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Entry version 130 (17 Jun 2020)
Sequence version 2 (16 Apr 2014)
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Protein

Vacuolar protein sorting-associated protein 13D

Gene

VPS13D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 13D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VPS13DImported
Synonyms:KIAA0453Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000048707.13

Human Gene Nomenclature Database

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HGNCi
HGNC:23595 VPS13D

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608877 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5THJ4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spinocerebellar ataxia, autosomal recessive 4 (SCAR4)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR4 patients manifest ataxic gait with spasticity and hyperreflexia of the lower limbs resulting in difficulty walking. The age at onset is highly variable, ranging from early childhood to adulthood.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081496662 – 4388Missing in SCAR4. 1 PublicationAdd BLAST3727
Natural variantiVAR_080911865T → A in SCAR4. 1 PublicationCorresponds to variant dbSNP:rs1383958401Ensembl.1
Natural variantiVAR_0814971106 – 4388Missing in SCAR4; altered mitochondrial morphology in patient cells. 1 PublicationAdd BLAST3283
Natural variantiVAR_0814981190G → D in SCAR4; altered mitochondrial morphology in patient cells. 1 Publication1
Natural variantiVAR_0809121200G → D in SCAR4. 1 PublicationCorresponds to variant dbSNP:rs768331333Ensembl.1
Natural variantiVAR_0814991307M → L in SCAR4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs775845475Ensembl.1
Natural variantiVAR_0815001803 – 4388Missing in SCAR4; decreased protein abundance; altered mitochondrial morphology in patient cells. 1 PublicationAdd BLAST2586
Natural variantiVAR_0815012277 – 4388Missing in SCAR4. 1 PublicationAdd BLAST2112
Natural variantiVAR_0815022572 – 4388Missing in SCAR4. 1 PublicationAdd BLAST1817
Natural variantiVAR_0809132900L → S in SCAR4. 1 Publication1
Natural variantiVAR_0809143253R → Q in SCAR4. 1 PublicationCorresponds to variant dbSNP:rs1191625571Ensembl.1
Natural variantiVAR_0809153521N → S in SCAR4. 1 Publication1
Natural variantiVAR_0815034107N → I in SCAR4; unknown pathological significance. 1 Publication1
Natural variantiVAR_0815044149G → S in SCAR4; unknown pathological significance. 1 Publication1
Natural variantiVAR_0815054210A → V in SCAR4; altered mitochondrial morphology in patient cells. 1 PublicationCorresponds to variant dbSNP:rs746736545EnsemblClinVar.1
Natural variantiVAR_0809164228R → Q in SCAR4. 1 Publication1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET

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DisGeNETi
55187

MalaCards human disease database

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MalaCardsi
VPS13D
MIMi607317 phenotype

Open Targets

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OpenTargetsi
ENSG00000048707

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134970144

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q5THJ4 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
VPS13D

Domain mapping of disease mutations (DMDM)

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DMDMi
74756617

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002629511 – 4388Vacuolar protein sorting-associated protein 13DAdd BLAST4388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei663PhosphoserineCombined sources1
Modified residuei1034PhosphoserineCombined sources1
Modified residuei1038PhosphoserineCombined sources1
Modified residuei1042PhosphoserineCombined sources1
Modified residuei1138PhosphoserineCombined sources1
Modified residuei1341PhosphoserineCombined sources1
Modified residuei1598PhosphoserineCombined sources1
Modified residuei1603PhosphoserineCombined sources1
Modified residuei1699PhosphoserineCombined sources1
Modified residuei1761PhosphothreonineCombined sources1
Modified residuei1765PhosphoserineCombined sources1
Modified residuei2435PhosphoserineCombined sources1
Modified residuei2671PhosphoserineCombined sources1
Modified residuei2861PhosphoserineCombined sources1
Modified residuei2864PhosphoserineCombined sources1
Modified residuei2983PhosphoserineCombined sources1
Modified residuei3524N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5THJ4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5THJ4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5THJ4

MaxQB - The MaxQuant DataBase

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MaxQBi
Q5THJ4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5THJ4

