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Protein

SH3 and PX domain-containing protein 2A

Gene

SH3PXD2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • extracellular matrix organization Source: Reactome
  • osteoclast fusion Source: CACAO
  • superoxide metabolic process Source: UniProtKB

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8941237 Invadopodia formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 and PX domain-containing protein 2A
Alternative name(s):
Adapter protein TKS5
Five SH3 domain-containing protein
SH3 multiple domains protein 1
Tyrosine kinase substrate with five SH3 domains
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SH3PXD2A
Synonyms:FISH, KIAA0418, SH3MD1, TKS5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000107957.16

Human Gene Nomenclature Database

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HGNCi
HGNC:23664 SH3PXD2A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TCZ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi42R → A: Loss of binding to (PtdIns(3)P) and (PtdIns(3,4)P2). 1 Publication1
Mutagenesisi93R → A: Loss of binding to (PtdIns(3)P) and (PtdIns(3,4)P2). 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9644

MalaCards human disease database

More...
MalaCardsi
SH3PXD2A

Open Targets

More...
OpenTargetsi
ENSG00000107957

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3148 Malignant peripheral nerve sheath tumor

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134956816

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SH3PXD2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74746151

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002784881 – 1133SH3 and PX domain-containing protein 2AAdd BLAST1133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei256PhosphothreonineBy similarity1
Modified residuei406PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei547PhosphoserineCombined sources1
Modified residuei567PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei644PhosphoserineCombined sources1
Modified residuei731PhosphothreonineCombined sources1
Modified residuei767PhosphoserineBy similarity1
Modified residuei769PhosphoserineBy similarity1
Modified residuei819PhosphoserineBy similarity1
Modified residuei829PhosphothreonineBy similarity1
Modified residuei1002PhosphoserineCombined sources1
Modified residuei1016PhosphoserineCombined sources1
Modified residuei1017PhosphoserineCombined sources1
Modified residuei1038PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5TCZ1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q5TCZ1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5TCZ1

PeptideAtlas

More...
PeptideAtlasi
Q5TCZ1

PRoteomics IDEntifications database

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PRIDEi
Q5TCZ1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
64997
64998 [Q5TCZ1-2]
64999 [Q5TCZ1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TCZ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TCZ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000107957 Expressed in 219 organ(s), highest expression level in uterine cervix

CleanEx database of gene expression profiles

More...
CleanExi
HS_SH3PXD2A

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5TCZ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5TCZ1 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA037922
HPA037923

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with CYBA (By similarity). Interacts with ADAM12, ADAM15 and ADAM19. Interacts with NOXO1. Interacts (via SH3 domains) with NOXA1. Interacts with FASLG.By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115002, 90 interactors

Protein interaction database and analysis system

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IntActi
Q5TCZ1, 14 interactors

Molecular INTeraction database

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MINTi
Q5TCZ1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348215

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11133
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q5TCZ1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5TCZ1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q5TCZ1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 128PXPROSITE-ProRule annotationAdd BLAST125
Domaini166 – 225SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini266 – 325SH3 2PROSITE-ProRule annotationAdd BLAST60
Domaini448 – 507SH3 3PROSITE-ProRule annotationAdd BLAST60
Domaini840 – 899SH3 4PROSITE-ProRule annotationAdd BLAST60
Domaini1072 – 1133SH3 5PROSITE-ProRule annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili917 – 946Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi634 – 724Ser-richAdd BLAST91

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and, to a lesser extent, phosphatidylinositol 4-phosphate (PtdIns4P), phosphatidylinositol 5-phosphate (PtdIns5P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain (By similarity).By similarity
The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19.2 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SH3PXD2 family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4773 Eukaryota
ENOG410YBFF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157732

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154376

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG089589

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5TCZ1

Identification of Orthologs from Complete Genome Data

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OMAi
PTQRNGI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00YX

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TCZ1

TreeFam database of animal gene trees

More...
TreeFami
TF329347

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06888 PX_FISH, 1 hit
cd12074 SH3_Tks5_1, 1 hit
cd12077 SH3_Tks5_2, 1 hit
cd12079 SH3_Tks5_3, 1 hit
cd12019 SH3_Tks5_4, 1 hit
cd12020 SH3_Tks5_5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR037961 SH3PXD2_PX
IPR034917 SH3PXD2A
IPR035450 SH3PXD2A_SH3_1
IPR035452 SH3PXD2A_SH3_2
IPR035449 SH3PXD2A_SH3_3
IPR035453 SH3PXD2A_SH3_4
IPR035454 SH3PXD2A_SH3_5

The PANTHER Classification System

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PANTHERi
PTHR15706:SF7 PTHR15706:SF7, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00787 PX, 1 hit
PF00018 SH3_1, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 5 hits
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5TCZ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLAYCVQDAT VVDVEKRRNP SKHYVYIINV TWSDSTSQTI YRRYSKFFDL
60 70 80 90 100
QMQLLDKFPI EGGQKDPKQR IIPFLPGKIL FRRSHIRDVA VKRLKPIDEY
110 120 130 140 150
CRALVRLPPH ISQCDEVFRF FEARPEDVNP PKEDYGSSKR KSVWLSSWAE
160 170 180 190 200
SPKKDVTGAD ATAEPMILEQ YVVVSNYKKQ ENSELSLQAG EVVDVIEKNE
210 220 230 240 250
SGWWFVSTSE EQGWVPATYL EAQNGTRDDS DINTSKTGEV SKRRKAHLRR
260 270 280 290 300
LDRRWTLGGM VNRQHSREEK YVTVQPYTSQ SKDEIGFEKG VTVEVIRKNL
310 320 330 340 350
EGWWYIRYLG KEGWAPASYL KKAKDDLPTR KKNLAGPVEI IGNIMEISNL
360 370 380 390 400
LNKKASGDKE TPPAEGEGHE APIAKKEISL PILCNASNGS AVGVPDRTVS
410 420 430 440 450
RLAQGSPAVA RIAPQRAQIS SPNLRTRPPP RRESSLGFQL PKPPEPPSVE
460 470 480 490 500
VEYYTIAEFQ SCISDGISFR GGQKAEVIDK NSGGWWYVQI GEKEGWAPAS
510 520 530 540 550
YIDKRKKPNL SRRTSTLTRP KVPPPAPPSK PKEAEEGPTG ASESQDSPRK
560 570 580 590 600
LKYEEPEYDI PAFGFDSEPE LSEEPVEDRA SGERRPAQPH RPSPASSLQR
610 620 630 640 650
ARFKVGESSE DVALEEETIY ENEGFRPYAE DTLSARGSSG DSDSPGSSSL
660 670 680 690 700
SLTRKNSPKS GSPKSSSLLK LKAEKNAQAE MGKNHSSASF SSSITINTTC
710 720 730 740 750
CSSSSSSSSS LSKTSGDLKP RSASDAGIRG TPKVRAKKDA DANAGLTSCP
760 770 780 790 800
RAKPSVRPKP FLNRAESQSQ EKMDISTLRR QLRPTGQLRG GLKGSKSEDS
810 820 830 840 850
ELPPQTASEA PSEGSRRSSS DLITLPATTP PCPTKKEWEG PATSYMTCSA
860 870 880 890 900
YQKVQDSEIS FPAGVEVQVL EKQESGWWYV RFGELEGWAP SHYLVLDENE
910 920 930 940 950
QPDPSGKELD TVPAKGRQNE GKSDSLEKIE RRVQALNTVN QSKKATPPIP
960 970 980 990 1000
SKPPGGFGKT SGTPAVKMRN GVRQVAVRPQ SVFVSPPPKD NNLSCALRRN
1010 1020 1030 1040 1050
ESLTATDGLR GVRRNSSFST ARSAAAEAKG RLAERAASQG SDSPLLPAQR
1060 1070 1080 1090 1100
NSIPVSPVRP KPIEKSQFIH NNLKDVYVSI ADYEGDEETA GFQEGVSMEV
1110 1120 1130
LERNPNGWWY CQILDGVKPF KGWVPSNYLE KKN
Length:1,133
Mass (Da):125,289
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD485F49E9192359C
GO
Isoform 2 (identifier: Q5TCZ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.
     240-267: Missing.

Show »
Length:940
Mass (Da):102,618
Checksum:i1CA24D7BC03B8AC3
GO
Isoform 3 (identifier: Q5TCZ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     240-267: Missing.

Note: Gene prediction based on similarity to mouse ortholog and partial transcript data.
Show »
Length:1,105
Mass (Da):121,836
Checksum:i384ECB9785EE3FAB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y507H0Y507_HUMAN
SH3 and PX domain-containing protei...
SH3PXD2A
1,060Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA24848 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030781659K → Q. Corresponds to variant dbSNP:rs11818820Ensembl.1
Natural variantiVAR_0307821035R → Q. Corresponds to variant dbSNP:rs3781365Ensembl.1
Natural variantiVAR_0569931073L → P. Corresponds to variant dbSNP:rs12764700Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0233121 – 165Missing in isoform 2. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_023313240 – 267Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB007878 mRNA Translation: BAA24848.2 Different initiation.
AL121929 Genomic DNA No translation available.
AL133355 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49623.1
CH471066 Genomic DNA Translation: EAW49624.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31278.1 [Q5TCZ1-3]

Protein sequence database of the Protein Information Resource

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PIRi
T00056

NCBI Reference Sequences

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RefSeqi
NP_055446.2, NM_014631.2 [Q5TCZ1-3]
XP_005270351.1, XM_005270294.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.678727

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000355946; ENSP00000348215; ENSG00000107957 [Q5TCZ1-3]
ENST00000369774; ENSP00000358789; ENSG00000107957 [Q5TCZ1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9644

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9644

UCSC genome browser

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UCSCi
uc001kxj.2 human [Q5TCZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007878 mRNA Translation: BAA24848.2 Different initiation.
AL121929 Genomic DNA No translation available.
AL133355 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49623.1
CH471066 Genomic DNA Translation: EAW49624.1
CCDSiCCDS31278.1 [Q5TCZ1-3]
PIRiT00056
RefSeqiNP_055446.2, NM_014631.2 [Q5TCZ1-3]
XP_005270351.1, XM_005270294.4
UniGeneiHs.678727

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DNUNMR-A268-325[»]
2EGANMR-A168-224[»]
2EGCNMR-A1072-1133[»]
2EKHNMR-A842-908[»]
ProteinModelPortaliQ5TCZ1
SMRiQ5TCZ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115002, 90 interactors
IntActiQ5TCZ1, 14 interactors
MINTiQ5TCZ1
STRINGi9606.ENSP00000348215

PTM databases

iPTMnetiQ5TCZ1
PhosphoSitePlusiQ5TCZ1

Polymorphism and mutation databases

BioMutaiSH3PXD2A
DMDMi74746151

Proteomic databases

EPDiQ5TCZ1
MaxQBiQ5TCZ1
PaxDbiQ5TCZ1
PeptideAtlasiQ5TCZ1
PRIDEiQ5TCZ1
ProteomicsDBi64997
64998 [Q5TCZ1-2]
64999 [Q5TCZ1-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9644
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355946; ENSP00000348215; ENSG00000107957 [Q5TCZ1-3]
ENST00000369774; ENSP00000358789; ENSG00000107957 [Q5TCZ1-1]
GeneIDi9644
KEGGihsa:9644
UCSCiuc001kxj.2 human [Q5TCZ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9644
DisGeNETi9644
EuPathDBiHostDB:ENSG00000107957.16

GeneCards: human genes, protein and diseases

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GeneCardsi
SH3PXD2A
HGNCiHGNC:23664 SH3PXD2A
HPAiHPA037922
HPA037923
MalaCardsiSH3PXD2A
neXtProtiNX_Q5TCZ1
OpenTargetsiENSG00000107957
Orphaneti3148 Malignant peripheral nerve sheath tumor
PharmGKBiPA134956816

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4773 Eukaryota
ENOG410YBFF LUCA
GeneTreeiENSGT00940000157732
HOGENOMiHOG000154376
HOVERGENiHBG089589
InParanoidiQ5TCZ1
OMAiPTQRNGI
OrthoDBiEOG091G00YX
PhylomeDBiQ5TCZ1
TreeFamiTF329347

Enzyme and pathway databases

ReactomeiR-HSA-8941237 Invadopodia formation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SH3PXD2A human
EvolutionaryTraceiQ5TCZ1

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SH3PXD2A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9644

Protein Ontology

More...
PROi
PR:Q5TCZ1

Gene expression databases

BgeeiENSG00000107957 Expressed in 219 organ(s), highest expression level in uterine cervix
CleanExiHS_SH3PXD2A
ExpressionAtlasiQ5TCZ1 baseline and differential
GenevisibleiQ5TCZ1 HS

Family and domain databases

CDDicd06888 PX_FISH, 1 hit
cd12074 SH3_Tks5_1, 1 hit
cd12077 SH3_Tks5_2, 1 hit
cd12079 SH3_Tks5_3, 1 hit
cd12019 SH3_Tks5_4, 1 hit
cd12020 SH3_Tks5_5, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR037961 SH3PXD2_PX
IPR034917 SH3PXD2A
IPR035450 SH3PXD2A_SH3_1
IPR035452 SH3PXD2A_SH3_2
IPR035449 SH3PXD2A_SH3_3
IPR035453 SH3PXD2A_SH3_4
IPR035454 SH3PXD2A_SH3_5
PANTHERiPTHR15706:SF7 PTHR15706:SF7, 3 hits
PfamiView protein in Pfam
PF00787 PX, 1 hit
PF00018 SH3_1, 4 hits
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 5 hits
SUPFAMiSSF50044 SSF50044, 5 hits
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPD2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TCZ1
Secondary accession number(s): D3DR98
, O43302, Q5TCZ2, Q5TDQ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 21, 2004
Last modified: December 5, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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