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Entry version 150 (07 Oct 2020)
Sequence version 1 (21 Dec 2004)
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Protein

Four and a half LIM domains protein 5

Gene

FHL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri8 – 32C4-typeSequence analysisAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q5TD97

SIGNOR Signaling Network Open Resource

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SIGNORi
Q5TD97

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Four and a half LIM domains protein 5
Short name:
FHL-5
Alternative name(s):
Activator of cAMP-responsive element modulator in testis
Short name:
Activator of CREM in testis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FHL5
Synonyms:ACT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000112214.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17371, FHL5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605126, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TD97

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9457

Open Targets

More...
OpenTargetsi
ENSG00000112214

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134971720

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5TD97, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FHL5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68565455

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000757421 – 284Four and a half LIM domains protein 5Add BLAST284

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5TD97

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TD97

PeptideAtlas

More...
PeptideAtlasi
Q5TD97

PRoteomics IDEntifications database

More...
PRIDEi
Q5TD97

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65008

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TD97

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TD97

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis-specific (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112214, Expressed in popliteal artery and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5TD97, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TD97, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000112214, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CREM (via the third LIM domain).

Interacts (via second LIM domain) with SPAG8.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q5TD97
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-750641,EBI-11096309
ADAM12 - isoform 4 [O43184-4]3EBI-750641,EBI-12006944
ADAMTSL5 [Q6ZMM2]3EBI-750641,EBI-9075891
AGXT [P21549]3EBI-750641,EBI-727098
ANKRD55 [Q3KP44]3EBI-750641,EBI-14493093
ANKS1A [Q49AR9]3EBI-750641,EBI-11954519
BANP - isoform 2 [Q8N9N5-2]3EBI-750641,EBI-11524452
BANP - isoform 7 [Q8N9N5-7]3EBI-750641,EBI-16429296
BBC3 [Q96PG8]3EBI-750641,EBI-17289784
BCL6B [A8KA13]3EBI-750641,EBI-10174813
CATSPER1 [Q8NEC5]3EBI-750641,EBI-744545
CDC20B - isoform 5 [Q86Y33-5]3EBI-750641,EBI-11983537
CFP [P27918]3EBI-750641,EBI-9038570
CNNM3 [Q8NE01]3EBI-750641,EBI-741032
CRYBA2 [P53672]3EBI-750641,EBI-750444
CRYBA4 [P53673]3EBI-750641,EBI-7519711
CTSZ [Q9UBR2]3EBI-750641,EBI-8636823
DCDC2B [A2VCK2]3EBI-750641,EBI-10173222
DLGAP4 - isoform 2 [Q9Y2H0-1]3EBI-750641,EBI-12000556
DMRT3 [Q9NQL9]3EBI-750641,EBI-9679045
DNAL4 [O96015]10EBI-750641,EBI-742362
DTX2 [Q86UW9]3EBI-750641,EBI-740376
FAM214B [Q7L5A3]5EBI-750641,EBI-745689
FAM71C [Q8NEG0]5EBI-750641,EBI-752049
FARS2 [O95363]3EBI-750641,EBI-2513774
FEZF1 [A0PJY2]3EBI-750641,EBI-11988727
GPS2 [Q13227]3EBI-750641,EBI-713355
GSTP1 [P09211]3EBI-750641,EBI-353467
HAPLN2 [Q9GZV7]3EBI-750641,EBI-11956675
HCK - isoform 2 [P08631-2]3EBI-750641,EBI-9834454
HDX [Q7Z353]3EBI-750641,EBI-1052734
HEY2 [Q9UBP5]3EBI-750641,EBI-750630
HOXA1 [P49639]3EBI-750641,EBI-740785
HOXB9 [P17482]3EBI-750641,EBI-745290
IL16 - isoform 2 [Q14005-2]5EBI-750641,EBI-17178971
IP6K3 [Q96PC2]3EBI-750641,EBI-10990676
KIR2DL4 [Q99706]3EBI-750641,EBI-10294579
LMO2 - isoform 3 [P25791-3]3EBI-750641,EBI-11959475
LRRC41 [Q15345]3EBI-750641,EBI-721408
MAGOHB [Q96A72]3EBI-750641,EBI-746778
MISP [Q8IVT2]3EBI-750641,EBI-2555085
MYOZ3 [Q8TDC0]3EBI-750641,EBI-5662487
NEK6 - isoform 4 [Q9HC98-4]3EBI-750641,EBI-11750983
NPDC1 [Q9NQX5]5EBI-750641,EBI-748927
NUFIP2 [Q7Z417]3EBI-750641,EBI-1210753
OTX1 [P32242]3EBI-750641,EBI-740446
PIN1 [Q13526]3EBI-750641,EBI-714158
PLEKHA2 [Q9HB19]3EBI-750641,EBI-4401947
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-750641,EBI-12014286
PPP1R18 [Q6NYC8]3EBI-750641,EBI-2557469
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-750641,EBI-12000762
QRICH1 [Q2TAL8]3EBI-750641,EBI-2798044
RAB26 [Q9ULW5]3EBI-750641,EBI-958239
RAB3IL1 [Q8TBN0]3EBI-750641,EBI-743796
RPS21 [P63220]3EBI-750641,EBI-714051
SAXO1 [Q8IYX7]3EBI-750641,EBI-3957636
SCNM1 [Q9BWG6]6EBI-750641,EBI-748391
SDCBP [O00560]3EBI-750641,EBI-727004
SEC31A - isoform 2 [O94979-2]3EBI-750641,EBI-17482477
SHFL - isoform 4 [Q9NUL5-4]3EBI-750641,EBI-11955083
SLIT1 [O75093]3EBI-750641,EBI-947791
SPRY1 [O43609]5EBI-750641,EBI-3866665
TUSC2 [O75896]3EBI-750641,EBI-1052725
TXN2 [Q99757]3EBI-750641,EBI-2932492
ZBTB16 [Q05516]3EBI-750641,EBI-711925
ZNF124 [Q15973]3EBI-750641,EBI-2555767
ZNF131 - isoform 2 [P52739-2]4EBI-750641,EBI-10213055
ZNF23 [P17027]3EBI-750641,EBI-5657766
ZNF250 - isoform 3 [P15622-3]5EBI-750641,EBI-10177272
ZNF251 [Q9BRH9]3EBI-750641,EBI-7254491
ZNF408 [Q9H9D4]3EBI-750641,EBI-347633
ZNF417 [Q8TAU3]3EBI-750641,EBI-740727
ZNF440 [Q8IYI8]3EBI-750641,EBI-726439
ZNF564 [Q8TBZ8]3EBI-750641,EBI-10273713
ZNF581 [Q9P0T4]3EBI-750641,EBI-745520
ZNF587 [Q96SQ5]3EBI-750641,EBI-6427977
ZNF613 [Q6PF04]3EBI-750641,EBI-12062855
ZNF688 [A0A0S2Z5X4]3EBI-750641,EBI-16429014
ZNF688 [A0A0S2Z6P0]3EBI-750641,EBI-16429989
ZNF764 [Q96H86]3EBI-750641,EBI-745775
ZNF766 [Q5HY98]3EBI-750641,EBI-2686489
ZNF792 [Q3KQV3]3EBI-750641,EBI-10240849
ZNHIT1 [O43257]3EBI-750641,EBI-347522
Hoxa1 [P09022] from Mus musculus.3EBI-750641,EBI-3957603

