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Entry version 122 (12 Aug 2020)
Sequence version 1 (21 Dec 2004)
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Protein

Protein THEMIS2

Gene

THEMIS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell adhesion Source: ProtInc
  • inflammatory response Source: UniProtKB-KW
  • T cell receptor signaling pathway Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Inflammatory response

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5TEJ8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein THEMIS2
Alternative name(s):
Induced by contact to basement membrane 1 protein
Short name:
Protein ICB-1
Thymocyte-expressed molecule involved in selection protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THEMIS2
Synonyms:C1orf38, ICB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000130775.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16839, THEMIS2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617856, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TEJ8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9473

Open Targets

More...
OpenTargetsi
ENSG00000130775

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA128394550

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q5TEJ8, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
THEMIS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73920021

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000841431 – 643Protein THEMIS2Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei593PhosphothreonineCombined sources1
Modified residuei632PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Tyr-632 is induced by LPS.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5TEJ8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5TEJ8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5TEJ8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5TEJ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TEJ8

PeptideAtlas

More...
PeptideAtlasi
Q5TEJ8

PRoteomics IDEntifications database

More...
PRIDEi
Q5TEJ8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65054 [Q5TEJ8-1]
65055 [Q5TEJ8-2]
65056 [Q5TEJ8-3]
65057 [Q5TEJ8-4]
65058 [Q5TEJ8-5]
65059 [Q5TEJ8-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TEJ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TEJ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By contact to a reconstituted basement membrane.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130775, Expressed in blood and 194 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5TEJ8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TEJ8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000130775, Tissue enhanced (blood, bone marrow, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

When phosphorylated, interacts with LYN.

Interacts with VAV1 and GRB2 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114858, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q5TEJ8, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363031

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5TEJ8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 238CABIT 1Add BLAST238
Regioni239 – 514CABIT 2Add BLAST276

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi404 – 409Poly-Glu6
Compositional biasi626 – 637Asp/Glu-richAdd BLAST12

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the themis family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QSJR, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063770

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1069427_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TEJ8

Identification of Orthologs from Complete Genome Data

More...
OMAi
EIPPQWL

Database of Orthologous Groups

More...
OrthoDBi
337909at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TEJ8

TreeFam database of animal gene trees

More...
TreeFami
TF333479

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025946, CABIT_dom
IPR039671, THEMIS

The PANTHER Classification System

More...
PANTHERi
PTHR15215, PTHR15215, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12736, CABIT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5TEJ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPVPLQDFV RALDPASLPR VLRVCSGVYF EGSIYEISGN ECCLSTGDLI
60 70 80 90 100
KVTQVRLQKV VCENPKTSQT MELAPNFQGY FTPLNTPQSY ETLEELVSAT
110 120 130 140 150
TQSSKQLPTC FMSTHRIVTE GRVVTEDQLL MLEAVVMHLG IRSARCVLGM
160 170 180 190 200
EGQQVILHLP LSQKGPFWTW EPSAPRTLLQ VLQDPALKDL VLTCPTLPWH
210 220 230 240 250
SLILRPQYEI QAIMHMRRTI VKIPSTLEVD VEDVTASSRH VHFIKPLLLS
260 270 280 290 300
EVLAWEGPFP LSMEILEVPE GRPIFLSPWV GSLQKGQRLC VYGLASPPWR
310 320 330 340 350
VLASSKGRKV PRHFLVSGGY QGKLRRRPRE FPTAYDLLGA FQPGRPLRVV
360 370 380 390 400
ATKDCEGERE ENPEFTSLAV GDRLEVLGPG QAHGAQGSDV DVLVCQRLSD
410 420 430 440 450
QAGEDEEEEC KEEAESPERV LLPFHFPGSF VEEMSDSRRY SLADLTAQFS
460 470 480 490 500
LPCEVKVVAK DTSHPTDPLT SFLGLRLEEK ITEPFLVVSL DSEPGMCFEI
510 520 530 540 550
PPRWLDLTVV KAKGQPDLPE GSLPIATVEE LTDTFYYRLR KLPACEIQAP
560 570 580 590 600
PPRPPKNQGL SKQRRHSSEG GVKSSQVLGL QQHARLPKPK AKTLPEFIKD
610 620 630 640
GSSTYSKIPA HRKGHRPAKP QRQDLDDDEH DYEEILEQFQ KTI
Length:643
Mass (Da):72,049
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1D5FA24F88D2F8EA
GO
Isoform 2 (identifier: Q5TEJ8-2) [UniParc]FASTAAdd to basket
Also known as: ICB1-beta

The sequence of this isoform differs from the canonical sequence as follows:
     216-260: MRRTIVKIPS...EVLAWEGPFP → IFSSLRIAAT...SCPQEGPQAR
     261-643: Missing.

