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Entry version 128 (02 Jun 2021)
Sequence version 1 (21 Dec 2004)
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Protein

Radial spoke head protein 4 homolog A

Gene

RSPH4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the axonemal radial spoke head which plays an important role in ciliary motility (PubMed:19200523).

Essential for triplet radial spokes (RS1, RS2 and RS3) head assembly in the motile cilia (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5TD94

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Radial spoke head protein 4 homolog A
Alternative name(s):
Radial spoke head-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RSPH4A
Synonyms:RSHL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21558, RSPH4A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612647, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TD94

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000111834.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ciliary dyskinesia, primary, 11 (CILD11)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05523587P → S in CILD11. 1 PublicationCorresponds to variant dbSNP:rs767490154EnsemblClinVar.1
Natural variantiVAR_070565464G → E in CILD11; unknown pathological significance. Corresponds to variant dbSNP:rs753041231EnsemblClinVar.1

Keywords - Diseasei

Ciliopathy, Disease variant, Kartagener syndrome, Primary ciliary dyskinesia

Organism-specific databases

DisGeNET

More...
DisGeNETi
345895

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
RSPH4A

MalaCards human disease database

More...
MalaCardsi
RSPH4A
MIMi612649, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000111834

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
244, Primary ciliary dyskinesia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164725568

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5TD94, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RSPH4A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74746178

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003137381 – 716Radial spoke head protein 4 homolog AAdd BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei396PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5TD94

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5TD94

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TD94

PeptideAtlas

More...
PeptideAtlasi
Q5TD94

PRoteomics IDEntifications database

More...
PRIDEi
Q5TD94

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65005 [Q5TD94-1]
65006 [Q5TD94-2]
65007 [Q5TD94-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TD94

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TD94

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in trachea, lungs, and testes (PubMed:23993197). Very strong expression is detected in nasal brushings (PubMed:19200523).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111834, Expressed in right uterine tube and 119 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TD94, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000111834, Tissue enhanced (brain, fallopian tube, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RSPH6A.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131368, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000229554

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5TD94, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 164DisorderedSequence analysisAdd BLAST164
Regioni375 – 410DisorderedSequence analysisAdd BLAST36
Regioni506 – 526DisorderedSequence analysisAdd BLAST21
Regioni697 – 716DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 23Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi50 – 65Polar residuesSequence analysisAdd BLAST16
Compositional biasi80 – 94Pro residuesSequence analysisAdd BLAST15
Compositional biasi142 – 158Polar residuesSequence analysisAdd BLAST17
Compositional biasi375 – 402Acidic residuesSequence analysisAdd BLAST28
Compositional biasi700 – 716Acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSU4, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044869

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021526_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TD94

Identification of Orthologs from Complete Genome Data

More...
OMAi
NQCGFSI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TD94

TreeFam database of animal gene trees

More...
TreeFami
TF324531

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006802, Radial_spoke

The PANTHER Classification System

More...
PANTHERi
PTHR13159, PTHR13159, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04712, Radial_spoke, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5TD94-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDSTSPKQE KENQEELGET RRPWEGKTAA SPQYSEPESS EPLEAKQGPE
60 70 80 90 100
TGRQSRSSRP WSPQSRAKTP LGGPAGPETS SPAPVSPREP SSSPSPLAPA
110 120 130 140 150
RQDLAAPPQS DRTTSVIPEA GTPYPDPLEQ SSDKRESTPH HTSQSEGNTF
160 170 180 190 200
QQSQQPKPHL CGRRDVSYNN AKQKELRFDV FQEEDSNSDY DLQQPAPGGS
210 220 230 240 250
EVAPSMLEIT IQNAKAYLLK TSSNSGFNLY DHLSNMLTKI LNERPENAVD
260 270 280 290 300
IFENISQDVK MAHFSKKFDA LQNENELLPT YEIAEKQKAL FLQGHLEGVD
310 320 330 340 350
QELEDEIAEN ALPNVMESAF YFEQAGVGLG TDETYRIFLA LKQLTDTHPI
360 370 380 390 400
QRCRFWGKIL GLEMNYIVAE VEFREGEDEE EVEEEDVAEE RDNGESEAHE
410 420 430 440 450
DEEDELPKSF YKAPQAIPKE ESRTGANKYV YFVCNEPGRP WVKLPPVIPA
460 470 480 490 500
QIVIARKIKK FFTGRLDAPI ISYPPFPGNE SNYLRAQIAR ISAGTHVSPL
510 520 530 540 550
GFYQFGEEEG EEEEEAEGGR NSFEENPDFE GIQVIDLVES LSNWVHHVQH
560 570 580 590 600
ILSQGRCNWF NSIQKNEEEE EEEDEEKDDS DYIEQEVGLP LLTPISEDLE
610 620 630 640 650
IQNIPPWTTR LSSNLIPQYA IAVLQSNLWP GAYAFSNGKK FENFYIGWGH
660 670 680 690 700
KYSPDNYTPP VPPPVYQEYP SGPEITEMDD PSVEEEQAFR AAQEAVLLAA
710
ENEESEEDED EEDDYD
Length:716
Mass (Da):80,733
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7951A85FBE6F6E7
GO
Isoform 2 (identifier: Q5TD94-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-554: Missing.

Show »
Length:469
Mass (Da):52,639
Checksum:i1181D047713591D4
GO
Isoform 3 (identifier: Q5TD94-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     555-600: GRCNWFNSIQ...LLTPISEDLE → RFRIYPPGQH...PMAKSLKIST
     601-716: Missing.

Show »
Length:600
Mass (Da):67,406
Checksum:i526B72E99DBBEF5D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05523587P → S in CILD11. 1 PublicationCorresponds to variant dbSNP:rs767490154EnsemblClinVar.1
Natural variantiVAR_037715149T → S. Corresponds to variant dbSNP:rs13213314EnsemblClinVar.1
Natural variantiVAR_070565464G → E in CILD11; unknown pathological significance. Corresponds to variant dbSNP:rs753041231EnsemblClinVar.1
Natural variantiVAR_037716556R → H. Corresponds to variant dbSNP:rs6927567EnsemblClinVar.1
Natural variantiVAR_037717589L → P1 PublicationCorresponds to variant dbSNP:rs784133EnsemblClinVar.1
Natural variantiVAR_037718627N → H. Corresponds to variant dbSNP:rs9488991EnsemblClinVar.1
Natural variantiVAR_037719700A → V. Corresponds to variant dbSNP:rs9488992EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030125308 – 554Missing in isoform 2. CuratedAdd BLAST247
Alternative sequenceiVSP_030126555 – 600GRCNW…SEDLE → RFRIYPPGQHGYPQISFHNM LLQSFNPTFGLEHMPSPMAK SLKIST in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_030127601 – 716Missing in isoform 3. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK299754 mRNA Translation: BAG61643.1
AL132795 Genomic DNA No translation available.
BC106949 mRNA Translation: AAI06950.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34521.1 [Q5TD94-1]
CCDS55051.1 [Q5TD94-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001010892.1, NM_001010892.2 [Q5TD94-1]
NP_001155136.1, NM_001161664.1 [Q5TD94-3]
XP_016866315.1, XM_017010826.1 [Q5TD94-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000229554; ENSP00000229554; ENSG00000111834 [Q5TD94-1]
ENST00000368580; ENSP00000357569; ENSG00000111834 [Q5TD94-2]
ENST00000368581; ENSP00000357570; ENSG00000111834 [Q5TD94-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
345895

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:345895

UCSC genome browser

More...
UCSCi
uc003pxe.3, human [Q5TD94-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299754 mRNA Translation: BAG61643.1
AL132795 Genomic DNA No translation available.
BC106949 mRNA Translation: AAI06950.1
CCDSiCCDS34521.1 [Q5TD94-1]
CCDS55051.1 [Q5TD94-3]
RefSeqiNP_001010892.1, NM_001010892.2 [Q5TD94-1]
NP_001155136.1, NM_001161664.1 [Q5TD94-3]
XP_016866315.1, XM_017010826.1 [Q5TD94-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi131368, 2 interactors
STRINGi9606.ENSP00000229554

PTM databases

iPTMnetiQ5TD94
PhosphoSitePlusiQ5TD94

Genetic variation databases

BioMutaiRSPH4A
DMDMi74746178

Proteomic databases

jPOSTiQ5TD94
MassIVEiQ5TD94
PaxDbiQ5TD94
PeptideAtlasiQ5TD94
PRIDEiQ5TD94
ProteomicsDBi65005 [Q5TD94-1]
65006 [Q5TD94-2]
65007 [Q5TD94-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32513, 55 antibodies

The DNASU plasmid repository

More...
DNASUi
345895

Genome annotation databases

EnsembliENST00000229554; ENSP00000229554; ENSG00000111834 [Q5TD94-1]
ENST00000368580; ENSP00000357569; ENSG00000111834 [Q5TD94-2]
ENST00000368581; ENSP00000357570; ENSG00000111834 [Q5TD94-3]
GeneIDi345895
KEGGihsa:345895
UCSCiuc003pxe.3, human [Q5TD94-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
345895
DisGeNETi345895

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RSPH4A
GeneReviewsiRSPH4A
HGNCiHGNC:21558, RSPH4A
HPAiENSG00000111834, Tissue enhanced (brain, fallopian tube, pituitary gland)
MalaCardsiRSPH4A
MIMi612647, gene
612649, phenotype
neXtProtiNX_Q5TD94
OpenTargetsiENSG00000111834
Orphaneti244, Primary ciliary dyskinesia
PharmGKBiPA164725568
VEuPathDBiHostDB:ENSG00000111834.12

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QSU4, Eukaryota
GeneTreeiENSGT00500000044869
HOGENOMiCLU_021526_1_0_1
InParanoidiQ5TD94
OMAiNQCGFSI
PhylomeDBiQ5TD94
TreeFamiTF324531

Enzyme and pathway databases

PathwayCommonsiQ5TD94

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
345895, 11 hits in 1000 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RSPH4A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
345895
PharosiQ5TD94, Tdark

Protein Ontology

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PROi
PR:Q5TD94
RNActiQ5TD94, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000111834, Expressed in right uterine tube and 119 other tissues
GenevisibleiQ5TD94, HS

Family and domain databases

InterProiView protein in InterPro
IPR006802, Radial_spoke
PANTHERiPTHR13159, PTHR13159, 1 hit
PfamiView protein in Pfam
PF04712, Radial_spoke, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRSH4A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TD94
Secondary accession number(s): B4DSI1, Q3KP24, Q5TD95
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 21, 2004
Last modified: June 2, 2021
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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