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UniProtKB - Q5TGU0 (TSPO2_HUMAN)

Entry version 103 (11 Dec 2019)
Sequence version 1 (21 Dec 2004)
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Protein

Translocator protein 2

Gene

TSPO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds cholesterol and mediates its redistribution during erythropoiesis which may play a role in erythrocyte maturation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translocator protein 2
Alternative name(s):
Peripheral-type benzodiazepine receptor-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSPO2
Synonyms:BZRPL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000112212.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:21256 TSPO2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5TGU0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000112212

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165618396

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5TGU0 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TSPO2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74746518

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002920051 – 170Translocator protein 2Add BLAST170

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5TGU0

PRoteomics IDEntifications database

More...PRIDEi		Q5TGU0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65129 [Q5TGU0-1]
65130 [Q5TGU0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5TGU0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5TGU0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000112212 Expressed in 70 organ(s), highest expression level in bone marrow

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5TGU0 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P478844EBI-12195249,EBI-11988863

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q5TGU0, 53 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362255

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5TGU0 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal region mediates cholesterol-binding.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TspO/BZRP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3797 Eukaryota
COG3476 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012980

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000224659

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5TGU0

Identification of Orthologs from Complete Genome Data

More...OMAi		KKPSWCP

Database of Orthologous Groups

More...OrthoDBi		1592225at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5TGU0

TreeFam database of animal gene trees

More...TreeFami		TF342852

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1260.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038330 TspO/MBR-related_sf
IPR004307 TspO_MBR

The PANTHER Classification System

More...PANTHERi		PTHR10057 PTHR10057, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03073 TspO_MBR, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005859 PBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5TGU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLQGAIFVL LPHLGPILVW LFTRDHMSGW CEGPRMLSWC PFYKVLLLVQ 
        60         70         80         90        100
TAIYSVVGYA SYLVWKDLGG GLGWPLALPL GLYAVQLTIS WTVLVLFFTV 
       110        120        130        140        150
HNPGLALLHL LLLYGLVVST ALIWHPINKL AALLLLPYLA WLTVTSALTY 
       160        170
HLWRDSLCPV HQPQPTEKSD
Length:170
Mass (Da):19,129
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B705EFA0E2E1ABB
GO
Isoform 2 (identifier: Q5TGU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-70: YASYLVWKDLGG → PCCTCCCCMGWW
     71-170: Missing.

Show »
Length:70
Mass (Da):8,039
Checksum:iF8FBDFD8448148A9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02636359 – 70YASYL…KDLGG → PCCTCCCCMGWW in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_02636471 – 170Missing in isoform 2. 1 PublicationAdd BLAST100

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL031778 Genomic DNA No translation available.
BC104440 mRNA Translation: AAI04441.1
BC104441 mRNA Translation: AAI04442.1
BC137560 mRNA Translation: AAI37561.1
BC137565 mRNA Translation: AAI37566.1
BC144710 mRNA Translation: AAI44711.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34444.1 [Q5TGU0-1]

NCBI Reference Sequences

More...RefSeqi		NP_001010873.1, NM_001010873.2 [Q5TGU0-1]
NP_001153198.1, NM_001159726.1 [Q5TGU0-1]
XP_011512698.1, XM_011514396.2 [Q5TGU0-1]
XP_011512699.1, XM_011514397.2 [Q5TGU0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373158; ENSP00000362252; ENSG00000112212 [Q5TGU0-2]
ENST00000373161; ENSP00000362255; ENSG00000112212 [Q5TGU0-1]
ENST00000470917; ENSP00000419985; ENSG00000112212 [Q5TGU0-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		222642

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:222642

UCSC genome browser

More...UCSCi		uc003opj.4 human [Q5TGU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031778 Genomic DNA No translation available.
BC104440 mRNA Translation: AAI04441.1
BC104441 mRNA Translation: AAI04442.1
BC137560 mRNA Translation: AAI37561.1
BC137565 mRNA Translation: AAI37566.1
BC144710 mRNA Translation: AAI44711.1
CCDSiCCDS34444.1 [Q5TGU0-1]
RefSeqiNP_001010873.1, NM_001010873.2 [Q5TGU0-1]
NP_001153198.1, NM_001159726.1 [Q5TGU0-1]
XP_011512698.1, XM_011514396.2 [Q5TGU0-1]
XP_011512699.1, XM_011514397.2 [Q5TGU0-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiQ5TGU0, 53 interactors
STRINGi9606.ENSP00000362255

PTM databases

iPTMnetiQ5TGU0
PhosphoSitePlusiQ5TGU0

Polymorphism and mutation databases

BioMutaiTSPO2
DMDMi74746518

Proteomic databases

PaxDbiQ5TGU0
PRIDEiQ5TGU0
ProteomicsDBi65129 [Q5TGU0-1]
65130 [Q5TGU0-2]

Genome annotation databases

EnsembliENST00000373158; ENSP00000362252; ENSG00000112212 [Q5TGU0-2]
ENST00000373161; ENSP00000362255; ENSG00000112212 [Q5TGU0-1]
ENST00000470917; ENSP00000419985; ENSG00000112212 [Q5TGU0-1]
GeneIDi222642
KEGGihsa:222642
UCSCiuc003opj.4 human [Q5TGU0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		222642
EuPathDBiHostDB:ENSG00000112212.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		TSPO2
HGNCiHGNC:21256 TSPO2
neXtProtiNX_Q5TGU0
OpenTargetsiENSG00000112212
PharmGKBiPA165618396

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3797 Eukaryota
COG3476 LUCA
GeneTreeiENSGT00390000012980
HOGENOMiHOG000224659
InParanoidiQ5TGU0
OMAiKKPSWCP
OrthoDBi1592225at2759
PhylomeDBiQ5TGU0
TreeFamiTF342852

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		222642
PharosiQ5TGU0 Tdark

Protein Ontology

More...PROi		PR:Q5TGU0
RNActiQ5TGU0 protein

Gene expression databases

BgeeiENSG00000112212 Expressed in 70 organ(s), highest expression level in bone marrow
GenevisibleiQ5TGU0 HS

Family and domain databases

Gene3Di1.20.1260.100, 1 hit
InterProiView protein in InterPro
IPR038330 TspO/MBR-related_sf
IPR004307 TspO_MBR
PANTHERiPTHR10057 PTHR10057, 1 hit
PfamiView protein in Pfam
PF03073 TspO_MBR, 1 hit
PIRSFiPIRSF005859 PBR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSPO2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TGU0
Secondary accession number(s): B2RPR2, B7ZMN8, Q3SX82
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 21, 2004
Last modified: December 11, 2019
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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