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Protein

Opioid growth factor receptor-like protein 1

Gene

OGFRL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Opioid growth factor receptor-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OGFRL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000119900.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21378 OGFRL1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TC84

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000119900

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394713

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3638334

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OGFRL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74746031

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003141421 – 451Opioid growth factor receptor-like protein 1Add BLAST451

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5TC84

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5TC84

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5TC84

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TC84

PeptideAtlas

More...
PeptideAtlasi
Q5TC84

PRoteomics IDEntifications database

More...
PRIDEi
Q5TC84

ProteomicsDB human proteome resource

More...
ProteomicsDBi
64945

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TC84

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TC84

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119900 Expressed in 219 organ(s), highest expression level in spinal cord

CleanEx database of gene expression profiles

More...
CleanExi
HS_OGFRL1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TC84 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027122

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122757, 1 interactor

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q5TC84

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5TC84

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH5X Eukaryota
ENOG4111XCW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018730

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231272

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG066276

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TC84

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSQTSMH

Database of Orthologous Groups

More...
OrthoDBi
1450738at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TC84

TreeFam database of animal gene trees

More...
TreeFami
TF331377

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006757 OGF_rcpt
IPR039574 OGFr

The PANTHER Classification System

More...
PANTHERi
PTHR14015 PTHR14015, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04664 OGFr_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5TC84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNLLGGVSF REPTTVEDCD STWQTDSEPE PEEPGPGGGS EGPGQESEQP
60 70 80 90 100
AQPPEQAGGR PGASPAPDED AEAAGAEQGG DSTEATAKPK RSFYAARDLY
110 120 130 140 150
KYRHQYPNFK DIRYQNDLSN LRFYKNKIPF KPDGVYIEEV LSKWKGDYEK
160 170 180 190 200
LEHNHTYIQW LFPLREQGLN FYAKELTTYE IEEFKKTKEA IRRFLLAYKM
210 220 230 240 250
MLEFFGIKLT DKTGNVARAV NWQERFQHLN ESQHNYLRIT RILKSLGELG
260 270 280 290 300
YESFKSPLVK FILHEALVEN TIPNIKQSAL EYFVYTIRDR RERRKLLRFA
310 320 330 340 350
QKHYTPSENF IWGPPRKEQS EGSKAQKMSS PLASSHNSQT SMHKKAKDSK
360 370 380 390 400
NSSSAVHLNS KTAEDKKVAP KEPVEETDRP SPEPSNEAAK PRNTEKDSNA
410 420 430 440 450
ENMNSQPEKT VTTPTEKKES VSPENNEEGG NDNQDNENPG NTNCHDVVLV

Q
Length:451
Mass (Da):51,252
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD33D708BEE382696
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IRI0A0A3B3IRI0_HUMAN
Opioid growth factor receptor-like ...
OGFRL1
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI11000 differs from that shown. Reason: Frameshift at position 339.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03784247S → P1 PublicationCorresponds to variant dbSNP:rs112585190Ensembl.1
Natural variantiVAR_037843396Missing 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136164 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48802.1
CH471051 Genomic DNA Translation: EAW48803.1
BC018688 mRNA Translation: AAH18688.1
BC110999 mRNA Translation: AAI11000.1 Frameshift.
AK024732 mRNA Translation: BAB14980.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34482.1

NCBI Reference Sequences

More...
RefSeqi
NP_001311195.1, NM_001324266.1
NP_078852.3, NM_024576.4
XP_011534419.1, XM_011536117.2
XP_011534420.1, XM_011536118.2
XP_016866795.1, XM_017011306.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.648434
Hs.656091
Hs.734751

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370435; ENSP00000359464; ENSG00000119900

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79627

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79627

UCSC genome browser

More...
UCSCi
uc003pfx.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136164 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48802.1
CH471051 Genomic DNA Translation: EAW48803.1
BC018688 mRNA Translation: AAH18688.1
BC110999 mRNA Translation: AAI11000.1 Frameshift.
AK024732 mRNA Translation: BAB14980.1
CCDSiCCDS34482.1
RefSeqiNP_001311195.1, NM_001324266.1
NP_078852.3, NM_024576.4
XP_011534419.1, XM_011536117.2
XP_011534420.1, XM_011536118.2
XP_016866795.1, XM_017011306.1
UniGeneiHs.648434
Hs.656091
Hs.734751

3D structure databases

ProteinModelPortaliQ5TC84
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122757, 1 interactor

Chemistry databases

BindingDBiQ5TC84
ChEMBLiCHEMBL3638334

PTM databases

iPTMnetiQ5TC84
PhosphoSitePlusiQ5TC84

Polymorphism and mutation databases

BioMutaiOGFRL1
DMDMi74746031

Proteomic databases

EPDiQ5TC84
jPOSTiQ5TC84
MaxQBiQ5TC84
PaxDbiQ5TC84
PeptideAtlasiQ5TC84
PRIDEiQ5TC84
ProteomicsDBi64945

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370435; ENSP00000359464; ENSG00000119900
GeneIDi79627
KEGGihsa:79627
UCSCiuc003pfx.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79627
EuPathDBiHostDB:ENSG00000119900.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
OGFRL1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0006001
HGNCiHGNC:21378 OGFRL1
HPAiHPA027122
neXtProtiNX_Q5TC84
OpenTargetsiENSG00000119900
PharmGKBiPA128394713

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH5X Eukaryota
ENOG4111XCW LUCA
GeneTreeiENSGT00390000018730
HOGENOMiHOG000231272
HOVERGENiHBG066276
InParanoidiQ5TC84
OMAiNSQTSMH
OrthoDBi1450738at2759
PhylomeDBiQ5TC84
TreeFamiTF331377

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
OGFRL1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79627

Protein Ontology

More...
PROi
PR:Q5TC84

Gene expression databases

BgeeiENSG00000119900 Expressed in 219 organ(s), highest expression level in spinal cord
CleanExiHS_OGFRL1
GenevisibleiQ5TC84 HS

Family and domain databases

InterProiView protein in InterPro
IPR006757 OGF_rcpt
IPR039574 OGFr
PANTHERiPTHR14015 PTHR14015, 1 hit
PfamiView protein in Pfam
PF04664 OGFr_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOGRL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TC84
Secondary accession number(s): Q2TAC1, Q8NEQ4, Q9H7B5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 21, 2004
Last modified: January 16, 2019
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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