationAdd BLAST | 99 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1 – 61 | Sequence analysisAdd BLAST | 61 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 195 – 199 | Poly-Glu | 5 | |
Compositional biasi | 210 – 215 | Poly-Glu | 6 | |
Compositional biasi | 417 – 420 | Poly-Glu | 4 | |
Compositional biasi | 736 – 739 | Poly-Glu | 4 |
Sequence similaritiesi
Belongs to the NBPF family.Curated
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | ENOG410KG3F Eukaryota ENOG4110SQ7 LUCA |
HOGENOMi | HOG000049041 |
InParanoidi | Q5TI25 |
PhylomeDBi | Q5TI25 |
Family and domain databases
InterProi | View protein in InterPro IPR010630 Olduvai_dom |
Pfami | View protein in Pfam PF06758 Olduvai, 10 hits |
SMARTi | View protein in SMART SM01148 DUF1220, 10 hits |
PROSITEi | View protein in PROSITE PS51316 NBPF, 10 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
Q5TI25-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRNERQFKE EKLAEQLKQA EELRQYKVLV HAQERELTQL REKLREGRDA
60 70 80 90 100
SRSLNEHLQA LLTPDEPDKS QGQDLQEQLA EGCRLAQHLV QKLSPENDND
110 120 130 140 150
DDEDVQVEVA EKVQKSSAPR EMQKAEEKEV PEDSLEECAI TCSNSHGPYD
160 170 180 190 200
SNQPHRKTKI TFEEDKVDST LIGSSSHVEW EDAVHIIPEN ESDDEEEEEK
210 220 230 240 250
GPVSPRNLQE SEEEEVPQES WDEGYSTLSI PPEMLASYKS YSSTFHSLEE
260 270 280 290 300
QQVCMAVDIG RHRWDQVKKE DHEATGPRLS RELLDEKGPE VLQDSLDRCY
310 320 330 340 350
STPSGCLELT DSCQPYRSAF YVLEQQRVGL AVNMDEIEKY QEVEEDQDPS
360 370 380 390 400
CPRLSRELLD EKEPEVLQDS LGRCYSTPSG YLELPDLGQP YSSAVYSLEE
410 420 430 440 450
QYLGLALDVD RIKKDQEEEE DQGPPCPRLS RELLEVVEPE VLQDSLDRCY
460 470 480 490 500
STPSSCLEQP DSCQPYGSSF YALEEKHVGF SLDVGEIEKK GKGKKRRGRR
510 520 530 540 550
SKKERRRGRK EGEEDQNPPC PRLSRELLDE KGPEVLQDSL DRCYSTPSGC
560 570 580 590 600
LELTDSCQPY RSAFYILEQQ RVGLAVDMDE IEKYQEVEED QDPSCPRLSG
610 620 630 640 650
ELLDEKEPEV LQESLDRCYS TPSGCLELTD SCQPYRSAFY ILEQQRVGLA
660 670 680 690 700
VDMDEIEKYQ EVEEDQDPSC PRLSRELLDE KEPEVLQDSL GRCYSTPSGY
710 720 730 740 750
LELPDLGQPY SSAVYSLEEQ YLGLALDVDR IKKDQEEEED QGPPCPRLSR
760 770 780 790 800
ELLEVVEPEV LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS
810 820 830 840 850
LDVGEIEKKG KGKKRRGRRS KKERRRGRKE GEEDQNPPCP RLNSMLMEVE
860 870 880 890 900
EPEVLQDSLD ICYSTPSMYF ELPDSFQHYR SVFYSFEEEH ISFALYVDNR
910 920
FFTLTVTSLH LVFQMGVIFP Q
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZJ2 | A0A087WZJ2_HUMAN | Neuroblastoma breakpoint family mem... | NBPF14 | 2,819 | Annotation score: | ||
A0A0B4J2B3 | A0A0B4J2B3_HUMAN | Neuroblastoma breakpoint family mem... | NBPF14 | 249 | Annotation score: | ||
A0A087WTQ0 | A0A087WTQ0_HUMAN | Neuroblastoma breakpoint family mem... | NBPF14 | 299 | Annotation score: | ||
A0A087WUR2 | A0A087WUR2_HUMAN | Neuroblastoma breakpoint family mem... | NBPF14 | 535 | Annotation score: | ||
A0A087WV19 | A0A087WV19_HUMAN | Neuroblastoma breakpoint family mem... | NBPF14 | 299 | Annotation score: | ||
A0A087WVU4 | A0A087WVU4_HUMAN | Neuroblastoma breakpoint family mem... | NBPF14 | 2,988 | Annotation score: | ||
A0A087WYI5 | A0A087WYI5_HUMAN | Neuroblastoma breakpoint family mem... | NBPF14 | 867 | Annotation score: | ||
A0A075B757 | A0A075B757_HUMAN | Neuroblastoma breakpoint family mem... | NBPF14 | 942 | Annotation score: | ||
A0A087WVE3 | A0A087WVE3_HUMAN | Neuroblastoma breakpoint family mem... | NBPF14 | 577 | Annotation score: | ||
A0A087WTW4 | A0A087WTW4_HUMAN | Neuroblastoma breakpoint family mem... | NBPF14 | 921 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
The sequence CAI20179 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI20180 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20181 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20182 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20183 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20184 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20185 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20186 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 333 | N → D in AAO15399 (PubMed:16079250).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032381 | 243 | S → G. Corresponds to variant dbSNP:rs3871941Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117237 mRNA Translation: CAB55305.1 AL022240 Genomic DNA Translation: CAI20179.1 Different initiation. AL022240 Genomic DNA Translation: CAI20180.1 Sequence problems. AL022240 Genomic DNA Translation: CAI20181.1 Sequence problems. AL022240 Genomic DNA Translation: CAI20182.1 Sequence problems. AL022240 Genomic DNA Translation: CAI20183.1 Sequence problems. AL022240 Genomic DNA Translation: CAI20184.1 Sequence problems. AL022240 Genomic DNA Translation: CAI20185.1 Sequence problems. AL022240 Genomic DNA Translation: CAI20186.1 Sequence problems. AF379631 mRNA Translation: AAO15399.1 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117237 mRNA Translation: CAB55305.1 AL022240 Genomic DNA Translation: CAI20179.1 Different initiation. AL022240 Genomic DNA Translation: CAI20180.1 Sequence problems. AL022240 Genomic DNA Translation: CAI20181.1 Sequence problems. AL022240 Genomic DNA Translation: CAI20182.1 Sequence problems. AL022240 Genomic DNA Translation: CAI20183.1 Sequence problems. AL022240 Genomic DNA Translation: CAI20184.1 Sequence problems. AL022240 Genomic DNA Translation: CAI20185.1 Sequence problems. AL022240 Genomic DNA Translation: CAI20186.1 Sequence problems. AF379631 mRNA Translation: AAO15399.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q5TI25, 2 interactors |
MINTi | Q5TI25 |
PTM databases
iPTMneti | Q5TI25 |
PhosphoSitePlusi | Q5TI25 |
Polymorphism and mutation databases
BioMutai | NBPF14 |
DMDMi | 152123242 |
Proteomic databases
EPDi | Q5TI25 |
jPOSTi | Q5TI25 |
MassIVEi | Q5TI25 |
MaxQBi | Q5TI25 |
PaxDbi | Q5TI25 |
PeptideAtlasi | Q5TI25 |
PRIDEi | Q5TI25 |
ProteomicsDBi | 65171 |
Organism-specific databases
DisGeNETi | 25832 |
GeneCardsi | NBPF14 |
HGNCi | HGNC:25232 NBPF14 |
HPAi | HPA042595 HPA043105 HPA043692 HPA044023 HPA046971 |
MIMi | 614003 gene |
neXtProti | NX_Q5TI25 |
PharmGKBi | PA142671273 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410KG3F Eukaryota ENOG4110SQ7 LUCA |
HOGENOMi | HOG000049041 |
InParanoidi | Q5TI25 |
PhylomeDBi | Q5TI25 |
Miscellaneous databases
ChiTaRSi | NBPF14 human |
Pharosi | Q5TI25 |
PROi | PR:Q5TI25 |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR010630 Olduvai_dom |
Pfami | View protein in Pfam PF06758 Olduvai, 10 hits |
SMARTi | View protein in SMART SM01148 DUF1220, 10 hits |
PROSITEi | View protein in PROSITE PS51316 NBPF, 10 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NBPFE_HUMAN | |
Accessioni | Q5TI25Primary (citable) accession number: Q5TI25 Secondary accession number(s): Q5TI23, Q8IX76, Q9UJI9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | May 29, 2007 | |
Last modified: | September 18, 2019 | |
This is version 96 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot