TTBK1

Functionⁱ

Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.

1 Publication

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.Curated

Catalytic activityⁱ

ATP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
L-seryl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
=
ADP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O-phospho-L-seryl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation."
  Sato S., Cerny R.L., Buescher J.L., Ikezu T.
  J. Neurochem. 98:1573-1584(2006) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, COFACTOR, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
EC:
2.7.11.1
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation."
  Sato S., Cerny R.L., Buescher J.L., Ikezu T.
  J. Neurochem. 98:1573-1584(2006) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, COFACTOR, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
L-seryl-[protein]
L-serine residue
zoom
=
ADP
+
H⁺
+
O-phospho-L-seryl-[protein]
O-phospho-L-serine residue
zoom
ATP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
L-threonyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
=
ADP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O-phospho-L-threonyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation."
  Sato S., Cerny R.L., Buescher J.L., Ikezu T.
  J. Neurochem. 98:1573-1584(2006) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, COFACTOR, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
EC:
2.7.11.1
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation."
  Sato S., Cerny R.L., Buescher J.L., Ikezu T.
  J. Neurochem. 98:1573-1584(2006) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, COFACTOR, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
L-threonyl-[protein]
L-threonine residue
zoom
=
ADP
+
H⁺
+
O-phospho-L-threonyl-[protein]
O-phospho-L-threonine residue
zoom

Cofactorⁱ

Mg²⁺1 Publication, Mn²⁺1 PublicationNote: Divalent metal cations. Mg²⁺ or, to a lesser extent, Mn²⁺, but not Ca²⁺ or Zn²⁺.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	63	ATPPROSITE-ProRule annotation		1
Active siteⁱ	154	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	40 – 48	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.26, 2681
PathwayCommonsⁱ	Q5TCY1
SignaLinkⁱ	Q5TCY1
SIGNORⁱ	Q5TCY1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tau-tubulin kinase 1 (EC:2.7.11.11 Publication) Alternative name(s): Brain-derived tau kinase
Gene namesⁱ	Name:TTBK1 Synonyms:BDTK, KIAA1855
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19140, TTBK1
neXtProtⁱ	NX_Q5TCY1
VEuPathDBⁱ	HostDB:ENSG00000146216.11

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84630
Open Targets More...OpenTargetsⁱ	ENSG00000146216
PharmGKBⁱ	PA134866142

Miscellaneous databases

Pharosⁱ	Q5TCY1, Tbio

Pharosⁱ

Q5TCY1, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL1926492

ChEMBLⁱ

CHEMBL1926492

Genetic variation databases

BioMutaⁱ	TTBK1
DMDMⁱ	97203020

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000234341	1 – 1321	Tau-tubulin kinase 1Add BLAST		1321

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	441	PhosphoserineBy similarity		1
Modified residueⁱ	540	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

jPOSTⁱ	Q5TCY1
MassIVEⁱ	Q5TCY1
PaxDbⁱ	Q5TCY1
PeptideAtlas More...PeptideAtlasⁱ	Q5TCY1
PRIDEⁱ	Q5TCY1
ProteomicsDBⁱ	64995 [Q5TCY1-1] 64996 [Q5TCY1-2]

PTM databases

iPTMnetⁱ	Q5TCY1
PhosphoSitePlusⁱ	Q5TCY1

Expressionⁱ

Tissue specificityⁱ

Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000146216, Expressed in cerebellum and 130 other tissues
ExpressionAtlasⁱ	Q5TCY1, baseline and differential
Genevisibleⁱ	Q5TCY1, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000146216, Tissue enhanced (brain)

HPAⁱ

ENSG00000146216, Tissue enhanced (brain)

Interactionⁱ

GO - Molecular functionⁱ

tau protein binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- Ref.1
  "Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation."
  Sato S., Cerny R.L., Buescher J.L., Ikezu T.
  J. Neurochem. 98:1573-1584(2006) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, COFACTOR, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	124159, 13 interactors
IntActⁱ	Q5TCY1, 5 interactors
STRINGⁱ	9606.ENSP00000259750

Chemistry databases

BindingDBⁱ

Q5TCY1

Miscellaneous databases

RNActⁱ	Q5TCY1, protein

RNActⁱ

Q5TCY1, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	31 – 33	Combined sources	3
Beta strandⁱ	34 – 42	Combined sources	9
Beta strandⁱ	43 – 45	Combined sources	3
Beta strandⁱ	47 – 53	Combined sources	7
Turnⁱ	54 – 56	Combined sources	3
Beta strandⁱ	58 – 66	Combined sources	9
Helixⁱ	74 – 83	Combined sources	10
Turnⁱ	84 – 86	Combined sources	3
Beta strandⁱ	93 – 98	Combined sources	6
Beta strandⁱ	100 – 108	Combined sources	9
Helixⁱ	114 – 119	Combined sources	6
Helixⁱ	128 – 147	Combined sources	20
Helixⁱ	157 – 159	Combined sources	3
Beta strandⁱ	160 – 162	Combined sources	3
Turnⁱ	166 – 170	Combined sources	5
Beta strandⁱ	172 – 174	Combined sources	3
Beta strandⁱ	188 – 190	Combined sources	3
Helixⁱ	203 – 205	Combined sources	3
Helixⁱ	208 – 211	Combined sources	4
Helixⁱ	218 – 234	Combined sources	17
Turnⁱ	238 – 241	Combined sources	4
Helixⁱ	245 – 254	Combined sources	10
Helixⁱ	257 – 261	Combined sources	5
Beta strandⁱ	262 – 264	Combined sources	3
Helixⁱ	268 – 277	Combined sources	10
Beta strandⁱ	280 – 282	Combined sources	3
Helixⁱ	286 – 299	Combined sources	14
Turnⁱ	309 – 311	Combined sources	3

Show more details

3D structure databases

SMRⁱ	Q5TCY1
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	34 – 297	Protein kinasePROSITE-ProRule annotationAdd BLAST		264

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	363 – 397	DisorderedSequence analysisAdd BLAST	35
Regionⁱ	416 – 677	DisorderedSequence analysisAdd BLAST	262
Regionⁱ	714 – 908	DisorderedSequence analysisAdd BLAST	195
Regionⁱ	997 – 1092	DisorderedSequence analysisAdd BLAST	96
Regionⁱ	1104 – 1321	DisorderedSequence analysisAdd BLAST	218

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	685 – 781	Sequence analysisAdd BLAST		97

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	453 – 480	Basic and acidic residuesSequence analysisAdd BLAST	28
Compositional biasⁱ	483 – 498	Polar residuesSequence analysisAdd BLAST	16
Compositional biasⁱ	532 – 555	Basic and acidic residuesSequence analysisAdd BLAST	24
Compositional biasⁱ	568 – 592	Basic and acidic residuesSequence analysisAdd BLAST	25
Compositional biasⁱ	620 – 634	Polar residuesSequence analysisAdd BLAST	15
Compositional biasⁱ	732 – 774	Acidic residuesSequence analysisAdd BLAST	43
Compositional biasⁱ	786 – 807	Polar residuesSequence analysisAdd BLAST	22
Compositional biasⁱ	812 – 831	Basic and acidic residuesSequence analysisAdd BLAST	20
Compositional biasⁱ	868 – 889	Polar residuesSequence analysisAdd BLAST	22
Compositional biasⁱ	1075 – 1092	Basic and acidic residuesSequence analysisAdd BLAST	18
Compositional biasⁱ	1105 – 1132	Polar residuesSequence analysisAdd BLAST	28
Compositional biasⁱ	1237 – 1262	Polar residuesSequence analysisAdd BLAST	26
Compositional biasⁱ	1265 – 1284	Pro residuesSequence analysisAdd BLAST	20

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG1164, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000160981
HOGENOMⁱ	CLU_003410_0_0_1
InParanoidⁱ	Q5TCY1
OMAⁱ	NSLPNGP
Database of Orthologous Groups More...OrthoDBⁱ	75271at2759
PhylomeDBⁱ	Q5TCY1
TreeFamⁱ	TF351646

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14130, STKc_TTBK1, 1 hit
InterProⁱ	View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR042714, TTBK1_STKc
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069, Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220, S_TKc, 1 hit
SUPFAMⁱ	SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q5TCY1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQCLAAALKD ETNMSGGGEQ ADILPANYVV KDRWKVLKKI GGGGFGEIYE 
        60         70         80         90        100
AMDLLTRENV ALKVESAQQP KQVLKMEVAV LKKLQGKDHV CRFIGCGRNE 
       110        120        130        140        150
KFNYVVMQLQ GRNLADLRRS QPRGTFTLST TLRLGKQILE SIEAIHSVGF 
       160        170        180        190        200
LHRDIKPSNF AMGRLPSTYR KCYMLDFGLA RQYTNTTGDV RPPRNVAGFR 
       210        220        230        240        250
GTVRYASVNA HKNREMGRHD DLWSLFYMLV EFAVGQLPWR KIKDKEQVGM 
       260        270        280        290        300
IKEKYEHRML LKHMPSEFHL FLDHIASLDY FTKPDYQLIM SVFENSMKER 
       310        320        330        340        350
GIAENEAFDW EKAGTDALLS TSTSTPPQQN TRQTAAMFGV VNVTPVPGDL 
       360        370        380        390        400
LRENTEDVLQ GEHLSDQENA PPILPGRPSE GLGPSPHLVP HPGGPEAEVW 
       410        420        430        440        450
EETDVNRNKL RINIGKSPCV EEEQSRGMGV PSSPVRAPPD SPTTPVRSLR 
       460        470        480        490        500
YRRVNSPESE RLSTADGRVE LPERRSRMDL PGSPSRQACS SQPAQMLSVD 
       510        520        530        540        550
TGHADRQASG RMDVSASVEQ EALSNAFRSV PLAEEEDFDS KEWVIIDKET 
       560        570        580        590        600
ELKDFPPGAE PSTSGTTDEE PEELRPLPEE GEERRRLGAE PTVRPRGRSM 
       610        620        630        640        650
QALAEEDLQH LPPQPLPPQL SQGDGRSETS QPPTPGSPSH SPLHSGPRPR 
       660        670        680        690        700
RRESDPTGPQ RQVFSVAPPF EVNGLPRAVP LSLPYQDFKR DLSDYRERAR 
       710        720        730        740        750
LLNRVRRVGF SHMLLTTPQV PLAPVQPQAN GKEEEEEEEE DEEEEEEDEE 
       760        770        780        790        800
EEEEEEEEEE EEEEEEEEEE EAAAAVALGE VLGPRSGSSS EGSERSTDRS 
       810        820        830        840        850
QEGAPSTLLA DDQKESRGRA SMADGDLEPE EGSKTLVLVS PGDMKKSPVT 
       860        870        880        890        900
AELAPDPDLG TLAALTPQHE RPQPTGSQLD VSEPGTLSSV LKSEPKPPGP 
       910        920        930        940        950
GAGLGAGTVT TGVGGVAVTS SPFTKVERTF VHIAEKTHLN VMSSGGQALR 
       960        970        980        990       1000
SEEFSAGGEL GLELASDGGA VEEGARAPLE NGLALSGLNG AEIEGSALSG 
      1010       1020       1030       1040       1050
APRETPSEMA TNSLPNGPAL ADGPAPVSPL EPSPEKVATI SPRRHAMPGS 
      1060       1070       1080       1090       1100
RPRSRIPVLL SEEDTGSEPS GSLSAKERWS KRARPQQDLA RLVMEKRQGR 
      1110       1120       1130       1140       1150
LLLRLASGAS SSSSEEQRRA SETLSGTGSE EDTPASEPAA ALPRKSGRAA 
      1160       1170       1180       1190       1200
ATRSRIPRPI GLRMPMPVAA QQPASRSHGA APALDTAITS RLQLQTPPGS 
      1210       1220       1230       1240       1250
ATAADLRPKQ PPGRGLGPGR AQAGARPPAP RSPRLPASTS AARNASASPR 
      1260       1270       1280       1290       1300
SQSLSRRESP SPSHQARPGV PPPRGVPPAR AQPDGTPSPG GSKKGPRGKL 
      1310       1320 
QAQRATTKGR AGGAEGRAGA R

Length:1,321

Mass (Da):142,737

Last modified:May 16, 2006 - v2

Checksum:ⁱ844FAA1EB7A45DE2

GO

Isoform 2 (identifier: Q5TCY1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.
     592-672: TVRPRGRSMQ...VFSVAPPFEV → FPLTPALGTP...RFPHSAQPLG
     673-1321: Missing.

« Hide

        10         20         30         40         50
MDLLTRENVA LKVESAQQPK QVLKMEVAVL KKLQGKDHVC RFIGCGRNEK 
        60         70         80         90        100
FNYVVMQLQG RNLADLRRSQ PRGTFTLSTT LRLGKQILES IEAIHSVGFL 
       110        120        130        140        150
HRDIKPSNFA MGRLPSTYRK CYMLDFGLAR QYTNTTGDVR PPRNVAGFRG 
       160        170        180        190        200
TVRYASVNAH KNREMGRHDD LWSLFYMLVE FAVGQLPWRK IKDKEQVGMI 
       210        220        230        240        250
KEKYEHRMLL KHMPSEFHLF LDHIASLDYF TKPDYQLIMS VFENSMKERG 
       260        270        280        290        300
IAENEAFDWE KAGTDALLST STSTPPQQNT RQTAAMFGVV NVTPVPGDLL 
       310        320        330        340        350
RENTEDVLQG EHLSDQENAP PILPGRPSEG LGPSPHLVPH PGGPEAEVWE 
       360        370        380        390        400
ETDVNRNKLR INIGKSPCVE EEQSRGMGVP SSPVRAPPDS PTTPVRSLRY 
       410        420        430        440        450
RRVNSPESER LSTADGRVEL PERRSRMDLP GSPSRQACSS QPAQMLSVDT 
       460        470        480        490        500
GHADRQASGR MDVSASVEQE ALSNAFRSVP LAEEEDFDSK EWVIIDKETE 
       510        520        530        540        550
LKDFPPGAEP STSGTTDEEP EELRPLPEEG EERRRLGAEP FPLTPALGTP 
       560        570        580        590        600
PSTERVGPHR PTETVGGGQT LGALPPAVQP PATTGVLRVL LLHAGDGALP 
       610        620 
SPRRRRLLGL LRFPHSAQPL G

Show »

Length:621

Mass (Da):69,084

Checksum:ⁱ4A99A34F76D7DD59

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	X6R456	X6R456_HUMAN		Tau-tubulin kinase 1 Tau-tubulin kinase 1	TTBK1	713	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	37	L → V in BAE78660 (PubMed:16923168).Curated	1
Sequence conflictⁱ	402	E → G in BAD18405 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1190	S → SS in AAH36764 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041252	613	P → L1 PublicationCorresponds to variant dbSNP:rs34993661EnsemblClinVar.	1
Natural variantⁱVAR_041253	623	G → A1 PublicationCorresponds to variant dbSNP:rs3800294Ensembl.	1
Natural variantⁱVAR_041254	649	P → R1 PublicationCorresponds to variant dbSNP:rs35175743Ensembl.	1
Natural variantⁱVAR_041255	741	D → E1 PublicationCorresponds to variant dbSNP:rs56377340Ensembl.	1
Natural variantⁱVAR_041256	744	E → D1 PublicationCorresponds to variant dbSNP:rs3800295Ensembl.	1
Natural variantⁱVAR_041257	806	S → F in a lung large cell carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041258	855	P → S in a metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs267601046Ensembl.	1
Natural variantⁱVAR_041259	1145	K → R1 PublicationCorresponds to variant dbSNP:rs3800297Ensembl.	1
Natural variantⁱVAR_041260	1184	L → S1 PublicationCorresponds to variant dbSNP:rs3800298Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_026497	1 – 51	Missing in isoform 2. 1 PublicationAdd BLAST	51
Alternative sequenceⁱVSP_026498	592 – 672	TVRPR…PPFEV → FPLTPALGTPPSTERVGPHR PTETVGGGQTLGALPPAVQP PATTGVLRVLLLHAGDGALP SPRRRRLLGLLRFPHSAQPL G in isoform 2. 1 PublicationAdd BLAST	81
Alternative sequenceⁱVSP_026499	673 – 1321	Missing in isoform 2. 1 PublicationAdd BLAST	649

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB218664 mRNA Translation: BAE78660.1 AK131217 mRNA Translation: BAD18405.1 AL133375 Genomic DNA No translation available. AB058758 mRNA Translation: BAB47484.1 BC036764 mRNA Translation: AAH36764.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34455.1 [Q5TCY1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_115927.1, NM_032538.2 [Q5TCY1-1]

Genome annotation databases

Ensemblⁱ	ENST00000259750; ENSP00000259750; ENSG00000146216 [Q5TCY1-1]
GeneIDⁱ	84630
KEGGⁱ	hsa:84630
UCSC genome browser More...UCSCⁱ	uc003ouq.2, human [Q5TCY1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5TCY1	Tau tubulin kinase 1		MACMU		1433	UniRef90_Q5TCY1
Tau tubulin kinase 1		MACNE		1324
Tau tubulin kinase 1		CERAT		1324
Tau tubulin kinase 1		MANLE		1324
Tau tubulin kinase 1		SAIBB		1322
+23

Protein	Similar proteins		Species	Score	Length	Source
Q5TCY1	Tau-tubulin kinase 1		MOUSE		1308	UniRef50_Q5TCY1
Tau tubulin kinase 1		MACMU		1433
Tau tubulin kinase 1		CERAT		1324
Tau tubulin kinase 1		MACNE		1324
Tau tubulin kinase 1		MANLE		1324
+787
Q5TCY1-2	Tau tubulin kinase 1		RABIT		634	UniRef50_Q5TCY1-2

