Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal-regulatory protein beta-1 isoform 3

Gene

SIRPB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-regulatory protein beta-1 isoform 3
Short name:
SIRP-beta-1 isoform 3
Gene namesi
Name:SIRPB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101307.15
HGNCiHGNC:15928 SIRPB1
neXtProtiNX_Q5TFQ8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 371ExtracellularSequence analysisAdd BLAST342
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 398CytoplasmicSequence analysis6

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10326
OpenTargetsiENSG00000101307
PharmGKBiPA38051

Polymorphism and mutation databases

BioMutaiZNF786
DMDMi205829937

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000034910830 – 398Signal-regulatory protein beta-1 isoform 3Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 120PROSITE-ProRule annotation1 Publication
Disulfide bondi169 ↔ 227PROSITE-ProRule annotation
Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi272 ↔ 330PROSITE-ProRule annotation
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ5TFQ8
MaxQBiQ5TFQ8
PaxDbiQ5TFQ8
PeptideAtlasiQ5TFQ8
PRIDEiQ5TFQ8
ProteomicsDBi65089

Expressioni

Gene expression databases

BgeeiENSG00000101307
CleanExiHS_SIRPB1
ExpressionAtlasiQ5TFQ8 baseline and differential
GenevisibleiQ5TFQ8 HS

Interactioni

Protein-protein interaction databases

BioGridi115609, 5 interactors
STRINGi9606.ENSP00000279477

Structurei

Secondary structure

1398
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 45Combined sources6
Beta strandi50 – 52Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi65 – 69Combined sources5
Beta strandi76 – 80Combined sources5
Beta strandi89 – 93Combined sources5
Beta strandi95 – 97Combined sources3
Beta strandi105 – 107Combined sources3
Helixi112 – 114Combined sources3
Beta strandi116 – 124Combined sources9
Beta strandi127 – 129Combined sources3
Beta strandi131 – 135Combined sources5
Beta strandi139 – 144Combined sources6

3D structure databases

ProteinModelPortaliQ5TFQ8
SMRiQ5TFQ8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5TFQ8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 136Ig-like V-typeAdd BLAST106
Domaini147 – 246Ig-like C1-type 1Add BLAST100
Domaini253 – 347Ig-like C1-type 2Add BLAST95

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKYM Eukaryota
ENOG410YKK2 LUCA
GeneTreeiENSGT00440000033339
HOGENOMiHOG000230874
HOVERGENiHBG056632
KOiK06551
OMAiCAHRDGV
OrthoDBiEOG091G05RP

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07654 C1-set, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00407 IGc1, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q5TFQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVPASWPHL PSPFLLMTLL LGRLTGVAGE EELQVIQPDK SISVAAGESA
60 70 80 90 100
TLHCTVTSLI PVGPIQWFRG AGPGRELIYN QKEGHFPRVT TVSDLTKRNN
110 120 130 140 150
MDFSIRISNI TPADAGTYYC VKFRKGSPDH VEFKSGAGTE LSVRAKPSAP
160 170 180 190 200
VVSGPAARAT PQHTVSFTCE SHGFSPRDIT LKWFKNGNEL SDFQTNVDPA
210 220 230 240 250
GDSVSYSIHS TAKVVLTRED VHSQVICEVA HVTLQGDPLR GTANLSETIR
260 270 280 290 300
VPPTLEVTQQ PVRAENQVNV TCQVRKFYPQ RLQLTWLENG NVSRTETAST
310 320 330 340 350
LTENKDGTYN WMSWLLVNVS AHRDDVKLTC QVEHDGQPAV SKSHDLKVSA
360 370 380 390
HPKEQGSNTA PGPALASAAP LLIAFLLGPK VLLVVGVSVI YVYWKQKA
Length:398
Mass (Da):43,359
Last modified:February 5, 2008 - v1
Checksum:i7F3B930235BD556C
GO
Isoform 1 (identifier: O00241-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry O00241.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:398
Mass (Da):43,211
GO
Isoform 2 (identifier: O00241-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry O00241.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:181
Mass (Da):19,394
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05607723R → G2 PublicationsCorresponds to variant dbSNP:rs1535882Ensembl.1
Natural variantiVAR_05941151T → I. Corresponds to variant dbSNP:rs1135196Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289866 mRNA Translation: BAF82555.1
BX537992 mRNA Translation: CAD97951.1
AL049634 Genomic DNA No translation available.
AL138804 Genomic DNA No translation available.
AL592544 Genomic DNA No translation available.
CCDSiCCDS46571.1 [Q5TFQ8-1]
RefSeqiNP_001129316.1, NM_001135844.3 [Q5TFQ8-1]
NP_001316086.1, NM_001329157.1 [Q5TFQ8-1]
UniGeneiHs.664861

Genome annotation databases

EnsembliENST00000279477; ENSP00000279477; ENSG00000101307 [Q5TFQ8-1]
ENST00000568365; ENSP00000456826; ENSG00000101307 [Q5TFQ8-1]
GeneIDi10326
KEGGihsa:10326
UCSCiuc002wfl.5 human [Q5TFQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSIRBL_HUMAN
AccessioniPrimary (citable) accession number: Q5TFQ8
Secondary accession number(s): Q7Z3B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 5, 2008
Last modified: June 20, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health