UniProtKB - Q5TD97 (FHL5_HUMAN)

BLAST

>sp|Q5TD97|FHL5_HUMAN Four and a half LIM domains protein 5 OS=Homo sapiens OX=9606 GN=FHL5 PE=1 SV=1
MTTAHFYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDR
HWHEGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKG
NYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGGITFCDQ
LWHKECFLCSGCRKDLCEEQFMSRDDYPFCVDCYNHLYANKCVACSKPISGLTGAKFICF
QDSQWHSECFNCGKCSVSLVGKGFLTQNKEIFCQKCGSGMDTDI

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History
Entry version 135 (07 Nov 2018)
Sequence version 1 (21 Dec 2004)
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Protein

Four and a half LIM domains protein 5

Gene

FHL5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	8 – 32	C4-typeSequence analysisAdd BLAST		25

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
transcription coactivator activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of transcription by RNA polymerase II Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Enzyme and pathway databases

SIGNORⁱ	Q5TD97

SIGNORⁱ

Q5TD97

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Four and a half LIM domains protein 5 Short name: FHL-5 Alternative name(s): Activator of cAMP-responsive element modulator in testis Short name: Activator of CREM in testis
Gene namesⁱ	Name:FHL5 Synonyms:ACT
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000112214.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17371 FHL5
MIMⁱ	605126 gene
neXtProtⁱ	NX_Q5TD97

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9457
Open Targets More...OpenTargetsⁱ	ENSG00000112214
PharmGKBⁱ	PA134971720

Polymorphism and mutation databases

BioMutaⁱ	FHL5
DMDMⁱ	68565455

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000075742	1 – 284	Four and a half LIM domains protein 5Add BLAST		284

Proteomic databases

PaxDbⁱ	Q5TD97
PeptideAtlas More...PeptideAtlasⁱ	Q5TD97
PRIDEⁱ	Q5TD97
ProteomicsDBⁱ	65008

PTM databases

iPTMnetⁱ	Q5TD97
PhosphoSitePlusⁱ	Q5TD97

Expressionⁱ

Tissue specificityⁱ

Testis-specific (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000112214 Expressed in 164 organ(s), highest expression level in popliteal artery
CleanExⁱ	HS_FHL5
ExpressionAtlasⁱ	Q5TD97 baseline and differential
Genevisibleⁱ	Q5TD97 HS

Interactionⁱ

Subunit structureⁱ

Interacts with CREM (via the third LIM domain). Interacts (via second LIM domain) with SPAG8.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BANP	Q8N9N5-7	3	EBI-750641,EBI-16429296
CRYBA4	P53673	3	EBI-750641,EBI-7519711
DNAL4	O96015	4	EBI-750641,EBI-742362
FAM214B	Q7L5A3	3	EBI-750641,EBI-745689
Hoxa1	P09022	3	EBI-750641,EBI-3957603	From Mus musculus.
ZNF688	A0A0S2Z5X4	3	EBI-750641,EBI-16429014
ZNF688	A0A0S2Z6P0	3	EBI-750641,EBI-16429989

Protein-protein interaction databases

BioGridⁱ	114846, 20 interactors
CORUMⁱ	Q5TD97
IntActⁱ	Q5TD97, 87 interactors
Molecular INTeraction database More...MINTⁱ	Q5TD97
STRINGⁱ	9606.ENSP00000326022

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	223 – 225	Combined sources	3
Turnⁱ	231 – 234	Combined sources	4
Beta strandⁱ	237 – 240	Combined sources	4
Beta strandⁱ	243 – 246	Combined sources	4
Helixⁱ	247 – 249	Combined sources	3
Turnⁱ	253 – 255	Combined sources	3
Beta strandⁱ	260 – 262	Combined sources	3
Beta strandⁱ	264 – 267	Combined sources	4
Beta strandⁱ	270 – 273	Combined sources	4
Turnⁱ	274 – 277	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q5TD97
SMRⁱ	Q5TD97
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q5TD97

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	39 – 100	LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST	62
Domainⁱ	101 – 160	LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	161 – 220	LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	223 – 283	LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST	61

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	8 – 32	C4-typeSequence analysisAdd BLAST		25

Keywords - Domainⁱ

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1704 Eukaryota ENOG410XP0W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118910
HOGENOMⁱ	HOG000231075
HOVERGENⁱ	HBG074526
InParanoidⁱ	Q5TD97
OMAⁱ	YCVSCYD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07C5
PhylomeDBⁱ	Q5TD97
TreeFamⁱ	TF314113

Family and domain databases

InterProⁱ	View protein in InterPro IPR037987 FHL2/3/5 IPR001781 Znf_LIM
PANTHERⁱ	PTHR24205 PTHR24205, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00412 LIM, 4 hits
SMARTⁱ	View protein in SMART SM00132 LIM, 4 hits
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 4 hits PS50023 LIM_DOMAIN_2, 4 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q5TD97-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTTAHFYCQY CTASLLGKKY VLKDDSPYCV TCYDRVFSNY CEECKKPIES 
        60         70         80         90        100
DSKDLCYKDR HWHEGCFKCT KCNHSLVEKP FAAKDERLLC TECYSNECSS 
       110        120        130        140        150
KCFHCKRTIM PGSRKMEFKG NYWHETCFVC ENCRQPIGTK PLISKESGNY 
       160        170        180        190        200
CVPCFEKEFA HYCNFCKKVI TSGGITFCDQ LWHKECFLCS GCRKDLCEEQ 
       210        220        230        240        250
FMSRDDYPFC VDCYNHLYAN KCVACSKPIS GLTGAKFICF QDSQWHSECF 
       260        270        280 
NCGKCSVSLV GKGFLTQNKE IFCQKCGSGM DTDI

Length:284

Mass (Da):32,720

Last modified:December 21, 2004 - v1

Checksum:ⁱ82C03B1EAA147C11

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	X6RED3	X6RED3_HUMAN		Four and a half LIM domains protein... Four and a half LIM domains protein 5	FHL5	210	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	55	L → F in AAF85978 (PubMed:11327716).Curated	1
Sequence conflictⁱ	191	G → D in AAH21723 (PubMed:15489334).Curated	1
Sequence conflictⁱ	191	G → D in AAH29490 (PubMed:15489334).Curated	1
Sequence conflictⁱ	254	K → R in AAF85978 (PubMed:11327716).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_056160	35	R → H. Corresponds to variant dbSNP:rs35157931Ensembl.	1
Natural variantⁱVAR_056161	204	R → G. Corresponds to variant dbSNP:rs2273621Ensembl.	1
Natural variantⁱVAR_022824	211	V → M3 PublicationsCorresponds to variant dbSNP:rs2252816Ensembl.	1
Natural variantⁱVAR_056162	243	S → R. Corresponds to variant dbSNP:rs9373985Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF278541 mRNA Translation: AAF85978.1 AK057611 mRNA Translation: BAG51940.1 AK223539 mRNA Translation: BAD97259.1 AK314608 mRNA Translation: BAG37178.1 AL132776 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48503.1 CH471051 Genomic DNA Translation: EAW48504.1 CH471051 Genomic DNA Translation: EAW48505.1 BC021723 mRNA Translation: AAH21723.1 BC029490 mRNA Translation: AAH29490.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5035.1
PIRⁱ	JC7686
NCBI Reference Sequences More...RefSeqⁱ	NP_001164278.1, NM_001170807.2 NP_001309395.1, NM_001322466.1 NP_001309396.1, NM_001322467.1 NP_065228.4, NM_020482.5
UniGeneⁱ	Hs.632608

Genome annotation databases

Ensemblⁱ	ENST00000326771; ENSP00000326022; ENSG00000112214 ENST00000541107; ENSP00000442357; ENSG00000112214
GeneIDⁱ	9457
KEGGⁱ	hsa:9457
UCSC genome browser More...UCSCⁱ	uc003pos.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5TD97	Four and a half LIM domains 5		GORGO		324	UniRef100_Q5TD97
Four and a half LIM domains protein 5 (Fragment)		HUMAN		210

Protein	Similar proteins		Species	Score	Length	Source
Q5TD97	Four and a half LIM domains protein 5		MACFA		284	UniRef90_Q5TD97
Four and a half LIM domains 5		GORGO		324
Four and a half LIM domains protein 5 (Fragment)		HUMAN		210
Uncharacterized protein		NOMLE		284
Four and a half LIM domains 5		CERAT		284
+28

