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Entry version 139 (31 Jul 2019)
Sequence version 2 (10 Aug 2010)
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Protein

Adenylate kinase 9

Gene

AK9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=48 µM for AMP (with ATP as phosphate donor)1 Publication
  2. KM=3600 µM for dAMP (with ATP as phosphate donor)1 Publication
  3. KM=940 µM for CMP (with ATP as phosphate donor)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei229AMP 1By similarity1
    Binding sitei1447AMP 3By similarity1
    Binding sitei1506AMP 3By similarity1
    Binding sitei1543AMP 3By similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi40 – 45ATP 1By similarity6
    Nucleotide bindingi87 – 89AMP 1By similarity3
    Nucleotide bindingi116 – 119AMP 1By similarity4
    Nucleotide bindingi1001 – 1006ATP 2By similarity6
    Nucleotide bindingi1050 – 1052AMP 2By similarity3
    Nucleotide bindingi1079 – 1082AMP 2By similarity4
    Nucleotide bindingi1421 – 1426ATP 3By similarity6
    Nucleotide bindingi1470 – 1472AMP 3By similarity3
    Nucleotide bindingi1499 – 1502AMP 3By similarity4

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    Biological processNucleotide metabolism
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-499943 Interconversion of nucleotide di- and triphosphates

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Adenylate kinase 9 (EC:2.7.4.4, EC:2.7.4.6)
    Short name:
    AK 9
    Alternative name(s):
    Adenylate kinase domain-containing protein 1
    Adenylate kinase domain-containing protein 2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:AK9
    Synonyms:AKD1, AKD2, C6orf199, C6orf224
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:33814 AK9

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    615358 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q5TCS8

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    221264

    MalaCards human disease database

    More...
    MalaCardsi
    AK9

    Open Targets

    More...
    OpenTargetsi
    ENSG00000155085

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    98913 Postsynaptic congenital myasthenic syndromes

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA162380441
    PA164715271

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    AK9

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    302393675

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003041381 – 1911Adenylate kinase 9Add BLAST1911

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q5TCS8

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q5TCS8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q5TCS8

    PeptideAtlas

    More...
    PeptideAtlasi
    Q5TCS8

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q5TCS8

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    64979 [Q5TCS8-4]
    64980 [Q5TCS8-1]
    64981 [Q5TCS8-2]
    64982 [Q5TCS8-3]
    64983 [Q5TCS8-5]
    64984 [Q5TCS8-6]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q5TCS8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q5TCS8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000155085 Expressed in 165 organ(s), highest expression level in testis

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q5TCS8 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q5TCS8 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA030804
    HPA030805
    HPA031779
    HPA031781
    HPA036324
    HPA036711

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    128702, 12 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q5TCS8, 2 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000410186

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q5TCS8

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni31 – 285Adenylate kinase 1CuratedAdd BLAST255
    Regioni60 – 89NMPbind 1By similarityAdd BLAST30
    Regioni160 – 205LID 1By similarityAdd BLAST46
    Regioni992 – 1203Adenylate kinase 2CuratedAdd BLAST212
    Regioni1021 – 1052NMPbind 2By similarityAdd BLAST32
    Regioni1124 – 1144LID 2By similarityAdd BLAST21
    Regioni1412 – 1601Adenylate kinase 3CuratedAdd BLAST190
    Regioni1441 – 1472NMPbind 3By similarityAdd BLAST32
    Regioni1536 – 1550LID 3By similarityAdd BLAST15

    Coiled coil

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili443 – 485Sequence analysisAdd BLAST43
    Coiled coili676 – 711Sequence analysisAdd BLAST36

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi198 – 275Glu-richAdd BLAST78

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the adenylate kinase family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3078 Eukaryota
    KOG3079 Eukaryota
    COG0563 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00740000115564

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q5TCS8

    KEGG Orthology (KO)

    More...
    KOi
    K18533

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HIVQYTL

    Database of Orthologous Groups

    More...
    OrthoDBi
    362962at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q5TCS8

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF330805

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd01428 ADK, 3 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR003593 AAA+_ATPase
    IPR000850 Adenylat/UMP-CMP_kin
    IPR027417 P-loop_NTPase

