PAPSS2

Functionⁱ

GO - Molecular functionⁱ

adenylylsulfate kinase activity Source: InterPro
ATP binding Source: InterPro
sulfate adenylyltransferase (ATP) activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

sulfate assimilation Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2, isoform CRA_bImported Submitted name: cDNA, FLJ92929, highly similar to Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), mRNAImported
Gene namesⁱ	Name:PAPSS2Imported ORF Names:hCG_23331Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198682.12

EuPathDBⁱ

HostDB:ENSG00000198682.12

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA383

PharmGKBⁱ

PA383

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198682 Expressed in 215 organ(s), highest expression level in metanephros

Bgeeⁱ

ENSG00000198682 Expressed in 215 organ(s), highest expression level in metanephros

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	223 – 375	PUA_2InterPro annotationAdd BLAST		153
Domainⁱ	384 – 606	ATP-sulfurylaseInterPro annotationAdd BLAST		223

Phylogenomic databases

eggNOGⁱ	KOG0635 Eukaryota KOG4238 Eukaryota COG0529 LUCA COG2046 LUCA
HOVERGENⁱ	HBG053503
KEGG Orthology (KO) More...KOⁱ	K13811

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02027 APSK, 1 hit cd00517 ATPS, 1 hit
Gene3Dⁱ	3.40.50.620, 1 hit
HAMAPⁱ	MF_00065 Adenylyl_sulf_kinase, 1 hit
InterProⁱ	View protein in InterPro IPR002891 APS_kinase IPR025980 ATP-Sase_PUA-like_dom IPR027417 P-loop_NTPase IPR015947 PUA-like_sf IPR014729 Rossmann-like_a/b/a_fold IPR024951 Sulfurylase_cat_dom IPR002650 Sulphate_adenylyltransferase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01747 ATP-sulfurylase, 1 hit PF14306 PUA_2, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit SSF88697 SSF88697, 1 hit
TIGRFAMsⁱ	TIGR00455 apsK, 1 hit TIGR00339 sopT, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5TB52-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSGIKKQKTE NQQKSTNVVY QAHHVSRNKR GQVVGTRGGF RGCTVWLTGL 
        60         70         80         90        100
SGAGKTTISF ALEEYLVSHA IPCYSLDGDN VRHGLNRNLG FSPGDREENI 
       110        120        130        140        150
RRIAEVAKLF ADAGLVCITS FISPFAKDRE NARKIHESAG LPFFEIFVDA 
       160        170        180        190        200
PLNICESRDV KGLYKRARAG EIKGFTGIDS DYEKPETPER VLKTNLSTVS 
       210        220        230        240        250
DCVHQVVELL QEQNIVPYTI IKDIHELFVP ENKLDHVRAE AETLPSLSIT 
       260        270        280        290        300
KLDLQWVQVL SEGWATPLKG FMREKEYLQV MHFDTLLDDG VINMSIPIVL 
       310        320        330        340        350
PVSAEDKTRL EGCSKFVLAH GGRRVAILRD AEFYEHRKEE RCSRVWGTTC 
       360        370        380        390        400
TKHPHIKMVM ESGDWLVGGD LQVLEKIRWN DGLDQYRLTP LELKQKCKEM 
       410        420        430        440        450
NADAVFAFQL RNPVHNGHAL LMQDTRRRLL ERGYKHPVLL LHPLGGWTKD 
       460        470        480        490        500
DDVPLDWRMK QHAAVLEEGV LDPKSTIVAI FPSPMLYAGP TEVQWHCRSR 
       510        520        530        540        550
MIAGANFYIV GRDPAGMPHP ETKKDLYEPT HGGKVLSMAP GLTSVEIIPF 
       560        570        580        590        600
RVAAYNKAKK AMDFYDPARH NEFDFISGTR MRKLAREGEN PPDGFMAPKA 
       610 
WKVLTDYYRS LEKN

