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Protein

Four and a half LIM domains protein 5

Gene

FHL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 32C4-typeSequence analysisAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ5TD97

Names & Taxonomyi

Protein namesi
Recommended name:
Four and a half LIM domains protein 5
Short name:
FHL-5
Alternative name(s):
Activator of cAMP-responsive element modulator in testis
Short name:
Activator of CREM in testis
Gene namesi
Name:FHL5
Synonyms:ACT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112214.10
HGNCiHGNC:17371 FHL5
MIMi605126 gene
neXtProtiNX_Q5TD97

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9457
OpenTargetsiENSG00000112214
PharmGKBiPA134971720

Polymorphism and mutation databases

BioMutaiFHL5
DMDMi68565455

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757421 – 284Four and a half LIM domains protein 5Add BLAST284

Proteomic databases

PaxDbiQ5TD97
PeptideAtlasiQ5TD97
PRIDEiQ5TD97
ProteomicsDBi65008

PTM databases

iPTMnetiQ5TD97
PhosphoSitePlusiQ5TD97

Expressioni

Tissue specificityi

Testis-specific (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000112214 Expressed in 164 organ(s), highest expression level in popliteal artery
CleanExiHS_FHL5
ExpressionAtlasiQ5TD97 baseline and differential
GenevisibleiQ5TD97 HS

Interactioni

Subunit structurei

Interacts with CREM (via the third LIM domain). Interacts (via second LIM domain) with SPAG8.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi114846, 20 interactors
CORUMiQ5TD97
IntActiQ5TD97, 87 interactors
MINTiQ5TD97
STRINGi9606.ENSP00000326022

Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ5TD97
SMRiQ5TD97
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5TD97

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 100LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini101 – 160LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60
Domaini161 – 220LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini223 – 283LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST61

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 32C4-typeSequence analysisAdd BLAST25

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000231075
HOVERGENiHBG074526
InParanoidiQ5TD97
OMAiYCVSCYD
OrthoDBiEOG091G07C5
PhylomeDBiQ5TD97
TreeFamiTF314113

Family and domain databases

InterProiView protein in InterPro
IPR037987 FHL2/3/5
IPR001781 Znf_LIM
PANTHERiPTHR24205 PTHR24205, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 4 hits
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5TD97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTAHFYCQY CTASLLGKKY VLKDDSPYCV TCYDRVFSNY CEECKKPIES
60 70 80 90 100
DSKDLCYKDR HWHEGCFKCT KCNHSLVEKP FAAKDERLLC TECYSNECSS
110 120 130 140 150
KCFHCKRTIM PGSRKMEFKG NYWHETCFVC ENCRQPIGTK PLISKESGNY
160 170 180 190 200
CVPCFEKEFA HYCNFCKKVI TSGGITFCDQ LWHKECFLCS GCRKDLCEEQ
210 220 230 240 250
FMSRDDYPFC VDCYNHLYAN KCVACSKPIS GLTGAKFICF QDSQWHSECF
260 270 280
NCGKCSVSLV GKGFLTQNKE IFCQKCGSGM DTDI
Length:284
Mass (Da):32,720
Last modified:December 21, 2004 - v1
Checksum:i82C03B1EAA147C11
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RED3X6RED3_HUMAN
Four and a half LIM domains protein...
FHL5
210Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55L → F in AAF85978 (PubMed:11327716).Curated1
Sequence conflicti191G → D in AAH21723 (PubMed:15489334).Curated1
Sequence conflicti191G → D in AAH29490 (PubMed:15489334).Curated1
Sequence conflicti254K → R in AAF85978 (PubMed:11327716).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05616035R → H. Corresponds to variant dbSNP:rs35157931Ensembl.1
Natural variantiVAR_056161204R → G. Corresponds to variant dbSNP:rs2273621Ensembl.1
Natural variantiVAR_022824211V → M3 PublicationsCorresponds to variant dbSNP:rs2252816Ensembl.1
Natural variantiVAR_056162243S → R. Corresponds to variant dbSNP:rs9373985Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF278541 mRNA Translation: AAF85978.1
AK057611 mRNA Translation: BAG51940.1
AK223539 mRNA Translation: BAD97259.1
AK314608 mRNA Translation: BAG37178.1
AL132776 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48503.1
CH471051 Genomic DNA Translation: EAW48504.1
CH471051 Genomic DNA Translation: EAW48505.1
BC021723 mRNA Translation: AAH21723.1
BC029490 mRNA Translation: AAH29490.1
CCDSiCCDS5035.1
PIRiJC7686
RefSeqiNP_001164278.1, NM_001170807.2
NP_001309395.1, NM_001322466.1
NP_001309396.1, NM_001322467.1
NP_065228.4, NM_020482.5
UniGeneiHs.632608

