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Entry version 131 (12 Aug 2020)
Sequence version 1 (21 Dec 2004)
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Protein

Protein furry homolog

Gene

FRY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5TBA9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein furry homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FRY
Synonyms:C13orf14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000073910.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20367, FRY

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614818, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TBA9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10129

Open Targets

More...
OpenTargetsi
ENSG00000073910

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134927490

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5TBA9, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FRY

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74745928

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002816741 – 3013Protein furry homologAdd BLAST3013

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei213PhosphotyrosineCombined sources1
Modified residuei1382PhosphoserineBy similarity1
Modified residuei1383PhosphoserineBy similarity1
Modified residuei1936PhosphoserineCombined sources1
Modified residuei1940PhosphoserineBy similarity1
Modified residuei2419PhosphoserineBy similarity1
Modified residuei2420PhosphoserineBy similarity1
Modified residuei2487PhosphoserineBy similarity1
Modified residuei2508Phosphothreonine; by CDK1By similarity1
Modified residuei2808PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by AURKA, CDK1 and PLK1.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5TBA9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5TBA9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5TBA9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5TBA9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TBA9

PeptideAtlas

More...
PeptideAtlasi
Q5TBA9

PRoteomics IDEntifications database

More...
PRIDEi
Q5TBA9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64893

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TBA9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TBA9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000073910, Expressed in forebrain and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5TBA9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TBA9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000073910, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

When phosphorylated by CDK1, interacts with PLK1; this interaction occurs in mitotic cells, but not in interphase cells, and leads to further phosphorylation by PLK1.

Interacts with AURKA.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115433, 8 interactors

Protein interaction database and analysis system

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IntActi
Q5TBA9, 6 interactors

Molecular INTeraction database

More...
MINTi
Q5TBA9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000445043

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5TBA9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the furry protein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1825, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00610000086058

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000483_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TBA9

Identification of Orthologs from Complete Genome Data

More...
OMAi
AFKHFRY

Database of Orthologous Groups

More...
OrthoDBi
11874at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TBA9

TreeFam database of animal gene trees

More...
TreeFami
TF313568

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025614, Cell_morpho_N
IPR025481, Cell_Morphogen_C
IPR039867, Furry/Tao3/Mor2
IPR029473, MOR2-PAG1_mid

