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Protein
Submitted name:

3'-phosphoadenosine 5'-phosphosulfate synthase 2, isoform CRA_b

Gene

PAPSS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
3'-phosphoadenosine 5'-phosphosulfate synthase 2, isoform CRA_bImported
Submitted name:
cDNA, FLJ92929, highly similar to Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), mRNAImported
Gene namesi
Name:PAPSS2Imported
ORF Names:hCG_23331Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000198682.12

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA383

Expressioni

Gene expression databases

BgeeiENSG00000198682 Expressed in 215 organ(s), highest expression level in metanephros

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini223 – 375PUA_2InterPro annotationAdd BLAST153
Domaini384 – 606ATP-sulfurylaseInterPro annotationAdd BLAST223

Phylogenomic databases

eggNOGiKOG0635 Eukaryota
KOG4238 Eukaryota
COG0529 LUCA
COG2046 LUCA
HOVERGENiHBG053503
KOiK13811

Family and domain databases

CDDicd02027 APSK, 1 hit
cd00517 ATPS, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00065 Adenylyl_sulf_kinase, 1 hit
InterProiView protein in InterPro
IPR002891 APS_kinase
IPR025980 ATP-Sase_PUA-like_dom
IPR027417 P-loop_NTPase
IPR015947 PUA-like_sf
IPR014729 Rossmann-like_a/b/a_fold
IPR024951 Sulfurylase_cat_dom
IPR002650 Sulphate_adenylyltransferase
PfamiView protein in Pfam
PF01747 ATP-sulfurylase, 1 hit
PF14306 PUA_2, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00455 apsK, 1 hit
TIGR00339 sopT, 1 hit

Sequencei

Sequence statusi: Complete.

Q5TB52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGIKKQKTE NQQKSTNVVY QAHHVSRNKR GQVVGTRGGF RGCTVWLTGL
60 70 80 90 100
SGAGKTTISF ALEEYLVSHA IPCYSLDGDN VRHGLNRNLG FSPGDREENI
110 120 130 140 150
RRIAEVAKLF ADAGLVCITS FISPFAKDRE NARKIHESAG LPFFEIFVDA
160 170 180 190 200
PLNICESRDV KGLYKRARAG EIKGFTGIDS DYEKPETPER VLKTNLSTVS
210 220 230 240 250
DCVHQVVELL QEQNIVPYTI IKDIHELFVP ENKLDHVRAE AETLPSLSIT
260 270 280 290 300
KLDLQWVQVL SEGWATPLKG FMREKEYLQV MHFDTLLDDG VINMSIPIVL
310 320 330 340 350
PVSAEDKTRL EGCSKFVLAH GGRRVAILRD AEFYEHRKEE RCSRVWGTTC
360 370 380 390 400
TKHPHIKMVM ESGDWLVGGD LQVLEKIRWN DGLDQYRLTP LELKQKCKEM
410 420 430 440 450
NADAVFAFQL RNPVHNGHAL LMQDTRRRLL ERGYKHPVLL LHPLGGWTKD
460 470 480 490 500
DDVPLDWRMK QHAAVLEEGV LDPKSTIVAI FPSPMLYAGP TEVQWHCRSR
510 520 530 540 550
MIAGANFYIV GRDPAGMPHP ETKKDLYEPT HGGKVLSMAP GLTSVEIIPF
560 570 580 590 600
RVAAYNKAKK AMDFYDPARH NEFDFISGTR MRKLAREGEN PPDGFMAPKA
610
WKVLTDYYRS LEKN
Length:614
Mass (Da):69,501
Last modified:May 10, 2005 - v1
Checksum:i52F4B6D972DDA91E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312556 mRNA Translation: BAG35453.1
CH471066 Genomic DNA Translation: EAW50182.1
RefSeqiNP_004661.2, NM_004670.3
UniGeneiHs.524491

Genome annotation databases

GeneIDi9060
KEGGihsa:9060
UCSCiuc001kex.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312556 mRNA Translation: BAG35453.1
CH471066 Genomic DNA Translation: EAW50182.1
RefSeqiNP_004661.2, NM_004670.3
UniGeneiHs.524491

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi9060
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9060
KEGGihsa:9060
UCSCiuc001kex.4 human

Organism-specific databases

CTDi9060
EuPathDBiHostDB:ENSG00000198682.12
PharmGKBiPA383

Phylogenomic databases

eggNOGiKOG0635 Eukaryota
KOG4238 Eukaryota
COG0529 LUCA
COG2046 LUCA
HOVERGENiHBG053503
KOiK13811

Miscellaneous databases

ChiTaRSiPAPSS2 human
GenomeRNAii9060

Gene expression databases

BgeeiENSG00000198682 Expressed in 215 organ(s), highest expression level in metanephros

Family and domain databases

CDDicd02027 APSK, 1 hit
cd00517 ATPS, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00065 Adenylyl_sulf_kinase, 1 hit
InterProiView protein in InterPro
IPR002891 APS_kinase
IPR025980 ATP-Sase_PUA-like_dom
IPR027417 P-loop_NTPase
IPR015947 PUA-like_sf
IPR014729 Rossmann-like_a/b/a_fold
IPR024951 Sulfurylase_cat_dom
IPR002650 Sulphate_adenylyltransferase
PfamiView protein in Pfam
PF01747 ATP-sulfurylase, 1 hit
PF14306 PUA_2, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00455 apsK, 1 hit
TIGR00339 sopT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5TB52_HUMAN
AccessioniPrimary (citable) accession number: Q5TB52
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 10, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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