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Protein

Transmembrane and coiled-coil domain-containing protein 4

Gene

TMCO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein family/group databases

ESTHERihuman-TMCO4 Duf_726

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and coiled-coil domain-containing protein 4
Gene namesi
Name:TMCO4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162542.13
HGNCiHGNC:27393 TMCO4
neXtProtiNX_Q5TGY1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi255104
OpenTargetsiENSG00000162542
PharmGKBiPA142670794

Polymorphism and mutation databases

BioMutaiTMCO4
DMDMi74746530

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051491 – 634Transmembrane and coiled-coil domain-containing protein 4Add BLAST634

Proteomic databases

EPDiQ5TGY1
MaxQBiQ5TGY1
PaxDbiQ5TGY1
PeptideAtlasiQ5TGY1
PRIDEiQ5TGY1
ProteomicsDBi65131
65132 [Q5TGY1-2]

PTM databases

iPTMnetiQ5TGY1
PhosphoSitePlusiQ5TGY1

Expressioni

Gene expression databases

BgeeiENSG00000162542
CleanExiHS_TMCO4
ExpressionAtlasiQ5TGY1 baseline and differential
GenevisibleiQ5TGY1 HS

Organism-specific databases

HPAiHPA014601
HPA014620

Interactioni

Protein-protein interaction databases

BioGridi129076, 2 interactors
IntActiQ5TGY1, 4 interactors
MINTiQ5TGY1
STRINGi9606.ENSP00000294543

Structurei

3D structure databases

ProteinModelPortaliQ5TGY1
SMRiQ5TGY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili150 – 190Sequence analysisAdd BLAST41

Sequence similaritiesi

Belongs to the TMCO4 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2385 Eukaryota
ENOG410YB1Z LUCA
GeneTreeiENSGT00390000001400
HOGENOMiHOG000019995
HOVERGENiHBG096742
InParanoidiQ5TGY1
OMAiSFCTEFM
OrthoDBiEOG091G0F0H
PhylomeDBiQ5TGY1
TreeFamiTF312951

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR007941 DUF726
PANTHERiPTHR17920 PTHR17920, 1 hit
PfamiView protein in Pfam
PF05277 DUF726, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TGY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMWNRPCQR LPQQPLVAEP TAEGEPHLPT GRELTEANRF AYAALCGISL
60 70 80 90 100
SQLFPEPEHS SFCTEFMAGL VQWLELSEAV LPTMTAFASG LGGEGADVFV
110 120 130 140 150
QILLKDPILK DDPTVITQDL LSFSLKDGHY DARARVLVCH MTSLLQVPLE
160 170 180 190 200
ELDVLEEMFL ESLKEIKEEE SEMAEASRKK KENRRKWKRY LLIGLATVGG
210 220 230 240 250
GTVIGVTGGL AAPLVAAGAA TIIGSAGAAA LGSAAGIAIM TSLFGAAGAG
260 270 280 290 300
LTGYKMKKRV GAIEEFTFLP LTEGRQLHIT IAVTGWLASG KYRTFSAPWA
310 320 330 340 350
ALAHSREQYC LAWEAKYLME LGNALETILS GLANMVAQEA LKYTVLSGIV
360 370 380 390 400
AALTWPASLL SVANVIDNPW GVCLHRSAEV GKHLAHILLS RQQGRRPVTL
410 420 430 440 450
IGFSLGARVI YFCLQEMAQE KDCQGIIEDV ILLGAPVEGE AKHWEPFRKV
460 470 480 490 500
VSGRIINGYC RGDWLLSFVY RTSSVQLRVA GLQPVLLQDR RVENVDLTSV
510 520 530 540 550
VSGHLDYAKQ MDAILKAVGI RTKPGWDEKG LLLAPGCLPS EEPRQAAAAA
560 570 580 590 600
SSGETPHQVG QTQGPISGDT SKLAMSTDPS QAQVPVGLDQ SEGASLPAAA
610 620 630
SPERPPICSH GMDPNPLGCP DCACKTQGPS TGLD
Length:634
Mass (Da):67,910
Last modified:December 21, 2004 - v1
Checksum:i9D2F5E263A9E98E3
GO
Isoform 2 (identifier: Q5TGY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-293: Missing.

Note: No experimental confirmation available.
Show »
Length:594
Mass (Da):63,318
Checksum:i988DFBC5AD13E392
GO

Sequence cautioni

The sequence CAB42850 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB42851 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI19015 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20091 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti605P → S in CAE45994 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03516972Q → K. Corresponds to variant dbSNP:rs10917536Ensembl.1
Natural variantiVAR_035170478R → H2 PublicationsCorresponds to variant dbSNP:rs4515815Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028242254 – 293Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640987 mRNA Translation: CAE45994.1
AL031727, AL031730 Genomic DNA Translation: CAI19015.1 Sequence problems.
AL031727, AL031730 Genomic DNA Translation: CAI19016.1
AL031730, AL031727 Genomic DNA Translation: CAI20091.1 Sequence problems.
AL031730, AL031727 Genomic DNA Translation: CAI20092.1
BC053600 mRNA Translation: AAH53600.1
AL049846 mRNA Translation: CAB42850.1 Different initiation.
AL049847 mRNA Translation: CAB42851.1 Different initiation.
CCDSiCCDS198.1 [Q5TGY1-1]
RefSeqiNP_859070.3, NM_181719.4 [Q5TGY1-1]
XP_005245879.1, XM_005245822.4 [Q5TGY1-1]
XP_005245881.1, XM_005245824.4 [Q5TGY1-1]
XP_005245884.1, XM_005245827.3 [Q5TGY1-2]
XP_011539487.1, XM_011541185.2 [Q5TGY1-1]
XP_011539488.1, XM_011541186.2 [Q5TGY1-1]
XP_016856402.1, XM_017000913.1 [Q5TGY1-2]
XP_016856407.1, XM_017000918.1 [Q5TGY1-1]
XP_016856408.1, XM_017000919.1 [Q5TGY1-1]
XP_016856409.1, XM_017000920.1 [Q5TGY1-1]
UniGeneiHs.466729
Hs.656313

Genome annotation databases

EnsembliENST00000294543; ENSP00000294543; ENSG00000162542 [Q5TGY1-1]
GeneIDi255104
KEGGihsa:255104
UCSCiuc001bcn.3 human [Q5TGY1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTMCO4_HUMAN
AccessioniPrimary (citable) accession number: Q5TGY1
Secondary accession number(s): Q5TGY2
, Q6MZN5, Q7Z6K6, Q9UQP4, Q9Y3K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 21, 2004
Last modified: July 18, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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