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB218664 mRNA Translation: BAE78660.1 AK131217 mRNA Translation: BAD18405.1 AL133375 Genomic DNA No translation available. AB058758 mRNA Translation: BAB47484.1 BC036764 mRNA Translation: AAH36764.1
CCDSⁱ	CCDS34455.1 [Q5TCY1-1]
RefSeqⁱ	NP_115927.1, NM_032538.2 [Q5TCY1-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4BTJ	X-ray	2.16	A/B	1-313	[»]
	4BTK	X-ray	2.00	A	1-313	[»]
	4BTM	X-ray	2.54	A/B	1-313	[»]
	4NFM	X-ray	2.12	A	14-343	[»]
	4NFN	X-ray	1.42	A	14-320	[»]
SMRⁱ	Q5TCY1
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	124159, 13 interactors
IntActⁱ	Q5TCY1, 5 interactors
STRINGⁱ	9606.ENSP00000259750

Chemistry databases

BindingDBⁱ	Q5TCY1
ChEMBLⁱ	CHEMBL1926492

PTM databases

iPTMnetⁱ	Q5TCY1
PhosphoSitePlusⁱ	Q5TCY1

Genetic variation databases

BioMutaⁱ	TTBK1
DMDMⁱ	97203020

Proteomic databases

jPOSTⁱ	Q5TCY1
MassIVEⁱ	Q5TCY1
PaxDbⁱ	Q5TCY1
PeptideAtlasⁱ	Q5TCY1
PRIDEⁱ	Q5TCY1
ProteomicsDBⁱ	64995 [Q5TCY1-1] 64996 [Q5TCY1-2]

Protocols and materials databases

Antibodypediaⁱ	30359, 192 antibodies
The DNASU plasmid repository More...DNASUⁱ	84630

Genome annotation databases

Ensemblⁱ	ENST00000259750; ENSP00000259750; ENSG00000146216 [Q5TCY1-1]
GeneIDⁱ	84630
KEGGⁱ	hsa:84630
UCSCⁱ	uc003ouq.2, human [Q5TCY1-1]

Organism-specific databases

CTDⁱ	84630
DisGeNETⁱ	84630
GeneCardsⁱ	TTBK1
HGNCⁱ	HGNC:19140, TTBK1
HPAⁱ	ENSG00000146216, Tissue enhanced (brain)
neXtProtⁱ	NX_Q5TCY1
OpenTargetsⁱ	ENSG00000146216
PharmGKBⁱ	PA134866142
VEuPathDBⁱ	HostDB:ENSG00000146216.11
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1164, Eukaryota
GeneTreeⁱ	ENSGT00940000160981
HOGENOMⁱ	CLU_003410_0_0_1
InParanoidⁱ	Q5TCY1
OMAⁱ	NSLPNGP
OrthoDBⁱ	75271at2759
PhylomeDBⁱ	Q5TCY1
TreeFamⁱ	TF351646

Enzyme and pathway databases

BRENDAⁱ	2.7.11.26, 2681
PathwayCommonsⁱ	Q5TCY1
SignaLinkⁱ	Q5TCY1
SIGNORⁱ	Q5TCY1

Miscellaneous databases

BioGRID-ORCSⁱ	84630, 9 hits in 1015 CRISPR screens
ChiTaRSⁱ	TTBK1, human
GenomeRNAiⁱ	84630
Pharosⁱ	Q5TCY1, Tbio
Protein Ontology More...PROⁱ	PR:Q5TCY1
RNActⁱ	Q5TCY1, protein

Gene expression databases

Bgeeⁱ	ENSG00000146216, Expressed in cerebellum and 130 other tissues
ExpressionAtlasⁱ	Q5TCY1, baseline and differential
Genevisibleⁱ	Q5TCY1, HS

Family and domain databases

CDDⁱ	cd14130, STKc_TTBK1, 1 hit
InterProⁱ	View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR042714, TTBK1_STKc
Pfamⁱ	View protein in Pfam PF00069, Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220, S_TKc, 1 hit
SUPFAMⁱ	SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TTBK1_HUMAN
Accessionⁱ	Q5TCY1Primary (citable) accession number: Q5TCY1 Secondary accession number(s): A2A2U5 , Q2L6C6, Q6ZNH0, Q8N444, Q96JH2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
	Last sequence update:	May 16, 2006
	Last modified:	June 2, 2021
	This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human and mouse protein kinases
Human and mouse protein kinases: classification and index
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5TCY1 (TTBK1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Tau-tubulin kinase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoplasm and Cytosol

Cytoskeleton

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Your basket is currently empty. ⁱ

Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