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Protein
Submitted name:

Serine/threonine-protein kinase Nek6

Gene

NEK6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

SignaLinkiQ5TBG2

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase Nek6Imported
Gene namesi
Name:NEK6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000119408.16
HGNCiHGNC:7749 NEK6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119408

PTM / Processingi

Proteomic databases

MaxQBiQ5TBG2
PeptideAtlasiQ5TBG2
PRIDEiQ5TBG2

Expressioni

Gene expression databases

BgeeiENSG00000119408 Expressed in 176 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiQ5TBG2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5TBG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 171Protein kinaseInterPro annotationAdd BLAST127

Phylogenomic databases

eggNOGiKOG0591 Eukaryota
ENOG410XNQP LUCA
GeneTreeiENSGT00760000118997
HOGENOMiHOG000233029
HOVERGENiHBG105886

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q5TBG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGQPGHMPH GGSSNNLCHT LGPVHPPDPQ RHPNTLSFRC SLADFQIEKK
60 70 80 90 100
IGRGQFSEVY KATCLLDRKT VALKKVQIFE MMDAKARQDC VKEIGLLKQL
110 120 130 140 150
NHPNIIKYLD SFIEDNELNI VLELADAGDL SQMIKYFKKQ KRLIPERTVW
160 170
KYFVQLCSAV EHMHSRRVMH R
Length:171
Mass (Da):19,681
Last modified:February 5, 2008 - v1
Checksum:i8DBA7D0E607121A5
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9HC98NEK6_HUMAN
Serine/threonine-protein kinase Nek...
NEK6
313Annotation score:
Q5TBG7Q5TBG7_HUMAN
Serine/threonine-protein kinase Nek...
NEK6
219Annotation score:
Q5TBH2Q5TBH2_HUMAN
Serine/threonine-protein kinase Nek...
NEK6
220Annotation score:
Q5TBH1Q5TBH1_HUMAN
Serine/threonine-protein kinase Nek...
NEK6
222Annotation score:
Q5TBG1Q5TBG1_HUMAN
Serine/threonine-protein kinase Nek...
NEK6
207Annotation score:
Q5TBG4Q5TBG4_HUMAN
Serine/threonine-protein kinase Nek...
NEK6
194Annotation score:
Q5TBH0Q5TBH0_HUMAN
Serine/threonine-protein kinase Nek...
NEK6
200Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei171Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137846 Genomic DNA No translation available.
AL162724 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000447379; ENSP00000403414; ENSG00000119408
UCSCiuc064vps.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137846 Genomic DNA No translation available.
AL162724 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliQ5TBG2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ5TBG2
PeptideAtlasiQ5TBG2
PRIDEiQ5TBG2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000447379; ENSP00000403414; ENSG00000119408
UCSCiuc064vps.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000119408.16
HGNCiHGNC:7749 NEK6
OpenTargetsiENSG00000119408
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0591 Eukaryota
ENOG410XNQP LUCA
GeneTreeiENSGT00760000118997
HOGENOMiHOG000233029
HOVERGENiHBG105886

Enzyme and pathway databases

SignaLinkiQ5TBG2

Miscellaneous databases

ChiTaRSiNEK6 human

Gene expression databases

BgeeiENSG00000119408 Expressed in 176 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiQ5TBG2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5TBG2_HUMAN
AccessioniPrimary (citable) accession number: Q5TBG2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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