UniProtKB - Q5TGU0 (TSPO2_HUMAN)
Protein
Translocator protein 2
Gene
TSPO2
Organism
Homo sapiens (Human)
Status
Functioni
Cholesterol-binding protein involved in the redistribution of cholesterol from lipid droplets to the endoplasmic reticulum (PubMed:19729679). Required to meet cholesterol demands during erythropoietic differentiation (PubMed:19729679). May play a role in transport processes at the plasma membrane of erythrocytes, including regulating VDAC-mediated ATP export, and import of the heme precursors protoporphyrin IX and 5-aminolevulinic acid (PubMed:27641616, PubMed:30061676, PubMed:31989647).4 Publications
GO - Molecular functioni
- cholesterol binding Source: UniProtKB
GO - Biological processi
- amino acid import across plasma membrane Source: UniProtKB
- enucleate erythrocyte differentiation Source: UniProtKB
- import across plasma membrane Source: UniProtKB
- intracellular cholesterol transport Source: UniProtKB
- lipid droplet organization Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q5TGU0 |
SIGNORi | Q5TGU0 |
Protein family/group databases
TCDBi | 9.A.24.1.17, the mitochondrial cholesterol/porphyrin/5-aminolevulinic acid uptake translocator protein (tspo) family |
Names & Taxonomyi
Protein namesi | Recommended name: Translocator protein 2Alternative name(s): Peripheral-type benzodiazepine receptor-like protein 1 |
Gene namesi | Name:TSPO2 Synonyms:BZRPL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21256, TSPO2 |
neXtProti | NX_Q5TGU0 |
VEuPathDBi | HostDB:ENSG00000112212.11 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Localizes to the plasma membrane and intracellular membranes in developing and mature erythrocytes.2 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: GO_Central
- organelle membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 3 – 23 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 45 – 65 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 78 – 98 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 104 – 124 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 130 – 150 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000112212 |
PharmGKBi | PA165618396 |
Miscellaneous databases
Pharosi | Q5TGU0, Tdark |
Genetic variation databases
BioMutai | TSPO2 |
DMDMi | 74746518 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000292005 | 1 – 170 | Translocator protein 2Add BLAST | 170 |
Proteomic databases
PaxDbi | Q5TGU0 |
PRIDEi | Q5TGU0 |
ProteomicsDBi | 65129 [Q5TGU0-1] 65130 [Q5TGU0-2] |
PTM databases
iPTMneti | Q5TGU0 |
PhosphoSitePlusi | Q5TGU0 |
Expressioni
Tissue specificityi
Expressed in erythrocytes (at protein level).1 Publication
Developmental stagei
Expression levels increase during erythrocyte differentiation.1 Publication
Gene expression databases
Bgeei | ENSG00000112212, Expressed in bone marrow and 90 other tissues |
Genevisiblei | Q5TGU0, HS |
Organism-specific databases
HPAi | ENSG00000112212, Tissue enriched (bone) |
Interactioni
Subunit structurei
Binary interactionsi
Q5TGU0
Protein-protein interaction databases
BioGRIDi | 128807, 58 interactors |
IntActi | Q5TGU0, 55 interactors |
STRINGi | 9606.ENSP00000362255 |
Miscellaneous databases
RNActi | Q5TGU0, protein |
Family & Domainsi
Domaini
The C-terminal region mediates cholesterol-binding.By similarity
Sequence similaritiesi
Belongs to the TspO/BZRP family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3797, Eukaryota |
GeneTreei | ENSGT00390000012980 |
HOGENOMi | CLU_091805_2_1_1 |
InParanoidi | Q5TGU0 |
OMAi | WLAMATC |
OrthoDBi | 1592225at2759 |
PhylomeDBi | Q5TGU0 |
TreeFami | TF342852 |
Family and domain databases
Gene3Di | 1.20.1260.100, 1 hit |
InterProi | View protein in InterPro IPR038330, TspO/MBR-related_sf IPR004307, TspO_MBR |
PANTHERi | PTHR10057, PTHR10057, 1 hit |
Pfami | View protein in Pfam PF03073, TspO_MBR, 1 hit |
PIRSFi | PIRSF005859, PBR, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q5TGU0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRLQGAIFVL LPHLGPILVW LFTRDHMSGW CEGPRMLSWC PFYKVLLLVQ
60 70 80 90 100
