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Protein

Adenylate kinase 9

Gene

AK9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP.1 Publication

Catalytic activityi

ATP + nucleoside phosphate = ADP + nucleoside diphosphate.1 Publication
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.1 Publication

Kineticsi

  1. KM=48 µM for AMP (with ATP as phosphate donor)1 Publication
  2. KM=3600 µM for dAMP (with ATP as phosphate donor)1 Publication
  3. KM=940 µM for CMP (with ATP as phosphate donor)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei229AMP 1By similarity1
    Binding sitei1447AMP 3By similarity1
    Binding sitei1506AMP 3By similarity1
    Binding sitei1543AMP 3By similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi40 – 45ATP 1By similarity6
    Nucleotide bindingi87 – 89AMP 1By similarity3
    Nucleotide bindingi116 – 119AMP 1By similarity4
    Nucleotide bindingi1001 – 1006ATP 2By similarity6
    Nucleotide bindingi1050 – 1052AMP 2By similarity3
    Nucleotide bindingi1079 – 1082AMP 2By similarity4
    Nucleotide bindingi1421 – 1426ATP 3By similarity6
    Nucleotide bindingi1470 – 1472AMP 3By similarity3
    Nucleotide bindingi1499 – 1502AMP 3By similarity4

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionKinase, Transferase
    Biological processNucleotide metabolism
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate kinase 9 (EC:2.7.4.4, EC:2.7.4.6)
    Short name:
    AK 9
    Alternative name(s):
    Adenylate kinase domain-containing protein 1
    Adenylate kinase domain-containing protein 2
    Gene namesi
    Name:AK9
    Synonyms:AKD1, AKD2, C6orf199, C6orf224
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 6

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000155085.15
    HGNCiHGNC:33814 AK9
    MIMi615358 gene
    neXtProtiNX_Q5TCS8

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi221264
    MalaCardsiAK9
    OpenTargetsiENSG00000155085
    PharmGKBiPA162380441
    PA164715271

    Polymorphism and mutation databases

    BioMutaiAK9
    DMDMi302393675

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003041381 – 1911Adenylate kinase 9Add BLAST1911

    Proteomic databases

    EPDiQ5TCS8
    PaxDbiQ5TCS8
    PeptideAtlasiQ5TCS8
    PRIDEiQ5TCS8
    ProteomicsDBi64979
    64980 [Q5TCS8-1]
    64981 [Q5TCS8-2]
    64982 [Q5TCS8-3]
    64983 [Q5TCS8-5]
    64984 [Q5TCS8-6]

    PTM databases

    iPTMnetiQ5TCS8
    PhosphoSitePlusiQ5TCS8

    Expressioni

    Gene expression databases

    BgeeiENSG00000155085 Expressed in 165 organ(s), highest expression level in testis
    CleanExiHS_C6orf199
    ExpressionAtlasiQ5TCS8 baseline and differential
    GenevisibleiQ5TCS8 HS

    Organism-specific databases

    HPAiHPA030804
    HPA030805
    HPA031779
    HPA031781
    HPA036324
    HPA036711

    Interactioni

    Protein-protein interaction databases

    BioGridi128702, 12 interactors
    IntActiQ5TCS8, 2 interactors
    STRINGi9606.ENSP00000410186

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TCS8
    SMRiQ5TCS8
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni31 – 285Adenylate kinase 1CuratedAdd BLAST255
    Regioni60 – 89NMPbind 1By similarityAdd BLAST30
    Regioni160 – 205LID 1By similarityAdd BLAST46
    Regioni992 – 1203Adenylate kinase 2CuratedAdd BLAST212
    Regioni1021 – 1052NMPbind 2By similarityAdd BLAST32
    Regioni1124 – 1144LID 2By similarityAdd BLAST21
    Regioni1412 – 1601Adenylate kinase 3CuratedAdd BLAST190
    Regioni1441 – 1472NMPbind 3By similarityAdd BLAST32
    Regioni1536 – 1550LID 3By similarityAdd BLAST15

    Coiled coil

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Coiled coili443 – 485Sequence analysisAdd BLAST43
    Coiled coili676 – 711Sequence analysisAdd BLAST36

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Compositional biasi198 – 275Glu-richAdd BLAST78

    Sequence similaritiesi

    Belongs to the adenylate kinase family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiKOG3078 Eukaryota
    KOG3079 Eukaryota
    COG0563 LUCA
    GeneTreeiENSGT00740000115564
    HOVERGENiHBG107661
    InParanoidiQ5TCS8
    KOiK18533
    OMAiYPVIHRQ
    OrthoDBiEOG091G00KI
    PhylomeDBiQ5TCS8
    TreeFamiTF330805