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR23359 PTHR23359, 3 hits

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00382 AAA, 3 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540 SSF52540, 6 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 4 (identifier: Q5TCS8-4) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MTSQEKTEEY PFADIFDEDE TERNFLLSKP VCFVVFGKPG VGKTTLARYI
    60 70 80 90 100
    TQAWKCIRVE ALPILEEQIA AETESGVMLQ SMLISGQSIP DELVIKLMLE
    110 120 130 140 150
    KLNSPEVCHF GYIITEIPSL SQDAMTTLQQ IELIKNLNLK PDVIINIKCP
    160 170 180 190 200
    DYDLCQRISG QRQHNNTGYI YSRDQWDPEV IENHRKKKKE AQKDGKGEEE
    210 220 230 240 250
    EEEEEQEEEE AFIAEMQMVA EILHHLVQRP EDYLENVENI VKLYKETILQ
    260 270 280 290 300
    TLEEVMAEHN PQYLIELNGN KPAEELFMIV MDRLKYLNLK RAAILTKLQG
    310 320 330 340 350
    AEEEINDTME NDELFRTLAS YKLIAPRYRW QRSKWGRTCP VNLKDGNIYS
    360 370 380 390 400
    GLPDYSVSFL GKIYCLSSEE ALKPFLLNPR PYLLPPMPGP PCKVFILGPQ
    410 420 430 440 450
    YSGKTTLCNM LAENYKGKVV DYAQLVQPRF DKARETLVEN TIAEATAAAI
    460 470 480 490 500
    KVVKEKLLRE LQARKQAETA LREFQRQYEK MEFGVFPMEA THSSIDEEGY
    510 520 530 540 550
    IQGSQRDRGS SLVDTEEAKT KSENVLHDQA AKVDKDDGKE TGETFTFKRH
    560 570 580 590 600
    SQDASQDVKL YSDTAPTEDL IEEVTADHPE VVTMIEETIK MSQDINFEQP
    610 620 630 640 650
    YEKHAEILQE VLGEVMEENK DRFPGAPKYG GWIVDNCPIV KELWMALIKK
    660 670 680 690 700
    GIIPDLVIYL SDTENNGKCL FNRIYLQKKS EIDSKILERL LEELQKKKKE
    710 720 730 740 750
    EEEARKATEE ELRLEEENRR LLELMKVKAK EAEETDNEDE EEIEGDELEV
    760 770 780 790 800
    HEEPEASHDT RGSWLPEEFE ASEVPETEPE AVSEPIEETT VETEIPKGSK
    810 820 830 840 850
    EGLEIEKLSE TVVLPEFPED SYPDVPEMEP FKEKIGSFII LWKQLEATIS
    860 870 880 890 900
    EAYIKILNLE IADRTPQELL QKVVETMEKP FQYTAWELTG EDYEEETEDY
    910 920 930 940 950
    QTEAEVDEEL EEEEEEEGED KMKERKRHLG DTKHFCPVVL KENFILQPGN
    960 970 980 990 1000
    TEEAAKYREK IYYFSSAEAK EKFLEHPEDY VAHEEPLKAP PLRICLVGPQ
    1010 1020 1030 1040 1050
    GSGKTMCGRQ LAEKLNIFHI QFEEVLQEKL LLKTEKKVGP EFEEDSENEQ
    1060 1070 1080 1090 1100
