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Protein
Submitted name:

Hairy/enhancer-of-split-related with YRPW motif protein 2

Gene

HEY2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Hairy/enhancer-of-split-related with YRPW motif protein 2Imported
Gene namesi
Name:HEY2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000135547.8
HGNCiHGNC:4881 HEY2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135547

PTM / Processingi

Proteomic databases

PeptideAtlasiQ5TF93
PRIDEiQ5TF93

Expressioni

Gene expression databases

BgeeiENSG00000135547 Expressed in 198 organ(s), highest expression level in heart right ventricle
ExpressionAtlasiQ5TF93 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ5TF93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 57BHLHInterPro annotationAdd BLAST56
Domaini76 – 111OrangeInterPro annotationAdd BLAST36

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00700000104130
HOGENOMiHOG000286035
HOVERGENiHBG003275

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5TF93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARKKRRGII EKRRRDRINN SLSELRRLVP TAFEKQGSAK LEKAEILQMT
60 70 80 90 100
VDHLKMLQAT GGKGYFDAHA LAMDFMSIGF RECLTEVARY LSSVEGLDSS
110 120 130 140 150
DPLRVRLVSH LSTCATQREA AAMTSSMAHH HHPLHPHHWA AAFHHLPAAL
160 170 180 190 200
LQPNGLHASE STPCRLSTTS EVPPAHGSAL LTATFAHADS ALRMPSTGSV
210 220 230 240 250
APCVPPLSTS LLSLSATVHA AAAAATAAAH SFPLSFAGAF PMLPPNAAAA
260 270 280 290
VAAATAISPP LSVSATSSPQ QTSSGTNNKP YRPWGTEVGA F
Length:291
Mass (Da):30,799
Last modified:December 21, 2004 - v1
Checksum:iA7FB9B5784FF0BA5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UBP5HEY2_HUMAN
Hairy/enhancer-of-split related wit...
HEY2 BHLHB32, CHF1, GRL, HERP, HERP1
337Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078594 Genomic DNA No translation available.
RefSeqiXP_016866116.1, XM_017010627.1
XP_016866117.1, XM_017010628.1
XP_016866118.1, XM_017010629.1
UniGeneiHs.144287

Genome annotation databases

EnsembliENST00000368365; ENSP00000357349; ENSG00000135547
GeneIDi23493
UCSCiuc011ebr.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078594 Genomic DNA No translation available.
RefSeqiXP_016866116.1, XM_017010627.1
XP_016866117.1, XM_017010628.1
XP_016866118.1, XM_017010629.1
UniGeneiHs.144287

3D structure databases

ProteinModelPortaliQ5TF93
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ5TF93
PRIDEiQ5TF93

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368365; ENSP00000357349; ENSG00000135547
GeneIDi23493
UCSCiuc011ebr.3 human

Organism-specific databases

CTDi23493
EuPathDBiHostDB:ENSG00000135547.8
HGNCiHGNC:4881 HEY2
OpenTargetsiENSG00000135547
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00700000104130
HOGENOMiHOG000286035
HOVERGENiHBG003275

Miscellaneous databases

ChiTaRSiHEY2 human
GenomeRNAii23493

Gene expression databases

BgeeiENSG00000135547 Expressed in 198 organ(s), highest expression level in heart right ventricle
ExpressionAtlasiQ5TF93 baseline and differential

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5TF93_HUMAN
AccessioniPrimary (citable) accession number: Q5TF93
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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