PeptideAtlas

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PeptideAtlasi
Q5THJ4

PRoteomics IDEntifications database

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PRIDEi
Q5THJ4

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
65151 [Q5THJ4-1]
65152 [Q5THJ4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5THJ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q5THJ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000048707 Expressed in skin of abdomen and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5THJ4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5THJ4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000048707 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
120485, 14 interactors

Protein interaction database and analysis system

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IntActi
Q5THJ4, 15 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000478104

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q5THJ4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2633 – 2676UBAPROSITE-ProRule annotationAdd BLAST44

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The UBA domain is required for mitochondrial size regulation.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS13 family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1796 Eukaryota
KOG1809 Eukaryota
COG5043 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183083

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5THJ4

KEGG Orthology (KO)

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KOi
K19527

Identification of Orthologs from Complete Genome Data

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OMAi
HMEEAQN

Database of Orthologous Groups

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OrthoDBi
4159at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q5THJ4

TreeFam database of animal gene trees

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TreeFami
TF300316

Family and domain databases

Conserved Domains Database

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CDDi
cd14306 UBA_VP13D, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009543 SHR-BD
IPR015940 UBA
IPR009060 UBA-like_sf
IPR041969 VP13D_UBA
IPR026847 VPS13
IPR031645 VPS13_C
IPR031642 VPS13_mid_rpt
IPR026854 VPS13_N
IPR031646 VPS13_N2

The PANTHER Classification System

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PANTHERi
PTHR16166 PTHR16166, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12624 Chorein_N, 1 hit
PF06650 SHR-BD, 1 hit
PF00627 UBA, 1 hit
PF16908 VPS13, 1 hit
PF16909 VPS13_C, 1 hit
PF16910 VPS13_mid_rpt, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00165 UBA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934 SSF46934, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50030 UBA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q5THJ4-1) [UniParc]FASTAAdd to basket
Also known as: 1A1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLEGLVAWVL NTYLGKYVNN LNTDQLSVAL LKGAVELENL PLKKDALKEL
60 70 80 90 100
ELPFEVKAGF IGKVTLQIPF YRPHVDPWVI SISSLHLIGA PEKIQDFNDE
110 120 130 140 150
KEKLLERERK KALLQALEEK WKNDRQQKGE SYWYSVTASV VTRIVENIEL
160 170 180 190 200
KIQDVHLRFE DGVTNPSHPF AFGICIKNVS MQNAVNEPVQ KLMRKKQLDV
210 220 230 240 250
AEFSIYWDVD CTLLGDLPQM ELQEAMARSM ESRSHHYVLE PVFASALLKR
260 270 280 290 300
NCSKKPLRSR HSPRIDCDIQ LETIPLKLSQ LQYRQIMEFL KELERKERQV
310 320 330 340 350
KFRRWKPKVA ISKNCREWWY FALNANLYEI REQRKRCTWD FMLHRARDAV
360 370 380 390 400
SYTDKYFNKL KGGLLSTDDK EEMCRIEEEQ SFEELKILRE LVHDRFHKQE
410 420 430 440 450
ELAESLREPQ FDSPGACPGA PEPGGGSGML QYLQSWFPGW GGWYGQQTPE
460 470 480 490 500
GNVVEGLSAE QQEQWIPEEI LGTEEFFDPT ADASCMNTYT KRDHVFAKLN
510 520 530 540 550
LQLQRGTVTL LHKEQGTPQM NESAFMQLEF SDVKLLAESL PRRNSSLLSV
560 570 580 590 600
RLGGLFLRDL ATEGTMFPLL VFPNPQKEVG RVSQSFGLQT TSADRSDHYP
610 620 630 640 650
AADPDGPVFE MLYERNPAHS HFERRLNVST RPLNIIYNPQ AIKKVADFFY
660 670 680 690 700
KGKVHTSGFG YQSELELRVA EAARRQYNKL KMQTKAEIRQ TLDRLLVGDF
710 720 730 740 750
IEESKRWTVR LDISAPQVIF PDDFKFKNPV LVVVDLGRML LTNTQDNSRR
760 770 780 790 800
KSRDGSASEE TQFSDDEYKT PLATPPNTPP PESSSSNGEK TPPFSGVEFS
810 820 830 840 850
EEQLQAHLMS TKMYERYSLS FMDLQIMVGR VKDNWKHVQD IDVGPTHVVE
860 870 880 890 900
KFNVHLQLER RLIYTSDPKY PGAVLSGNLP DLKIHINEDK ISALKNCFAL
910 920 930 940 950
LTTPEMKTSD TQIKEKIFPQ EEQRGSLQDS VMNLTQSIVL LEQHTREVLV
960 970 980 990 1000
ESQLLLAEFK VNCMQLGVES NGRYISVLKV FGTNAHFVKR PYDAEVSLTV
1010 1020 1030 1040 1050
HGLLLVDTMQ TYGADFDLLM ASHKNLSFDI PTGSLRDSRA QSPVSGPNVA
1060 1070 1080 1090 1100
HLTDGATLND RSATSVSLDK ILTKEQESLI KLEYQFVSSE CPSMNLDSTL
1110 1120 1130 1140 1150
QVISLQVNNL DIILNPETIV ELIGFLQKSF PKEKDDLSPQ PLMTDFERSF
1160 1170 1180 1190 1200
REQGTYQSTY EQNTEVAVEI HRLNLLLLRT VGMANREKYG RKIATASIGG
1210 1220 1230 1240 1250
TKVNVSMGST FDMNGSLGCL QLMDLTQDNV KNQYVVSIGN SVGYENIISD
1260 1270 1280 1290 1300
IGYFESVFVR MEDAALTEAL SFTFVERSKQ ECFLNLKMAS LHYNHSAKFL
1310 1320 1330 1340 1350
KELTLSMDEL EENFRGMLKS AATKVTTVLA TKTAEYSEMV SLFETPRKTR
1360 1370 1380 1390 1400
EPFILEENEI YGFDLASSHL DTVKLILNIN IESPVVSIPR KPGSPELLVG
1410 1420 1430 1440 1450
HLGQIFIQNF VAGDDESRSD RLQVEIKDIK LYSLNCTQLA GREAVGSEGS
1460 1470 1480 1490 1500
RMFCPPSGSG SANSQEEAHF TRHDFFESLH RGQAFHILNN TTIQFKLEKI
1510 1520 1530 1540 1550
PIERESELTF SLSPDDLGTS SIMKIEGKFV NPVQVVLAKH VYEQVLQTLD
1560 1570 1580 1590 1600
NLVYSEDLNK YPASATSSPC PDSPLPPLST CGESSVERKE NGLFSHSSLS
1610 1620 1630 1640 1650
NTSQKSLSVK EVKSFTQIQA TFCISELQVQ LSGDLTLGAQ GLVSLKFQDF
1660 1670 1680 1690 1700
EVEFSKDHPQ TLSIQIALHS LLMEDLLEKN PDSKYKNLMV SRGAPKPSSL
1710 1720 1730 1740 1750
AQKEYLSQSC PSVSNVEYPD MPRSLPSHME EAPNVFQLYQ RPTSASRKKQ
1760 1770 1780 1790 1800
KEVQDKDYPL TPPPSPTVDE PKILVGKSKF DDSLVHINIF LVDKKHPEFS
1810 1820 1830 1840 1850
SSYNRVNRSI DVDFNCLDVL ITLQTWVVIL DFFGIGSTAD NHAMRLPPEG
1860 1870 1880 1890 1900
ILHNVKLEPH ASMESGLQDP VNTKLDLKVH SLSLVLNKTT SELAKANVSK
1910 1920 1930 1940 1950
LVAHLEMIEG DLALQGSIGS LSLSDLTCHG EFYRERFTTS GEEALIFQTF
1960 1970 1980 1990 2000
KYGRPDPLLR REHDIRVSLR MASVQYVHTQ RFQAEVVAFI QHFTQLQDVL
2010 2020 2030 2040 2050
GRQRAAIEGQ TVRDQAQRCS RVLLDIEAGA PVLLIPESSR SNNLIVANLG
2060 2070 2080 2090 2100
KLKVKNKFLF AGFPGTFSLQ DKESVPSASP TGIPKHSLRK TTSTEEPRGT
2110 2120 2130 2140 2150
HSQGQFTMPL AGMSLGSLKS EFVPSTSTKQ QGPQPTLSVG QESSSPEDHV
2160 2170 2180 2190 2200
CLLDCVVVDL QDMDIFAAER HPREYSKAPE DSSGDLIFPS YFVRQTGGSL
2210 2220 2230 2240 2250
LTEPCRLKLQ VERNLDKEIS HTVPDISIHG NLSSVHCSLD LYKYKLIRGL
2260 2270 2280 2290 2300
LENNLGEPIE EFMRPYDLQD PRIHTVLSGE VYTCMCFLID MVNVSLELKD
2310 2320 2330 2340 2350
PKRKEGAGSL ARFDFKKCKL LYESFSNQTK SINLVSHSMM AFDTRYAGQK
2360 2370 2380 2390 2400
TSPGMTNVFS CIFQPAKNSS TTQGSIQIEL HFRSTKDSSC FTVVLNNLRV
2410 2420 2430 2440 2450
FLIFDWLLLV HDFLHTPSDI KKQNHVTPSR HRNSSSESAI VPKTVKSGVV
2460 2470 2480 2490 2500
TKRSSLPVSN ERHLEVKVNV TGTEFVVIED VSCFDTNAII LKGTTVLTYK
2510 2520 2530 2540 2550
PRFVDRPFSG SLFGIEVFSC RLGNEHDTAL SIVDPVQIQM ELVGNSSYQN
2560 2570 2580 2590 2600
SSGLMDAFNS EDFPPVLEIQ LQALDIRLSY NDVQLFLAIA KSIPEQANAA
2610 2620 2630 2640 2650
VPDSVALESD SVGTYLPGAS RVGEEIREGT RHTLDPVLEL QLARLQELGF
2660 2670 2680 2690 2700
SMDDCRKALL ACQGQLKKAA SWLFKNAEPL KSLSLASTSR DSPGAVAAPL
2710 2720 2730 2740 2750
ISGVEIKAES VCICFIDDCM DCDVPLAELT FSRLNFLQRV RTSPEGYAHF
2760 2770 2780 2790 2800
TLSGDYYNRA LSGWEPFIEP WPCSVSWQQQ AASRLHPPRL KLEAKAKPRL
2810 2820 2830 2840 2850
DINITSVLID QYVSTKESWM ADYCKDDKDI ESAKSEDWMG SSVDPPCFGQ
2860 2870 2880 2890 2900
SLPLVYLRTR STASLTNLEH QIYARAEVKT PKRRQPFVPF ALRNHTGCTL
2910 2920 2930 2940 2950
WFATLTTTPT RAALSHSGSP GVVPEGNGTF LDDTHNVSEW REVLTGEEIP
2960 2970 2980 2990 3000
FEFEARGKLR HRHTHDLRIH QLQVRVNGWE QVSPVSVDKV GTFFRYAAPD
3010 3020 3030 3040 3050
KNSSSSTIGS PSSRTNIIHP QVYFSSLPPV RVVFAVTMEG SARKVITVRS
3060 3070 3080 3090 3100
ALIVRNRLET PMELRLDSPS APDKPVVLPA IMPGDSFAVP LHLTSWRLQA
3110 3120 3130 3140 3150
RPKGLGVFFC KAPIHWTNVV KTAEISSSKR ECHSMDTEKS RFFRFCVAIK
3160 3170 3180 3190 3200
KENYPDYMPS NIFSDSAKQI FRQPGHTIYL LPTVVICNLL PCELDFYVKG
3210 3220 3230 3240 3250
MPINGTLKPG KEAALHTADT SQNIELGVSL ENFPLCKELL IPPGTQNYMV
3260 3270 3280 3290 3300
RMRLYDVNRR QLNLTIRIVC RAEGSLKIFI SAPYWLINKT GLPLIFRQDN
3310 3320 3330 3340 3350
AKTDAAGQFE EHELARSLSP LLFCYADKEQ PNLCTMRIGR GIHPEGMPGW
3360 3370 3380 3390 3400
CQGFSLDGGS GVRALKVIQQ GNRPGLIYNI GIDVKKGRGR YIDTCMVIFA
3410 3420 3430 3440 3450
PRYLLDNKSS HKLAFAQREF ARGQGTANPE GYISTLPGSS VVFHWPRNDY
3460 3470 3480 3490 3500
DQLLCVRLMD VPNCIWSGGF EVNKNNSFHI NMRDTLGKCF FLRVEITLRG
3510 3520 3530 3540 3550
ATYRISFSDT DQLPPPFRID NFSKVPVVFT QHGVAEPRLR TEVKPMTSLD
3560 3570 3580 3590 3600
YAWDEPTLPP FITLTVKGAG SSEINCNMND FQDNRQLYYE NFIYIAATYT
3610 3620 3630 3640 3650
FSGLQEGTGR PVASNKAITC AELVLDVSPK TQRVILKKKE PGKRSQLWRM
3660 3670 3680 3690 3700
TGTGMLAHEG SSVPHNPNKP SAARSTEGSA ILDIAGLAAV TDNRYEPLML
3710 3720 3730 3740 3750
RKPDRRRSTT QTWSFREGKL TCGLHGLVVQ AKGGLSGLFD GAEVVLGPDT
3760 3770 3780 3790 3800
SMELLGPVPP EQQFINQKMR PGSGMLSIRV IPDGPTRALQ ITDFCHRKSS
3810 3820 3830 3840 3850
RSYEVDELPV TEQELQKLKN PDTEQELEVL VRLEGGIGLS LINKVPEELV
3860 3870 3880 3890 3900
FASLTGINVH YTQLATSHML ELSIQDVQVD NQLIGTTQPF MLYVTPLSNE
3910 3920 3930 3940 3950
NEVIETGPAV QVNAVKFPSK SALTNIYKHL MITAQRFTVQ IEEKLLLKLL
3960 3970 3980 3990 4000
SFFGYDQAES EVEKYDENLH EKTAEQGGTP IRYYFENLKI SIPQIKLSVF
4010 4020 4030 4040 4050
TSNKLPLDLK ALKSTLGFPL IRFEDAVINL DPFTRVHPYE TKEFIINDIL
4060 4070 4080 4090 4100
KHFQEELLSQ AARILGSVDF LGNPMGLLND VSEGVTGLIK YGNVGGLIRN
4110 4120 4130 4140 4150
VTHGVSNSAA KFAGTLSDGL GKTMDNRHQS EREYIRYHAA TSGEHLVAGI
4160 4170 4180 4190 4200
HGLAHGIIGG LTSVITSTVE GVKTEGGVSG FISGLGKGLV GTVTKPVAGA
4210 4220 4230 4240 4250
LDFASETAQA VRDTATLSGP RTQAQRVRKP RCCTGPQGLL PRYSESQAEG
4260 4270 4280 4290 4300
QEQLFKLTDN IQDEFFIAVE NIDSYCVLIS SKAVYFLKSG DYVDREAIFL
4310 4320 4330 4340 4350
EVKYDDLYHC LVSKDHGKVY VQVTKKAVST SSGVSIPGPS HQKPMVHVKS
4360 4370 4380
EVLAVKLSQE INYAKSLYYE QQLMLRLSEN REQLELDS
Length:4,388
Mass (Da):491,916
Last modified:April 16, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i799681E3BE2D1DDD
GO
Isoform 21 Publication (identifier: Q5THJ4-2) [UniParc]FASTAAdd to basket
Also known as: 2A1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     2851-2876: SLPLVYLRTRSTASLTNLEHQIYARA → T

