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Entry version 121 (26 Feb 2020)
Sequence version 3 (15 May 2007)
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Protein

Brefeldin A-inhibited guanine nucleotide-exchange protein 3

Gene

ARFGEF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Brefeldin A-inhibited guanine nucleotide-exchange protein 3Curated
Alternative name(s):
ARFGEF family member 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARFGEF3Imported
Synonyms:BIG3, C6orf92, KIAA1244
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21213 ARFGEF3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617411 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TH69

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1492 – 1512HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57221

Open Targets

More...
OpenTargetsi
ENSG00000112379

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134888863

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5TH69 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARFGEF3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
147742985

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002866711 – 2177Brefeldin A-inhibited guanine nucleotide-exchange protein 3Add BLAST2177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei471PhosphoserineBy similarity1
Modified residuei632PhosphoserineBy similarity1
Modified residuei636PhosphoserineBy similarity1
Modified residuei1049PhosphoserineBy similarity1
Modified residuei1991PhosphoserineCombined sources1
Modified residuei2079PhosphoserineBy similarity1
Modified residuei2081PhosphoserineBy similarity1
Modified residuei2095PhosphoserineBy similarity1
Modified residuei2101PhosphoserineBy similarity1
Modified residuei2103PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5TH69

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5TH69

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5TH69

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5TH69

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TH69

PeptideAtlas

More...
PeptideAtlasi
Q5TH69

PRoteomics IDEntifications database

More...
PRIDEi
Q5TH69

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65144

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TH69

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TH69

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in breast cancer cell lines. Not expressed in normal tissues such as duct, mammary gland, lung, heart, liver, kidnay, bone marrow.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112379 Expressed in parotid gland and 165 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TH69 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036350

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PHB2.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121457, 33 interactors

Protein interaction database and analysis system

More...
IntActi
Q5TH69, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000251691

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5TH69 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5TH69

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini583 – 796SEC7Add BLAST214

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1846 Eukaryota
ENOG410XNND LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064150

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000867_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TH69

KEGG Orthology (KO)

More...
KOi
K17572

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCCWDSM

Database of Orthologous Groups

More...
OrthoDBi
1191353at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TH69

