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UniProtKB - Q5TC12 (ATPF1_HUMAN)

Entry version 99 (10 Feb 2021)
Sequence version 1 (05 Feb 2008)
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Protein

ATP synthase mitochondrial F1 complex assembly factor 1

Gene

ATPAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play an essential role for the assembly of the mitochondrial F1-F0 complex.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:ENSG00000123472-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5TC12

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP synthase mitochondrial F1 complex assembly factor 1
Alternative name(s):
ATP11 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATPAF1
Synonyms:ATP11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18803, ATPAF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608917, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5TC12

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000123472.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		64756

MalaCards human disease database

More...MalaCardsi		ATPAF1

Open Targets

More...OpenTargetsi		ENSG00000123472

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		254913, Isolated ATP synthase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38687

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5TC12, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATPAF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		170652901

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 57MitochondrionSequence analysisAdd BLAST57
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031891558 – 328ATP synthase mitochondrial F1 complex assembly factor 1Add BLAST271

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5TC12

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5TC12

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5TC12

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5TC12

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5TC12

PeptideAtlas

More...PeptideAtlasi		Q5TC12

PRoteomics IDEntifications database

More...PRIDEi		Q5TC12

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		64936 [Q5TC12-1]
6856
6874

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5TC12

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5TC12

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Weakly expressed in muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000123472, Expressed in left ventricle myocardium and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5TC12, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5TC12, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000123472, Tissue enhanced (heart)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ATP5B.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122270, 34 interactors

Protein interaction database and analysis system

More...IntActi		Q5TC12, 21 interactors

Molecular INTeraction database

More...MINTi		Q5TC12

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000460964

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5TC12, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5TC12

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATP11 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3281, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012765

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1485271_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5TC12

Database of Orthologous Groups

More...OrthoDBi		1108259at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5TC12

TreeFam database of animal gene trees

More...TreeFami		TF325166

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010591, ATP11

The PANTHER Classification System

More...PANTHERi		PTHR13126, PTHR13126, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06644, ATP11, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5TC12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVVVAAAG GAGPAVLQVA GLYRGLCAVR SRALGLGLVS PAQLRVFPVR 
        60         70         80         90        100
PGSGRPEGGA DSSGVGAEAE LQANPFYDRY RDKIQLLRRS DPAAFESRLE 
       110        120        130        140        150
KRSEFRKQPV GHSRQGDFIK CVEQKTDALG KQSVNRGFTK DKTLSSIFNI 
       160        170        180        190        200
EMVKEKTAEE IKQIWQQYFA AKDTVYAVIP AEKFDLIWNR AQSCPTFLCA 
       210        220        230        240        250
LPRREGYEFF VGQWTGTELH FTALINIQTR GEAAASQLIL YHYPELKEEK 
       260        270        280        290        300
GIVLMTAEMD STFLNVAEAQ CIANQVQLFY ATDRKETYGL VETFNLRPNE 
       310        320 
FKYMSVIAEL EQSGLGAELK CAQNQNKT
Length:328
Mass (Da):36,437
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8981BC21AADE3AA
GO
Isoform 2 (identifier: Q5TC12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Show »
Length:177
Mass (Da):20,281
Checksum:i578BE5DF30D0AF1A
GO
Isoform 3 (identifier: Q5TC12-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MAAVVVAAAG...YRDKIQLLRR → M

Show »
Length:240
Mass (Da):27,438
Checksum:i1F6696F39ADD37E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L448I3L448_HUMAN
ATP synthase mitochondrial F1 compl...
ATPAF1
351Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MRA7A8MRA7_HUMAN
ATP synthase mitochondrial F1 compl...
ATPAF1
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCA6H0YCA6_HUMAN
ATP synthase mitochondrial F1 compl...
ATPAF1
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEW4H0YEW4_HUMAN
ATP synthase mitochondrial F1 compl...
ATPAF1
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD21H0YD21_HUMAN
ATP synthase mitochondrial F1 compl...
ATPAF1
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPX6E9PPX6_HUMAN
ATP synthase mitochondrial F1 compl...
ATPAF1
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDD6H0YDD6_HUMAN
ATP synthase mitochondrial F1 compl...
ATPAF1
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03890662S → G2 PublicationsCorresponds to variant dbSNP:rs11211337Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0454371 – 151Missing in isoform 2. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_0454381 – 89MAAVV…QLLRR → M in isoform 3. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK026004 mRNA Translation: BAB15316.1
AK301874 mRNA Translation: BAH13572.1
AK302090 mRNA Translation: BAH13622.1
AL136373 Genomic DNA No translation available.
AL593856 Genomic DNA No translation available.
BC008498 mRNA Translation: AAH08498.1
BC018781 mRNA Translation: AAH18781.1
BC071731 mRNA Translation: AAH71731.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS57997.1 [Q5TC12-2]
CCDS57998.1 [Q5TC12-3]

