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Protein

PX domain-containing protein 1

Gene

PXDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PX domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PXDC1
Synonyms:C6orf145
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168994.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21361 PXDC1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TGL8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000168994

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134944183

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PXDC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274177

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002975731 – 231PX domain-containing protein 1Add BLAST231

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5TGL8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5TGL8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5TGL8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TGL8

PeptideAtlas

More...
PeptideAtlasi
Q5TGL8

PRoteomics IDEntifications database

More...
PRIDEi
Q5TGL8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65122

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q5TGL8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TGL8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TGL8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168994 Expressed in 226 organ(s), highest expression level in thoracic aorta

CleanEx database of gene expression profiles

More...
CleanExi
HS_C6orf145

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5TGL8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TGL8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019246

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128751, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q5TGL8, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369636

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5TGL8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5TGL8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 134PXAdd BLAST134

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEEQ Eukaryota
ENOG411016X LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009209

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000063722

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG096286

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TGL8

Identification of Orthologs from Complete Genome Data

More...
OMAi
RNDKVHR

Database of Orthologous Groups

More...
OrthoDBi
1192509at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TGL8

TreeFam database of animal gene trees

More...
TreeFami
TF331154

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR040288 PXDC1

The PANTHER Classification System

More...
PANTHERi
PTHR31433 PTHR31433, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00787 PX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF64268 SSF64268, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5TGL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAVFEGTS LVNMFVRGCW VNGIRRLIVS RRGDEEEFFE IRTEWSDRSV
60 70 80 90 100
LYLHRSLADL GRLWQRLRDA FPEDRSELAQ GPLRQGLVAI KEAHDIETRL
110 120 130 140 150
NEVEKLLKTI ISMPCKYSRS EVVLTFFERS PLDQVLKNDN VHKIQPSFQS
160 170 180 190 200
PVKISEIMRS NGFCLANTET IVIDHSIPNG RDQQLGVDPT EHLFENGSEF
210 220 230
PSELEDGDDP AAYVTNLSYY HLVPFETDIW D
Length:231
Mass (Da):26,560
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22FD56F8F1562CFE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y3G1H0Y3G1_HUMAN
PX domain-containing protein 1
PXDC1
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034643184Q → H2 PublicationsCorresponds to variant dbSNP:rs226959Ensembl.1
Natural variantiVAR_034644189P → Q1 PublicationCorresponds to variant dbSNP:rs17855666Ensembl.1
Natural variantiVAR_035619203E → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs368727869Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK289598 mRNA Translation: BAF82287.1
AL832792 mRNA Translation: CAI46167.1
AL391422 Genomic DNA No translation available.
AL033523 Genomic DNA No translation available.
BC045715 mRNA Translation: AAH45715.3
BC056908 mRNA Translation: AAH56908.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4486.1

NCBI Reference Sequences

More...
RefSeqi
NP_899229.2, NM_183373.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.484500

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380283; ENSP00000369636; ENSG00000168994

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
221749

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:221749

UCSC genome browser

More...
UCSCi
uc003mvt.3 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289598 mRNA Translation: BAF82287.1
AL832792 mRNA Translation: CAI46167.1
AL391422 Genomic DNA No translation available.
AL033523 Genomic DNA No translation available.
BC045715 mRNA Translation: AAH45715.3
BC056908 mRNA Translation: AAH56908.1
CCDSiCCDS4486.1
RefSeqiNP_899229.2, NM_183373.3
UniGeneiHs.484500

3D structure databases

ProteinModelPortaliQ5TGL8
SMRiQ5TGL8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128751, 5 interactors
IntActiQ5TGL8, 2 interactors
STRINGi9606.ENSP00000369636

PTM databases

iPTMnetiQ5TGL8
PhosphoSitePlusiQ5TGL8

Polymorphism and mutation databases

BioMutaiPXDC1
DMDMi215274177

Proteomic databases

EPDiQ5TGL8
jPOSTiQ5TGL8
MaxQBiQ5TGL8
PaxDbiQ5TGL8
PeptideAtlasiQ5TGL8
PRIDEiQ5TGL8
ProteomicsDBi65122
TopDownProteomicsiQ5TGL8

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
221749
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380283; ENSP00000369636; ENSG00000168994
GeneIDi221749
KEGGihsa:221749
UCSCiuc003mvt.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
221749
EuPathDBiHostDB:ENSG00000168994.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PXDC1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0005545
HIX0122211
HGNCiHGNC:21361 PXDC1
HPAiHPA019246
neXtProtiNX_Q5TGL8
OpenTargetsiENSG00000168994
PharmGKBiPA134944183

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEEQ Eukaryota
ENOG411016X LUCA
GeneTreeiENSGT00390000009209
HOGENOMiHOG000063722
HOVERGENiHBG096286
InParanoidiQ5TGL8
OMAiRNDKVHR
OrthoDBi1192509at2759
PhylomeDBiQ5TGL8
TreeFamiTF331154

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
221749

Protein Ontology

More...
PROi
PR:Q5TGL8

Gene expression databases

BgeeiENSG00000168994 Expressed in 226 organ(s), highest expression level in thoracic aorta
CleanExiHS_C6orf145
ExpressionAtlasiQ5TGL8 baseline and differential
GenevisibleiQ5TGL8 HS

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR040288 PXDC1
PANTHERiPTHR31433 PTHR31433, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPXDC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TGL8
Secondary accession number(s): A8K0N3, Q6PGP0, Q86XB7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: November 25, 2008
Last modified: January 16, 2019
This is version 105 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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