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114846, 98 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q5TD97

Protein interaction database and analysis system

More...
IntActi
Q5TD97, 92 interactors

Molecular INTeraction database

More...
MINTi
Q5TD97

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000326022

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5TD97, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5TD97

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q5TD97

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 100LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini101 – 160LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60
Domaini161 – 220LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini223 – 283LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST61

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 32C4-typeSequence analysisAdd BLAST25

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1704, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183028

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001357_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TD97

Identification of Orthologs from Complete Genome Data

More...
OMAi
DDNPYCV

Database of Orthologous Groups

More...
OrthoDBi
642235at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TD97

TreeFam database of animal gene trees

More...
TreeFami
TF314113

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09428, LIM2_FHL5, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037987, FHL2/3/5
IPR042947, FHL5_LIM2
IPR001781, Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR24205, PTHR24205, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00412, LIM, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00132, LIM, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00478, LIM_DOMAIN_1, 4 hits
PS50023, LIM_DOMAIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5TD97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTAHFYCQY CTASLLGKKY VLKDDSPYCV TCYDRVFSNY CEECKKPIES
60 70 80 90 100
DSKDLCYKDR HWHEGCFKCT KCNHSLVEKP FAAKDERLLC TECYSNECSS
110 120 130 140 150
KCFHCKRTIM PGSRKMEFKG NYWHETCFVC ENCRQPIGTK PLISKESGNY
160 170 180 190 200
CVPCFEKEFA HYCNFCKKVI TSGGITFCDQ LWHKECFLCS GCRKDLCEEQ
210 220 230 240 250
FMSRDDYPFC VDCYNHLYAN KCVACSKPIS GLTGAKFICF QDSQWHSECF
260 270 280
NCGKCSVSLV GKGFLTQNKE IFCQKCGSGM DTDI
Length:284
Mass (Da):32,720
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82C03B1EAA147C11
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RED3X6RED3_HUMAN
Four and a half LIM domains protein...
FHL5
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55L → F in AAF85978 (PubMed:11327716).Curated1
Sequence conflicti191G → D in AAH21723 (PubMed:15489334).Curated1
Sequence conflicti191G → D in AAH29490 (PubMed:15489334).Curated1
Sequence conflicti254K → R in AAF85978 (PubMed:11327716).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05616035R → H. Corresponds to variant dbSNP:rs35157931Ensembl.1
Natural variantiVAR_056161204R → G. Corresponds to variant dbSNP:rs2273621Ensembl.1
Natural variantiVAR_022824211V → M3 PublicationsCorresponds to variant dbSNP:rs2252816Ensembl.1
Natural variantiVAR_056162243S → R. Corresponds to variant dbSNP:rs9373985Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF278541 mRNA Translation: AAF85978.1
AK057611 mRNA Translation: BAG51940.1
AK223539 mRNA Translation: BAD97259.1
AK314608 mRNA Translation: BAG37178.1
AL132776 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48503.1
CH471051 Genomic DNA Translation: EAW48504.1
CH471051 Genomic DNA Translation: EAW48505.1
BC021723 mRNA Translation: AAH21723.1
BC029490 mRNA Translation: AAH29490.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5035.1

Protein sequence database of the Protein Information Resource

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PIRi
JC7686

NCBI Reference Sequences

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RefSeqi
NP_001164278.1, NM_001170807.2
NP_001309395.1, NM_001322466.1
NP_001309396.1, NM_001322467.1
NP_065228.4, NM_020482.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000326771; ENSP00000326022; ENSG00000112214
ENST00000541107; ENSP00000442357; ENSG00000112214

Database of genes from NCBI RefSeq genomes

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GeneIDi
9457

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9457

UCSC genome browser

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UCSCi
uc003pos.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF278541 mRNA Translation: AAF85978.1
AK057611 mRNA Translation: BAG51940.1
AK223539 mRNA Translation: BAD97259.1
AK314608 mRNA Translation: BAG37178.1
AL132776 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48503.1
CH471051 Genomic DNA Translation: EAW48504.1
CH471051 Genomic DNA Translation: EAW48505.1
BC021723 mRNA Translation: AAH21723.1
BC029490 mRNA Translation: AAH29490.1
CCDSiCCDS5035.1
PIRiJC7686
RefSeqiNP_001164278.1, NM_001170807.2
NP_001309395.1, NM_001322466.1
NP_001309396.1, NM_001322467.1
NP_065228.4, NM_020482.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X68NMR-A222-284[»]
SMRiQ5TD97
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114846, 98 interactors
CORUMiQ5TD97
IntActiQ5TD97, 92 interactors
MINTiQ5TD97
STRINGi9606.ENSP00000326022

PTM databases

iPTMnetiQ5TD97
PhosphoSitePlusiQ5TD97

Polymorphism and mutation databases

BioMutaiFHL5
DMDMi68565455

Proteomic databases

MassIVEiQ5TD97
PaxDbiQ5TD97
PeptideAtlasiQ5TD97
PRIDEiQ5TD97
ProteomicsDBi65008

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31954, 152 antibodies

The DNASU plasmid repository

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DNASUi
9457

Genome annotation databases

EnsembliENST00000326771; ENSP00000326022; ENSG00000112214
ENST00000541107; ENSP00000442357; ENSG00000112214
GeneIDi9457
KEGGihsa:9457
UCSCiuc003pos.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9457
DisGeNETi9457
EuPathDBiHostDB:ENSG00000112214.10

GeneCards: human genes, protein and diseases

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GeneCardsi
FHL5
HGNCiHGNC:17371, FHL5
HPAiENSG00000112214, Tissue enriched (testis)
MIMi605126, gene
neXtProtiNX_Q5TD97
OpenTargetsiENSG00000112214
PharmGKBiPA134971720

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1704, Eukaryota
GeneTreeiENSGT00950000183028
HOGENOMiCLU_001357_2_0_1
InParanoidiQ5TD97
OMAiDDNPYCV
OrthoDBi642235at2759
PhylomeDBiQ5TD97
TreeFamiTF314113

Enzyme and pathway databases

PathwayCommonsiQ5TD97
SIGNORiQ5TD97

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9457, 7 hits in 871 CRISPR screens
EvolutionaryTraceiQ5TD97

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FHL5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9457
PharosiQ5TD97, Tbio

Protein Ontology

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PROi
PR:Q5TD97
RNActiQ5TD97, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112214, Expressed in popliteal artery and 179 other tissues
ExpressionAtlasiQ5TD97, baseline and differential
GenevisibleiQ5TD97, HS

Family and domain databases

CDDicd09428, LIM2_FHL5, 1 hit
InterProiView protein in InterPro
IPR037987, FHL2/3/5
IPR042947, FHL5_LIM2
IPR001781, Znf_LIM
PANTHERiPTHR24205, PTHR24205, 1 hit
PfamiView protein in Pfam
PF00412, LIM, 4 hits
SMARTiView protein in SMART
SM00132, LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478, LIM_DOMAIN_1, 4 hits
PS50023, LIM_DOMAIN_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFHL5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TD97
Secondary accession number(s): B2RBD1
, E1P526, Q5TD98, Q8WW21, Q9NQU2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: October 7, 2020
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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