Show »
Length:4,363
Mass (Da):489,060
Checksum:iE18E3D1D0532EF68
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BLS7H3BLS7_HUMAN
Vacuolar protein sorting-associated...
VPS13D
3,210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YD87A0A2R8YD87_HUMAN
Vacuolar protein sorting-associated...
VPS13D
1,556Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y876A0A2R8Y876_HUMAN
Vacuolar protein sorting-associated...
VPS13D
388Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GX56F5GX56_HUMAN
Vacuolar protein sorting-associated...
VPS13D
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMW1R4GMW1_HUMAN
Vacuolar protein sorting-associated...
VPS13D
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC86054 differs from that shown. Reason: Frameshift.Curated
The sequence CAE46021 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2332I → V in CAE46021 (PubMed:17974005).Curated1
Sequence conflicti2361C → R in CAE46021 (PubMed:17974005).Curated1
Sequence conflicti2783S → G in CAE75586 (PubMed:15498460).Curated1
Sequence conflicti2783S → G in CAE75587 (PubMed:15498460).Curated1
Sequence conflicti2876Missing in BAA32298 (PubMed:17974005).Curated1
Sequence conflicti3203I → T in AAH28115 (PubMed:15489334).Curated1
Sequence conflicti3332N → S in CAE46021 (PubMed:17974005).Curated1
Sequence conflicti3379N → S in CAE46021 (PubMed:17974005).Curated1
Sequence conflicti3400A → T in CAE46021 (PubMed:17974005).Curated1
Sequence conflicti3678G → E in CAE46021 (PubMed:17974005).Curated1
Sequence conflicti3994Q → R in CAE46021 (PubMed:17974005).Curated1
Sequence conflicti4268A → T in CAE46021 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029557225A → T. Corresponds to variant dbSNP:rs12057307Ensembl.1
Natural variantiVAR_081496662 – 4388Missing in SCAR4. 1 PublicationAdd BLAST3727
Natural variantiVAR_080911865T → A in SCAR4. 1 PublicationCorresponds to variant dbSNP:rs1383958401Ensembl.1
Natural variantiVAR_0814971106 – 4388Missing in SCAR4; altered mitochondrial morphology in patient cells. 1 PublicationAdd BLAST3283
Natural variantiVAR_0814981190G → D in SCAR4; altered mitochondrial morphology in patient cells. 1 Publication1
Natural variantiVAR_0809121200G → D in SCAR4. 1 PublicationCorresponds to variant dbSNP:rs768331333Ensembl.1
Natural variantiVAR_0814991307M → L in SCAR4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs775845475Ensembl.1
Natural variantiVAR_0295581341S → L. Corresponds to variant dbSNP:rs12407578Ensembl.1
Natural variantiVAR_0295591505E → V. Corresponds to variant dbSNP:rs4845898Ensembl.1
Natural variantiVAR_0621691624I → T. Corresponds to variant dbSNP:rs41279454Ensembl.1
Natural variantiVAR_0295601707S → F. Corresponds to variant dbSNP:rs958068Ensembl.1
Natural variantiVAR_0815001803 – 4388Missing in SCAR4; decreased protein abundance; altered mitochondrial morphology in patient cells. 1 PublicationAdd BLAST2586
Natural variantiVAR_0815012277 – 4388Missing in SCAR4. 1 PublicationAdd BLAST2112
Natural variantiVAR_0815022572 – 4388Missing in SCAR4. 1 PublicationAdd BLAST1817
Natural variantiVAR_0809132900L → S in SCAR4. 1 Publication1
Natural variantiVAR_0809143253R → Q in SCAR4. 1 PublicationCorresponds to variant dbSNP:rs1191625571Ensembl.1
Natural variantiVAR_0809153521N → S in SCAR4. 1 Publication1
Natural variantiVAR_0815034107N → I in SCAR4; unknown pathological significance. 1 Publication1
Natural variantiVAR_0815044149G → S in SCAR4; unknown pathological significance. 1 Publication1
Natural variantiVAR_0815054210A → V in SCAR4; altered mitochondrial morphology in patient cells. 1 PublicationCorresponds to variant dbSNP:rs746736545EnsemblClinVar.1
Natural variantiVAR_0809164228R → Q in SCAR4. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0522492851 – 2876SLPLV…IYARA → T in isoform 2. 3 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ608774 mRNA Translation: CAE75586.1
AJ608775 mRNA Translation: CAE75587.1
BX784395 BX784396 Genomic DNA Translation: CAI19412.1
BX784396 BX784395 Genomic DNA Translation: CAI19414.1
AL162331 mRNA Translation: CAB82724.1
AB007922 mRNA Translation: BAA32298.3
AK125118 mRNA Translation: BAC86054.1 Sequence problems.
BX641035 mRNA Translation: CAE46021.1 Frameshift.
BC028115 mRNA Translation: AAH28115.1
BC051804 mRNA Translation: AAH51804.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30588.1 [Q5THJ4-1]
CCDS30589.1 [Q5THJ4-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00067

NCBI Reference Sequences

More...
RefSeqi
NP_056193.2, NM_015378.3 [Q5THJ4-1]
NP_060626.2, NM_018156.3 [Q5THJ4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000613099; ENSP00000482233; ENSG00000048707 [Q5THJ4-2]
ENST00000620676; ENSP00000478104; ENSG00000048707 [Q5THJ4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55187

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55187

UCSC genome browser

More...
UCSCi
uc031tou.2 human [Q5THJ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ608774 mRNA Translation: CAE75586.1
AJ608775 mRNA Translation: CAE75587.1
BX784395 BX784396 Genomic DNA Translation: CAI19412.1
BX784396 BX784395 Genomic DNA Translation: CAI19414.1
AL162331 mRNA Translation: CAB82724.1
AB007922 mRNA Translation: BAA32298.3
AK125118 mRNA Translation: BAC86054.1 Sequence problems.
BX641035 mRNA Translation: CAE46021.1 Frameshift.
BC028115 mRNA Translation: AAH28115.1
BC051804 mRNA Translation: AAH51804.1
CCDSiCCDS30588.1 [Q5THJ4-1]
CCDS30589.1 [Q5THJ4-2]
PIRiT00067
RefSeqiNP_056193.2, NM_015378.3 [Q5THJ4-1]
NP_060626.2, NM_018156.3 [Q5THJ4-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120485, 14 interactors
IntActiQ5THJ4, 15 interactors
STRINGi9606.ENSP00000478104

PTM databases

iPTMnetiQ5THJ4
PhosphoSitePlusiQ5THJ4

Polymorphism and mutation databases

BioMutaiVPS13D
DMDMi74756617

Proteomic databases

EPDiQ5THJ4
jPOSTiQ5THJ4
MassIVEiQ5THJ4
MaxQBiQ5THJ4
PaxDbiQ5THJ4
PeptideAtlasiQ5THJ4
PRIDEiQ5THJ4
ProteomicsDBi65151 [Q5THJ4-1]
65152 [Q5THJ4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
63052 30 antibodies

Genome annotation databases

EnsembliENST00000613099; ENSP00000482233; ENSG00000048707 [Q5THJ4-2]
ENST00000620676; ENSP00000478104; ENSG00000048707 [Q5THJ4-1]
GeneIDi55187
KEGGihsa:55187
UCSCiuc031tou.2 human [Q5THJ4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55187
DisGeNETi55187
EuPathDBiHostDB:ENSG00000048707.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
VPS13D
HGNCiHGNC:23595 VPS13D
HPAiENSG00000048707 Low tissue specificity
MalaCardsiVPS13D
MIMi607317 phenotype
608877 gene
neXtProtiNX_Q5THJ4
OpenTargetsiENSG00000048707
PharmGKBiPA134970144

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1796 Eukaryota
KOG1809 Eukaryota
COG5043 LUCA
GeneTreeiENSGT00950000183083
InParanoidiQ5THJ4
KOiK19527
OMAiHMEEAQN
OrthoDBi4159at2759
PhylomeDBiQ5THJ4
TreeFamiTF300316

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55187 521 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
VPS13D human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
VPS13D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55187
PharosiQ5THJ4 Tdark

Protein Ontology

More...
PROi
PR:Q5THJ4
RNActiQ5THJ4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000048707 Expressed in skin of abdomen and 226 other tissues
ExpressionAtlasiQ5THJ4 baseline and differential
GenevisibleiQ5THJ4 HS

Family and domain databases

CDDicd14306 UBA_VP13D, 1 hit
InterProiView protein in InterPro
IPR009543 SHR-BD
IPR015940 UBA
IPR009060 UBA-like_sf
IPR041969 VP13D_UBA
IPR026847 VPS13
IPR031645 VPS13_C
IPR031642 VPS13_mid_rpt
IPR026854 VPS13_N
IPR031646 VPS13_N2
PANTHERiPTHR16166 PTHR16166, 1 hit
PfamiView protein in Pfam
PF12624 Chorein_N, 1 hit
PF06650 SHR-BD, 1 hit
PF00627 UBA, 1 hit
PF16908 VPS13, 1 hit
PF16909 VPS13_C, 1 hit
PF16910 VPS13_mid_rpt, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVP13D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5THJ4
Secondary accession number(s): J3KP14
, Q58F10, Q6MZK9, Q6ZV12, Q709C4, Q709C5, Q86UB4, Q9NSJ3, Q9UIM0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 16, 2014
Last modified: June 17, 2020
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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