    AAKQELEELA IQANVKVEEE NTKKQLPEVQ LTEEEEVIKS SLMENEPLPP
    1110 1120 1130 1140 1150
    EILEVILSEW WLKEPIRSTG FILDGFPRYP EEAQFLGDRG FFPDAAVFIQ
    1160 1170 1180 1190 1200
    VDDQDIFDRL LPAQIEKWKL KQKKKLERKK LIKDMKAKIR VDTIAKRRAE
    1210 1220 1230 1240 1250
    LILERDKKRR ENVVRDDEEI SEEELEEDND DIENILEDEF PKDEEEMSGE
    1260 1270 1280 1290 1300
    EDEEQETDAI ERLRGELGEK FEADTHNLQI IQDELERYLI PIISINGARR
    1310 1320 1330 1340 1350
    NHIVQYTLNM KLKPLVENRA SIFEKCHPIP APLAQKMLTF TYKYISSFGY
    1360 1370 1380 1390 1400
    WDPVKLSEGE TIKPVENAEN PIYPVIHRQY IYFLSSKETK EKFMKNPIKY
    1410 1420 1430 1440 1450
    IRQPKPKPTV PIRIIIVGPP KSGKTTVAKK ITSEYGLKHL SIGGALRYVL
    1460 1470 1480 1490 1500
    NNHPETELAL MLNWHLHKGM TAPDELAIQA LELSLMESVC NTAGVVIDGY
    1510 1520 1530 1540 1550
    PVTKHQMNLL EARSIIPMVI FELSVPSKEI FKRLLLEKEN EQRLPYPLHN
    1560 1570 1580 1590 1600
    SAQIVAVNNV KYRKNIGEIR QYYQEQHQNW YVIDGFHSKW WVWNEVIKNV
    1610 1620 1630 1640 1650
    QMVNKYMQTY LERIKAGKAA CIDKLCITPQ ELLSRLGEFE QFCPVSLAES
    1660 1670 1680 1690 1700
    QELFDCSATD SLEFAAEFRG HYYKMSSQEK LNKFLENPEL YVPPLAPHPL
    1710 1720 1730 1740 1750
    PSADMIPKRL TLSELKSRFP KCAELQGYCP VTYKDGNQRY EALVPGSINY
    1760 1770 1780 1790 1800
    ALEYHNRIYI CENKEKLQKF LRSPLKYWEQ KLPHKLPPLR EPILLTSLPL
    1810 1820 1830 1840 1850
    PGYLEQGIAT SLIKAMNAAG CLKPKFPFLS IRRSALLYIA LHLKAFNPKG
    1860 1870 1880 1890 1900
    SEYTRKKYKK KMEQFMESCE LITYLGAKMT RKYKEPQFRA IDFDHKLKTF
    1910
    LSLRNIDPIN G
    Length:1,911
    Mass (Da):221,413
    Last modified:August 10, 2010 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16A1888E727C51A4
    GO
    Isoform 1 (identifier: Q5TCS8-1) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         703-751: EARKATEEEL...EIEGDELEVH → KSHRRGIETR...CYCKQLQYFK
         752-1911: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:751
    Mass (Da):86,644
    Checksum:i5154893EA585590F
    GO
    Isoform 2 (identifier: Q5TCS8-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         420-421: VD → TN
         422-1911: Missing.

    Show »
    Length:421
    Mass (Da):48,501
    Checksum:i18B996C20324D892
    GO
    Isoform 3 (identifier: Q5TCS8-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         989-1014: APPLRICLVGPQGSGKTMCGRQLAEK → VRQYSYLNDCSHRIFLGLITNHHQFT
         1015-1911: Missing.

    Show »
    Length:1,014
    Mass (Da):117,361
    Checksum:iA8A3319DC3635FA1
    GO
    Isoform 5 (identifier: Q5TCS8-5) [UniParc] [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-921: Missing.
         1212-1257: NVVRDDEEIS...SGEEDEEQET → VSSFVFFFKT...GSSHLSLSKC
         1258-1911: Missing.

    Show »
    Length:336
    Mass (Da):39,019
    Checksum:i5FB4ED6C265E1CFE
    GO
    Isoform 6 (identifier: Q5TCS8-6) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1212-1283: NVVRDDEEIS...DTHNLQIIQD → PNKEKRKRGI...LSKQNIHNQK
         1284-1911: Missing.

    Show »
    Length:1,283
    Mass (Da):148,193
    Checksum:i7A51010EC1323CE3
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    J3KP89J3KP89_HUMAN
    Adenylate kinase 9
    AK9
    736Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YCD1H0YCD1_HUMAN
    Adenylate kinase 9
    AK9
    192Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A075B7F5A0A075B7F5_HUMAN
    Adenylate kinase 9
    AK9
    137Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PPU7E9PPU7_HUMAN
    Adenylate kinase 9
    AK9
    259Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7C517H7C517_HUMAN
    Adenylate kinase 9
    AK9
    749Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PPM3E9PPM3_HUMAN
    Adenylate kinase 9
    AK9
    227Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0Y8C5H0Y8C5_HUMAN
    Adenylate kinase 9
    AK9
    312Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7C505H7C505_HUMAN
    Adenylate kinase 9
    AK9
    218Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAI01715 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence AAI11949 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence BAC05368 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti222I → T in BAB70945 (PubMed:14702039).Curated1
    Sequence conflicti1716K → R in BAC05368 (PubMed:14702039).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0396381 – 921Missing in isoform 5. 1 PublicationAdd BLAST921
    Alternative sequenceiVSP_028008420 – 421VD → TN in isoform 2. 2 Publications2
    Alternative sequenceiVSP_028009422 – 1911Missing in isoform 2. 2 PublicationsAdd BLAST1490
    Alternative sequenceiVSP_039639703 – 751EARKA…ELEVH → KSHRRGIETRRRKSKATGTY ESEGKRQAQIAMTDDVSWYC YCKQLQYFK in isoform 1. CuratedAdd BLAST49
    Alternative sequenceiVSP_039640752 – 1911Missing in isoform 1. CuratedAdd BLAST1160
    Alternative sequenceiVSP_028010989 – 1014APPLR…QLAEK → VRQYSYLNDCSHRIFLGLIT NHHQFT in isoform 3. 1 PublicationAdd BLAST26
    Alternative sequenceiVSP_0280111015 – 1911Missing in isoform 3. 1 PublicationAdd BLAST897
    Alternative sequenceiVSP_0396411212 – 1283NVVRD…QIIQD → PNKEKRKRGISENTTCYKCN HMSPWCEYAGLPYRGLLILY SATATATAGTKHCRSGAKVI VALSKQNIHNQK in isoform 6. 1 PublicationAdd BLAST72
    Alternative sequenceiVSP_0396421212 – 1257NVVRD…EEQET → VSSFVFFFKTGSHSVAQGRV QWHNHSSLQPRTPGLKGSSH LSLSKC in isoform 5. 1 PublicationAdd BLAST46
    Alternative sequenceiVSP_0396431258 – 1911Missing in isoform 5. 1 PublicationAdd BLAST654
    Alternative sequenceiVSP_0396441284 – 1911Missing in isoform 6. 1 PublicationAdd BLAST628

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK055538 mRNA Translation: BAB70945.1
    AK098657 mRNA Translation: BAC05368.1 Different initiation.
    AK124171 mRNA No translation available.
    AK131244 mRNA Translation: BAD18424.1
    AK315561 mRNA Translation: BAG37937.1
    AL121788 Genomic DNA No translation available.
    AL133472 Genomic DNA No translation available.
    AL109947 Genomic DNA No translation available.
    AL139391 Genomic DNA No translation available.
    CH471051 Genomic DNA Translation: EAW48333.1
    BC022031 mRNA Translation: AAH22031.1
    BC087860 mRNA Translation: AAH87860.1
    BC101714 mRNA Translation: AAI01715.1 Different initiation.
    BC111948 mRNA Translation: AAI11949.1 Different initiation.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS5077.1 [Q5TCS8-2]
    CCDS55048.1 [Q5TCS8-4]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001138600.2, NM_001145128.2 [Q5TCS8-4]
    NP_001316531.1, NM_001329602.1 [Q5TCS8-2]
    NP_659462.1, NM_145025.4 [Q5TCS8-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000285397; ENSP00000285397; ENSG00000155085 [Q5TCS8-2]
    ENST00000355283; ENSP00000347431; ENSG00000155085 [Q5TCS8-5]
    ENST00000424296; ENSP00000410186; ENSG00000155085 [Q5TCS8-4]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    221264