    Family and domain databases

    CDDicd01428 ADK, 3 hits
    InterProiView protein in InterPro
    IPR003593 AAA+_ATPase
    IPR000850 Adenylat/UMP-CMP_kin
    IPR027417 P-loop_NTPase
    PANTHERiPTHR23359 PTHR23359, 3 hits
    SMARTiView protein in SMART
    SM00382 AAA, 3 hits
    SUPFAMiSSF52540 SSF52540, 11 hits

    Sequences (6+)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 4 (identifier: Q5TCS8-4) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MTSQEKTEEY PFADIFDEDE TERNFLLSKP VCFVVFGKPG VGKTTLARYI
    60 70 80 90 100
    TQAWKCIRVE ALPILEEQIA AETESGVMLQ SMLISGQSIP DELVIKLMLE
    110 120 130 140 150
    KLNSPEVCHF GYIITEIPSL SQDAMTTLQQ IELIKNLNLK PDVIINIKCP
    160 170 180 190 200
    DYDLCQRISG QRQHNNTGYI YSRDQWDPEV IENHRKKKKE AQKDGKGEEE
    210 220 230 240 250
    EEEEEQEEEE AFIAEMQMVA EILHHLVQRP EDYLENVENI VKLYKETILQ
    260 270 280 290 300
    TLEEVMAEHN PQYLIELNGN KPAEELFMIV MDRLKYLNLK RAAILTKLQG
    310 320 330 340 350
    AEEEINDTME NDELFRTLAS YKLIAPRYRW QRSKWGRTCP VNLKDGNIYS
    360 370 380 390 400
    GLPDYSVSFL GKIYCLSSEE ALKPFLLNPR PYLLPPMPGP PCKVFILGPQ
    410 420 430 440 450
    YSGKTTLCNM LAENYKGKVV DYAQLVQPRF DKARETLVEN TIAEATAAAI
    460 470 480 490 500
    KVVKEKLLRE LQARKQAETA LREFQRQYEK MEFGVFPMEA THSSIDEEGY
    510 520 530 540 550
    IQGSQRDRGS SLVDTEEAKT KSENVLHDQA AKVDKDDGKE TGETFTFKRH
    560 570 580 590 600
    SQDASQDVKL YSDTAPTEDL IEEVTADHPE VVTMIEETIK MSQDINFEQP
    610 620 630 640 650
    YEKHAEILQE VLGEVMEENK DRFPGAPKYG GWIVDNCPIV KELWMALIKK
    660 670 680 690 700
    GIIPDLVIYL SDTENNGKCL FNRIYLQKKS EIDSKILERL LEELQKKKKE
    710 720 730 740 750
    EEEARKATEE ELRLEEENRR LLELMKVKAK EAEETDNEDE EEIEGDELEV
    760 770 780 790 800
    HEEPEASHDT RGSWLPEEFE ASEVPETEPE AVSEPIEETT VETEIPKGSK
    810 820 830 840 850
    EGLEIEKLSE TVVLPEFPED SYPDVPEMEP FKEKIGSFII LWKQLEATIS
    860 870 880 890 900
    EAYIKILNLE IADRTPQELL QKVVETMEKP FQYTAWELTG EDYEEETEDY
    910 920 930 940 950
    QTEAEVDEEL EEEEEEEGED KMKERKRHLG DTKHFCPVVL KENFILQPGN
    960 970 980 990 1000
    TEEAAKYREK IYYFSSAEAK EKFLEHPEDY VAHEEPLKAP PLRICLVGPQ
    1010 1020 1030 1040 1050
    GSGKTMCGRQ LAEKLNIFHI QFEEVLQEKL LLKTEKKVGP EFEEDSENEQ
    1060 1070 1080 1090 1100
    AAKQELEELA IQANVKVEEE NTKKQLPEVQ LTEEEEVIKS SLMENEPLPP
    1110 1120 1130 1140 1150
    EILEVILSEW WLKEPIRSTG FILDGFPRYP EEAQFLGDRG FFPDAAVFIQ
    1160 1170 1180 1190 1200
    VDDQDIFDRL LPAQIEKWKL KQKKKLERKK LIKDMKAKIR VDTIAKRRAE
    1210 1220 1230 1240 1250
    LILERDKKRR ENVVRDDEEI SEEELEEDND DIENILEDEF PKDEEEMSGE
    1260 1270 1280 1290 1300
    EDEEQETDAI ERLRGELGEK FEADTHNLQI IQDELERYLI PIISINGARR
    1310 1320 1330 1340 1350
    NHIVQYTLNM KLKPLVENRA SIFEKCHPIP APLAQKMLTF TYKYISSFGY
    1360 1370 1380 1390 1400
    WDPVKLSEGE TIKPVENAEN PIYPVIHRQY IYFLSSKETK EKFMKNPIKY
    1410 1420 1430 1440 1450
    IRQPKPKPTV PIRIIIVGPP KSGKTTVAKK ITSEYGLKHL SIGGALRYVL
    1460 1470 1480 1490 1500
    NNHPETELAL MLNWHLHKGM TAPDELAIQA LELSLMESVC NTAGVVIDGY
    1510 1520 1530 1540 1550
    PVTKHQMNLL EARSIIPMVI FELSVPSKEI FKRLLLEKEN EQRLPYPLHN
    1560 1570 1580 1590 1600
    SAQIVAVNNV KYRKNIGEIR QYYQEQHQNW YVIDGFHSKW WVWNEVIKNV
    1610 1620 1630 1640 1650
    QMVNKYMQTY LERIKAGKAA CIDKLCITPQ ELLSRLGEFE QFCPVSLAES
    1660 1670 1680 1690 1700
    QELFDCSATD SLEFAAEFRG HYYKMSSQEK LNKFLENPEL YVPPLAPHPL
    1710 1720 1730 1740 1750
    PSADMIPKRL TLSELKSRFP KCAELQGYCP VTYKDGNQRY EALVPGSINY
    1760 1770 1780 1790 1800
    ALEYHNRIYI CENKEKLQKF LRSPLKYWEQ KLPHKLPPLR EPILLTSLPL
    1810 1820 1830 1840 1850
    PGYLEQGIAT SLIKAMNAAG CLKPKFPFLS IRRSALLYIA LHLKAFNPKG
    1860 1870 1880 1890 1900
    SEYTRKKYKK KMEQFMESCE LITYLGAKMT RKYKEPQFRA IDFDHKLKTF
    1910
    LSLRNIDPIN G
    Length:1,911
    Mass (Da):221,413
    Last modified:August 10, 2010 - v2
    Checksum:i16A1888E727C51A4
    GO
    Isoform 1 (identifier: Q5TCS8-1) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         703-751: EARKATEEEL...EIEGDELEVH → KSHRRGIETR...CYCKQLQYFK
         752-1911: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:751
    Mass (Da):86,644
    Checksum:i5154893EA585590F
    GO
    Isoform 2 (identifier: Q5TCS8-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         420-421: VD → TN
         422-1911: Missing.

    Show »
    Length:421
    Mass (Da):48,501
    Checksum:i18B996C20324D892
    GO
    Isoform 3 (identifier: Q5TCS8-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         989-1014: APPLRICLVGPQGSGKTMCGRQLAEK → VRQYSYLNDCSHRIFLGLITNHHQFT
         1015-1911: Missing.

    Show »
    Length:1,014
    Mass (Da):117,361
    Checksum:iA8A3319DC3635FA1
    GO
    Isoform 5 (identifier: Q5TCS8-5) [UniParc] [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-921: Missing.
         1212-1257: NVVRDDEEIS...SGEEDEEQET → VSSFVFFFKT...GSSHLSLSKC
         1258-1911: Missing.

    Show »
    Length:336
    Mass (Da):39,019
    Checksum:i5FB4ED6C265E1CFE
    GO
    Isoform 6 (identifier: Q5TCS8-6) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1212-1283: NVVRDDEEIS...DTHNLQIIQD → PNKEKRKRGI...LSKQNIHNQK
         1284-1911: Missing.

    Show »
    Length:1,283
    Mass (Da):148,193
    Checksum:i7A51010EC1323CE3
    GO

    Computationally mapped potential isoform sequencesi

    There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    J3KP89J3KP89_HUMAN
    Adenylate kinase 9
    AK9
    736Annotation score:
    E9PPU7E9PPU7_HUMAN
    Adenylate kinase 9
    AK9
    259Annotation score:
    H7C517H7C517_HUMAN
    Adenylate kinase 9
    AK9
    749Annotation score:
    E9PPM3E9PPM3_HUMAN
    Adenylate kinase 9
    AK9
    227Annotation score:
    A0A075B7F5A0A075B7F5_HUMAN
    Adenylate kinase 9
    AK9
    137Annotation score:
    H0YCD1H0YCD1_HUMAN
    Adenylate kinase 9
    AK9
    192Annotation score:
    H7C505H7C505_HUMAN
    Adenylate kinase 9
    AK9
    218Annotation score:
    H0Y8C5H0Y8C5_HUMAN
    Adenylate kinase 9
    AK9
    312Annotation score:

    Sequence cautioni

    The sequence AAI01715 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence AAI11949 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence BAC05368 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti222I → T in BAB70945 (PubMed:14702039).Curated1
    Sequence conflicti1716K → R in BAC05368 (PubMed:14702039).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0396381 – 921Missing in isoform 5. 1 PublicationAdd BLAST921
    Alternative sequenceiVSP_028008420 – 421VD → TN in isoform 2. 2 Publications2
    Alternative sequenceiVSP_028009422 – 1911Missing in isoform 2. 2 PublicationsAdd BLAST1490
    Alternative sequenceiVSP_039639703 – 751EARKA…ELEVH → KSHRRGIETRRRKSKATGTY ESEGKRQAQIAMTDDVSWYC YCKQLQYFK in isoform 1. CuratedAdd BLAST49
    Alternative sequenceiVSP_039640752 – 1911Missing in isoform 1. CuratedAdd BLAST1160
    Alternative sequenceiVSP_028010989 – 1014APPLR…QLAEK → VRQYSYLNDCSHRIFLGLIT NHHQFT in isoform 3. 1 PublicationAdd BLAST26
    Alternative sequenceiVSP_0280111015 – 1911Missing in isoform 3. 1 PublicationAdd BLAST897
    Alternative sequenceiVSP_0396411212 – 1283NVVRD…QIIQD → PNKEKRKRGISENTTCYKCN HMSPWCEYAGLPYRGLLILY SATATATAGTKHCRSGAKVI VALSKQNIHNQK in isoform 6. 1 PublicationAdd BLAST72
    Alternative sequenceiVSP_0396421212 – 1257NVVRD…EEQET → VSSFVFFFKTGSHSVAQGRV QWHNHSSLQPRTPGLKGSSH LSLSKC in isoform 5. 1 PublicationAdd BLAST46
    Alternative sequenceiVSP_0396431258 – 1911Missing in isoform 5. 1 PublicationAdd BLAST654
    Alternative sequenceiVSP_0396441284 – 1911Missing in isoform 6. 1 PublicationAdd BLAST628

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK055538 mRNA Translation: BAB70945.1
    AK098657 mRNA Translation: BAC05368.1 Different initiation.
    AK124171 mRNA No translation available.
    AK131244 mRNA Translation: BAD18424.1
    AK315561 mRNA Translation: BAG37937.1
    AL121788 Genomic DNA No translation available.
    AL133472 Genomic DNA No translation available.
    AL109947 Genomic DNA No translation available.
    AL139391 Genomic DNA No translation available.
    CH471051 Genomic DNA Translation: EAW48333.1
    BC022031 mRNA Translation: AAH22031.1
    BC087860 mRNA Translation: AAH87860.1
    BC101714 mRNA Translation: AAI01715.1 Different initiation.
    BC111948 mRNA Translation: AAI11949.1 Different initiation.
    CCDSiCCDS5077.1 [Q5TCS8-2]
    CCDS55048.1 [Q5TCS8-4]
    RefSeqiNP_001138600.2, NM_001145128.2 [Q5TCS8-4]
    NP_001316531.1, NM_001329602.1 [Q5TCS8-2]
    NP_659462.1, NM_145025.4 [Q5TCS8-2]
    UniGeneiHs.205144

    Genome annotation databases

    EnsembliENST00000285397; ENSP00000285397; ENSG00000155085 [Q5TCS8-2]
    ENST00000355283; ENSP00000347431; ENSG00000155085 [Q5TCS8-5]
    ENST00000424296; ENSP00000410186; ENSG00000155085 [Q5TCS8-4]
    GeneIDi221264
    KEGGihsa:221264
    UCSCiuc003ptn.2 human [Q5TCS8-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK055538 mRNA Translation: BAB70945.1
    AK098657 mRNA Translation: BAC05368.1 Different initiation.
    AK124171 mRNA No translation available.
    AK131244 mRNA Translation: BAD18424.1
    AK315561 mRNA Translation: BAG37937.1
    AL121788 Genomic DNA No translation available.
    AL133472 Genomic DNA No translation available.
    AL109947 Genomic DNA No translation available.
    AL139391 Genomic DNA No translation available.
    CH471051 Genomic DNA Translation: EAW48333.1
    BC022031 mRNA Translation: AAH22031.1
    BC087860 mRNA Translation: AAH87860.1
    BC101714 mRNA Translation: AAI01715.1 Different initiation.
    BC111948 mRNA Translation: AAI11949.1 Different initiation.
    CCDSiCCDS5077.1 [Q5TCS8-2]
    CCDS55048.1 [Q5TCS8-4]
    RefSeqiNP_001138600.2, NM_001145128.2 [Q5TCS8-4]
    NP_001316531.1, NM_001329602.1 [Q5TCS8-2]
    NP_659462.1, NM_145025.4 [Q5TCS8-2]
    UniGeneiHs.205144

    3D structure databases

    ProteinModelPortaliQ5TCS8
    SMRiQ5TCS8
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi128702, 12 interactors
    IntActiQ5TCS8, 2 interactors
    STRINGi9606.ENSP00000410186

    PTM databases

    iPTMnetiQ5TCS8
    PhosphoSitePlusiQ5TCS8

    Polymorphism and mutation databases

    BioMutaiAK9
    DMDMi302393675

    Proteomic databases

    EPDiQ5TCS8
    PaxDbiQ5TCS8
    PeptideAtlasiQ5TCS8
    PRIDEiQ5TCS8
    ProteomicsDBi64979
    64980 [Q5TCS8-1]
    64981 [Q5TCS8-2]
    64982 [Q5TCS8-3]
    64983 [Q5TCS8-5]
    64984 [Q5TCS8-6]

    Protocols and materials databases

    DNASUi221264
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000285397; ENSP00000285397; ENSG00000155085 [Q5TCS8-2]
    ENST00000355283; ENSP00000347431; ENSG00000155085 [Q5TCS8-5]
    ENST00000424296; ENSP00000410186; ENSG00000155085 [Q5TCS8-4]
    GeneIDi221264
    KEGGihsa:221264
    UCSCiuc003ptn.2 human [Q5TCS8-4]

    Organism-specific databases

    CTDi221264
    DisGeNETi221264
    EuPathDBiHostDB:ENSG00000155085.15
    GeneCardsiAK9
    H-InvDBiHIX0025110
    HIX0207381
    HGNCiHGNC:33814 AK9
    HPAiHPA030804
    HPA030805
    HPA031779
    HPA031781
    HPA036324
    HPA036711
    MalaCardsiAK9
    MIMi615358 gene
    neXtProtiNX_Q5TCS8
    OpenTargetsiENSG00000155085
    PharmGKBiPA162380441
    PA164715271
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG3078 Eukaryota
    KOG3079 Eukaryota
    COG0563 LUCA
    GeneTreeiENSGT00740000115564
    HOVERGENiHBG107661
    InParanoidiQ5TCS8
    KOiK18533
    OMAiYPVIHRQ
    OrthoDBiEOG091G00KI
    PhylomeDBiQ5TCS8
    TreeFamiTF330805

    Enzyme and pathway databases

    ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates

    Miscellaneous databases

    GenomeRNAii221264
    PROiPR:Q5TCS8
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000155085 Expressed in 165 organ(s), highest expression level in testis
    CleanExiHS_C6orf199
    ExpressionAtlasiQ5TCS8 baseline and differential
    GenevisibleiQ5TCS8 HS

    Family and domain databases

    CDDicd01428 ADK, 3 hits
    InterProiView protein in InterPro
    IPR003593 AAA+_ATPase
    IPR000850 Adenylat/UMP-CMP_kin
    IPR027417 P-loop_NTPase
    PANTHERiPTHR23359 PTHR23359, 3 hits
    SMARTiView protein in SMART
    SM00382 AAA, 3 hits
    SUPFAMiSSF52540 SSF52540, 11 hits
    ProtoNetiSearch...

    Entry informationi

    Entry nameiKAD9_HUMAN
    AccessioniPrimary (citable) accession number: Q5TCS8
    Secondary accession number(s): A6NL75
    , B2RDJ0, B6ZDM7, Q3MIS4, Q5I0W8, Q6ZNF1, Q6ZVR7, Q8N7C6, Q8WW00, Q96NF4
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: August 10, 2010
    Last modified: September 12, 2018
    This is version 133 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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    Main funding by: National Institutes of Health

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