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UniProtKB - Q5TCZ1 (SPD2A_HUMAN)

Entry version 149 (17 Jun 2020)
Sequence version 1 (21 Dec 2004)
Previous versions | rss
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Protein

SH3 and PX domain-containing protein 2A

Gene

SH3PXD2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8941237 Invadopodia formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 and PX domain-containing protein 2A
Alternative name(s):
Adapter protein TKS5
Five SH3 domain-containing protein
SH3 multiple domains protein 1
Tyrosine kinase substrate with five SH3 domains
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SH3PXD2A
Synonyms:FISH, KIAA0418, SH3MD1, TKS5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000107957.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:23664 SH3PXD2A

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5TCZ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi42R → A: Loss of binding to (PtdIns(3)P) and (PtdIns(3,4)P2). 1 Publication1
Mutagenesisi93R → A: Loss of binding to (PtdIns(3)P) and (PtdIns(3,4)P2). 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9644

MalaCards human disease database

More...MalaCardsi		SH3PXD2A

Open Targets

More...OpenTargetsi		ENSG00000107957

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		3148 Malignant peripheral nerve sheath tumor

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134956816

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5TCZ1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SH3PXD2A

Domain mapping of disease mutations (DMDM)

More...DMDMi		74746151

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002784881 – 1133SH3 and PX domain-containing protein 2AAdd BLAST1133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei256PhosphothreonineBy similarity1
Modified residuei406PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei547PhosphoserineCombined sources1
Modified residuei567PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei644PhosphoserineCombined sources1
Modified residuei731PhosphothreonineCombined sources1
Modified residuei767PhosphoserineBy similarity1
Modified residuei769PhosphoserineBy similarity1
Modified residuei819PhosphoserineBy similarity1
Modified residuei829PhosphothreonineBy similarity1
Modified residuei1002PhosphoserineCombined sources1
Modified residuei1016PhosphoserineCombined sources1
Modified residuei1017PhosphoserineCombined sources1
Modified residuei1038PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5TCZ1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5TCZ1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5TCZ1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5TCZ1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5TCZ1

PeptideAtlas

More...PeptideAtlasi		Q5TCZ1

PRoteomics IDEntifications database

More...PRIDEi		Q5TCZ1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		64997 [Q5TCZ1-1]
64998 [Q5TCZ1-2]
64999 [Q5TCZ1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5TCZ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5TCZ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000107957 Expressed in uterine cervix and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5TCZ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5TCZ1 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000107957 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with CYBA (By similarity).

Interacts with ADAM12, ADAM15 and ADAM19.

Interacts with NOXO1.

Interacts (via SH3 domains) with NOXA1.

Interacts with FASLG.

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115002, 93 interactors

Protein interaction database and analysis system

More...IntActi		Q5TCZ1, 23 interactors

Molecular INTeraction database

More...MINTi		Q5TCZ1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000348215

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5TCZ1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11133
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5TCZ1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q5TCZ1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 128PXPROSITE-ProRule annotationAdd BLAST125
Domaini166 – 225SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini266 – 325SH3 2PROSITE-ProRule annotationAdd BLAST60
Domaini448 – 507SH3 3PROSITE-ProRule annotationAdd BLAST60
Domaini840 – 899SH3 4PROSITE-ProRule annotationAdd BLAST60
Domaini1072 – 1133SH3 5PROSITE-ProRule annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili917 – 946Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi634 – 724Ser-richAdd BLAST91

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and, to a lesser extent, phosphatidylinositol 4-phosphate (PtdIns4P), phosphatidylinositol 5-phosphate (PtdIns5P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain (By similarity).By similarity
The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SH3PXD2 family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4773 Eukaryota
ENOG410YBFF LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157732

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013051_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5TCZ1

KEGG Orthology (KO)

More...KOi		K24032

Identification of Orthologs from Complete Genome Data

More...OMAi		AKDSHYM

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5TCZ1

TreeFam database of animal gene trees

More...TreeFami		TF329347

Family and domain databases

Conserved Domains Database

More...CDDi		cd06888 PX_FISH, 1 hit
cd12074 SH3_Tks5_1, 1 hit
cd12077 SH3_Tks5_2, 1 hit
cd12079 SH3_Tks5_3, 1 hit
cd12019 SH3_Tks5_4, 1 hit
cd12020 SH3_Tks5_5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR037961 SH3PXD2_PX
IPR034917 SH3PXD2A
IPR035450 SH3PXD2A_SH3_1
IPR035452 SH3PXD2A_SH3_2
IPR035449 SH3PXD2A_SH3_3
IPR035453 SH3PXD2A_SH3_4
IPR035454 SH3PXD2A_SH3_5

The PANTHER Classification System

More...PANTHERi		PTHR15706:SF22 PTHR15706:SF22, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00787 PX, 1 hit
PF00018 SH3_1, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50044 SSF50044, 5 hits
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5TCZ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLAYCVQDAT VVDVEKRRNP SKHYVYIINV TWSDSTSQTI YRRYSKFFDL 
        60         70         80         90        100
QMQLLDKFPI EGGQKDPKQR IIPFLPGKIL FRRSHIRDVA VKRLKPIDEY 
       110        120        130        140        150
CRALVRLPPH ISQCDEVFRF FEARPEDVNP PKEDYGSSKR KSVWLSSWAE 
       160        170        180        190        200
SPKKDVTGAD ATAEPMILEQ YVVVSNYKKQ ENSELSLQAG EVVDVIEKNE 
       210        220        230        240        250
SGWWFVSTSE EQGWVPATYL EAQNGTRDDS DINTSKTGEV SKRRKAHLRR 
       260        270        280        290        300
LDRRWTLGGM VNRQHSREEK YVTVQPYTSQ SKDEIGFEKG VTVEVIRKNL 
       310        320        330        340        350
EGWWYIRYLG KEGWAPASYL KKAKDDLPTR KKNLAGPVEI IGNIMEISNL 
       360        370        380        390        400
LNKKASGDKE TPPAEGEGHE APIAKKEISL PILCNASNGS AVGVPDRTVS 
       410        420        430        440        450
RLAQGSPAVA RIAPQRAQIS SPNLRTRPPP RRESSLGFQL PKPPEPPSVE 
       460        470        480        490        500
VEYYTIAEFQ SCISDGISFR GGQKAEVIDK NSGGWWYVQI GEKEGWAPAS 
       510        520        530        540        550
YIDKRKKPNL SRRTSTLTRP KVPPPAPPSK PKEAEEGPTG ASESQDSPRK 
       560        570        580        590        600
LKYEEPEYDI PAFGFDSEPE LSEEPVEDRA SGERRPAQPH RPSPASSLQR 
       610        620        630        640        650
ARFKVGESSE DVALEEETIY ENEGFRPYAE DTLSARGSSG DSDSPGSSSL 
       660        670        680        690        700
SLTRKNSPKS GSPKSSSLLK LKAEKNAQAE MGKNHSSASF SSSITINTTC 
       710        720        730        740        750
CSSSSSSSSS LSKTSGDLKP RSASDAGIRG TPKVRAKKDA DANAGLTSCP 
       760        770        780        790        800
RAKPSVRPKP FLNRAESQSQ EKMDISTLRR QLRPTGQLRG GLKGSKSEDS 
       810        820        830        840        850
ELPPQTASEA PSEGSRRSSS DLITLPATTP PCPTKKEWEG PATSYMTCSA 
       860        870        880        890        900
YQKVQDSEIS FPAGVEVQVL EKQESGWWYV RFGELEGWAP SHYLVLDENE 
       910        920        930        940        950
QPDPSGKELD TVPAKGRQNE GKSDSLEKIE RRVQALNTVN QSKKATPPIP 
       960        970        980        990       1000
SKPPGGFGKT SGTPAVKMRN GVRQVAVRPQ SVFVSPPPKD NNLSCALRRN 
      1010       1020       1030       1040       1050
ESLTATDGLR GVRRNSSFST ARSAAAEAKG RLAERAASQG SDSPLLPAQR 
      1060       1070       1080       1090       1100
NSIPVSPVRP KPIEKSQFIH NNLKDVYVSI ADYEGDEETA GFQEGVSMEV 
      1110       1120       1130 
LERNPNGWWY CQILDGVKPF KGWVPSNYLE KKN
Length:1,133
Mass (Da):125,289
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD485F49E9192359C
GO
Isoform 2 (identifier: Q5TCZ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.
     240-267: Missing.

Show »
Length:940
Mass (Da):102,618
Checksum:i1CA24D7BC03B8AC3
GO
Isoform 3 (identifier: Q5TCZ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     240-267: Missing.

Note: and partial transcript data.Curated
Show »
Length:1,105
Mass (Da):121,836
Checksum:i384ECB9785EE3FAB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y507H0Y507_HUMAN
SH3 and PX domain-containing protei...
SH3PXD2A
1,060Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA24848 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030781659K → Q. Corresponds to variant dbSNP:rs11818820Ensembl.1
Natural variantiVAR_0307821035R → Q. Corresponds to variant dbSNP:rs3781365Ensembl.1
Natural variantiVAR_0569931073L → P. Corresponds to variant dbSNP:rs12764700Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0233121 – 165Missing in isoform 2. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_023313240 – 267Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB007878 mRNA Translation: BAA24848.2 Different initiation.
AL121929 Genomic DNA No translation available.
AL133355 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49623.1
CH471066 Genomic DNA Translation: EAW49624.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31278.1 [Q5TCZ1-3]

Protein sequence database of the Protein Information Resource

More...PIRi		T00056

NCBI Reference Sequences

More...RefSeqi		NP_055446.2, NM_014631.2 [Q5TCZ1-3]
XP_005270351.1, XM_005270294.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355946; ENSP00000348215; ENSG00000107957 [Q5TCZ1-3]
ENST00000369774; ENSP00000358789; ENSG00000107957 [Q5TCZ1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9644

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9644

UCSC genome browser

More...UCSCi		uc001kxj.2 human [Q5TCZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007878 mRNA Translation: BAA24848.2 Different initiation.
AL121929 Genomic DNA No translation available.
AL133355 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49623.1
CH471066 Genomic DNA Translation: EAW49624.1
CCDSiCCDS31278.1 [Q5TCZ1-3]
PIRiT00056
RefSeqiNP_055446.2, NM_014631.2 [Q5TCZ1-3]
XP_005270351.1, XM_005270294.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DNUNMR-A268-325[»]
2EGANMR-A168-224[»]
2EGCNMR-A1072-1133[»]
2EKHNMR-A842-908[»]
SMRiQ5TCZ1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115002, 93 interactors
IntActiQ5TCZ1, 23 interactors
MINTiQ5TCZ1
STRINGi9606.ENSP00000348215

PTM databases

iPTMnetiQ5TCZ1
PhosphoSitePlusiQ5TCZ1

Polymorphism and mutation databases

BioMutaiSH3PXD2A
DMDMi74746151

Proteomic databases

EPDiQ5TCZ1
jPOSTiQ5TCZ1
MassIVEiQ5TCZ1
MaxQBiQ5TCZ1
PaxDbiQ5TCZ1
PeptideAtlasiQ5TCZ1
PRIDEiQ5TCZ1
ProteomicsDBi64997 [Q5TCZ1-1]
64998 [Q5TCZ1-2]
64999 [Q5TCZ1-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q5TCZ1 9 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		46067 151 antibodies

The DNASU plasmid repository

More...DNASUi		9644

Genome annotation databases

EnsembliENST00000355946; ENSP00000348215; ENSG00000107957 [Q5TCZ1-3]
ENST00000369774; ENSP00000358789; ENSG00000107957 [Q5TCZ1-1]
GeneIDi9644
KEGGihsa:9644
UCSCiuc001kxj.2 human [Q5TCZ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9644
DisGeNETi9644
EuPathDBiHostDB:ENSG00000107957.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		SH3PXD2A
HGNCiHGNC:23664 SH3PXD2A
HPAiENSG00000107957 Low tissue specificity
MalaCardsiSH3PXD2A
neXtProtiNX_Q5TCZ1
OpenTargetsiENSG00000107957
Orphaneti3148 Malignant peripheral nerve sheath tumor
PharmGKBiPA134956816

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4773 Eukaryota
ENOG410YBFF LUCA
GeneTreeiENSGT00940000157732
HOGENOMiCLU_013051_0_0_1
InParanoidiQ5TCZ1
KOiK24032
OMAiAKDSHYM
PhylomeDBiQ5TCZ1
TreeFamiTF329347

Enzyme and pathway databases

ReactomeiR-HSA-8941237 Invadopodia formation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9644 8 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SH3PXD2A human
EvolutionaryTraceiQ5TCZ1

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SH3PXD2A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9644
PharosiQ5TCZ1 Tbio

Protein Ontology

More...PROi		PR:Q5TCZ1
RNActiQ5TCZ1 protein

Gene expression databases

BgeeiENSG00000107957 Expressed in uterine cervix and 218 other tissues
ExpressionAtlasiQ5TCZ1 baseline and differential
GenevisibleiQ5TCZ1 HS

Family and domain databases

CDDicd06888 PX_FISH, 1 hit
cd12074 SH3_Tks5_1, 1 hit
cd12077 SH3_Tks5_2, 1 hit
cd12079 SH3_Tks5_3, 1 hit
cd12019 SH3_Tks5_4, 1 hit
cd12020 SH3_Tks5_5, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR037961 SH3PXD2_PX
IPR034917 SH3PXD2A
IPR035450 SH3PXD2A_SH3_1
IPR035452 SH3PXD2A_SH3_2
IPR035449 SH3PXD2A_SH3_3
IPR035453 SH3PXD2A_SH3_4
IPR035454 SH3PXD2A_SH3_5
PANTHERiPTHR15706:SF22 PTHR15706:SF22, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
PF00018 SH3_1, 4 hits
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 5 hits
SUPFAMiSSF50044 SSF50044, 5 hits
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPD2A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TCZ1
Secondary accession number(s): D3DR98
, O43302, Q5TCZ2, Q5TDQ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 21, 2004
Last modified: June 17, 2020
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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