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Entry version 93 (12 Aug 2020)
Sequence version 2 (09 Jan 2007)
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Protein

Uncharacterized protein C6orf163

Gene

C6orf163

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q5TEZ5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C6orf163
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000203872.6

Human Gene Nomenclature Database

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HGNCi
HGNC:21403, C6orf163

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TEZ5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000203872

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134938121

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5TEZ5, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C6orf163

Domain mapping of disease mutations (DMDM)

More...
DMDMi
122063305

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002713611 – 329Uncharacterized protein C6orf163Add BLAST329

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5TEZ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5TEZ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TEZ5

PeptideAtlas

More...
PeptideAtlasi
Q5TEZ5

PRoteomics IDEntifications database

More...
PRIDEi
Q5TEZ5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65068

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TEZ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TEZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000203872, Expressed in kidney and 131 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5TEZ5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TEZ5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000203872, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
128504, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373575

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5TEZ5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili57 – 120Sequence analysisAdd BLAST64
Coiled coili225 – 251Sequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502RDFA, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000010837

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_836681_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TEZ5

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYTNFVC

Database of Orthologous Groups

More...
OrthoDBi
1331159at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TEZ5

TreeFam database of animal gene trees

More...
TreeFami
TF335705

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038927, C6orf163

The PANTHER Classification System

More...
PANTHERi
PTHR34645, PTHR34645, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5TEZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIRNSDYKNF VCCAVCNKII PPAPFGKTFK RIHEYKPLKT RFYTHKDILD
60 70 80 90 100
IGANILKKEE QFQEDILREH IAKAEAEVWA QANERQKQAV EKALEEANDR
110 120 130 140 150
HKIEIQILKE EHQKDLQEVT AKTKTEMYQN MDDEMKREHL AAEQRMVHRI
160 170 180 190 200
QRIMMECHRE KVEAVEKARA EERHIAQEAI QAQKSKAVEE IVNTGVTVIK
210 220 230 240 250
DEKTSVARLM REKEHEMSIL YGIAQRQRQE EVQEVLQEAE KTHQATLGNM
260 270 280 290 300
MDKLANTQGE LLSIAKQLGI MTNWKDFLEE ELQETRMAFQ KYINYTFPKL
310 320
SPGHADFILP ERKKTPSNLV IKENKTTLD
Length:329
Mass (Da):38,553
Last modified:January 9, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE76946A5C3C768D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GZ22V9GZ22_HUMAN
Uncharacterized protein C6orf163
C6orf163
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL096817 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55042.1

NCBI Reference Sequences

More...
RefSeqi
NP_001010868.2, NM_001010868.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000388923; ENSP00000373575; ENSG00000203872

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
206412

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:206412

UCSC genome browser

More...
UCSCi
uc021zcl.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096817 Genomic DNA No translation available.
CCDSiCCDS55042.1
RefSeqiNP_001010868.2, NM_001010868.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi128504, 1 interactor
STRINGi9606.ENSP00000373575

PTM databases

iPTMnetiQ5TEZ5
PhosphoSitePlusiQ5TEZ5

Polymorphism and mutation databases

BioMutaiC6orf163
DMDMi122063305

Proteomic databases

EPDiQ5TEZ5
MassIVEiQ5TEZ5
PaxDbiQ5TEZ5
PeptideAtlasiQ5TEZ5
PRIDEiQ5TEZ5
ProteomicsDBi65068

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
51525, 61 antibodies

Genome annotation databases

EnsembliENST00000388923; ENSP00000373575; ENSG00000203872
GeneIDi206412
KEGGihsa:206412
UCSCiuc021zcl.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
206412
EuPathDBiHostDB:ENSG00000203872.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C6orf163
HGNCiHGNC:21403, C6orf163
HPAiENSG00000203872, Tissue enriched (testis)
neXtProtiNX_Q5TEZ5
OpenTargetsiENSG00000203872
PharmGKBiPA134938121

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RDFA, Eukaryota
GeneTreeiENSGT00390000010837
HOGENOMiCLU_836681_0_0_1
InParanoidiQ5TEZ5
OMAiNYTNFVC
OrthoDBi1331159at2759
PhylomeDBiQ5TEZ5
TreeFamiTF335705

Enzyme and pathway databases

PathwayCommonsiQ5TEZ5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
206412, 6 hits in 865 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
206412
PharosiQ5TEZ5, Tdark

Protein Ontology

More...
PROi
PR:Q5TEZ5
RNActiQ5TEZ5, protein

Gene expression databases

BgeeiENSG00000203872, Expressed in kidney and 131 other tissues
ExpressionAtlasiQ5TEZ5, baseline and differential
GenevisibleiQ5TEZ5, HS

Family and domain databases

InterProiView protein in InterPro
IPR038927, C6orf163
PANTHERiPTHR34645, PTHR34645, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCF163_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TEZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: August 12, 2020
This is version 93 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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