Show »
Length:260
Mass (Da):29,118
Checksum:iB4B5C4BFF16682D7
GO
Isoform 3 (identifier: Q5TEJ8-3) [UniParc]FASTAAdd to basket
Also known as: ICB1-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     252-396: Missing.

Show »
Length:498
Mass (Da):56,130
Checksum:iF87DC9EA1DF4901D
GO
Isoform 4 (identifier: Q5TEJ8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-123: GYFTPLNTPQ...THRIVTEGRV → VFSSLRIAAT...SCPQEGPQAR
     124-643: Missing.

Show »
Length:123
Mass (Da):13,628
Checksum:iFA37B14081402515
GO
Isoform 5 (identifier: Q5TEJ8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-396: Missing.

Show »
Length:514
Mass (Da):57,943
Checksum:iC5FA6EECF503BD9C
GO
Isoform 6 (identifier: Q5TEJ8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-381: Missing.

Show »
Length:447
Mass (Da):50,028
Checksum:i5E02ACFCD1435979
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C124H7C124_HUMAN
Protein THEMIS2
THEMIS2
391Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RK39X6RK39_HUMAN
Protein THEMIS2
THEMIS2
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TEK2Q5TEK2_HUMAN
Protein THEMIS2
THEMIS2
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC16284 differs from that shown. Reason: Frameshift.Curated
The sequence BAA96464 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB33313 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG64201 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAI21769 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI21771 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI21773 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti451L → M in AAC16284 (Ref. 6) Curated1
Sequence conflicti466T → N in AAC16284 (Ref. 6) Curated1
Sequence conflicti504W → R in AAC16284 (Ref. 6) Curated1
Sequence conflicti538R → C in AAC16284 (Ref. 6) Curated1
Sequence conflicti584A → V in AAC16284 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051060431V → L. Corresponds to variant dbSNP:rs35995543Ensembl.1
Natural variantiVAR_051061511K → E2 PublicationsCorresponds to variant dbSNP:rs3766400Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01532879 – 123GYFTP…TEGRV → VFSSLRIAATRSAAQTQGED LARVHQGWLQYVQQDSCPQE GPQAR in isoform 4. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_015329124 – 643Missing in isoform 4. 1 PublicationAdd BLAST520
Alternative sequenceiVSP_037966186 – 381Missing in isoform 6. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_015326216 – 260MRRTI…EGPFP → IFSSLRIAATRSAAQTQGED LARVHQGWLQYVQQDSCPQE GPQAR in isoform 2. 2 PublicationsAdd BLAST45
Alternative sequenceiVSP_015330252 – 396Missing in isoform 3. 1 PublicationAdd BLAST145
Alternative sequenceiVSP_015327261 – 643Missing in isoform 2. 2 PublicationsAdd BLAST383
Alternative sequenceiVSP_037967268 – 396Missing in isoform 5. 1 PublicationAdd BLAST129

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR749321 mRNA Translation: CAH18176.1
AK303090 mRNA Translation: BAG64201.1 Different initiation.
AK303141 mRNA Translation: BAG64245.1
AL109927 Genomic DNA Translation: CAI21769.1 Sequence problems.
AL109927 Genomic DNA Translation: CAI21770.1
AL109927 Genomic DNA Translation: CAI21771.1 Sequence problems.
AL109927 Genomic DNA Translation: CAI21772.1
AL109927 Genomic DNA Translation: CAI21773.1 Sequence problems.
BC031655 mRNA Translation: AAH31655.2
BC132692 mRNA Translation: AAI32693.1
BC133049 mRNA Translation: AAI33050.1
AF044895 mRNA Translation: AAC16284.1 Frameshift.
AB050854 mRNA Translation: BAB33313.1 Different initiation.
AB035482 mRNA Translation: BAA96464.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS30653.1 [Q5TEJ8-2]
CCDS30654.1 [Q5TEJ8-4]
CCDS41290.1 [Q5TEJ8-1]
CCDS65461.1 [Q5TEJ8-5]

NCBI Reference Sequences

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RefSeqi
NP_001034566.1, NM_001039477.2 [Q5TEJ8-4]
NP_001099026.1, NM_001105556.2 [Q5TEJ8-1]
NP_001273042.1, NM_001286113.1 [Q5TEJ8-5]
NP_001273044.1, NM_001286115.1 [Q5TEJ8-6]
NP_004839.2, NM_004848.3 [Q5TEJ8-2]
XP_006711113.1, XM_006711050.1 [Q5TEJ8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000328928; ENSP00000329862; ENSG00000130775 [Q5TEJ8-5]
ENST00000373921; ENSP00000363031; ENSG00000130775 [Q5TEJ8-1]
ENST00000373925; ENSP00000363035; ENSG00000130775 [Q5TEJ8-2]
ENST00000373927; ENSP00000363037; ENSG00000130775 [Q5TEJ8-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9473

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9473

UCSC genome browser

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UCSCi
uc001boz.5, human [Q5TEJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749321 mRNA Translation: CAH18176.1
AK303090 mRNA Translation: BAG64201.1 Different initiation.
AK303141 mRNA Translation: BAG64245.1
AL109927 Genomic DNA Translation: CAI21769.1 Sequence problems.
AL109927 Genomic DNA Translation: CAI21770.1
AL109927 Genomic DNA Translation: CAI21771.1 Sequence problems.
AL109927 Genomic DNA Translation: CAI21772.1
AL109927 Genomic DNA Translation: CAI21773.1 Sequence problems.
BC031655 mRNA Translation: AAH31655.2
BC132692 mRNA Translation: AAI32693.1
BC133049 mRNA Translation: AAI33050.1
AF044895 mRNA Translation: AAC16284.1 Frameshift.
AB050854 mRNA Translation: BAB33313.1 Different initiation.
AB035482 mRNA Translation: BAA96464.1 Different initiation.
CCDSiCCDS30653.1 [Q5TEJ8-2]
CCDS30654.1 [Q5TEJ8-4]
CCDS41290.1 [Q5TEJ8-1]
CCDS65461.1 [Q5TEJ8-5]
RefSeqiNP_001034566.1, NM_001039477.2 [Q5TEJ8-4]
NP_001099026.1, NM_001105556.2 [Q5TEJ8-1]
NP_001273042.1, NM_001286113.1 [Q5TEJ8-5]
NP_001273044.1, NM_001286115.1 [Q5TEJ8-6]
NP_004839.2, NM_004848.3 [Q5TEJ8-2]
XP_006711113.1, XM_006711050.1 [Q5TEJ8-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi114858, 3 interactors
IntActiQ5TEJ8, 5 interactors
STRINGi9606.ENSP00000363031

PTM databases

iPTMnetiQ5TEJ8
PhosphoSitePlusiQ5TEJ8

Polymorphism and mutation databases

BioMutaiTHEMIS2
DMDMi73920021

Proteomic databases

EPDiQ5TEJ8
jPOSTiQ5TEJ8
MassIVEiQ5TEJ8
MaxQBiQ5TEJ8
PaxDbiQ5TEJ8
PeptideAtlasiQ5TEJ8
PRIDEiQ5TEJ8
ProteomicsDBi65054 [Q5TEJ8-1]
65055 [Q5TEJ8-2]
65056 [Q5TEJ8-3]
65057 [Q5TEJ8-4]
65058 [Q5TEJ8-5]
65059 [Q5TEJ8-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30867, 98 antibodies

The DNASU plasmid repository

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DNASUi
9473

Genome annotation databases

EnsembliENST00000328928; ENSP00000329862; ENSG00000130775 [Q5TEJ8-5]
ENST00000373921; ENSP00000363031; ENSG00000130775 [Q5TEJ8-1]
ENST00000373925; ENSP00000363035; ENSG00000130775 [Q5TEJ8-2]
ENST00000373927; ENSP00000363037; ENSG00000130775 [Q5TEJ8-4]
GeneIDi9473
KEGGihsa:9473
UCSCiuc001boz.5, human [Q5TEJ8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9473
DisGeNETi9473
EuPathDBiHostDB:ENSG00000130775.15

GeneCards: human genes, protein and diseases

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GeneCardsi
THEMIS2
HGNCiHGNC:16839, THEMIS2
HPAiENSG00000130775, Tissue enhanced (blood, bone marrow, lymphoid tissue)
MIMi617856, gene
neXtProtiNX_Q5TEJ8
OpenTargetsiENSG00000130775
PharmGKBiPA128394550

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QSJR, Eukaryota
GeneTreeiENSGT00530000063770
HOGENOMiCLU_1069427_0_0_1
InParanoidiQ5TEJ8
OMAiEIPPQWL
OrthoDBi337909at2759
PhylomeDBiQ5TEJ8
TreeFamiTF333479

Enzyme and pathway databases

PathwayCommonsiQ5TEJ8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9473, 10 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
THEMIS2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9473
PharosiQ5TEJ8, Tbio

Protein Ontology

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PROi
PR:Q5TEJ8
RNActiQ5TEJ8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130775, Expressed in blood and 194 other tissues
ExpressionAtlasiQ5TEJ8, baseline and differential
GenevisibleiQ5TEJ8, HS

Family and domain databases

InterProiView protein in InterPro
IPR025946, CABIT_dom
IPR039671, THEMIS
PANTHERiPTHR15215, PTHR15215, 1 hit
PfamiView protein in Pfam
PF12736, CABIT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHMS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TEJ8
Secondary accession number(s): A2RTZ3
, B4DZT9, B4DZY3, O60560, Q5TEJ1, Q5TEJ9, Q5TEK1, Q68DP4, Q9BYB6, Q9NS90
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 21, 2004
Last modified: August 12, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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