NCBI Reference Sequences

More...RefSeqi		NP_001036011.2, NM_001042546.2
NP_001230657.1, NM_001243728.1 [Q5TC12-3]
NP_001243347.1, NM_001256418.1 [Q5TC12-2]
NP_073582.3, NM_022745.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000532925; ENSP00000435732; ENSG00000123472 [Q5TC12-3]
ENST00000542495; ENSP00000443588; ENSG00000123472 [Q5TC12-2]
ENST00000574428; ENSP00000459167; ENSG00000123472 [Q5TC12-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64756

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64756

UCSC genome browser

More...UCSCi		uc009vyk.4, human [Q5TC12-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026004 mRNA Translation: BAB15316.1
AK301874 mRNA Translation: BAH13572.1
AK302090 mRNA Translation: BAH13622.1
AL136373 Genomic DNA No translation available.
AL593856 Genomic DNA No translation available.
BC008498 mRNA Translation: AAH08498.1
BC018781 mRNA Translation: AAH18781.1
BC071731 mRNA Translation: AAH71731.1
CCDSiCCDS57997.1 [Q5TC12-2]
CCDS57998.1 [Q5TC12-3]
RefSeqiNP_001036011.2, NM_001042546.2
NP_001230657.1, NM_001243728.1 [Q5TC12-3]
NP_001243347.1, NM_001256418.1 [Q5TC12-2]
NP_073582.3, NM_022745.4

3D structure databases

SMRiQ5TC12
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122270, 34 interactors
IntActiQ5TC12, 21 interactors
MINTiQ5TC12
STRINGi9606.ENSP00000460964

PTM databases

iPTMnetiQ5TC12
PhosphoSitePlusiQ5TC12

Genetic variation databases

BioMutaiATPAF1
DMDMi170652901

Proteomic databases

EPDiQ5TC12
jPOSTiQ5TC12
MassIVEiQ5TC12
MaxQBiQ5TC12
PaxDbiQ5TC12
PeptideAtlasiQ5TC12
PRIDEiQ5TC12
ProteomicsDBi64936 [Q5TC12-1]
6856
6874

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32819, 80 antibodies

The DNASU plasmid repository

More...DNASUi		64756

Genome annotation databases

EnsembliENST00000532925; ENSP00000435732; ENSG00000123472 [Q5TC12-3]
ENST00000542495; ENSP00000443588; ENSG00000123472 [Q5TC12-2]
ENST00000574428; ENSP00000459167; ENSG00000123472 [Q5TC12-1]
GeneIDi64756
KEGGihsa:64756
UCSCiuc009vyk.4, human [Q5TC12-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64756
DisGeNETi64756

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATPAF1
HGNCiHGNC:18803, ATPAF1
HPAiENSG00000123472, Tissue enhanced (heart)
MalaCardsiATPAF1
MIMi608917, gene
neXtProtiNX_Q5TC12
OpenTargetsiENSG00000123472
Orphaneti254913, Isolated ATP synthase deficiency
PharmGKBiPA38687
VEuPathDBiHostDB:ENSG00000123472.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3281, Eukaryota
GeneTreeiENSGT00390000012765
HOGENOMiCLU_1485271_0_0_1
InParanoidiQ5TC12
OrthoDBi1108259at2759
PhylomeDBiQ5TC12
TreeFamiTF325166

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000123472-MONOMER
PathwayCommonsiQ5TC12

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64756, 6 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATPAF1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ATPAF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64756
PharosiQ5TC12, Tdark

Protein Ontology

More...PROi		PR:Q5TC12
RNActiQ5TC12, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000123472, Expressed in left ventricle myocardium and 217 other tissues
ExpressionAtlasiQ5TC12, baseline and differential
GenevisibleiQ5TC12, HS

Family and domain databases

InterProiView protein in InterPro
IPR010591, ATP11
PANTHERiPTHR13126, PTHR13126, 1 hit
PfamiView protein in Pfam
PF06644, ATP11, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATPF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TC12
Secondary accession number(s): B1AQW7
, B7Z7D6, B7Z7I6, Q9H6E3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 5, 2008
Last modified: February 10, 2021
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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