TreeFam database of animal gene trees

More...
TreeFami
TF300714

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00171 Sec7, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR015403 Sec7_C
IPR000904 Sec7_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00222 Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5TH69-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEILRKLQK EASGSKYKAI KESCTWALET LGGLDTIVKI PPHVLREKCL
60 70 80 90 100
LPLQLALESK NVKLAQHALA GMQKLLSEER FVSMETDSDE KQLLNQILNA
110 120 130 140 150
VKVTPSLNED LQVEVMKVLL CITYTPTFDL NGSAVLKIAE VCIETYISSC
160 170 180 190 200
HQRSINTAVR ATLSQMLSDL TLQLRQRQEN TIIENPDVPQ DFGNQGSTVE
210 220 230 240 250
SLCDDVVSVL TVLCEKLQAA INDSQQLQLL YLECILSVLS SSSSSMHLHR
260 270 280 290 300
RFTDLIWKNL CPALIVILGN PIHDKTITSA HTSSTSTSLE SDSASPGVSD
310 320 330 340 350
HGRGSGCSCT APALSGPVAR TIYYIAAELV RLVGSVDSMK PVLQSLYHRV
360 370 380 390 400
LLYPPPQHRV EAIKIMKEIL GSPQRLCDLA GPSSTESESR KRSISKRKSH
410 420 430 440 450
LDLLKLIMDG MTEACIKGGI EACYAAVSCV CTLLGALDEL SQGKGLSEGQ
460 470 480 490 500
VQLLLLRLEE LKDGAEWSRD SMEINEADFR WQRRVLSSEH TPWESGNERS
510 520 530 540 550
LDISISVTTD TGQTTLEGEL GQTTPEDHSG NHKNSLKSPA IPEGKETLSK
560 570 580 590 600
VLETEAVDQP DVVQRSHTVP YPDITNFLSV DCRTRSYGSR YSESNFSVDD
610 620 630 640 650
QDLSRTEFDS CDQYSMAAEK DSGRSDVSDI GSDNCSLADE EQTPRDCLGH
660 670 680 690 700
RSLRTAALSL KLLKNQEADQ HSARLFIQSL EGLLPRLLSL SNVEEVDTAL
710 720 730 740 750
QNFASTFCSG MMHSPGFDGN SSLSFQMLMN ADSLYTAAHC ALLLNLKLSH
760 770 780 790 800
GDYYRKRPTL APGVMKDFMK QVQTSGVLMV FSQAWIEELY HQVLDRNMLG
810 820 830 840 850
EAGYWGSPED NSLPLITMLT DIDGLESSAI GGQLMASAAT ESPFAQSRRI
860 870 880 890 900
DDSTVAGVAF ARYILVGCWK NLIDTLSTPL TGRMAGSSKG LAFILGAEGI
910 920 930 940 950
KEQNQKERDA ICMSLDGLRK AARLSCALGV AANCASALAQ MAAASCVQEE
960 970 980 990 1000
KEEREAQEPS DAITQVKLKV EQKLEQIGKV QGVWLHTAHV LCMEAILSVG
1010 1020 1030 1040 1050
LEMGSHNPDC WPHVFRVCEY VGTLEHNHFS DGASQPPLTI SQPQKATGSA
1060 1070 1080 1090 1100
GLLGDPECEG SPPEHSPEQG RSLSTAPVVQ PLSIQDLVRE GSRGRASDFR
1110 1120 1130 1140 1150
GGSLMSGSSA AKVVLTLSTQ ADRLFEDATD KLNLMALGGF LYQLKKASQS
1160 1170 1180 1190 1200
QLFHSVTDTV DYSLAMPGEV KSTQDRKSAL HLFRLGNAML RIVRSKARPL
1210 1220 1230 1240 1250
LHVMRCWSLV APHLVEAACH KERHVSQKAV SFIHDILTEV LTDWNEPPHF
1260 1270 1280 1290 1300
HFNEALFRPF ERIMQLELCD EDVQDQVVTS IGELVEVCST QIQSGWRPLF
1310 1320 1330 1340 1350
SALETVHGGN KSEMKEYLVG DYSMGKGQAP VFDVFEAFLN TDNIQVFANA
1360 1370 1380 1390 1400
ATSYIMCLMK FVKGLGEVDC KEIGDCAPAP GAPSTDLCLP ALDYLRRCSQ
1410 1420 1430 1440 1450
LLAKIYKMPL KPIFLSGRLA GLPRRLQEQS ASSEDGIESV LSDFDDDTGL
1460 1470 1480 1490 1500
IEVWIILLEQ LTAAVSNCPR QHQPPTLDLL FELLRDVTKT PGPGFGIYAV
1510 1520 1530 1540 1550
VHLLLPVMSV WLRRSHKDHS YWDMASANFK HAIGLSCELV VEHIQSFLHS
1560 1570 1580 1590 1600
DIRYESMINT MLKDLFELLV ACVAKPTETI SRVGCSCIRY VLVTAGPVFT
1610 1620 1630 1640 1650
EEMWRLACCA LQDAFSATLK PVKDLLGCFH SGTESFSGEG CQVRVAAPSS
1660 1670 1680 1690 1700
SPSAEAEYWR IRAMAQQVFM LDTQCSPKTP NNFDHAQSCQ LIIELPPDEK
1710 1720 1730 1740 1750
PNGHTKKSVS FREIVVSLLS HQVLLQNLYD ILLEEFVKGP SPGEEKTIQV
1760 1770 1780 1790 1800
PEAKLAGFLR YISMQNLAVI FDLLLDSYRT AREFDTSPGL KCLLKKVSGI
1810 1820 1830 1840 1850
GGAANLYRQS AMSFNIYFHA LVCAVLTNQE TITAEQVKKV LFEDDERSTD
1860 1870 1880 1890 1900
SSQQCSSEDE DIFEETAQVS PPRGKEKRQW RARMPLLSVQ PVSNADWVWL
1910 1920 1930 1940 1950
VKRLHKLCME LCNNYIQMHL DLENCMEEPP IFKGDPFFIL PSFQSESSTP
1960 1970 1980 1990 2000
STGGFSGKET PSEDDRSQSR EHMGESLSLK AGGGDLLLPP SPKVEKKDPS
2010 2020 2030 2040 2050
RKKEWWENAG NKIYTMAADK TISKLMTEYK KRKQQHNLSA FPKEVKVEKK
2060 2070 2080 2090 2100
GEPLGPRGQD SPLLQRPQHL MDQGQMRHSF SAGPELLRQD KRPRSGSTGS
2110 2120 2130 2140 2150
SLSVSVRDAE AQIQAWTNMV LTVLNQIQIL PDQTFTALQP AVFPCISQLT
2160 2170
CHVTDIRVRQ AVREWLGRVG RVYDIIV
Length:2,177
Mass (Da):240,652
Last modified:May 15, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F48EDB5BFF37454
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1876Missing in AAH14227 (PubMed:15489334).Curated1
Sequence conflicti1876Missing in AAH33191 (PubMed:15489334).Curated1
Sequence conflicti1883R → L in AAH14227 (PubMed:15489334).Curated1
Sequence conflicti1883R → L in AAH33191 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051925413E → D. Corresponds to variant dbSNP:rs9376338Ensembl.1
Natural variantiVAR_032154689S → A. Corresponds to variant dbSNP:rs7764091Ensembl.1
Natural variantiVAR_0321551571A → T. Corresponds to variant dbSNP:rs3736706Ensembl.1
Natural variantiVAR_0321562031K → R. Corresponds to variant dbSNP:rs35964895Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB252196 mRNA Translation: BAH83562.1
AL031433 Genomic DNA No translation available.
AL391240 Genomic DNA No translation available.
AL031003 Genomic DNA No translation available.
AB033070 mRNA Translation: BAA86558.2
AF413080 mRNA Translation: AAL04174.1
BC014227 mRNA Translation: AAH14227.2
BC033191 mRNA Translation: AAH33191.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5189.2

