UniProtKB - Q5TD97 (FHL5_HUMAN)
Protein
Four and a half LIM domains protein 5
Gene
FHL5
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 8 – 32 | C4-typeSequence analysisAdd BLAST | 25 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- transcription coactivator activity Source: GO_Central
- transcription coregulator activity Source: GO_Central
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q5TD97 |
SIGNORi | Q5TD97 |
Names & Taxonomyi
Protein namesi | Recommended name: Four and a half LIM domains protein 5Short name: FHL-5 Alternative name(s): Activator of cAMP-responsive element modulator in testis Short name: Activator of CREM in testis |
Gene namesi | Name:FHL5 Synonyms:ACT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000112214.10 |
HGNCi | HGNC:17371, FHL5 |
MIMi | 605126, gene |
neXtProti | NX_Q5TD97 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Note: Nuclei of round and elongated spermatids.
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9457 |
OpenTargetsi | ENSG00000112214 |
PharmGKBi | PA134971720 |
Miscellaneous databases
Pharosi | Q5TD97, Tbio |
Polymorphism and mutation databases
BioMutai | FHL5 |
DMDMi | 68565455 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075742 | 1 – 284 | Four and a half LIM domains protein 5Add BLAST | 284 |
Proteomic databases
MassIVEi | Q5TD97 |
PaxDbi | Q5TD97 |
PeptideAtlasi | Q5TD97 |
PRIDEi | Q5TD97 |
ProteomicsDBi | 65008 |
PTM databases
iPTMneti | Q5TD97 |
PhosphoSitePlusi | Q5TD97 |
Expressioni
Tissue specificityi
Testis-specific (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000112214, Expressed in popliteal artery and 179 other tissues |
ExpressionAtlasi | Q5TD97, baseline and differential |
Genevisiblei | Q5TD97, HS |
Organism-specific databases
HPAi | ENSG00000112214, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with CREM (via the third LIM domain).
Interacts (via second LIM domain) with SPAG8.
By similarityBinary interactionsi
Q5TD97
Protein-protein interaction databases
BioGRIDi | 114846, 98 interactors |
CORUMi | Q5TD97 |
IntActi | Q5TD97, 92 interactors |
MINTi | Q5TD97 |
STRINGi | 9606.ENSP00000326022 |
Miscellaneous databases
RNActi | Q5TD97, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q5TD97 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q5TD97 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 100 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 101 – 160 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 161 – 220 | LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 223 – 283 | LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST | 61 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 8 – 32 | C4-typeSequence analysisAdd BLAST | 25 |
Keywords - Domaini
LIM domain, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1704, Eukaryota |
GeneTreei | ENSGT00950000183028 |
HOGENOMi | CLU_001357_2_0_1 |
InParanoidi | Q5TD97 |
OMAi | DDNPYCV |
OrthoDBi | 642235at2759 |
PhylomeDBi | Q5TD97 |
TreeFami | TF314113 |
Family and domain databases
CDDi | cd09428, LIM2_FHL5, 1 hit |
InterProi | View protein in InterPro IPR037987, FHL2/3/5 IPR042947, FHL5_LIM2 IPR001781, Znf_LIM |
PANTHERi | PTHR24205, PTHR24205, 1 hit |
Pfami | View protein in Pfam PF00412, LIM, 4 hits |
SMARTi | View protein in SMART SM00132, LIM, 4 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 4 hits PS50023, LIM_DOMAIN_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5TD97-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTAHFYCQY CTASLLGKKY VLKDDSPYCV TCYDRVFSNY CEECKKPIES
60 70 80 90 100
DSKDLCYKDR HWHEGCFKCT KCNHSLVEKP FAAKDERLLC TECYSNECSS
110 120 130 140 150
KCFHCKRTIM PGSRKMEFKG NYWHETCFVC ENCRQPIGTK PLISKESGNY
160 170 180 190 200
CVPCFEKEFA HYCNFCKKVI TSGGITFCDQ LWHKECFLCS GCRKDLCEEQ
210 220 230 240 250
FMSRDDYPFC VDCYNHLYAN KCVACSKPIS GLTGAKFICF QDSQWHSECF
260 270 280
NCGKCSVSLV GKGFLTQNKE IFCQKCGSGM DTDI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX6RED3 | X6RED3_HUMAN | Four and a half LIM domains protein... | FHL5 | 210 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | L → F in AAF85978 (PubMed:11327716).Curated | 1 | |
Sequence conflicti | 191 | G → D in AAH21723 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 191 | G → D in AAH29490 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 254 | K → R in AAF85978 (PubMed:11327716).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056160 | 35 | R → H. Corresponds to variant dbSNP:rs35157931Ensembl. | 1 | |
Natural variantiVAR_056161 | 204 | R → G. Corresponds to variant dbSNP:rs2273621Ensembl. | 1 | |
Natural variantiVAR_022824 | 211 | V → M3 PublicationsCorresponds to variant dbSNP:rs2252816Ensembl. | 1 | |
Natural variantiVAR_056162 | 243 | S → R. Corresponds to variant dbSNP:rs9373985Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF278541 mRNA Translation: AAF85978.1 AK057611 mRNA Translation: BAG51940.1 AK223539 mRNA Translation: BAD97259.1 AK314608 mRNA Translation: BAG37178.1 AL132776 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48503.1 CH471051 Genomic DNA Translation: EAW48504.1 CH471051 Genomic DNA Translation: EAW48505.1 BC021723 mRNA Translation: AAH21723.1 BC029490 mRNA Translation: AAH29490.1 |
CCDSi | CCDS5035.1 |
PIRi | JC7686 |
RefSeqi | NP_001164278.1, NM_001170807.2 NP_001309395.1, NM_001322466.1 NP_001309396.1, NM_001322467.1 NP_065228.4, NM_020482.5 |
Genome annotation databases
Ensembli | ENST00000326771; ENSP00000326022; ENSG00000112214 ENST00000541107; ENSP00000442357; ENSG00000112214 |
GeneIDi | 9457 |
KEGGi | hsa:9457 |
UCSCi | uc003pos.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF278541 mRNA Translation: AAF85978.1 AK057611 mRNA Translation: BAG51940.1 AK223539 mRNA Translation: BAD97259.1 AK314608 mRNA Translation: BAG37178.1 AL132776 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48503.1 CH471051 Genomic DNA Translation: EAW48504.1 CH471051 Genomic DNA Translation: EAW48505.1 BC021723 mRNA Translation: AAH21723.1 BC029490 mRNA Translation: AAH29490.1 |
CCDSi | CCDS5035.1 |
PIRi | JC7686 |
RefSeqi | NP_001164278.1, NM_001170807.2 NP_001309395.1, NM_001322466.1 NP_001309396.1, NM_001322467.1 NP_065228.4, NM_020482.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1X68 | NMR | - | A | 222-284 | [»] | |
SMRi | Q5TD97 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114846, 98 interactors |
CORUMi | Q5TD97 |
IntActi | Q5TD97, 92 interactors |
MINTi | Q5TD97 |
STRINGi | 9606.ENSP00000326022 |
PTM databases
iPTMneti | Q5TD97 |
PhosphoSitePlusi | Q5TD97 |
Polymorphism and mutation databases
BioMutai | FHL5 |
DMDMi | 68565455 |
Proteomic databases
MassIVEi | Q5TD97 |
PaxDbi | Q5TD97 |
PeptideAtlasi | Q5TD97 |
PRIDEi | Q5TD97 |
ProteomicsDBi | 65008 |
Protocols and materials databases
Antibodypediai | 31954, 152 antibodies |
DNASUi | 9457 |
Genome annotation databases
Ensembli | ENST00000326771; ENSP00000326022; ENSG00000112214 ENST00000541107; ENSP00000442357; ENSG00000112214 |
GeneIDi | 9457 |
KEGGi | hsa:9457 |
UCSCi | uc003pos.3, human |
Organism-specific databases
CTDi | 9457 |
DisGeNETi | 9457 |
EuPathDBi | HostDB:ENSG00000112214.10 |
GeneCardsi | FHL5 |
HGNCi | HGNC:17371, FHL5 |
HPAi | ENSG00000112214, Tissue enriched (testis) |
MIMi | 605126, gene |
neXtProti | NX_Q5TD97 |
OpenTargetsi | ENSG00000112214 |
PharmGKBi | PA134971720 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1704, Eukaryota |
GeneTreei | ENSGT00950000183028 |
HOGENOMi | CLU_001357_2_0_1 |
InParanoidi | Q5TD97 |
OMAi | DDNPYCV |
OrthoDBi | 642235at2759 |
PhylomeDBi | Q5TD97 |
TreeFami | TF314113 |
Enzyme and pathway databases
PathwayCommonsi | Q5TD97 |
SIGNORi | Q5TD97 |
Miscellaneous databases
BioGRID-ORCSi | 9457, 7 hits in 845 CRISPR screens |
EvolutionaryTracei | Q5TD97 |
GeneWikii | FHL5 |
GenomeRNAii | 9457 |
Pharosi | Q5TD97, Tbio |
PROi | PR:Q5TD97 |
RNActi | Q5TD97, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112214, Expressed in popliteal artery and 179 other tissues |
ExpressionAtlasi | Q5TD97, baseline and differential |
Genevisiblei | Q5TD97, HS |
Family and domain databases
CDDi | cd09428, LIM2_FHL5, 1 hit |
InterProi | View protein in InterPro IPR037987, FHL2/3/5 IPR042947, FHL5_LIM2 IPR001781, Znf_LIM |
PANTHERi | PTHR24205, PTHR24205, 1 hit |
Pfami | View protein in Pfam PF00412, LIM, 4 hits |
SMARTi | View protein in SMART SM00132, LIM, 4 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 4 hits PS50023, LIM_DOMAIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FHL5_HUMAN | |
Accessioni | Q5TD97Primary (citable) accession number: Q5TD97 Secondary accession number(s): B2RBD1 Q9NQU2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations