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Entry version 134 (31 Jul 2019)
Sequence version 2 (16 May 2006)
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Protein

Tau-tubulin kinase 1

Gene

TTBK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.1 Publication

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+1 PublicationNote: Divalent metal cations. Mg2+ or, to a lesser extent, Mn2+, but not Ca2+ or Zn2+.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei63ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei154Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi40 – 48ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q5TCY1

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q5TCY1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tau-tubulin kinase 1 (EC:2.7.11.11 Publication)
Alternative name(s):
Brain-derived tau kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTBK1
Synonyms:BDTK, KIAA1855
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19140 TTBK1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TCY1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84630

Open Targets

More...
OpenTargetsi
ENSG00000146216

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134866142

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1926492

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTBK1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
97203020

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002343411 – 1321Tau-tubulin kinase 1Add BLAST1321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei441PhosphoserineBy similarity1
Modified residuei540PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5TCY1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TCY1

PeptideAtlas

More...
PeptideAtlasi
Q5TCY1

PRoteomics IDEntifications database

More...
PRIDEi
Q5TCY1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
64995 [Q5TCY1-1]
64996 [Q5TCY1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TCY1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TCY1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146216 Expressed in 121 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5TCY1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TCY1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031735
HPA031736

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124159, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q5TCY1, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000259750

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q5TCY1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11321
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5TCY1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 297Protein kinasePROSITE-ProRule annotationAdd BLAST264

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili685 – 781Sequence analysisAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi733 – 771Glu-richAdd BLAST39
Compositional biasi772 – 777Poly-Ala6
Compositional biasi1110 – 1114Poly-Ser5
Compositional biasi1197 – 1289Pro-richAdd BLAST93

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1164 Eukaryota
ENOG410XPGP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160981

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154701

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TCY1

KEGG Orthology (KO)

More...
KOi
K08815

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSLPNGP

Database of Orthologous Groups

More...
OrthoDBi
75271at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TCY1

TreeFam database of animal gene trees

More...
TreeFami
TF351646

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5TCY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQCLAAALKD ETNMSGGGEQ ADILPANYVV KDRWKVLKKI GGGGFGEIYE
60 70 80 90 100
AMDLLTRENV ALKVESAQQP KQVLKMEVAV LKKLQGKDHV CRFIGCGRNE
110 120 130 140 150
KFNYVVMQLQ GRNLADLRRS QPRGTFTLST TLRLGKQILE SIEAIHSVGF
160 170 180 190 200
LHRDIKPSNF AMGRLPSTYR KCYMLDFGLA RQYTNTTGDV RPPRNVAGFR
210 220 230 240 250
GTVRYASVNA HKNREMGRHD DLWSLFYMLV EFAVGQLPWR KIKDKEQVGM
260 270 280 290 300
IKEKYEHRML LKHMPSEFHL FLDHIASLDY FTKPDYQLIM SVFENSMKER
310 320 330 340 350
GIAENEAFDW EKAGTDALLS TSTSTPPQQN TRQTAAMFGV VNVTPVPGDL
360 370 380 390 400
LRENTEDVLQ GEHLSDQENA PPILPGRPSE GLGPSPHLVP HPGGPEAEVW
410 420 430 440 450
EETDVNRNKL RINIGKSPCV EEEQSRGMGV PSSPVRAPPD SPTTPVRSLR
460 470 480 490 500
YRRVNSPESE RLSTADGRVE LPERRSRMDL PGSPSRQACS SQPAQMLSVD
510 520 530 540 550
TGHADRQASG RMDVSASVEQ EALSNAFRSV PLAEEEDFDS KEWVIIDKET
560 570 580 590 600
ELKDFPPGAE PSTSGTTDEE PEELRPLPEE GEERRRLGAE PTVRPRGRSM
610 620 630 640 650
QALAEEDLQH LPPQPLPPQL SQGDGRSETS QPPTPGSPSH SPLHSGPRPR
660 670 680 690 700
RRESDPTGPQ RQVFSVAPPF EVNGLPRAVP LSLPYQDFKR DLSDYRERAR
710 720 730 740 750
LLNRVRRVGF SHMLLTTPQV PLAPVQPQAN GKEEEEEEEE DEEEEEEDEE
760 770 780 790 800
EEEEEEEEEE EEEEEEEEEE EAAAAVALGE VLGPRSGSSS EGSERSTDRS
810 820 830 840 850
QEGAPSTLLA DDQKESRGRA SMADGDLEPE EGSKTLVLVS PGDMKKSPVT
860 870 880 890 900
AELAPDPDLG TLAALTPQHE RPQPTGSQLD VSEPGTLSSV LKSEPKPPGP
910 920 930 940 950
GAGLGAGTVT TGVGGVAVTS SPFTKVERTF VHIAEKTHLN VMSSGGQALR
960 970 980 990 1000
SEEFSAGGEL GLELASDGGA VEEGARAPLE NGLALSGLNG AEIEGSALSG
1010 1020 1030 1040 1050
APRETPSEMA TNSLPNGPAL ADGPAPVSPL EPSPEKVATI SPRRHAMPGS
1060 1070 1080 1090 1100
RPRSRIPVLL SEEDTGSEPS GSLSAKERWS KRARPQQDLA RLVMEKRQGR
1110 1120 1130 1140 1150
LLLRLASGAS SSSSEEQRRA SETLSGTGSE EDTPASEPAA ALPRKSGRAA
1160 1170 1180 1190 1200
ATRSRIPRPI GLRMPMPVAA QQPASRSHGA APALDTAITS RLQLQTPPGS
1210 1220 1230 1240 1250
ATAADLRPKQ PPGRGLGPGR AQAGARPPAP RSPRLPASTS AARNASASPR
1260 1270 1280 1290 1300
SQSLSRRESP SPSHQARPGV PPPRGVPPAR AQPDGTPSPG GSKKGPRGKL
1310 1320
QAQRATTKGR AGGAEGRAGA R
Length:1,321
Mass (Da):142,737
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i844FAA1EB7A45DE2
GO
Isoform 2 (identifier: Q5TCY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.
     592-672: TVRPRGRSMQ...VFSVAPPFEV → FPLTPALGTP...RFPHSAQPLG
     673-1321: Missing.

Note: No experimental confirmation available.
Show »
Length:621
Mass (Da):69,084
Checksum:i4A99A34F76D7DD59
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R456X6R456_HUMAN
Tau-tubulin kinase 1
TTBK1
713Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37L → V in BAE78660 (PubMed:16923168).Curated1
Sequence conflicti402E → G in BAD18405 (PubMed:14702039).Curated1
Sequence conflicti1190S → SS in AAH36764 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041252613P → L1 PublicationCorresponds to variant dbSNP:rs34993661Ensembl.1
Natural variantiVAR_041253623G → A1 PublicationCorresponds to variant dbSNP:rs3800294Ensembl.1
Natural variantiVAR_041254649P → R1 PublicationCorresponds to variant dbSNP:rs35175743Ensembl.1
Natural variantiVAR_041255741D → E1 PublicationCorresponds to variant dbSNP:rs56377340Ensembl.1
Natural variantiVAR_041256744E → D1 PublicationCorresponds to variant dbSNP:rs3800295Ensembl.1
Natural variantiVAR_041257806S → F in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041258855P → S in a metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs267601046Ensembl.1
Natural variantiVAR_0412591145K → R1 PublicationCorresponds to variant dbSNP:rs3800297Ensembl.1
Natural variantiVAR_0412601184L → S1 PublicationCorresponds to variant dbSNP:rs3800298Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0264971 – 51Missing in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_026498592 – 672TVRPR…PPFEV → FPLTPALGTPPSTERVGPHR PTETVGGGQTLGALPPAVQP PATTGVLRVLLLHAGDGALP SPRRRRLLGLLRFPHSAQPL G in isoform 2. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_026499673 – 1321Missing in isoform 2. 1 PublicationAdd BLAST649

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB218664 mRNA Translation: BAE78660.1
AK131217 mRNA Translation: BAD18405.1
AL133375 Genomic DNA No translation available.
AB058758 mRNA Translation: BAB47484.1
BC036764 mRNA Translation: AAH36764.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34455.1 [Q5TCY1-1]

NCBI Reference Sequences

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RefSeqi
NP_115927.1, NM_032538.2 [Q5TCY1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000259750; ENSP00000259750; ENSG00000146216 [Q5TCY1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84630

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84630

UCSC genome browser

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UCSCi
uc003ouq.2 human [Q5TCY1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB218664 mRNA Translation: BAE78660.1
AK131217 mRNA Translation: BAD18405.1
AL133375 Genomic DNA No translation available.
AB058758 mRNA Translation: BAB47484.1
BC036764 mRNA Translation: AAH36764.1
CCDSiCCDS34455.1 [Q5TCY1-1]
RefSeqiNP_115927.1, NM_032538.2 [Q5TCY1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BTJX-ray2.16A/B1-313[»]
4BTKX-ray2.00A1-313[»]
4BTMX-ray2.54A/B1-313[»]
4NFMX-ray2.12A14-343[»]
4NFNX-ray1.42A14-320[»]
SMRiQ5TCY1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124159, 6 interactors
IntActiQ5TCY1, 5 interactors
STRINGi9606.ENSP00000259750

Chemistry databases

BindingDBiQ5TCY1
ChEMBLiCHEMBL1926492

PTM databases

iPTMnetiQ5TCY1
PhosphoSitePlusiQ5TCY1

Polymorphism and mutation databases

BioMutaiTTBK1
DMDMi97203020

Proteomic databases

jPOSTiQ5TCY1
PaxDbiQ5TCY1
PeptideAtlasiQ5TCY1
PRIDEiQ5TCY1
ProteomicsDBi64995 [Q5TCY1-1]
64996 [Q5TCY1-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
84630
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259750; ENSP00000259750; ENSG00000146216 [Q5TCY1-1]
GeneIDi84630
KEGGihsa:84630
UCSCiuc003ouq.2 human [Q5TCY1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84630
DisGeNETi84630

GeneCards: human genes, protein and diseases

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GeneCardsi
TTBK1
HGNCiHGNC:19140 TTBK1
HPAiHPA031735
HPA031736
neXtProtiNX_Q5TCY1
OpenTargetsiENSG00000146216
PharmGKBiPA134866142

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1164 Eukaryota
ENOG410XPGP LUCA
GeneTreeiENSGT00940000160981
HOGENOMiHOG000154701
InParanoidiQ5TCY1
KOiK08815
OMAiNSLPNGP
OrthoDBi75271at2759
PhylomeDBiQ5TCY1
TreeFamiTF351646

Enzyme and pathway databases

SignaLinkiQ5TCY1
SIGNORiQ5TCY1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TTBK1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84630

Protein Ontology

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PROi
PR:Q5TCY1

Gene expression databases

BgeeiENSG00000146216 Expressed in 121 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ5TCY1 baseline and differential
GenevisibleiQ5TCY1 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTBK1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TCY1
Secondary accession number(s): A2A2U5
, Q2L6C6, Q6ZNH0, Q8N444, Q96JH2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: July 31, 2019
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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