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UniProtKB - Q5TB52 (Q5TB52_HUMAN)
Protein
Submitted name:
3'-phosphoadenosine 5'-phosphosulfate synthase 2, isoform CRA_b
Gene
PAPSS2
Organism
Homo sapiens (Human)
Status
Functioni
: sulfate assimilation Pathwayi
This protein is involved in the pathway sulfate assimilation, which is part of Sulfur metabolism.ARBA annotationView all proteins of this organism that are known to be involved in the pathway sulfate assimilation and in Sulfur metabolism.
GO - Molecular functioni
- adenylylsulfate kinase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
- sulfate adenylyltransferase (ATP) activity Source: UniProtKB-EC
GO - Biological processi
- sulfate assimilation Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Multifunctional enzymeARBA annotation, NucleotidyltransferaseARBA annotation, Transferase |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00097 |
Names & Taxonomyi
Protein namesi | Submitted name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2, isoform CRA_bImportedSubmitted name: Epididymis secretory sperm binding proteinImportedSubmitted name: cDNA, FLJ92929, highly similar to Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), mRNAImported |
Gene namesi | Name:PAPSS2Imported ORF Names:hCG_23331Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000198682 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198682, Expressed in metanephros and 226 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 223 – 375 | PUA_2InterPro annotationAdd BLAST | 153 | |
Domaini | 384 – 606 | ATP-sulfurylaseInterPro annotationAdd BLAST | 223 |
Sequence similaritiesi
In the C-terminal section; belongs to the sulfate adenylyltransferase family.ARBA annotation
In the N-terminal section; belongs to the APS kinase family.ARBA annotation
Phylogenomic databases
HOGENOMi | CLU_009463_3_0_1 |
Family and domain databases
CDDi | cd02027, APSK, 1 hit cd00517, ATPS, 1 hit |
Gene3Di | 3.40.50.300, 1 hit 3.40.50.620, 1 hit |
HAMAPi | MF_00065, Adenylyl_sulf_kinase, 1 hit |
InterProi | View protein in InterPro IPR002891, APS_kinase IPR025980, ATP-Sase_PUA-like_dom IPR027417, P-loop_NTPase IPR015947, PUA-like_sf IPR014729, Rossmann-like_a/b/a_fold IPR024951, Sulfurylase_cat_dom IPR002650, Sulphate_adenylyltransferase |
Pfami | View protein in Pfam PF01747, ATP-sulfurylase, 1 hit PF14306, PUA_2, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF88697, SSF88697, 1 hit |
TIGRFAMsi | TIGR00455, apsK, 1 hit TIGR00339, sopT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5TB52-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGIKKQKTE NQQKSTNVVY QAHHVSRNKR GQVVGTRGGF RGCTVWLTGL
60 70 80 90 100
SGAGKTTISF ALEEYLVSHA IPCYSLDGDN VRHGLNRNLG FSPGDREENI
110 120 130 140 150
RRIAEVAKLF ADAGLVCITS FISPFAKDRE NARKIHESAG LPFFEIFVDA
160 170 180 190 200
PLNICESRDV KGLYKRARAG EIKGFTGIDS DYEKPETPER VLKTNLSTVS
210 220 230 240 250
DCVHQVVELL QEQNIVPYTI IKDIHELFVP ENKLDHVRAE AETLPSLSIT
260 270 280 290 300
KLDLQWVQVL SEGWATPLKG FMREKEYLQV MHFDTLLDDG VINMSIPIVL
310 320 330 340 350
PVSAEDKTRL EGCSKFVLAH GGRRVAILRD AEFYEHRKEE RCSRVWGTTC
360 370 380 390 400
TKHPHIKMVM ESGDWLVGGD LQVLEKIRWN DGLDQYRLTP LELKQKCKEM
410 420 430 440 450
NADAVFAFQL RNPVHNGHAL LMQDTRRRLL ERGYKHPVLL LHPLGGWTKD
460 470 480 490 500
DDVPLDWRMK QHAAVLEEGV LDPKSTIVAI FPSPMLYAGP TEVQWHCRSR
510 520 530 540 550
MIAGANFYIV GRDPAGMPHP ETKKDLYEPT HGGKVLSMAP GLTSVEIIPF
560 570 580 590 600
RVAAYNKAKK AMDFYDPARH NEFDFISGTR MRKLAREGEN PPDGFMAPKA
610
WKVLTDYYRS LEKN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ891452 mRNA Translation: ADO22314.1 AK312556 mRNA Translation: BAG35453.1 CH471066 Genomic DNA Translation: EAW50182.1 |
RefSeqi | NP_004661.2, NM_004670.3 |
Genome annotation databases
GeneIDi | 9060 |
KEGGi | hsa:9060 |
UCSCi | uc001kex.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ891452 mRNA Translation: ADO22314.1 AK312556 mRNA Translation: BAG35453.1 CH471066 Genomic DNA Translation: EAW50182.1 |
RefSeqi | NP_004661.2, NM_004670.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 30161, 240 antibodies from 25 providers |
DNASUi | 9060 |
Genome annotation databases
GeneIDi | 9060 |
KEGGi | hsa:9060 |
UCSCi | uc001kex.4, human |
Organism-specific databases
CTDi | 9060 |
PharmGKBi | PA383 |
VEuPathDBi | HostDB:ENSG00000198682 |
Phylogenomic databases
HOGENOMi | CLU_009463_3_0_1 |
Enzyme and pathway databases
UniPathwayi | UPA00097 |
Miscellaneous databases
BioGRID-ORCSi | 9060, 6 hits in 1039 CRISPR screens |
ChiTaRSi | PAPSS2, human |
GenomeRNAii | 9060 |
Gene expression databases
Bgeei | ENSG00000198682, Expressed in metanephros and 226 other tissues |
Family and domain databases
CDDi | cd02027, APSK, 1 hit cd00517, ATPS, 1 hit |
Gene3Di | 3.40.50.300, 1 hit 3.40.50.620, 1 hit |
HAMAPi | MF_00065, Adenylyl_sulf_kinase, 1 hit |
InterProi | View protein in InterPro IPR002891, APS_kinase IPR025980, ATP-Sase_PUA-like_dom IPR027417, P-loop_NTPase IPR015947, PUA-like_sf IPR014729, Rossmann-like_a/b/a_fold IPR024951, Sulfurylase_cat_dom IPR002650, Sulphate_adenylyltransferase |
Pfami | View protein in Pfam PF01747, ATP-sulfurylase, 1 hit PF14306, PUA_2, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF88697, SSF88697, 1 hit |
TIGRFAMsi | TIGR00455, apsK, 1 hit TIGR00339, sopT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5TB52_HUMAN | |
Accessioni | Q5TB52Primary (citable) accession number: Q5TB52 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | January 19, 2022 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |