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Protein

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

Gene

MAGI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.1 Publication

Miscellaneous

MAGI3 PDZ domains are used to design peptide ligands that bind and inhibit PDZ domains.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi121 – 128ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • guanylate kinase activity Source: UniProtKB
  • protein-containing complex scaffold activity Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q5TCQ9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Alternative name(s):
Membrane-associated guanylate kinase inverted 3
Short name:
MAGI-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAGI3
Synonyms:KIAA1634
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000081026.18

Human Gene Nomenclature Database

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HGNCi
HGNC:29647 MAGI3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615943 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TCQ9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
260425

Open Targets

More...
OpenTargetsi
ENSG00000081026

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671485

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5212

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAGI3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
190359882

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003414071 – 1481Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3Add BLAST1481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei234PhosphoserineBy similarity1
Modified residuei595PhosphoserineCombined sources1
Modified residuei699PhosphoserineBy similarity1
Modified residuei832PhosphoserineCombined sources1
Modified residuei915PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5TCQ9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5TCQ9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TCQ9

PeptideAtlas

More...
PeptideAtlasi
Q5TCQ9

PRoteomics IDEntifications database

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PRIDEi
Q5TCQ9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
64973
64974 [Q5TCQ9-2]
64975 [Q5TCQ9-3]
64976 [Q5TCQ9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TCQ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TCQ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000081026 Expressed in 197 organ(s), highest expression level in epithelium of mammary gland

CleanEx database of gene expression profiles

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CleanExi
HS_MAGI3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5TCQ9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5TCQ9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007923
HPA008444

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ADRB1, FZD4, FZD7, PTPRB, TGFA and VANGL2. Interacts with unidentified tyrosine phosphorylated proteins (By similarity). Interacts with ADGRB1, LPAR2/EDG4, GRIN2B and PTEN. Does not interact with HTLV TAX2 or TAX3 proteins. Interacts with DLL1 (By similarity).By similarity2 Publications
(Microbial infection) Interacts with HTLV1 Tax protein, possibly affecting the transformation ability of Tax.1 Publication
(Microbial infection) Interacts with human papillomavirus/HPV type 16 and 18 E6 proteins.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
129277, 22 interactors

Protein interaction database and analysis system

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IntActi
Q5TCQ9, 9 interactors

Molecular INTeraction database

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MINTi
Q5TCQ9

STRING: functional protein association networks

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STRINGi
9606.ENSP00000304604

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11481
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SOEX-ray1.60A576-666[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q5TCQ9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5TCQ9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 106PDZ 1PROSITE-ProRule annotationAdd BLAST89
Domaini114 – 288Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST175
Domaini293 – 326WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini339 – 372WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini410 – 492PDZ 2PROSITE-ProRule annotationAdd BLAST83
Domaini578 – 654PDZ 3PROSITE-ProRule annotationAdd BLAST77
Domaini726 – 808PDZ 4PROSITE-ProRule annotationAdd BLAST83
Domaini851 – 938PDZ 5PROSITE-ProRule annotationAdd BLAST88
Domaini1021 – 1103PDZ 6PROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 106Interaction with ADRB1 and TGFABy similarityAdd BLAST89
Regioni410 – 492Interaction with PTEN1 PublicationAdd BLAST83
Regioni726 – 808Interaction with ADGRB11 PublicationAdd BLAST83
Regioni851 – 938Interaction with LPAR2 and GRIN2B2 PublicationsAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 9Poly-Lys4
Compositional biasi238 – 243Poly-Glu6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0707 Eukaryota
KOG3209 Eukaryota
COG5021 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156496

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG007091

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5TCQ9

KEGG Orthology (KO)

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KOi
K06112

Identification of Orthologs from Complete Genome Data

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OMAi
RDPPNSH

Database of Orthologous Groups

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OrthoDBi
284488at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q5TCQ9