The PANTHER Classification System

More...
PANTHERi
PTHR12295, PTHR12295, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14225, MOR2-PAG1_C, 1 hit
PF14228, MOR2-PAG1_mid, 4 hits
PF14222, MOR2-PAG1_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q5TBA9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASQQDSGFF EISIKYLLKS WSNTSPVGNG YIKPPVPPAS GTHREKGPPT
60 70 80 90 100
MLPINVDPDS KPGEYVLKSL FVNFTTQAER KIRIIMAEPL EKPLTKSLQR
110 120 130 140 150
GEDPQFDQVI SSMSSLSEYC LPSILRTLFD WYKRQNGIED ESHEYRPRTS
160 170 180 190 200
NKSKSDEQQR DYLMERRDLA IDFIFSLVLI EVLKQIPLHP VIDSLIHDVI
210 220 230 240 250
NLAFKHFKYK EGYLGPNTGN MHIVADLYAE VIGVLAQAKF PAVKKKFMAE
260 270 280 290 300
LKELRHKEQN PYVVQSIISL IMGMKFFRIK MYPVEDFEAS LQFMQECAHY
310 320 330 340 350
FLEVKDKDIK HALAGLFVEI LVPVAAAVKN EVNVPCLRNF VESLYDTTLE
360 370 380 390 400
LSSRKKHSLA LYPLVTCLLC VSQKQLFLNR WHIFLNNCLS NLKNKDPKMA
410 420 430 440 450
RVALESLYRL LWVYMIRIKC ESNTATQSRL ITIITTLFPK GSRGVVPRDM
460 470 480 490 500
PLNIFVKIIQ FIAQERLDFA MKEIIFDFLC VGKPAKAFSL NPERMNIGLR
510 520 530 540 550
AFLVIADSLQ QKDGEPPMPV TGAVLPSGNT LRVKKTYLSK TLTEEEAKMI
560 570 580 590 600
GMSLYYSQVR KAVDNILRHL DKEVGRCMML TNVQMLNKEP EDMITGERKP
610 620 630 640 650
KIDLFRTCVA AIPRLLPDGM SKLELIDLLA RLSIHMDDEL RHIAQNSLQG
660 670 680 690 700
LLVDFSDWRE DVLFGFTNFL LREVNDMHHT LLDSSLKLLL QLLTQWKLVI
710 720 730 740 750
QTQGKVYEQA NKIRNSELIA NGSSHRIQSE RGPHCSVLHA VEGFALVLLC
760 770 780 790 800
SFQVATRKLS VLILKEIRAL FIALGQPEDD DRPMIDVMDQ LSSSILESFI
810 820 830 840 850
HVAVSDSATL PLTHNVDLQW LVEWNAVLVN SHYDVKSPSH VWIFAQSVKD
860 870 880 890 900
PWVLCLFSFL RQENLPKHCP TALSYAWPYA FTRLQSVMPL VDPNSPINAK
910 920 930 940 950
KTSTAGSGDN YVTLWRNYLI LCFGVAKPSI MSPGHLRAST PEIMATTPDG
960 970 980 990 1000
TVSYDNKAIG TPSVGVLLKQ LVPLMRLESI EITESLVLGF GRTNSLVFRE
1010 1020 1030 1040 1050
LVEELHPLMK EALERRPENK KRRERRDLLR LQLLRIFELL ADAGVISDST
1060 1070 1080 1090 1100
NGALERDTLA LGALFLEYVD LTRMLLEAEN DKEVEILKDI RAHFSAMVAN
1110 1120 1130 1140 1150
LIQCVPVHHR RFLFPQQSLR HHLFILFSQW AGPFSIMFTP LDRYSDRNHQ
1160 1170 1180 1190 1200
ITRYQYCALK AMSAVLCCGP VFDNVGLSPD GYLYKWLDNI LACQDLRVHQ
1210 1220 1230 1240 1250
LGCEVVVLLL ELNPDQINLF NWAIDRCYTG SYQLASGCFK AIATVCGSRN
1260 1270 1280 1290 1300
YPFDIVTLLN LVLFKASDTN REIYEISMQL MQILEAKLFV YSKKVAEQRP
1310 1320 1330 1340 1350
GSILYGTHGP LPPLYSVSLA LLSCELARMY PELTLPLFSE VSQRFPTTHP
1360 1370 1380 1390 1400
NGRQIMLTYL LPWLHNIELV DSRLLLPGSS PSSPEDEVKD REGDVTASHG
1410 1420 1430 1440 1450
LRGNGWGSPE ATSLVLNNLM YMTAKYGDEV PGPEMENAWN ALANNEKWSN
1460 1470 1480 1490 1500
NLRITLQFLI SLCGVSSDTV LLPYIKKVAI YLCRNNTIQT MEELLFELQQ
1510 1520 1530 1540 1550
TEPVNPIVQH CDNPPFYRFT ASSKASAAAS GTTSSSNTVV AGQENFPDAE
1560 1570 1580 1590 1600
ENKILKESDE RFSNVIRAHT RLESRYSNSS GGSYDEDKND PISPYTGWLL
1610 1620 1630 1640 1650
TITETKQPQP LPMPCTGGCW APLVDYLPET ITPRGPLHRC NIAVIFMTEM
1660 1670 1680 1690 1700
VVDHSVREDW ALHLPLLLHA VFLGLDHYRP EVFEHSKKLL LHLLIALSCN
1710 1720 1730 1740 1750
SNFHSIASVL LQTREMGEAK TLTVQPAYQP EYLYTGGFDF LREDQSSPVP
1760 1770 1780 1790 1800
DSGLSSSSTS SSISLGGSSG NLPQMTQEVE DVDTAAETDE KANKLIEFLT
1810 1820 1830 1840 1850
TRAFGPLWCH EDITPKNQNS KSAEQLTNFL RHVVSVFKDS KSGFHLEHQL