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:221264

    UCSC genome browser

    More...
    UCSCi
    uc003ptn.2 human [Q5TCS8-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK055538 mRNA Translation: BAB70945.1
    AK098657 mRNA Translation: BAC05368.1 Different initiation.
    AK124171 mRNA No translation available.
    AK131244 mRNA Translation: BAD18424.1
    AK315561 mRNA Translation: BAG37937.1
    AL121788 Genomic DNA No translation available.
    AL133472 Genomic DNA No translation available.
    AL109947 Genomic DNA No translation available.
    AL139391 Genomic DNA No translation available.
    CH471051 Genomic DNA Translation: EAW48333.1
    BC022031 mRNA Translation: AAH22031.1
    BC087860 mRNA Translation: AAH87860.1
    BC101714 mRNA Translation: AAI01715.1 Different initiation.
    BC111948 mRNA Translation: AAI11949.1 Different initiation.
    CCDSiCCDS5077.1 [Q5TCS8-2]
    CCDS55048.1 [Q5TCS8-4]
    RefSeqiNP_001138600.2, NM_001145128.2 [Q5TCS8-4]
    NP_001316531.1, NM_001329602.1 [Q5TCS8-2]
    NP_659462.1, NM_145025.4 [Q5TCS8-2]

    3D structure databases

    SMRiQ5TCS8
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi128702, 12 interactors
    IntActiQ5TCS8, 2 interactors
    STRINGi9606.ENSP00000410186

    PTM databases

    iPTMnetiQ5TCS8
    PhosphoSitePlusiQ5TCS8

    Polymorphism and mutation databases

    BioMutaiAK9
    DMDMi302393675

    Proteomic databases

    EPDiQ5TCS8
    jPOSTiQ5TCS8
    PaxDbiQ5TCS8
    PeptideAtlasiQ5TCS8
    PRIDEiQ5TCS8
    ProteomicsDBi64979 [Q5TCS8-4]
    64980 [Q5TCS8-1]
    64981 [Q5TCS8-2]
    64982 [Q5TCS8-3]
    64983 [Q5TCS8-5]
    64984 [Q5TCS8-6]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    221264
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000285397; ENSP00000285397; ENSG00000155085 [Q5TCS8-2]
    ENST00000355283; ENSP00000347431; ENSG00000155085 [Q5TCS8-5]
    ENST00000424296; ENSP00000410186; ENSG00000155085 [Q5TCS8-4]
    GeneIDi221264
    KEGGihsa:221264
    UCSCiuc003ptn.2 human [Q5TCS8-4]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    221264
    DisGeNETi221264

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    AK9
    HGNCiHGNC:33814 AK9
    HPAiHPA030804
    HPA030805
    HPA031779
    HPA031781
    HPA036324
    HPA036711
    MalaCardsiAK9
    MIMi615358 gene
    neXtProtiNX_Q5TCS8
    OpenTargetsiENSG00000155085
    Orphaneti98913 Postsynaptic congenital myasthenic syndromes
    PharmGKBiPA162380441
    PA164715271

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3078 Eukaryota
    KOG3079 Eukaryota
    COG0563 LUCA
    GeneTreeiENSGT00740000115564
    InParanoidiQ5TCS8
    KOiK18533
    OMAiHIVQYTL
    OrthoDBi362962at2759
    PhylomeDBiQ5TCS8
    TreeFamiTF330805

    Enzyme and pathway databases

    ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates

    Miscellaneous databases

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    221264

    Protein Ontology

    More...
    PROi
    PR:Q5TCS8

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000155085 Expressed in 165 organ(s), highest expression level in testis
    ExpressionAtlasiQ5TCS8 baseline and differential
    GenevisibleiQ5TCS8 HS

    Family and domain databases

    CDDicd01428 ADK, 3 hits
    InterProiView protein in InterPro
    IPR003593 AAA+_ATPase
    IPR000850 Adenylat/UMP-CMP_kin
    IPR027417 P-loop_NTPase
    PANTHERiPTHR23359 PTHR23359, 3 hits
    SMARTiView protein in SMART
    SM00382 AAA, 3 hits
    SUPFAMiSSF52540 SSF52540, 6 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAD9_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TCS8
    Secondary accession number(s): A6NL75
    , B2RDJ0, B6ZDM7, Q3MIS4, Q5I0W8, Q6ZNF1, Q6ZVR7, Q8N7C6, Q8WW00, Q96NF4
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: August 10, 2010
    Last modified: July 31, 2019
    This is version 139 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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