Genome annotation databases

EnsembliENST00000326771; ENSP00000326022; ENSG00000112214
ENST00000541107; ENSP00000442357; ENSG00000112214
GeneIDi9457
KEGGihsa:9457
UCSCiuc003pos.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF278541 mRNA Translation: AAF85978.1
AK057611 mRNA Translation: BAG51940.1
AK223539 mRNA Translation: BAD97259.1
AK314608 mRNA Translation: BAG37178.1
AL132776 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48503.1
CH471051 Genomic DNA Translation: EAW48504.1
CH471051 Genomic DNA Translation: EAW48505.1
BC021723 mRNA Translation: AAH21723.1
BC029490 mRNA Translation: AAH29490.1
CCDSiCCDS5035.1
PIRiJC7686
RefSeqiNP_001164278.1, NM_001170807.2
NP_001309395.1, NM_001322466.1
NP_001309396.1, NM_001322467.1
NP_065228.4, NM_020482.5
UniGeneiHs.632608

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X68NMR-A222-284[»]
ProteinModelPortaliQ5TD97
SMRiQ5TD97
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114846, 20 interactors
CORUMiQ5TD97
IntActiQ5TD97, 87 interactors
MINTiQ5TD97
STRINGi9606.ENSP00000326022

PTM databases

iPTMnetiQ5TD97
PhosphoSitePlusiQ5TD97

Polymorphism and mutation databases

BioMutaiFHL5
DMDMi68565455

Proteomic databases

PaxDbiQ5TD97
PeptideAtlasiQ5TD97
PRIDEiQ5TD97
ProteomicsDBi65008

Protocols and materials databases

DNASUi9457
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326771; ENSP00000326022; ENSG00000112214
ENST00000541107; ENSP00000442357; ENSG00000112214
GeneIDi9457
KEGGihsa:9457
UCSCiuc003pos.3 human

Organism-specific databases

CTDi9457
DisGeNETi9457
EuPathDBiHostDB:ENSG00000112214.10
GeneCardsiFHL5
H-InvDBiHIX0006080
HGNCiHGNC:17371 FHL5
MIMi605126 gene
neXtProtiNX_Q5TD97
OpenTargetsiENSG00000112214
PharmGKBiPA134971720
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000231075
HOVERGENiHBG074526
InParanoidiQ5TD97
OMAiYCVSCYD
OrthoDBiEOG091G07C5
PhylomeDBiQ5TD97
TreeFamiTF314113

Enzyme and pathway databases

SIGNORiQ5TD97

Miscellaneous databases

EvolutionaryTraceiQ5TD97
GeneWikiiFHL5
GenomeRNAii9457
PROiPR:Q5TD97
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112214 Expressed in 164 organ(s), highest expression level in popliteal artery
CleanExiHS_FHL5
ExpressionAtlasiQ5TD97 baseline and differential
GenevisibleiQ5TD97 HS

Family and domain databases

InterProiView protein in InterPro
IPR037987 FHL2/3/5
IPR001781 Znf_LIM
PANTHERiPTHR24205 PTHR24205, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 4 hits
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFHL5_HUMAN
AccessioniPrimary (citable) accession number: Q5TD97
Secondary accession number(s): B2RBD1
, E1P526, Q5TD98, Q8WW21, Q9NQU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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