Length:614

Mass (Da):69,501

Last modified:May 10, 2005 - v1

Checksum:ⁱ52F4B6D972DDA91E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK312556 mRNA Translation: BAG35453.1 CH471066 Genomic DNA Translation: EAW50182.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004661.2, NM_004670.3
UniGeneⁱ	Hs.524491

Genome annotation databases

GeneIDⁱ	9060
KEGGⁱ	hsa:9060
UCSC genome browser More...UCSCⁱ	uc001kex.4 human

Protein	Similar proteins		Species	Score	Length	Source
Q5TB52	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	)	HUMAN		614	UniRef100_O95340
3'-phosphoadenosine 5'-phosphosulfate synthase 2		PANTR		614
Uncharacterized protein		PANPA		614
3'-phosphoadenosine 5'-phosphosulfate synthase 2		GORGO		614

Protein	Similar proteins		Species	Score	Length	Source
Q5TB52	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	)	HUMAN		614	UniRef90_O95340
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2		MOUSE		621
3'-phosphoadenosine 5'-phosphosulfate synthase 2		PANTR		614
Uncharacterized protein		PANPA		614
3'-phosphoadenosine 5'-phosphosulfate synthase 2		GORGO		614
+188

Protein	Similar proteins		Species	Score	Length	Source
Q5TB52	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1	)	HUMAN		624	UniRef50_O43252
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1		CAVPO		624
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1		MOUSE		624
3'-phosphoadenosine 5'-phosphosulfate synthase 1		PANTR		700
3'-phosphoadenosine 5'-phosphosulfate synthase 1		GORGO		603
+821

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK312556 mRNA Translation: BAG35453.1 CH471066 Genomic DNA Translation: EAW50182.1
RefSeqⁱ	NP_004661.2, NM_004670.3
UniGeneⁱ	Hs.524491

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9060
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	9060
KEGGⁱ	hsa:9060
UCSCⁱ	uc001kex.4 human

Organism-specific databases

CTDⁱ	9060
EuPathDBⁱ	HostDB:ENSG00000198682.12
PharmGKBⁱ	PA383

Phylogenomic databases

eggNOGⁱ	KOG0635 Eukaryota KOG4238 Eukaryota COG0529 LUCA COG2046 LUCA
HOVERGENⁱ	HBG053503
KOⁱ	K13811

Miscellaneous databases

ChiTaRSⁱ	PAPSS2 human
GenomeRNAiⁱ	9060

Gene expression databases

Bgeeⁱ	ENSG00000198682 Expressed in 215 organ(s), highest expression level in metanephros

Bgeeⁱ

ENSG00000198682 Expressed in 215 organ(s), highest expression level in metanephros

Family and domain databases

CDDⁱ	cd02027 APSK, 1 hit cd00517 ATPS, 1 hit
Gene3Dⁱ	3.40.50.620, 1 hit
HAMAPⁱ	MF_00065 Adenylyl_sulf_kinase, 1 hit
InterProⁱ	View protein in InterPro IPR002891 APS_kinase IPR025980 ATP-Sase_PUA-like_dom IPR027417 P-loop_NTPase IPR015947 PUA-like_sf IPR014729 Rossmann-like_a/b/a_fold IPR024951 Sulfurylase_cat_dom IPR002650 Sulphate_adenylyltransferase
Pfamⁱ	View protein in Pfam PF01747 ATP-sulfurylase, 1 hit PF14306 PUA_2, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit SSF88697 SSF88697, 1 hit
TIGRFAMsⁱ	TIGR00455 apsK, 1 hit TIGR00339 sopT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5TB52_HUMAN
Accessionⁱ	Q5TB52Primary (citable) accession number: Q5TB52
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	October 10, 2018
	This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - Q5TB52 (Q5TB52_HUMAN)

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3'-phosphoadenosine 5'-phosphosulfate synthase 2, isoform CRA_b

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Organism-specific databases

Pathology & Biotechⁱ

Organism-specific databases

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

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Annotation systems

Supporting data

UniProtKB - Q5TB52 (Q5TB52_HUMAN)

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3'-phosphoadenosine 5'-phosphosulfate synthase 2, isoform CRA_b

PAPSS2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Expressionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