Protein	Similar proteins		Species	Score	Length	Source
Q5TD97	Four and a half LIM domains protein 5		MACFA		284	UniRef50_Q5TD97
Four and a half LIM domains protein 5		MOUSE		284
Four and a half LIM domains protein 5		RAT		284
Four and a half LIM domains 5		GORGO		324
Four and a half LIM domains protein 5 (Fragment)		HUMAN		210
+199

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF278541 mRNA Translation: AAF85978.1 AK057611 mRNA Translation: BAG51940.1 AK223539 mRNA Translation: BAD97259.1 AK314608 mRNA Translation: BAG37178.1 AL132776 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48503.1 CH471051 Genomic DNA Translation: EAW48504.1 CH471051 Genomic DNA Translation: EAW48505.1 BC021723 mRNA Translation: AAH21723.1 BC029490 mRNA Translation: AAH29490.1
CCDSⁱ	CCDS5035.1
PIRⁱ	JC7686
RefSeqⁱ	NP_001164278.1, NM_001170807.2 NP_001309395.1, NM_001322466.1 NP_001309396.1, NM_001322467.1 NP_065228.4, NM_020482.5
UniGeneⁱ	Hs.632608

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1X68	NMR	-	A	222-284	[»]
ProteinModelPortalⁱ	Q5TD97
SMRⁱ	Q5TD97
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114846, 20 interactors
CORUMⁱ	Q5TD97
IntActⁱ	Q5TD97, 87 interactors
MINTⁱ	Q5TD97
STRINGⁱ	9606.ENSP00000326022

PTM databases

iPTMnetⁱ	Q5TD97
PhosphoSitePlusⁱ	Q5TD97

Polymorphism and mutation databases

BioMutaⁱ	FHL5
DMDMⁱ	68565455

Proteomic databases

PaxDbⁱ	Q5TD97
PeptideAtlasⁱ	Q5TD97
PRIDEⁱ	Q5TD97
ProteomicsDBⁱ	65008

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9457
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000326771; ENSP00000326022; ENSG00000112214 ENST00000541107; ENSP00000442357; ENSG00000112214
GeneIDⁱ	9457
KEGGⁱ	hsa:9457
UCSCⁱ	uc003pos.3 human

Organism-specific databases

CTDⁱ	9457
DisGeNETⁱ	9457
EuPathDBⁱ	HostDB:ENSG00000112214.10
GeneCardsⁱ	FHL5
H-InvDBⁱ	HIX0006080
HGNCⁱ	HGNC:17371 FHL5
MIMⁱ	605126 gene
neXtProtⁱ	NX_Q5TD97
OpenTargetsⁱ	ENSG00000112214
PharmGKBⁱ	PA134971720
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1704 Eukaryota ENOG410XP0W LUCA
GeneTreeⁱ	ENSGT00760000118910
HOGENOMⁱ	HOG000231075
HOVERGENⁱ	HBG074526
InParanoidⁱ	Q5TD97
OMAⁱ	YCVSCYD
OrthoDBⁱ	EOG091G07C5
PhylomeDBⁱ	Q5TD97
TreeFamⁱ	TF314113

Enzyme and pathway databases

SIGNORⁱ	Q5TD97

SIGNORⁱ

Q5TD97

Miscellaneous databases

EvolutionaryTraceⁱ	Q5TD97
GeneWikiⁱ	FHL5
GenomeRNAiⁱ	9457
Protein Ontology More...PROⁱ	PR:Q5TD97
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000112214 Expressed in 164 organ(s), highest expression level in popliteal artery
CleanExⁱ	HS_FHL5
ExpressionAtlasⁱ	Q5TD97 baseline and differential
Genevisibleⁱ	Q5TD97 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR037987 FHL2/3/5 IPR001781 Znf_LIM
PANTHERⁱ	PTHR24205 PTHR24205, 1 hit
Pfamⁱ	View protein in Pfam PF00412 LIM, 4 hits
SMARTⁱ	View protein in SMART SM00132 LIM, 4 hits
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 4 hits PS50023 LIM_DOMAIN_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FHL5_HUMAN
Accessionⁱ	Q5TD97Primary (citable) accession number: Q5TD97 Secondary accession number(s): B2RBD1 , E1P526, Q5TD98, Q8WW21, Q9NQU2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
	Last sequence update:	December 21, 2004
	Last modified:	November 7, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniProtKB - Q5TD97 (FHL5_HUMAN)

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Four and a half LIM domains protein 5

FHL5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