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Protein

Opioid growth factor receptor-like protein 1

Gene

OGFRL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Opioid growth factor receptor-like protein 1
Gene namesi
Name:OGFRL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000119900.7
HGNCiHGNC:21378 OGFRL1
neXtProtiNX_Q5TC84

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119900
PharmGKBiPA128394713

Chemistry databases

ChEMBLiCHEMBL3638334

Polymorphism and mutation databases

BioMutaiOGFRL1
DMDMi74746031

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003141421 – 451Opioid growth factor receptor-like protein 1Add BLAST451

Proteomic databases

EPDiQ5TC84
MaxQBiQ5TC84
PaxDbiQ5TC84
PeptideAtlasiQ5TC84
PRIDEiQ5TC84
ProteomicsDBi64945

PTM databases

iPTMnetiQ5TC84
PhosphoSitePlusiQ5TC84

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000119900 Expressed in 219 organ(s), highest expression level in spinal cord
CleanExiHS_OGFRL1
GenevisibleiQ5TC84 HS

Organism-specific databases

HPAiHPA027122

Interactioni

Protein-protein interaction databases

BioGridi122757, 1 interactor

Chemistry databases

BindingDBiQ5TC84

Structurei

3D structure databases

ProteinModelPortaliQ5TC84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IH5X Eukaryota
ENOG4111XCW LUCA
GeneTreeiENSGT00390000018730
HOGENOMiHOG000231272
HOVERGENiHBG066276
InParanoidiQ5TC84
OMAiNSQTSMH
OrthoDBiEOG091G04CN
PhylomeDBiQ5TC84
TreeFamiTF331377

Family and domain databases

InterProiView protein in InterPro
IPR006757 OGF_rcpt
PfamiView protein in Pfam
PF04664 OGFr_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q5TC84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNLLGGVSF REPTTVEDCD STWQTDSEPE PEEPGPGGGS EGPGQESEQP
60 70 80 90 100
AQPPEQAGGR PGASPAPDED AEAAGAEQGG DSTEATAKPK RSFYAARDLY
110 120 130 140 150
KYRHQYPNFK DIRYQNDLSN LRFYKNKIPF KPDGVYIEEV LSKWKGDYEK
160 170 180 190 200
LEHNHTYIQW LFPLREQGLN FYAKELTTYE IEEFKKTKEA IRRFLLAYKM
210 220 230 240 250
MLEFFGIKLT DKTGNVARAV NWQERFQHLN ESQHNYLRIT RILKSLGELG
260 270 280 290 300
YESFKSPLVK FILHEALVEN TIPNIKQSAL EYFVYTIRDR RERRKLLRFA
310 320 330 340 350
QKHYTPSENF IWGPPRKEQS EGSKAQKMSS PLASSHNSQT SMHKKAKDSK
360 370 380 390 400
NSSSAVHLNS KTAEDKKVAP KEPVEETDRP SPEPSNEAAK PRNTEKDSNA
410 420 430 440 450
ENMNSQPEKT VTTPTEKKES VSPENNEEGG NDNQDNENPG NTNCHDVVLV

Q
Length:451
Mass (Da):51,252
Last modified:December 21, 2004 - v1
Checksum:iD33D708BEE382696
GO

Sequence cautioni

The sequence AAI11000 differs from that shown. Reason: Frameshift at position 339.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03784247S → P1 PublicationCorresponds to variant dbSNP:rs112585190Ensembl.1
Natural variantiVAR_037843396Missing 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136164 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48802.1
CH471051 Genomic DNA Translation: EAW48803.1
BC018688 mRNA Translation: AAH18688.1
BC110999 mRNA Translation: AAI11000.1 Frameshift.
AK024732 mRNA Translation: BAB14980.1
CCDSiCCDS34482.1
RefSeqiNP_001311195.1, NM_001324266.1
NP_078852.3, NM_024576.4
XP_011534419.1, XM_011536117.2
XP_011534420.1, XM_011536118.2
XP_016866795.1, XM_017011306.1
UniGeneiHs.648434
Hs.656091
Hs.734751

Genome annotation databases

EnsembliENST00000370435; ENSP00000359464; ENSG00000119900
GeneIDi79627
KEGGihsa:79627
UCSCiuc003pfx.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136164 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48802.1
CH471051 Genomic DNA Translation: EAW48803.1
BC018688 mRNA Translation: AAH18688.1
BC110999 mRNA Translation: AAI11000.1 Frameshift.
AK024732 mRNA Translation: BAB14980.1
CCDSiCCDS34482.1
RefSeqiNP_001311195.1, NM_001324266.1
NP_078852.3, NM_024576.4
XP_011534419.1, XM_011536117.2
XP_011534420.1, XM_011536118.2
XP_016866795.1, XM_017011306.1
UniGeneiHs.648434
Hs.656091
Hs.734751

3D structure databases

ProteinModelPortaliQ5TC84
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122757, 1 interactor

Chemistry databases

BindingDBiQ5TC84
ChEMBLiCHEMBL3638334

PTM databases

iPTMnetiQ5TC84
PhosphoSitePlusiQ5TC84

Polymorphism and mutation databases

BioMutaiOGFRL1
DMDMi74746031

Proteomic databases

EPDiQ5TC84
MaxQBiQ5TC84
PaxDbiQ5TC84
PeptideAtlasiQ5TC84
PRIDEiQ5TC84
ProteomicsDBi64945

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370435; ENSP00000359464; ENSG00000119900
GeneIDi79627
KEGGihsa:79627
UCSCiuc003pfx.2 human

Organism-specific databases

CTDi79627
EuPathDBiHostDB:ENSG00000119900.7
GeneCardsiOGFRL1
H-InvDBiHIX0006001
HGNCiHGNC:21378 OGFRL1
HPAiHPA027122
neXtProtiNX_Q5TC84
OpenTargetsiENSG00000119900
PharmGKBiPA128394713
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH5X Eukaryota
ENOG4111XCW LUCA
GeneTreeiENSGT00390000018730
HOGENOMiHOG000231272
HOVERGENiHBG066276
InParanoidiQ5TC84
OMAiNSQTSMH
OrthoDBiEOG091G04CN
PhylomeDBiQ5TC84
TreeFamiTF331377

Miscellaneous databases

ChiTaRSiOGFRL1 human
GenomeRNAii79627
PROiPR:Q5TC84

Gene expression databases

BgeeiENSG00000119900 Expressed in 219 organ(s), highest expression level in spinal cord
CleanExiHS_OGFRL1
GenevisibleiQ5TC84 HS

Family and domain databases

InterProiView protein in InterPro
IPR006757 OGF_rcpt
PfamiView protein in Pfam
PF04664 OGFr_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOGRL1_HUMAN
AccessioniPrimary (citable) accession number: Q5TC84
Secondary accession number(s): Q2TAC1, Q8NEQ4, Q9H7B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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