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Protein

Intermediate filament family orphan 2

Gene

IFFO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate filament family orphan 2
Gene namesi
Name:IFFO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000169991.10
HGNCiHGNC:27006 IFFO2
neXtProtiNX_Q5TF58

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169991

Polymorphism and mutation databases

BioMutaiIFFO2
DMDMi327478574

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261851 – 517Intermediate filament family orphan 2Add BLAST517

Proteomic databases

EPDiQ5TF58
MaxQBiQ5TF58
PaxDbiQ5TF58
PeptideAtlasiQ5TF58
PRIDEiQ5TF58
ProteomicsDBi65074

PTM databases

iPTMnetiQ5TF58
PhosphoSitePlusiQ5TF58

Expressioni

Gene expression databases

BgeeiENSG00000169991 Expressed in 175 organ(s), highest expression level in upper arm skin
CleanExiHS_IFFO2
ExpressionAtlasiQ5TF58 baseline and differential
GenevisibleiQ5TF58 HS

Organism-specific databases

HPAiHPA015987
HPA064603

Interactioni

Protein-protein interaction databases

BioGridi126024, 4 interactors
IntActiQ5TF58, 1 interactor
STRINGi9606.ENSP00000387941

Structurei

3D structure databases

ProteinModelPortaliQ5TF58
SMRiQ5TF58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 484IF rodPROSITE-ProRule annotationAdd BLAST432

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2455 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00510000046803
HOGENOMiHOG000049269
HOVERGENiHBG107991
InParanoidiQ5TF58
OMAiIQDEISD
OrthoDBiEOG091G048Y
PhylomeDBiQ5TF58
TreeFamiTF331217

Family and domain databases

InterProiView protein in InterPro
IPR039008 IF_rod_dom
PfamiView protein in Pfam
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q5TF58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNSLLFGEM ALAFGCPPGG GGGGCPGGGG GGGGAGPGPS PVTAALRDDL
60 70 80 90 100
GSNIHLLKGL NVRFRCFLAK VHELERRNRL LEKQLEQQQS ERERRLRYKT
110 120 130 140 150
FSREQAVQTG PELLRPPAPG GGHGLSSGAA AGANANAVAL GGLPPGGGSH
160 170 180 190 200
PQHYGRLPGT IWSYTQVRRT GGGGVETVQG PGVSWVHPDG VGVQIDTITP
210 220 230 240 250
EIRALYNVLA KVKRERDEYK RRWEEELAKR MNLQTMVDTL QEAAQEADAI
260 270 280 290 300
QEEMNEKIER LKAELVVFKG LMSDPMTDLD TKIQEKAMKV DMDICRRIDI
310 320 330 340 350
TAKLCDVAQQ RNSEDVSKIF QVVPKKKERK VASDDDISEQ DGEVNRFSDD
360 370 380 390 400
EVGSMNITDE MKRMFNQLRE TFDFDDDCDS LTWEENEDTL LLWEDFTNCN
410 420 430 440 450
PTIDLQGEQE ENLGNLIHET ESFFKTRDKE YQETIGQIEL ELATAKSDMN
460 470 480 490 500
RHLHEYMEMC SMKRGLDVQM ETCRRLIKGS ADRNSPSPSS VASSDSGSTD
510
EIQDEFEREA DVEPMVS
Length:517
Mass (Da):57,328
Last modified:April 5, 2011 - v3
Checksum:iF5A9FCEA675DF445
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4W3H0Y4W3_HUMAN
Intermediate filament family orphan...
IFFO2
259Annotation score:
J3KNZ4J3KNZ4_HUMAN
Intermediate filament family orphan...
IFFO2
88Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080251 Genomic DNA No translation available.
AK024480 mRNA Translation: BAB15770.1
CCDSiCCDS44076.1
RefSeqiNP_001129737.1, NM_001136265.1
UniGeneiHs.466625

Genome annotation databases

EnsembliENST00000455833; ENSP00000387941; ENSG00000169991
GeneIDi126917
KEGGihsa:126917
UCSCiuc001bbd.3 human

Similar proteinsi

Entry informationi

Entry nameiIFFO2_HUMAN
AccessioniPrimary (citable) accession number: Q5TF58
Secondary accession number(s): Q9H7K0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 96 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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