UniProtKB - Q5TCX1 (Q5TCX1_HUMAN)
Protein
Submitted name:
Triggering receptor expressed on myeloid cells 2
Gene
TREM2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Triggering receptor expressed on myeloid cells 2ImportedSubmitted name: cDNA, FLJ92504, Homo sapiens triggering receptor expressed on myeloid cells 2(TREM2), mRNAImported |
Gene namesi | Name:TREM2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000095970.16 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 175 – 197 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_5014309966 | 19 – 230 | Sequence analysisAdd BLAST | 212 |
Expressioni
Gene expression databases
Bgeei | ENSG00000095970, Expressed in substantia nigra and 155 other tissues |
ExpressionAtlasi | Q5TCX1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 128 | IGvInterPro annotationAdd BLAST | 105 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_076120_0_0_1 |
OMAi | AWHGQKQ |
OrthoDBi | 1385259at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5TCX1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPLRLLILL FVTELSGAHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW
60 70 80 90 100
CRQLGEKGPC QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL
110 120 130 140 150
QPHDAGLYQC QSLHGSEADT LRKVLVEVLA DPLDHRDAGD LWFPGESESF
160 170 180 190 200
EDAHVEHSIS RSLLEGEIPF PPTSILLLLA CIFLIKILAA SALWAAAWHG
210 220 230
QKPGTHPPSE LDCGHDPGYQ LQTLPGLRDT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ217932 Genomic DNA Translation: ABB01002.1 AK312215 mRNA Translation: BAG35148.1 |
RefSeqi | NP_061838.1, NM_018965.3 |
Genome annotation databases
GeneIDi | 54209 |
KEGGi | hsa:54209 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ217932 Genomic DNA Translation: ABB01002.1 AK312215 mRNA Translation: BAG35148.1 |
RefSeqi | NP_061838.1, NM_018965.3 |
3D structure databases
SMRi | Q5TCX1 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 2280, 559 antibodies |
DNASUi | 54209 |
Genome annotation databases
GeneIDi | 54209 |
KEGGi | hsa:54209 |
Organism-specific databases
CTDi | 54209 |
PharmGKBi | PA38468 |
VEuPathDBi | HostDB:ENSG00000095970.16 |
Phylogenomic databases
HOGENOMi | CLU_076120_0_0_1 |
OMAi | AWHGQKQ |
OrthoDBi | 1385259at2759 |
Miscellaneous databases
BioGRID-ORCSi | 54209, 4 hits in 867 CRISPR screens |
ChiTaRSi | TREM2, human |
GenomeRNAii | 54209 |
Gene expression databases
Bgeei | ENSG00000095970, Expressed in substantia nigra and 155 other tissues |
ExpressionAtlasi | Q5TCX1, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5TCX1_HUMAN | |
Accessioni | Q5TCX1Primary (citable) accession number: Q5TCX1 Secondary accession number(s): A6NDG2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 10, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |