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UniProtKB - Q5TEA3 (CT194_HUMAN)

Entry version 114 (10 Feb 2021)
Sequence version 1 (21 Dec 2004)
Previous versions | rss
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Protein

Uncharacterized protein C20orf194

Gene

C20orf194

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as an effector for ARL3.

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5TEA3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C20orf194
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C20orf194
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17721, C20orf194

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614146, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5TEA3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000088854.12

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		25943

Open Targets

More...OpenTargetsi		ENSG00000088854

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134905007

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5TEA3, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C20orf194

Domain mapping of disease mutations (DMDM)

More...DMDMi		74746271

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002360421 – 1177Uncharacterized protein C20orf194Add BLAST1177

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5TEA3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5TEA3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5TEA3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5TEA3

PeptideAtlas

More...PeptideAtlasi		Q5TEA3

PRoteomics IDEntifications database

More...PRIDEi		Q5TEA3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65039

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5TEA3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5TEA3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000088854, Expressed in quadriceps femoris and 222 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5TEA3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000088854, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARL3.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117440, 2 interactors

Database of interacting proteins

More...DIPi		DIP-61818N

Protein interaction database and analysis system

More...IntActi		Q5TEA3, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000252032

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5TEA3, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUJP, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003692

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008324_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5TEA3

Identification of Orthologs from Complete Genome Data

More...OMAi		KMTFHIH

Database of Orthologous Groups

More...OrthoDBi		226711at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5TEA3

TreeFam database of animal gene trees

More...TreeFami		TF329802

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040342, C20orf194-like

The PANTHER Classification System

More...PANTHERi		PTHR33664, PTHR33664, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5TEA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVYPPRRQG LPRARSPGGS SRGSPSVSCS RLRQVQSILT QSSKSRPDGI 
        60         70         80         90        100
LCILGIDSRY NEGCRELANY LLFGLYNQNT SDFEKTGFSE EVLDDVIILI 
       110        120        130        140        150
KSDSVHLYCN PVNFRYLLPY VAHWRNLHFH CMTENEYEDE EAAEEFKITS 
       160        170        180        190        200
FVDMVRDCSR IGIPYSSQGH LQIFDMFVVE KWPIVQAFAL EGIGGDGFFT 
       210        220        230        240        250
MKYELQDVSL NLWNVYSKMD PMSLESLLSD DLVAFEHQWT SFFANFDTEI 
       260        270        280        290        300
PFLLELSESQ AGEPFRSYFS HGMISSHITE NSPNRQPFVL FGNHSTRENL 
       310        320        330        340        350
NAGNFNFPSE GHLVRSTGPG GSFAKHMVAQ CVSPKGPLAC SRTYFFGATH 
       360        370        380        390        400
VPYLGGDSKL PKKTEQIRLL SQIYAAVIEA VLAGIACYAK TSSLTKAKEV 
       410        420        430        440        450
AEQTLGSGLD SFELIPFKAA LRSKMTFHIH AVNNQGRIVP LDSEDSLSFV 
       460        470        480        490        500
KTACMAVYDI PDLLGGNGCL GSVVFSESFL TSQILVKEKD GTVTTETSSV 
       510        520        530        540        550
VLTAAVPRFC SWLVEDNEVK LSEKTQQAVR GDESFLGTYL TGGEGAYLYS 
       560        570        580        590        600
SNLQSWPEEG NVHFFSSGLL FSHCRHRSII ISKDHMNSIS FYDGDSTSTV 
       610        620        630        640        650
AALLIDFKSS LLPHLPVHFH GSSNFLMIAL FPKSKIYQAF YSEVFSLWKQ 
       660        670        680        690        700
QDNSGISLKV IQEDGLSVEQ KRLHSSAQKL FSALSQPAGE KRSSLKLLSA 
       710        720        730        740        750
KLPELDWFLQ HFAISSISQE PVMRTHLPVL LQQAEINTTH RIESDKVIIS 
       760        770        780        790        800
IVTGLPGCHA SELCAFLVTL HKECGRWMVY RQIMDSSECF HAAHFQRYLS 
       810        820        830        840        850
SALEAQQNRS ARQSAYIRKK TRLLVVLQGY TDVIDVVQAL QTHPDSNVKA 
       860        870        880        890        900
SFTIGAITAC VEPMSCYMEH RFLFPKCLDQ CSQGLVSNVV FTSHTTEQRH 
       910        920        930        940        950
PLLVQLQSLI RAANPAAAFI LAENGIVTRN EDIELILSEN SFSSPEMLRS 
       960        970        980        990       1000
RYLMYPGWYE GKLNAGSVYP LMVQICVWFG RPLEKTRFVA KCKAIQSSIK 
      1010       1020       1030       1040       1050
PSPFSGNIYH ILGKVKFSDS ERTMEVCYNT LANSLSIMPV LEGPTPPPDS 
      1060       1070       1080       1090       1100
KSVSQDSSGQ QECYLVFIGC SLKEDSIKDW LRQSAKQKPQ RKALKTRGML 
      1110       1120       1130       1140       1150
TQQEIRSIHV KRHLEPLPAG YFYNGTQFVN FFGDKTDFHP LMDQFMNDYV 
      1160       1170 
EEANREIEKY NQELEQQEYH DLFELKP
Length:1,177
Mass (Da):132,287
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CDC79CC97B6DB1D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti345F → L in CAB53697 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05963786T → M. Corresponds to variant dbSNP:rs8124486Ensembl.1
Natural variantiVAR_065913265F → L1 PublicationCorresponds to variant dbSNP:rs149767043Ensembl.1
Natural variantiVAR_050923481T → P. Corresponds to variant dbSNP:rs16988463Ensembl.1
Natural variantiVAR_050924577R → G1 PublicationCorresponds to variant dbSNP:rs2422864Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL117334 Genomic DNA No translation available.
AL109976 Genomic DNA No translation available.
AL110249 mRNA Translation: CAB53697.1
BC064352 mRNA Translation: AAH64352.1
BC080528 mRNA Translation: AAH80528.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42851.1

Protein sequence database of the Protein Information Resource

More...PIRi		T14777

NCBI Reference Sequences

More...RefSeqi		NP_001009984.1, NM_001009984.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000252032; ENSP00000252032; ENSG00000088854

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25943

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25943

UCSC genome browser

More...UCSCi		uc002wii.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117334 Genomic DNA No translation available.
AL109976 Genomic DNA No translation available.
AL110249 mRNA Translation: CAB53697.1
BC064352 mRNA Translation: AAH64352.1
BC080528 mRNA Translation: AAH80528.1
CCDSiCCDS42851.1
PIRiT14777
RefSeqiNP_001009984.1, NM_001009984.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117440, 2 interactors
DIPiDIP-61818N
IntActiQ5TEA3, 2 interactors
STRINGi9606.ENSP00000252032

PTM databases

iPTMnetiQ5TEA3
PhosphoSitePlusiQ5TEA3

Genetic variation databases

BioMutaiC20orf194
DMDMi74746271

Proteomic databases

EPDiQ5TEA3
MassIVEiQ5TEA3
MaxQBiQ5TEA3
PaxDbiQ5TEA3
PeptideAtlasiQ5TEA3
PRIDEiQ5TEA3
ProteomicsDBi65039

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23528, 75 antibodies

Genome annotation databases

EnsembliENST00000252032; ENSP00000252032; ENSG00000088854
GeneIDi25943
KEGGihsa:25943
UCSCiuc002wii.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25943
DisGeNETi25943

GeneCards: human genes, protein and diseases

More...GeneCardsi		C20orf194
HGNCiHGNC:17721, C20orf194
HPAiENSG00000088854, Low tissue specificity
MIMi614146, gene
neXtProtiNX_Q5TEA3
OpenTargetsiENSG00000088854
PharmGKBiPA134905007
VEuPathDBiHostDB:ENSG00000088854.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QUJP, Eukaryota
GeneTreeiENSGT00390000003692
HOGENOMiCLU_008324_0_0_1
InParanoidiQ5TEA3
OMAiKMTFHIH
OrthoDBi226711at2759
PhylomeDBiQ5TEA3
TreeFamiTF329802

Enzyme and pathway databases

PathwayCommonsiQ5TEA3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		25943, 3 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C20orf194, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25943
PharosiQ5TEA3, Tdark

Protein Ontology

More...PROi		PR:Q5TEA3
RNActiQ5TEA3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000088854, Expressed in quadriceps femoris and 222 other tissues
GenevisibleiQ5TEA3, HS

Family and domain databases

InterProiView protein in InterPro
IPR040342, C20orf194-like
PANTHERiPTHR33664, PTHR33664, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCT194_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TEA3
Secondary accession number(s): Q66K86, Q6P2R9, Q9UFX9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: February 10, 2021
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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