UniProtKB - Q5TE63 (Q5TE63_HUMAN)
Protein
Apoptosis regulator Bcl-X
Gene
BCL2L1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- apoptotic process Source: UniProtKB-UniRule
- regulation of apoptotic process Source: InterPro
Keywordsi
Biological process | ApoptosisPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Apoptosis regulator Bcl-XARBA annotationAlternative name(s): Bcl-2-like protein 1ARBA annotation |
Gene namesi | Name:BCL2L1Imported ORF Names:hCG_38811Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000171552.12 |
Subcellular locationi
Cytoskeleton
- centrosome ARBA annotation
Nucleus
- Nucleus membrane ARBA annotation; Single-pass membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Mitochondrion
- Mitochondrion matrix ARBA annotation
Cytoplasm and Cytosol
- cytosol ARBA annotation
Other locations
- synaptic vesicle membrane ARBA annotation
- Membrane ARBA annotation
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- cytosol Source: UniProtKB-SubCell
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- synaptic vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 150 – 168 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoplasmic vesicleARBA annotation, CytoskeletonARBA annotation, Membrane, MitochondrionARBA annotation, NucleusARBA annotation, SynapseARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000171552, Expressed in upper lobe of left lung and 237 other tissues |
ExpressionAtlasi | Q5TE63, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 24 | BH4_2InterPro annotationAdd BLAST | 20 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 28 – 73 | DisorderedSequence analysisAdd BLAST | 46 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 5 – 24 | BH4PROSITE-ProRule annotationAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the Bcl-2 family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisFamily and domain databases
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR013279, Apop_reg_BclX IPR002475, Bcl2-like IPR020728, Bcl2_BH3_motif_CS IPR003093, Bcl2_BH4 IPR020731, Bcl2_BH4_motif_CS IPR036834, Blc2-like_sf IPR026298, Blc2_fam |
PANTHERi | PTHR11256, PTHR11256, 2 hits PTHR11256:SF12, PTHR11256:SF12, 2 hits |
Pfami | View protein in Pfam PF02180, BH4, 1 hit |
PRINTSi | PR01864, APOPREGBCLX |
SMARTi | View protein in SMART SM00265, BH4, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit PS01259, BH3, 1 hit PS01260, BH4_1, 1 hit PS50063, BH4_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5TE63-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA
60 70 80 90 100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR
110 120 130 140 150
YRRAFSDLTS QLHITPGTAY QSFEQDTFVE LYGNNAAAES RKGQERFNRW
160 170
FLTGMTVAGV VLLGSLFSRK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU177939 mRNA Translation: ALQ33397.1 AK290968 mRNA Translation: BAF83657.1 CH471077 Genomic DNA Translation: EAW76427.1 CH471077 Genomic DNA Translation: EAW76428.1 |
RefSeqi | NP_001182.1, NM_001191.3 |
Genome annotation databases
GeneIDi | 598 |
UCSCi | uc002wwm.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU177939 mRNA Translation: ALQ33397.1 AK290968 mRNA Translation: BAF83657.1 CH471077 Genomic DNA Translation: EAW76427.1 CH471077 Genomic DNA Translation: EAW76428.1 |
RefSeqi | NP_001182.1, NM_001191.3 |
3D structure databases
SMRi | Q5TE63 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q5TE63 |
Protocols and materials databases
Antibodypediai | 3430, 1962 antibodies |
DNASUi | 598 |
Genome annotation databases
GeneIDi | 598 |
UCSCi | uc002wwm.4, human |
Organism-specific databases
CTDi | 598 |
PharmGKBi | PA76 |
VEuPathDBi | HostDB:ENSG00000171552.12 |
Miscellaneous databases
BioGRID-ORCSi | 598, 525 hits in 1010 CRISPR screens |
ChiTaRSi | BCL2L1, human |
GenomeRNAii | 598 |
Gene expression databases
Bgeei | ENSG00000171552, Expressed in upper lobe of left lung and 237 other tissues |
ExpressionAtlasi | Q5TE63, baseline and differential |
Family and domain databases
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR013279, Apop_reg_BclX IPR002475, Bcl2-like IPR020728, Bcl2_BH3_motif_CS IPR003093, Bcl2_BH4 IPR020731, Bcl2_BH4_motif_CS IPR036834, Blc2-like_sf IPR026298, Blc2_fam |
PANTHERi | PTHR11256, PTHR11256, 2 hits PTHR11256:SF12, PTHR11256:SF12, 2 hits |
Pfami | View protein in Pfam PF02180, BH4, 1 hit |
PRINTSi | PR01864, APOPREGBCLX |
SMARTi | View protein in SMART SM00265, BH4, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit PS01259, BH3, 1 hit PS01260, BH4_1, 1 hit PS50063, BH4_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5TE63_HUMAN | |
Accessioni | Q5TE63Primary (citable) accession number: Q5TE63 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |