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Entry version 131 (22 Apr 2020)
Sequence version 1 (12 Apr 2005)
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Protein

Ribonuclease H2 subunit B

Gene

RNASEH2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS13612-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.26.4 2681

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonuclease H2 subunit B
Short name:
RNase H2 subunit B
Alternative name(s):
Aicardi-Goutieres syndrome 2 protein
Short name:
AGS2
Deleted in lymphocytic leukemia 8
Ribonuclease HI subunit B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNASEH2B
Synonyms:DLEU8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25671 RNASEH2B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610326 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TBB1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Aicardi-Goutieres syndrome 2 (AGS2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07061143P → H in AGS2. 1 PublicationCorresponds to variant dbSNP:rs79564863Ensembl.1
Natural variantiVAR_02728060L → R in AGS2; heterozygous compound with T-177. 2 PublicationsCorresponds to variant dbSNP:rs75325951Ensembl.1
Natural variantiVAR_07061273W → L in AGS2; reduces stability of the RNase complex. 2 PublicationsCorresponds to variant dbSNP:rs78071087Ensembl.1
Natural variantiVAR_07061383G → S in AGS2; reduces stability of the RNase complex. 2 PublicationsCorresponds to variant dbSNP:rs76158094Ensembl.1
Natural variantiVAR_02728186H → R in AGS2; heterozygous compound with T-177; reduces stability of the RNase complex. 3 PublicationsCorresponds to variant dbSNP:rs77931005Ensembl.1
Natural variantiVAR_070614138L → F in AGS2. 1 PublicationCorresponds to variant dbSNP:rs78705382EnsemblClinVar.1
Natural variantiVAR_070615159S → I in AGS2. 1 PublicationCorresponds to variant dbSNP:rs76219783Ensembl.1
Natural variantiVAR_027282162K → T in AGS2. 2 PublicationsCorresponds to variant dbSNP:rs75971463Ensembl.1
Natural variantiVAR_027283163T → I in AGS2; heterozygous compound with T-177. 2 PublicationsCorresponds to variant dbSNP:rs79310911Ensembl.1
Natural variantiVAR_027284177A → T in AGS2; frequent mutation. 2 PublicationsCorresponds to variant dbSNP:rs75184679EnsemblClinVar.1
Natural variantiVAR_070616183V → M in AGS2. 1 PublicationCorresponds to variant dbSNP:rs77377571Ensembl.1
Natural variantiVAR_027285185V → G in AGS2. 2 PublicationsCorresponds to variant dbSNP:rs74555752EnsemblClinVar.1
Natural variantiVAR_027286219Y → H in AGS2; heterozygous compound with a nonsense mutation; reduces stability of the RNase complex. 3 PublicationsCorresponds to variant dbSNP:rs77391331Ensembl.1
Natural variantiVAR_070617229S → P in AGS2. 1 PublicationCorresponds to variant dbSNP:rs768565639Ensembl.1

Keywords - Diseasei

Aicardi-Goutieres syndrome, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
79621

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
RNASEH2B

MalaCards human disease database

More...
MalaCardsi
RNASEH2B
MIMi610181 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000136104

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
51 Aicardi-Goutieres syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162401418

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5TBB1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RNASEH2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74745929

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002483782 – 312Ribonuclease H2 subunit BAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei295N6-acetyllysineCombined sources1
Modified residuei296PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5TBB1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5TBB1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5TBB1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5TBB1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TBB1

PeptideAtlas

More...
PeptideAtlasi
Q5TBB1

PRoteomics IDEntifications database

More...
PRIDEi
Q5TBB1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
33763
64894 [Q5TBB1-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TBB1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TBB1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136104 Expressed in heart and 178 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5TBB1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TBB1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000136104 Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122751, 43 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-745 RNase H2 complex

Protein interaction database and analysis system

More...
IntActi
Q5TBB1, 31 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337623

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5TBB1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1312
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5TBB1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q5TBB1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNase H2 subunit B family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4705 Eukaryota
ENOG410YS7I LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011439

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_059802_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TBB1

KEGG Orthology (KO)

More...
KOi
K10744

Identification of Orthologs from Complete Genome Data

More...
OMAi
RVQSSAY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TBB1

TreeFam database of animal gene trees

More...
TreeFami
TF105250

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09270 RNase_H2-B, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040456 RNase_H2_suB
IPR019024 RNase_H2_suB_wHTH
IPR041195 Rnh202_N

