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UniProtKB - Q5TGU0 (TSPO2_HUMAN)

Entry version 114 (23 Feb 2022)
Sequence version 1 (21 Dec 2004)
Previous versions | rss
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Protein

Translocator protein 2

Gene

TSPO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cholesterol-binding protein involved in the redistribution of cholesterol from lipid droplets to the endoplasmic reticulum (PubMed:19729679).

Required to meet cholesterol demands during erythropoietic differentiation (PubMed:19729679).

May play a role in transport processes at the plasma membrane of erythrocytes, including regulating VDAC-mediated ATP export, and import of the heme precursors protoporphyrin IX and 5-aminolevulinic acid (PubMed:27641616, PubMed:30061676, PubMed:31989647).

4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5TGU0

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q5TGU0

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q5TGU0

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.24.1.17, the mitochondrial cholesterol/porphyrin/5-aminolevulinic acid uptake translocator protein (tspo) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translocator protein 2
Alternative name(s):
Peripheral-type benzodiazepine receptor-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSPO2
Synonyms:BZRPL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21256, TSPO2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		619409, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5TGU0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000112212

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000112212

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165618396

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5TGU0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TSPO2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74746518

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002920051 – 170Translocator protein 2Add BLAST170

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5TGU0

PRoteomics IDEntifications database

More...PRIDEi		Q5TGU0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5TGU0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5TGU0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in erythrocytes (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression levels increase during erythrocyte differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000112212, Expressed in bone marrow and 92 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5TGU0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000112212, Tissue enriched (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer (PubMed:27641616). May also form homodimer (PubMed:27641616).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q5TGU0
With#Exp.IntAct
AHNAK2 - isoform 3 [Q8IVF2-3]3EBI-12195249,EBI-12078468
AQP6 [Q13520]3EBI-12195249,EBI-13059134
ARL13B [Q3SXY8]3EBI-12195249,EBI-11343438
ASGR2 - isoform 3 [P07307-3]3EBI-12195249,EBI-12808270
ASZ1 [Q8WWH4]3EBI-12195249,EBI-12239061
BIK [Q13323]3EBI-12195249,EBI-700794
CD53 [P19397]3EBI-12195249,EBI-6657396
CD69 [Q07108]3EBI-12195249,EBI-2836595
CD79A [P11912]3EBI-12195249,EBI-7797864
CERS4 [Q9HA82]3EBI-12195249,EBI-2622997
CLDN4 [O14493]3EBI-12195249,EBI-9316372
CNR2 [P34972]3EBI-12195249,EBI-2835940
COL4A5 - isoform 2 [P29400-2]3EBI-12195249,EBI-12211159
CPLX4 [Q7Z7G2]3EBI-12195249,EBI-18013275
CREB3L1 [Q96BA8]5EBI-12195249,EBI-6942903
DKK4 [Q9UBT3]3EBI-12195249,EBI-18030204
EBP [Q15125]3EBI-12195249,EBI-3915253
EFNA5 [P52803]3EBI-12195249,EBI-1753674
EMP1 [P54849]3EBI-12195249,EBI-4319440
ERGIC3 [Q9Y282]3EBI-12195249,EBI-781551
ERP29 [P30040]3EBI-12195249,EBI-946830
FCGR1A [P12314]3EBI-12195249,EBI-2869867
FFAR2 [O15552]3EBI-12195249,EBI-2833872
FNDC9 [Q8TBE3]3EBI-12195249,EBI-12142257
FXYD3 - isoform 3 [Q14802-3]3EBI-12195249,EBI-12175685
GGT7 [Q9UJ14]3EBI-12195249,EBI-1058791
GJB5 [O95377]3EBI-12195249,EBI-3909454
GPR152 [Q8TDT2]3EBI-12195249,EBI-13345167
GPR42 [O15529]3EBI-12195249,EBI-18076404
IGFBP5 [P24593]3EBI-12195249,EBI-720480
KCNJ6 [P48051]3EBI-12195249,EBI-12017638
KLRC1 [P26715]3EBI-12195249,EBI-9018187
LRRC59 [Q96AG4]3EBI-12195249,EBI-358888
MAL [P21145]3EBI-12195249,EBI-3932027
MARCHF2 [Q9P0N8]3EBI-12195249,EBI-10317612
MFF - isoform 5 [Q9GZY8-5]3EBI-12195249,EBI-11956541
MFSD6 [Q6ZSS7]3EBI-12195249,EBI-2858252
MS4A1 [P11836]3EBI-12195249,EBI-2808234
PDZK1IP1 [Q13113]3EBI-12195249,EBI-716063
PLEKHO1 [Q53GL0]3EBI-12195249,EBI-949945
RELL2 [Q8NC24]3EBI-12195249,EBI-10269209
RETREG3 [Q86VR2]5EBI-12195249,EBI-10192441
RPRM [Q9NS64]3EBI-12195249,EBI-1052363
SLC10A1 [Q14973]3EBI-12195249,EBI-3923031
SLC10A6 [Q3KNW5]3EBI-12195249,EBI-18159983
SLC34A2 - isoform 2 [O95436-2]3EBI-12195249,EBI-12811757
SLC41A3 [Q96GZ6]3EBI-12195249,EBI-7225508
SLC7A1 [P30825]3EBI-12195249,EBI-4289564
SPAG4 [Q9NPE6]3EBI-12195249,EBI-10819434
STOM [P27105]3EBI-12195249,EBI-1211440
SYT2 [Q8N9I0]3EBI-12195249,EBI-8032987
TMEM140 [Q9NV12]3EBI-12195249,EBI-2844246
TMEM54 [Q969K7]3EBI-12195249,EBI-3922833
TMEM80 [Q96HE8]3EBI-12195249,EBI-11742770
VSIR [Q9H7M9]3EBI-12195249,EBI-744988

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128807, 58 interactors

Protein interaction database and analysis system

More...IntActi		Q5TGU0, 55 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362255

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5TGU0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5TGU0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal region mediates cholesterol-binding.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TspO/BZRP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3797, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012980

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_091805_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5TGU0

Identification of Orthologs from Complete Genome Data

More...OMAi		RDSLCPE

Database of Orthologous Groups

More...OrthoDBi		1592225at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5TGU0

TreeFam database of animal gene trees

More...TreeFami		TF342852

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1260.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038330, TspO/MBR-related_sf
IPR004307, TspO_MBR

The PANTHER Classification System

More...PANTHERi		PTHR10057, PTHR10057, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03073, TspO_MBR, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005859, PBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5TGU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLQGAIFVL LPHLGPILVW LFTRDHMSGW CEGPRMLSWC PFYKVLLLVQ 
        60         70         80         90        100
TAIYSVVGYA SYLVWKDLGG GLGWPLALPL GLYAVQLTIS WTVLVLFFTV 
       110        120        130        140        150
HNPGLALLHL LLLYGLVVST ALIWHPINKL AALLLLPYLA WLTVTSALTY 
       160        170
HLWRDSLCPV HQPQPTEKSD
Length:170
Mass (Da):19,129
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B705EFA0E2E1ABB
GO
Isoform 2 (identifier: Q5TGU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-70: YASYLVWKDLGG → PCCTCCCCMGWW
     71-170: Missing.

Show »
Length:70
Mass (Da):8,039
Checksum:iF8FBDFD8448148A9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02636359 – 70YASYL…KDLGG → PCCTCCCCMGWW in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_02636471 – 170Missing in isoform 2. 1 PublicationAdd BLAST100

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL031778 Genomic DNA No translation available.
BC104440 mRNA Translation: AAI04441.1
BC104441 mRNA Translation: AAI04442.1
BC137560 mRNA Translation: AAI37561.1
BC137565 mRNA Translation: AAI37566.1
BC144710 mRNA Translation: AAI44711.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34444.1 [Q5TGU0-1]

NCBI Reference Sequences

More...RefSeqi		NP_001010873.1, NM_001010873.2 [Q5TGU0-1]
NP_001153198.1, NM_001159726.1 [Q5TGU0-1]
XP_011512698.1, XM_011514396.2 [Q5TGU0-1]
XP_011512699.1, XM_011514397.2 [Q5TGU0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373158; ENSP00000362252; ENSG00000112212 [Q5TGU0-2]
ENST00000373161; ENSP00000362255; ENSG00000112212
ENST00000470917; ENSP00000419985; ENSG00000112212

Database of genes from NCBI RefSeq genomes

More...GeneIDi		222642

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:222642

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000373161.6; ENSP00000362255.1; NM_001010873.3; NP_001010873.1

UCSC genome browser

More...UCSCi		uc003opj.4, human [Q5TGU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031778 Genomic DNA No translation available.
BC104440 mRNA Translation: AAI04441.1
BC104441 mRNA Translation: AAI04442.1
BC137560 mRNA Translation: AAI37561.1
BC137565 mRNA Translation: AAI37566.1
BC144710 mRNA Translation: AAI44711.1
CCDSiCCDS34444.1 [Q5TGU0-1]
RefSeqiNP_001010873.1, NM_001010873.2 [Q5TGU0-1]
NP_001153198.1, NM_001159726.1 [Q5TGU0-1]
XP_011512698.1, XM_011514396.2 [Q5TGU0-1]
XP_011512699.1, XM_011514397.2 [Q5TGU0-1]

3D structure databases

SMRiQ5TGU0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128807, 58 interactors
IntActiQ5TGU0, 55 interactors
STRINGi9606.ENSP00000362255

Protein family/group databases

TCDBi9.A.24.1.17, the mitochondrial cholesterol/porphyrin/5-aminolevulinic acid uptake translocator protein (tspo) family

PTM databases

iPTMnetiQ5TGU0
PhosphoSitePlusiQ5TGU0

Genetic variation databases

BioMutaiTSPO2
DMDMi74746518

Proteomic databases

PaxDbiQ5TGU0
PRIDEiQ5TGU0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		76908, 4 antibodies from 4 providers

The DNASU plasmid repository

More...DNASUi		222642

Genome annotation databases

EnsembliENST00000373158; ENSP00000362252; ENSG00000112212 [Q5TGU0-2]
ENST00000373161; ENSP00000362255; ENSG00000112212
ENST00000470917; ENSP00000419985; ENSG00000112212
GeneIDi222642
KEGGihsa:222642
MANE-SelectiENST00000373161.6; ENSP00000362255.1; NM_001010873.3; NP_001010873.1
UCSCiuc003opj.4, human [Q5TGU0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		222642

GeneCards: human genes, protein and diseases

More...GeneCardsi		TSPO2
HGNCiHGNC:21256, TSPO2
HPAiENSG00000112212, Tissue enriched (bone)
MIMi619409, gene
neXtProtiNX_Q5TGU0
OpenTargetsiENSG00000112212
PharmGKBiPA165618396
VEuPathDBiHostDB:ENSG00000112212

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3797, Eukaryota
GeneTreeiENSGT00390000012980
HOGENOMiCLU_091805_2_1_1
InParanoidiQ5TGU0
OMAiRDSLCPE
OrthoDBi1592225at2759
PhylomeDBiQ5TGU0
TreeFamiTF342852

Enzyme and pathway databases

PathwayCommonsiQ5TGU0
SignaLinkiQ5TGU0
SIGNORiQ5TGU0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		222642, 5 hits in 1029 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		222642
PharosiQ5TGU0, Tbio

Protein Ontology

More...PROi		PR:Q5TGU0
RNActiQ5TGU0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000112212, Expressed in bone marrow and 92 other tissues
GenevisibleiQ5TGU0, HS

Family and domain databases

Gene3Di1.20.1260.100, 1 hit
InterProiView protein in InterPro
IPR038330, TspO/MBR-related_sf
IPR004307, TspO_MBR
PANTHERiPTHR10057, PTHR10057, 1 hit
PfamiView protein in Pfam
PF03073, TspO_MBR, 1 hit
PIRSFiPIRSF005859, PBR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSPO2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TGU0
Secondary accession number(s): B2RPR2, B7ZMN8, Q3SX82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 21, 2004
Last modified: February 23, 2022
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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