TreeFam database of animal gene trees

More...
TreeFami
TF316816

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00201 WW, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR030035 MAGI3
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001202 WW_dom
IPR036020 WW_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR10316:SF10 PTHR10316:SF10, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 2 hits
PF00397 WW, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 6 hits
SM00456 WW, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50156 SSF50156, 6 hits
SSF51045 SSF51045, 2 hits
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 6 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5TCQ9-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKTLKKKKH WLSKVQECAV SWAGPPGDFG AEIRGGAERG EFPYLGRLRE
60 70 80 90 100
EPGGGTCCVV SGKAPSPGDV LLEVNGTPVS GLTNRDTLAV IRHFREPIRL
110 120 130 140 150
KTVKPGKVIN KDLRHYLSLQ FQKGSIDHKL QQVIRDNLYL RTIPCTTRAP
160 170 180 190 200
RDGEVPGVDY NFISVEQFKA LEESGALLES GTYDGNFYGT PKPPAEPSPF
210 220 230 240 250
QPDPVDQVLF DNEFDAESQR KRTTSVSKME RMDSSLPEEE EDEDKEAING
260 270 280 290 300
SGNAENRERH SESSDWMKTV PSYNQTNSSM DFRNYMMRDE TLEPLPKNWE
310 320 330 340 350
MAYTDTGMIY FIDHNTKTTT WLDPRLCKKA KAPEDCEDGE LPYGWEKIED
360 370 380 390 400
PQYGTYYVDH LNQKTQFENP VEEAKRKKQL GQVEIGSSKP DMEKSHFTRD
410 420 430 440 450
PSQLKGVLVR ASLKKSTMGF GFTIIGGDRP DEFLQVKNVL KDGPAAQDGK
460 470 480 490 500
IAPGDVIVDI NGNCVLGHTH ADVVQMFQLV PVNQYVNLTL CRGYPLPDDS
510 520 530 540 550
EDPVVDIVAA TPVINGQSLT KGETCMNPQD FKPGAMVLEQ NGKSGHTLTG
560 570 580 590 600
DGLNGPSDAS EQRVSMASSG SSQPELVTIP LIKGPKGFGF AIADSPTGQK
610 620 630 640 650
VKMILDSQWC QGLQKGDIIK EIYHQNVQNL THLQVVEVLK QFPVGADVPL
660 670 680 690 700
LILRGGPPSP TKTAKMKTDK KENAGSLEAI NEPIPQPMPF PPSIIRSGSP
710 720 730 740 750
KLDPSEVYLK SKTLYEDKPP NTKDLDVFLR KQESGFGFRV LGGDGPDQSI
760 770 780 790 800
YIGAIIPLGA AEKDGRLRAA DELMCIDGIP VKGKSHKQVL DLMTTAARNG
810 820 830 840 850
HVLLTVRRKI FYGEKQPEDD SSQAFISTQN GSPRLNRAEV PARPAPQEPY
860 870 880 890 900
DVVLQRKENE GFGFVILTSK NKPPPGVIPH KIGRVIEGSP ADRCGKLKVG
910 920 930 940 950
DHISAVNGQS IVELSHDNIV QLIKDAGVTV TLTVIAEEEH HGPPSGTNSA
960 970 980 990 1000
RQSPALQHRP MGQSQANHIP GDRSALEGEI GKDVSTSYRH SWSDHKHLAQ
1010 1020 1030 1040 1050
PDTAVISVVG SRHNQNLGCY PVELERGPRG FGFSLRGGKE YNMGLFILRL
1060 1070 1080 1090 1100
AEDGPAIKDG RIHVGDQIVE INGEPTQGIT HTRAIELIQA GGNKVLLLLR
1110 1120 1130 1140 1150
PGTGLIPDHG DWDINNPSSS NVIYDEQSPL PPSSHFASIF EESHVPVIEE
1160 1170 1180 1190 1200
SLRVQICEKA EELKDIVPEK KSTLNENQPE IKHQSLLQKN VSKRDPPSSH
1210 1220 1230 1240 1250
GHSNKKNLLK VENGVTRRGR SVSPKKPASQ HSEEHLDKIP SPLKNNPKRR
1260 1270 1280 1290 1300
PRDQSLSPSK GENKSCQVST RAGSGQDQCR KSRGRSASPK KQQKIEGSKA
1310 1320 1330 1340 1350
PSNAEAKLLE GKSRRIAGYT GSNAEQIPDG KEKSDVIRKD AKQNQLEKSR
1360 1370 1380 1390 1400
TRSPEKKIKR MVEKSLPSKM TNKTTSKEVS ENEKGKKVTT GETSSSNDKI
1410 1420 1430 1440 1450
GENVQLSEKR LKQEPEEKVV SNKTEDHKGK ELEAADKNKE TGRFKPESSS
1460 1470 1480
PVKKTLITPG PWKVPSGNKV TGTIGMAEKR Q
Note: No experimental confirmation available.
Length:1,481
Mass (Da):162,949
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C2B604D9B1B1B97
GO
Isoform 4 (identifier: Q5TCQ9-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: D → DFTLVAQAGVQWHDLGSLQPPPPGFN

Note: No experimental confirmation available.
Show »
Length:1,506
Mass (Da):165,608
Checksum:i0EA98F09F9AB109F
GO
Isoform 2 (identifier: Q5TCQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: D → DFTLVAQAGVQWHDLGSLQPPPPGFN
     1111-1125: DWDINNPSSSNVIYD → LAPSGLCSYVKPEQH
     1126-1481: Missing.

Show »
Length:1,150
Mass (Da):125,998
Checksum:i14DED25795278E3C
GO
Isoform 3 (identifier: Q5TCQ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1111-1125: DWDINNPSSSNVIYD → LAPSGLCSYVKPEQH
     1126-1481: Missing.

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Length:1,125
Mass (Da):123,339
Checksum:iFA2340EA152503E9
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15479 differs from that shown. Reason: Frameshift at position 1348.Curated
The sequence BAB15479 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9K → R in AAG43837 (PubMed:15652357).Curated1
Sequence conflicti59V → I in AAG24545 (PubMed:10748157).Curated1
Sequence conflicti66 – 68SPG → NPS in AAG24545 (PubMed:10748157).Curated3
Sequence conflicti246E → G in AAG24545 (PubMed:10748157).Curated1
Sequence conflicti257R → G in AAG43837 (PubMed:15652357).Curated1
Sequence conflicti466L → F in AAG24545 (PubMed:10748157).Curated1
Sequence conflicti548L → S in AAG24545 (PubMed:10748157).Curated1
Sequence conflicti616G → E in AAG24545 (PubMed:10748157).Curated1
Sequence conflicti660P → T in AAG24545 (PubMed:10748157).Curated1
Sequence conflicti776I → V in AAG43837 (PubMed:15652357).Curated1
Sequence conflicti798R → P in AAG43837 (PubMed:15652357).Curated1
Sequence conflicti917D → A in AAG24545 (PubMed:10748157).Curated1
Sequence conflicti993S → P in AAG43837 (PubMed:15652357).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059502359D → DFTLVAQAGVQWHDLGSLQP PPPGFN in isoform 4 and isoform 2. 3 Publications1
Alternative sequenceiVSP_0595031111 – 1125DWDIN…NVIYD → LAPSGLCSYVKPEQH in isoform 3 and isoform 2. 4 PublicationsAdd BLAST15
Alternative sequenceiVSP_0595041126 – 1481Missing in isoform 3 and isoform 2. 4 PublicationsAdd BLAST356

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF257238 mRNA Translation: AAG24545.1
AF213259 mRNA Translation: AAG43837.1
AL133517 Genomic DNA No translation available.
AL365225 Genomic DNA No translation available.
AL389921 Genomic DNA No translation available.
AL390759 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56561.1
CH471122 Genomic DNA Translation: EAW56559.1
CH471122 Genomic DNA Translation: EAW56560.1
CH471122 Genomic DNA Translation: EAW56563.1
CH471122 Genomic DNA Translation: EAW56562.1
BC130409 mRNA Translation: AAI30410.1
AB046854 mRNA Translation: BAB13460.1
AK026417 mRNA Translation: BAB15479.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS44196.1 [Q5TCQ9-4]
CCDS860.1 [Q5TCQ9-3]

NCBI Reference Sequences

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RefSeqi
NP_001136254.1, NM_001142782.1 [Q5TCQ9-4]
NP_690864.2, NM_152900.2 [Q5TCQ9-3]
XP_005270794.1, XM_005270737.3 [Q5TCQ9-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.486189

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000307546; ENSP00000304604; ENSG00000081026 [Q5TCQ9-4]
ENST00000369611; ENSP00000358624; ENSG00000081026 [Q5TCQ9-3]
ENST00000369615; ENSP00000358628; ENSG00000081026 [Q5TCQ9-3]
ENST00000369617; ENSP00000358630; ENSG00000081026 [Q5TCQ9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
260425

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:260425

UCSC genome browser

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UCSCi
uc001edh.4 human [Q5TCQ9-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257238 mRNA Translation: AAG24545.1
AF213259 mRNA Translation: AAG43837.1
AL133517 Genomic DNA No translation available.
AL365225 Genomic DNA No translation available.
AL389921 Genomic DNA No translation available.
AL390759 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56561.1
CH471122 Genomic DNA Translation: EAW56559.1
CH471122 Genomic DNA Translation: EAW56560.1
CH471122 Genomic DNA Translation: EAW56563.1
CH471122 Genomic DNA Translation: EAW56562.1
BC130409 mRNA Translation: AAI30410.1
AB046854 mRNA Translation: BAB13460.1
AK026417 mRNA Translation: BAB15479.1 Sequence problems.
CCDSiCCDS44196.1 [Q5TCQ9-4]
CCDS860.1 [Q5TCQ9-3]
RefSeqiNP_001136254.1, NM_001142782.1 [Q5TCQ9-4]
NP_690864.2, NM_152900.2 [Q5TCQ9-3]
XP_005270794.1, XM_005270737.3 [Q5TCQ9-3]
UniGeneiHs.486189

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SOEX-ray1.60A576-666[»]
ProteinModelPortaliQ5TCQ9
SMRiQ5TCQ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129277, 22 interactors
IntActiQ5TCQ9, 9 interactors
MINTiQ5TCQ9
STRINGi9606.ENSP00000304604

Chemistry databases

ChEMBLiCHEMBL5212

PTM databases

iPTMnetiQ5TCQ9
PhosphoSitePlusiQ5TCQ9

Polymorphism and mutation databases

BioMutaiMAGI3
DMDMi190359882

Proteomic databases

EPDiQ5TCQ9
jPOSTiQ5TCQ9
PaxDbiQ5TCQ9
PeptideAtlasiQ5TCQ9
PRIDEiQ5TCQ9
ProteomicsDBi64973
64974 [Q5TCQ9-2]
64975 [Q5TCQ9-3]
64976 [Q5TCQ9-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307546; ENSP00000304604; ENSG00000081026 [Q5TCQ9-4]
ENST00000369611; ENSP00000358624; ENSG00000081026 [Q5TCQ9-3]
ENST00000369615; ENSP00000358628; ENSG00000081026 [Q5TCQ9-3]
ENST00000369617; ENSP00000358630; ENSG00000081026 [Q5TCQ9-2]
GeneIDi260425
KEGGihsa:260425
UCSCiuc001edh.4 human [Q5TCQ9-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
260425
DisGeNETi260425
EuPathDBiHostDB:ENSG00000081026.18

GeneCards: human genes, protein and diseases

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GeneCardsi
MAGI3

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0000900
HGNCiHGNC:29647 MAGI3
HPAiHPA007923
HPA008444
MIMi615943 gene
neXtProtiNX_Q5TCQ9
OpenTargetsiENSG00000081026
PharmGKBiPA142671485

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0707 Eukaryota
KOG3209 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00940000156496
HOVERGENiHBG007091
InParanoidiQ5TCQ9
KOiK06112
OMAiRDPPNSH
OrthoDBi284488at2759
PhylomeDBiQ5TCQ9
TreeFamiTF316816

Enzyme and pathway databases

SignaLinkiQ5TCQ9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MAGI3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MAGI3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
260425

Protein Ontology

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PROi
PR:Q5TCQ9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000081026 Expressed in 197 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_MAGI3
ExpressionAtlasiQ5TCQ9 baseline and differential
GenevisibleiQ5TCQ9 HS

Family and domain databases

CDDicd00201 WW, 2 hits
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR030035 MAGI3
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001202 WW_dom
IPR036020 WW_dom_sf
PANTHERiPTHR10316:SF10 PTHR10316:SF10, 1 hit
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 2 hits
PF00397 WW, 2 hits
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 6 hits
SM00456 WW, 2 hits
SUPFAMiSSF50156 SSF50156, 6 hits
SSF51045 SSF51045, 2 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 6 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAGI3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TCQ9
Secondary accession number(s): A0A024R0E9
, A0A024R0H3, Q5TCQ8, Q5TCR0, Q9H2V6, Q9H5Y8, Q9HBC4, Q9HCD8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 28, 2018
Last modified: January 16, 2019
This is version 110 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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