TAIYSVVGYA SYLVWKDLGG GLGWPLALPL GLYAVQLTIS WTVLVLFFTV
110 120 130 140 150
HNPGLALLHL LLLYGLVVST ALIWHPINKL AALLLLPYLA WLTVTSALTY
160 170
HLWRDSLCPV HQPQPTEKSD
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026363 | 59 – 70 | YASYL…KDLGG → PCCTCCCCMGWW in isoform 2. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_026364 | 71 – 170 | Missing in isoform 2. 1 PublicationAdd BLAST | 100 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031778 Genomic DNA No translation available. BC104440 mRNA Translation: AAI04441.1 BC104441 mRNA Translation: AAI04442.1 BC137560 mRNA Translation: AAI37561.1 BC137565 mRNA Translation: AAI37566.1 BC144710 mRNA Translation: AAI44711.1 |
CCDSi | CCDS34444.1 [Q5TGU0-1] |
RefSeqi | NP_001010873.1, NM_001010873.2 [Q5TGU0-1] NP_001153198.1, NM_001159726.1 [Q5TGU0-1] XP_011512698.1, XM_011514396.2 [Q5TGU0-1] XP_011512699.1, XM_011514397.2 [Q5TGU0-1] |
Genome annotation databases
Ensembli | ENST00000373158; ENSP00000362252; ENSG00000112212 [Q5TGU0-2] ENST00000373161; ENSP00000362255; ENSG00000112212 [Q5TGU0-1] ENST00000470917; ENSP00000419985; ENSG00000112212 [Q5TGU0-1] |
GeneIDi | 222642 |
KEGGi | hsa:222642 |
UCSCi | uc003opj.4, human [Q5TGU0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031778 Genomic DNA No translation available. BC104440 mRNA Translation: AAI04441.1 BC104441 mRNA Translation: AAI04442.1 BC137560 mRNA Translation: AAI37561.1 BC137565 mRNA Translation: AAI37566.1 BC144710 mRNA Translation: AAI44711.1 |
CCDSi | CCDS34444.1 [Q5TGU0-1] |
RefSeqi | NP_001010873.1, NM_001010873.2 [Q5TGU0-1] NP_001153198.1, NM_001159726.1 [Q5TGU0-1] XP_011512698.1, XM_011514396.2 [Q5TGU0-1] XP_011512699.1, XM_011514397.2 [Q5TGU0-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 128807, 58 interactors |
IntActi | Q5TGU0, 55 interactors |
STRINGi | 9606.ENSP00000362255 |
Protein family/group databases
TCDBi | 9.A.24.1.17, the mitochondrial cholesterol/porphyrin/5-aminolevulinic acid uptake translocator protein (tspo) family |
PTM databases
iPTMneti | Q5TGU0 |
PhosphoSitePlusi | Q5TGU0 |
Genetic variation databases
BioMutai | TSPO2 |
DMDMi | 74746518 |
Proteomic databases
PaxDbi | Q5TGU0 |
PRIDEi | Q5TGU0 |
ProteomicsDBi | 65129 [Q5TGU0-1] 65130 [Q5TGU0-2] |
Protocols and materials databases
Antibodypediai | 76908, 4 antibodies |
Genome annotation databases
Ensembli | ENST00000373158; ENSP00000362252; ENSG00000112212 [Q5TGU0-2] ENST00000373161; ENSP00000362255; ENSG00000112212 [Q5TGU0-1] ENST00000470917; ENSP00000419985; ENSG00000112212 [Q5TGU0-1] |
GeneIDi | 222642 |
KEGGi | hsa:222642 |
UCSCi | uc003opj.4, human [Q5TGU0-1] |
Organism-specific databases
CTDi | 222642 |
GeneCardsi | TSPO2 |
HGNCi | HGNC:21256, TSPO2 |
HPAi | ENSG00000112212, Tissue enriched (bone) |
neXtProti | NX_Q5TGU0 |
OpenTargetsi | ENSG00000112212 |
PharmGKBi | PA165618396 |
VEuPathDBi | HostDB:ENSG00000112212.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3797, Eukaryota |
GeneTreei | ENSGT00390000012980 |
HOGENOMi | CLU_091805_2_1_1 |
InParanoidi | Q5TGU0 |
OMAi | WLAMATC |
OrthoDBi | 1592225at2759 |
PhylomeDBi | Q5TGU0 |
TreeFami | TF342852 |
Enzyme and pathway databases
PathwayCommonsi | Q5TGU0 |
SIGNORi | Q5TGU0 |
Miscellaneous databases
BioGRID-ORCSi | 222642, 5 hits in 868 CRISPR screens |
GenomeRNAii | 222642 |
Pharosi | Q5TGU0, Tdark |
PROi | PR:Q5TGU0 |
RNActi | Q5TGU0, protein |
Gene expression databases
Bgeei | ENSG00000112212, Expressed in bone marrow and 90 other tissues |
Genevisiblei | Q5TGU0, HS |
Family and domain databases
Gene3Di | 1.20.1260.100, 1 hit |
InterProi | View protein in InterPro IPR038330, TspO/MBR-related_sf IPR004307, TspO_MBR |
PANTHERi | PTHR10057, PTHR10057, 1 hit |
Pfami | View protein in Pfam PF03073, TspO_MBR, 1 hit |
PIRSFi | PIRSF005859, PBR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TSPO2_HUMAN | |
Accessioni | Q5TGU0Primary (citable) accession number: Q5TGU0 Secondary accession number(s): B2RPR2, B7ZMN8, Q3SX82 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 10, 2021 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families