The PANTHER Classification System

More...
PANTHERi
PTHR13383 PTHR13383, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09468 RNase_H2-Ydr279, 1 hit
PF17745 Ydr279_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 29 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5TBB1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGVDCGDG VGARQHVFLV SEYLKDASKK MKNGLMFVKL VNPCSGEGAI
60 70 80 90 100
YLFNMCLQQL FEVKVFKEKH HSWFINQSVQ SGGLLHFATP VDPLFLLLHY
110 120 130 140 150
LIKADKEGKF QPLDQVVVDN VFPNCILLLK LPGLEKLLHH VTEEKGNPEI
160 170 180 190 200
DNKKYYKYSK EKTLKWLEKK VNQTVAALKT NNVNVSSRVQ STAFFSGDQA
210 220 230 240 250
STDKEEDYIR YAHGLISDYI PKELSDDLSK YLKLPEPSAS LPNPPSKKIK
260 270 280 290 300
LSDEPVEAKE DYTKFNTKDL KTEKKNSKMT AAQKALAKVD KSGMKSIDTF
310
FGVKNKKKIG KV
Length:312
Mass (Da):35,139
Last modified:April 12, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98B1A8E073A50D68
GO
Isoform 2 (identifier: Q5TBB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-257: KIKLSDEPVE → MAAQRQKRGK
     258-312: Missing.

Show »
Length:257
Mass (Da):29,005
Checksum:iD96DCA78CB52F6DF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 29 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZJ6A0A087WZJ6_HUMAN
Ribonuclease H2 subunit B
RNASEH2B
289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXR7A0A087WXR7_HUMAN
Ribonuclease H2 subunit B
RNASEH2B
282Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4S2A0A2R8Y4S2_HUMAN
Ribonuclease H2 subunit B
RNASEH2B
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y761A0A2R8Y761_HUMAN
Ribonuclease H2 subunit B
RNASEH2B
289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6M7A0A2R8Y6M7_HUMAN
Ribonuclease H2 subunit B
RNASEH2B
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6Q6A0A2R8Y6Q6_HUMAN
Ribonuclease H2 subunit B
RNASEH2B
300Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCJ4A0A2R8YCJ4_HUMAN
Ribonuclease H2 subunit B
RNASEH2B
293Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCP1A0A2R8YCP1_HUMAN
Ribonuclease H2 subunit B
RNASEH2B
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCX2A0A2R8YCX2_HUMAN
Ribonuclease H2 subunit B
RNASEH2B
273Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YEH2A0A2R8YEH2_HUMAN
Ribonuclease H2 subunit B
RNASEH2B
324Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH01397 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH07332 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH10174 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61F → L in AAX13343 (Ref. 1) Curated1
Sequence conflicti61F → L in BAB13892 (PubMed:14702039).Curated1
Sequence conflicti305N → K in AAH05088 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07061143P → H in AGS2. 1 PublicationCorresponds to variant dbSNP:rs79564863Ensembl.1
Natural variantiVAR_02728060L → R in AGS2; heterozygous compound with T-177. 2 PublicationsCorresponds to variant dbSNP:rs75325951Ensembl.1
Natural variantiVAR_07061273W → L in AGS2; reduces stability of the RNase complex. 2 PublicationsCorresponds to variant dbSNP:rs78071087Ensembl.1
Natural variantiVAR_07061383G → S in AGS2; reduces stability of the RNase complex. 2 PublicationsCorresponds to variant dbSNP:rs76158094Ensembl.1
Natural variantiVAR_02728186H → R in AGS2; heterozygous compound with T-177; reduces stability of the RNase complex. 3 PublicationsCorresponds to variant dbSNP:rs77931005Ensembl.1
Natural variantiVAR_070614138L → F in AGS2. 1 PublicationCorresponds to variant dbSNP:rs78705382EnsemblClinVar.1
Natural variantiVAR_070615159S → I in AGS2. 1 PublicationCorresponds to variant dbSNP:rs76219783Ensembl.1
Natural variantiVAR_027282162K → T in AGS2. 2 PublicationsCorresponds to variant dbSNP:rs75971463Ensembl.1
Natural variantiVAR_027283163T → I in AGS2; heterozygous compound with T-177. 2 PublicationsCorresponds to variant dbSNP:rs79310911Ensembl.1
Natural variantiVAR_027284177A → T in AGS2; frequent mutation. 2 PublicationsCorresponds to variant dbSNP:rs75184679EnsemblClinVar.1
Natural variantiVAR_070616183V → M in AGS2. 1 PublicationCorresponds to variant dbSNP:rs77377571Ensembl.1
Natural variantiVAR_027285185V → G in AGS2. 2 PublicationsCorresponds to variant dbSNP:rs74555752EnsemblClinVar.1
Natural variantiVAR_027286219Y → H in AGS2; heterozygous compound with a nonsense mutation; reduces stability of the RNase complex. 3 PublicationsCorresponds to variant dbSNP:rs77391331Ensembl.1
Natural variantiVAR_070617229S → P in AGS2. 1 PublicationCorresponds to variant dbSNP:rs768565639Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054039248 – 257KIKLSDEPVE → MAAQRQKRGK in isoform 2. Curated10
Alternative sequenceiVSP_054040258 – 312Missing in isoform 2. CuratedAdd BLAST55

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY764036 mRNA Translation: AAX13343.1
AK021774 mRNA Translation: BAB13892.1
AK223340 mRNA Translation: BAD97060.1
AL137881 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08864.1
BC001397 mRNA Translation: AAH01397.1 Sequence problems.
BC005088 mRNA Translation: AAH05088.1
BC007332 mRNA Translation: AAH07332.1 Sequence problems.
BC010174 mRNA Translation: AAH10174.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS45047.1 [Q5TBB1-2]
CCDS9425.1 [Q5TBB1-1]

NCBI Reference Sequences

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RefSeqi
NP_001135751.1, NM_001142279.2 [Q5TBB1-2]
NP_078846.2, NM_024570.3 [Q5TBB1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336617; ENSP00000337623; ENSG00000136104 [Q5TBB1-1]
ENST00000422660; ENSP00000389877; ENSG00000136104 [Q5TBB1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79621

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79621

UCSC genome browser

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UCSCi
uc001vfa.4 human [Q5TBB1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY764036 mRNA Translation: AAX13343.1
AK021774 mRNA Translation: BAB13892.1
AK223340 mRNA Translation: BAD97060.1
AL137881 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08864.1
BC001397 mRNA Translation: AAH01397.1 Sequence problems.
BC005088 mRNA Translation: AAH05088.1
BC007332 mRNA Translation: AAH07332.1 Sequence problems.
BC010174 mRNA Translation: AAH10174.1 Sequence problems.
CCDSiCCDS45047.1 [Q5TBB1-2]
CCDS9425.1 [Q5TBB1-1]
RefSeqiNP_001135751.1, NM_001142279.2 [Q5TBB1-2]
NP_078846.2, NM_024570.3 [Q5TBB1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P56X-ray4.06B/E2-226[»]
3P87X-ray2.99G/H/I/J/K/L290-312[»]
3PUFX-ray3.10B/E/H/K/N/Q14-233[»]
SMRiQ5TBB1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi122751, 43 interactors
ComplexPortaliCPX-745 RNase H2 complex
IntActiQ5TBB1, 31 interactors
STRINGi9606.ENSP00000337623

PTM databases

iPTMnetiQ5TBB1
PhosphoSitePlusiQ5TBB1

Polymorphism and mutation databases

BioMutaiRNASEH2B
DMDMi74745929

Proteomic databases

EPDiQ5TBB1
jPOSTiQ5TBB1
MassIVEiQ5TBB1
MaxQBiQ5TBB1
PaxDbiQ5TBB1
PeptideAtlasiQ5TBB1
PRIDEiQ5TBB1
ProteomicsDBi33763
64894 [Q5TBB1-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
42315 196 antibodies

The DNASU plasmid repository

More...
DNASUi
79621

Genome annotation databases

EnsembliENST00000336617; ENSP00000337623; ENSG00000136104 [Q5TBB1-1]
ENST00000422660; ENSP00000389877; ENSG00000136104 [Q5TBB1-2]
GeneIDi79621
KEGGihsa:79621
UCSCiuc001vfa.4 human [Q5TBB1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79621
DisGeNETi79621

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RNASEH2B
GeneReviewsiRNASEH2B
HGNCiHGNC:25671 RNASEH2B
HPAiENSG00000136104 Tissue enhanced (lymphoid)
MalaCardsiRNASEH2B
MIMi610181 phenotype
610326 gene
neXtProtiNX_Q5TBB1
OpenTargetsiENSG00000136104
Orphaneti51 Aicardi-Goutieres syndrome
PharmGKBiPA162401418

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4705 Eukaryota
ENOG410YS7I LUCA
GeneTreeiENSGT00390000011439
HOGENOMiCLU_059802_0_0_1
InParanoidiQ5TBB1
KOiK10744
OMAiRVQSSAY
PhylomeDBiQ5TBB1
TreeFamiTF105250

Enzyme and pathway databases

BioCyciMetaCyc:HS13612-MONOMER
BRENDAi3.1.26.4 2681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RNASEH2B human
EvolutionaryTraceiQ5TBB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79621
PharosiQ5TBB1 Tbio

Protein Ontology

More...
PROi
PR:Q5TBB1
RNActiQ5TBB1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136104 Expressed in heart and 178 other tissues
ExpressionAtlasiQ5TBB1 baseline and differential
GenevisibleiQ5TBB1 HS

Family and domain databases

CDDicd09270 RNase_H2-B, 1 hit
InterProiView protein in InterPro
IPR040456 RNase_H2_suB
IPR019024 RNase_H2_suB_wHTH
IPR041195 Rnh202_N
PANTHERiPTHR13383 PTHR13383, 1 hit
PfamiView protein in Pfam
PF09468 RNase_H2-Ydr279, 1 hit
PF17745 Ydr279_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNH2B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TBB1
Secondary accession number(s): G3XAJ1
, Q05DR2, Q6PK48, Q9HAF7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: April 12, 2005
Last modified: April 22, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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