1860 1870 1880 1890 1900
SEVALQTALA SSSRHYAGRS FQIFRALKQP LSAHALSDLL SRLVEVIGEH
1910 1920 1930 1940 1950
GDEIQGYVME ALLTLEAAVD NLSDCLKNSD LLTVLSRSSS PDLSSSSKLT
1960 1970 1980 1990 2000
ASRKSTGQLN MNPGTTSGNT ATAERSRHQR SFSVPKKFGV IDRSSDPPRS
2010 2020 2030 2040 2050
ATLDRIQACT QQGLSSKTRS SSSLKDSLTD PSHINHPTNL LATIFWVTVA
2060 2070 2080 2090 2100
LMESDFEFEY LMALRLLSRL LAHMPLDKAE NREKLEKLQA QLKWADFSGL
2110 2120 2130 2140 2150
QQLLLKGFTS LTTTDLTLQL FSLLTPVSKI SMVDASHAIG FPLNVLCLLP
2160 2170 2180 2190 2200
QLIQHFENPN QFCKDIAERI AQVCLEEKNP KLSNLAHVMT LYKTHSYTRD
2210 2220 2230 2240 2250
CATWVNVVCR YLHEAYADIT LNMVTYLAEL LEKGLPSVQQ PLLQVIYSLL
2260 2270 2280 2290 2300
SYMDLSVVPV KQFNVEVLKT IEKYVQSVHW REALNILKLV VSRSASLVLP
2310 2320 2330 2340 2350
SYQHSDLSKI EIHRVWTSAS KELPGKTLDF HFDISETPII GRRYDELQNS
2360 2370 2380 2390 2400
SGRDGKPRAM AVTRSTSSTS SGSNSNVLVP VSWKRPQYSQ KRTKEKLVHV
2410 2420 2430 2440 2450
LSLCGQEVGL SKNPSVIFSS CGDLDLLEHQ TSLVSSEDGA REQENMDDTN
2460 2470 2480 2490 2500
SEQQFRVFRD FDFLDVELED GEGESMDNFN WGVRRRSLDS LDKCDMQILE
2510 2520 2530 2540 2550
ERQLSGSTPS LNKMHHEDSD ESSEEEDLTA SQILEHSDLI MTLSPSEETN
2560 2570 2580 2590 2600
PMELLTTACD STPAEPHSFN TRMSSFDASL PDMNNLQISE GSKAEAVREE
2610 2620 2630 2640 2650
EDTTVHEDDL SSSINELPAA FECSDSFSLD MTEGEEKGNR ALDQFTLASF
2660 2670 2680 2690 2700
GEGDRGVSPP PSPFFSAILA AFQPAACDDA EEAWRSHINQ LMCDSDGSCA
2710 2720 2730 2740 2750
VYTFHVFSSL FKNIQKRFCF LTCDAASYLG DNLRGIGSKF VSSSQMLTSC
2760 2770 2780 2790 2800
SECPTLFVDA ETLLSCGLLD KLKFSVLELQ EYLDTYNNRK EATLSWLANC
2810 2820 2830 2840 2850
KATFAGGSRD GVITCQPGDS EEKQLELCQR LYKLHFQLLL LFQSYCKLIG
2860 2870 2880 2890 2900
QVHEVSSMPE LLNMSRELSD LKKHLKEASA VIAADPLYSD GAWSEPTFTS
2910 2920 2930 2940 2950
TEAAIQSMLE CLKNNELGKA LRQIRECRSL WPNDIFGSSS DDEVQTLLNI
2960 2970 2980 2990 3000
YFRHQTLGQT GTYALVGSNQ SLTEICTKLM ELNMEIRDMI RRAQSYRVLT
3010
TFLPDSSVSG TSL
Length:3,013
Mass (Da):338,875
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2AB5EDB7D2529538
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFX2A0A0C4DFX2_HUMAN
Protein furry homolog
FRY
3,012Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YFA9A0A286YFA9_HUMAN
Protein furry homolog
FRY
3,016Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCY2A0A2R8YCY2_HUMAN
Protein furry homolog
FRY
2,963Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5V8A0A2R8Y5V8_HUMAN
Protein furry homolog
FRY
3,058Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE00H0YE00_HUMAN
Protein furry homolog
FRY
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ALA1B1ALA1_HUMAN
Protein furry homolog
FRY
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7Y8A0A2R8Y7Y8_HUMAN
Protein furry homolog
FRY
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB42442 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0538311968G → S. Corresponds to variant dbSNP:rs2806639Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL049784 mRNA Translation: CAB42442.1 Frameshift.
AL137143 Genomic DNA No translation available.
AL138692 Genomic DNA No translation available.
AL445212 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS41875.1

NCBI Reference Sequences

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RefSeqi
NP_075463.2, NM_023037.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000542859; ENSP00000445043; ENSG00000073910

Database of genes from NCBI RefSeq genomes

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GeneIDi
10129

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10129

UCSC genome browser

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UCSCi
uc001utx.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049784 mRNA Translation: CAB42442.1 Frameshift.
AL137143 Genomic DNA No translation available.
AL138692 Genomic DNA No translation available.
AL445212 Genomic DNA No translation available.
CCDSiCCDS41875.1
RefSeqiNP_075463.2, NM_023037.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi115433, 8 interactors
IntActiQ5TBA9, 6 interactors
MINTiQ5TBA9
STRINGi9606.ENSP00000445043

PTM databases

iPTMnetiQ5TBA9
PhosphoSitePlusiQ5TBA9

Polymorphism and mutation databases

BioMutaiFRY
DMDMi74745928

Proteomic databases

EPDiQ5TBA9
jPOSTiQ5TBA9
MassIVEiQ5TBA9
MaxQBiQ5TBA9
PaxDbiQ5TBA9
PeptideAtlasiQ5TBA9
PRIDEiQ5TBA9
ProteomicsDBi64893

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
63056, 40 antibodies

Genome annotation databases

EnsembliENST00000542859; ENSP00000445043; ENSG00000073910
GeneIDi10129
KEGGihsa:10129
UCSCiuc001utx.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10129
DisGeNETi10129
EuPathDBiHostDB:ENSG00000073910.19

GeneCards: human genes, protein and diseases

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GeneCardsi
FRY
HGNCiHGNC:20367, FRY
HPAiENSG00000073910, Low tissue specificity
MIMi614818, gene
neXtProtiNX_Q5TBA9
OpenTargetsiENSG00000073910
PharmGKBiPA134927490

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1825, Eukaryota
GeneTreeiENSGT00610000086058
HOGENOMiCLU_000483_0_0_1
InParanoidiQ5TBA9
OMAiAFKHFRY
OrthoDBi11874at2759
PhylomeDBiQ5TBA9
TreeFamiTF313568

Enzyme and pathway databases

PathwayCommonsiQ5TBA9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
10129, 4 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FRY, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10129
PharosiQ5TBA9, Tbio

Protein Ontology

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PROi
PR:Q5TBA9
RNActiQ5TBA9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000073910, Expressed in forebrain and 237 other tissues
ExpressionAtlasiQ5TBA9, baseline and differential
GenevisibleiQ5TBA9, HS

Family and domain databases

InterProiView protein in InterPro
IPR025614, Cell_morpho_N
IPR025481, Cell_Morphogen_C
IPR039867, Furry/Tao3/Mor2
IPR029473, MOR2-PAG1_mid
PANTHERiPTHR12295, PTHR12295, 1 hit
PfamiView protein in Pfam
PF14225, MOR2-PAG1_C, 1 hit
PF14228, MOR2-PAG1_mid, 4 hits
PF14222, MOR2-PAG1_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRY_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TBA9
Secondary accession number(s): Q9Y3N6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 21, 2004
Last modified: August 12, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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