NCBI Reference Sequences

More...
RefSeqi
NP_065073.3, NM_020340.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000251691; ENSP00000251691; ENSG00000112379

Database of genes from NCBI RefSeq genomes

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GeneIDi
57221

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57221

UCSC genome browser

More...
UCSCi
uc003qhu.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB252196 mRNA Translation: BAH83562.1
AL031433 Genomic DNA No translation available.
AL391240 Genomic DNA No translation available.
AL031003 Genomic DNA No translation available.
AB033070 mRNA Translation: BAA86558.2
AF413080 mRNA Translation: AAL04174.1
BC014227 mRNA Translation: AAH14227.2
BC033191 mRNA Translation: AAH33191.1
CCDSiCCDS5189.2
RefSeqiNP_065073.3, NM_020340.4

3D structure databases

SMRiQ5TH69
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121457, 33 interactors
IntActiQ5TH69, 14 interactors
STRINGi9606.ENSP00000251691

PTM databases

iPTMnetiQ5TH69
PhosphoSitePlusiQ5TH69

Polymorphism and mutation databases

BioMutaiARFGEF3
DMDMi147742985

Proteomic databases

EPDiQ5TH69
jPOSTiQ5TH69
MassIVEiQ5TH69
MaxQBiQ5TH69
PaxDbiQ5TH69
PeptideAtlasiQ5TH69
PRIDEiQ5TH69
ProteomicsDBi65144

Genome annotation databases

EnsembliENST00000251691; ENSP00000251691; ENSG00000112379
GeneIDi57221
KEGGihsa:57221
UCSCiuc003qhu.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57221
DisGeNETi57221

GeneCards: human genes, protein and diseases

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GeneCardsi
ARFGEF3
HGNCiHGNC:21213 ARFGEF3
HPAiHPA036350
MIMi617411 gene
neXtProtiNX_Q5TH69
OpenTargetsiENSG00000112379
PharmGKBiPA134888863

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1846 Eukaryota
ENOG410XNND LUCA
GeneTreeiENSGT00530000064150
HOGENOMiCLU_000867_1_0_1
InParanoidiQ5TH69
KOiK17572
OMAiTCCWDSM
OrthoDBi1191353at2759
PhylomeDBiQ5TH69
TreeFamiTF300714

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARFGEF3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57221
PharosiQ5TH69 Tdark

Protein Ontology

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PROi
PR:Q5TH69
RNActiQ5TH69 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000112379 Expressed in parotid gland and 165 other tissues
GenevisibleiQ5TH69 HS

Family and domain databases

CDDicd00171 Sec7, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR015403 Sec7_C
IPR000904 Sec7_dom
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
SMARTiView protein in SMART
SM00222 Sec7, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBIG3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TH69
Secondary accession number(s): C5NM88
, Q76MU8, Q8N4Y4, Q96CH9, Q96P46, Q9ULH6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: February 26, 2020
This is version 121 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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