Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DEP domain-containing protein 1A

Gene

DEPDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DEP domain-containing protein 1A
Gene namesi
Name:DEPDC1
Synonyms:DEPDC1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000024526.16
HGNCiHGNC:22949 DEPDC1
MIMi612002 gene
neXtProtiNX_Q5TB30

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55635
OpenTargetsiENSG00000024526
PharmGKBiPA134974825

Polymorphism and mutation databases

DMDMi300669641

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002847861 – 811DEP domain-containing protein 1AAdd BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei512PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5TB30
MaxQBiQ5TB30
PaxDbiQ5TB30
PeptideAtlasiQ5TB30
PRIDEiQ5TB30
ProteomicsDBi64887
64888 [Q5TB30-2]

PTM databases

iPTMnetiQ5TB30
PhosphoSitePlusiQ5TB30

Expressioni

Tissue specificityi

Expressed in testis. Up-regulated in bladder cancer cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000024526 Expressed in 111 organ(s), highest expression level in heart
CleanExiHS_DEPDC1
ExpressionAtlasiQ5TB30 baseline and differential
GenevisibleiQ5TB30 HS

Organism-specific databases

HPAiCAB017845

Interactioni

Subunit structurei

Isoform 2 and isoform 5 can form homodimers and heterodimers. Interacts with ZNF224.2 Publications

Protein-protein interaction databases

BioGridi120774, 19 interactors
IntActiQ5TB30, 6 interactors
MINTiQ5TB30
STRINGi9606.ENSP00000412292

Structurei

Secondary structure

1811
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ5TB30
SMRiQ5TB30
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5TB30

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 108DEPPROSITE-ProRule annotationAdd BLAST85
Domaini281 – 321Rho-GAPAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni598 – 653Interaction with ZNF2241 PublicationAdd BLAST56

Phylogenomic databases

eggNOGiENOG410IEI5 Eukaryota
ENOG410YMM7 LUCA
GeneTreeiENSGT00530000063030
HOVERGENiHBG059792
InParanoidiQ5TB30
OMAiIKPRCYS
OrthoDBiEOG091G04WW
PhylomeDBiQ5TB30
TreeFamiTF328365

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR008936 Rho_GTPase_activation_prot
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5TB30-5) [UniParc]FASTAAdd to basket
Also known as: DEPDC1-V1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESQGVPPGP YRATKLWNEV TTSFRAGMPL RKHRQHFKKY GNCFTAGEAV
60 70 80 90 100
DWLYDLLRNN SNFGPEVTRQ QTIQLLRKFL KNHVIEDIKG RWGSENVDDN
110 120 130 140 150
NQLFRFPATS PLKTLPRRYP ELRKNNIENF SKDKDSIFKL RNLSRRTPKR
160 170 180 190 200
HGLHLSQENG EKIKHEIINE DQENAIDNRE LSQEDVEEVW RYVILIYLQT
210 220 230 240 250
ILGVPSLEEV INPKQVIPQY IMYNMANTSK RGVVILQNKS DDLPHWVLSA
260 270 280 290 300
MKCLANWPRS NDMNNPTYVG FERDVFRTIA DYFLDLPEPL LTFEYYELFV
310 320 330 340 350
NILVVCGYIT VSDRSSGIHK IQDDPQSSKF LHLNNLNSFK STECLLLSLL
360 370 380 390 400
HREKNKEESD STERLQISNP GFQERCAKKM QLVNLRNRRV SANDIMGGSC
410 420 430 440 450
HNLIGLSNMH DLSSNSKPRC CSLEGIVDVP GNSSKEASSV FHQSFPNIEG
460 470 480 490 500
QNNKLFLESK PKQEFLLNLH SEENIQKPFS AGFKRTSTLT VQDQEELCNG
510 520 530 540 550
KCKSKQLCRS QSLLLRSSTR RNSYINTPVA EIIMKPNVGQ GSTSVQTAME
560 570 580 590 600
SELGESSATI NKRLCKSTIE LSENSLLPAS SMLTGTQSLL QPHLERVAID
610 620 630 640 650
ALQLCCLLLP PPNRRKLQLL MRMISRMSQN VDMPKLHDAM GTRSLMIHTF
660 670 680 690 700
SRCVLCCAEE VDLDELLAGR LVSFLMDHHQ EILQVPSYLQ TAVEKHLDYL
710 720 730 740 750
KKGHIENPGD GLFAPLPTYS YCKQISAQEF DEQKVSTSQA AIAELLENII
760 770 780 790 800
KNRSLPLKEK RKKLKQFQKE YPLIYQKRFP TTESEAALFG DKPTIKQPML
810
ILRKPKFRSL R
Length:811
Mass (Da):92,960
Last modified:July 13, 2010 - v2
Checksum:iF694E10FB79AF3B0
GO
Isoform 2 (identifier: Q5TB30-2) [UniParc]FASTAAdd to basket
Also known as: DEPDC1-V2

The sequence of this isoform differs from the canonical sequence as follows:
     304-304: V → G
     305-588: Missing.

Show »
Length:527
Mass (Da):61,493
Checksum:i8DFCF1DC7F13AFD7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YES2H0YES2_HUMAN
DEP domain-containing protein 1A
DEPDC1
308Annotation score:
E9PL61E9PL61_HUMAN
DEP domain-containing protein 1A
DEPDC1
34Annotation score:

Sequence cautioni

The sequence AAH03511 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91201 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14246 differs from that shown. Probable cloning artifact.Curated
The sequence BAB14246 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti720S → P in BAA91201 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059798404I → R. Corresponds to variant dbSNP:rs3790479Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024652304V → G in isoform 2. 3 Publications1
Alternative sequenceiVSP_024653305 – 588Missing in isoform 2. 3 PublicationsAdd BLAST284

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278112 mRNA Translation: CAB92444.1
AB281187 mRNA Translation: BAF91373.1
AB281274 mRNA Translation: BAF91374.1
AL138789 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06475.1
CH471059 Genomic DNA Translation: EAX06476.1
BC003511 mRNA Translation: AAH03511.1 Sequence problems.
BC065304 mRNA Translation: AAH65304.1
AK000490 mRNA Translation: BAA91201.1 Different initiation.
AK022792 mRNA Translation: BAB14246.1 Sequence problems.
CCDSiCCDS44159.1 [Q5TB30-5]
CCDS644.1 [Q5TB30-2]
RefSeqiNP_001107592.1, NM_001114120.2 [Q5TB30-5]
NP_060249.2, NM_017779.5 [Q5TB30-2]
UniGeneiHs.445098

Genome annotation databases

EnsembliENST00000370966; ENSP00000360005; ENSG00000024526 [Q5TB30-2]
ENST00000456315; ENSP00000412292; ENSG00000024526 [Q5TB30-5]
GeneIDi55635
KEGGihsa:55635
UCSCiuc001del.5 human [Q5TB30-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278112 mRNA Translation: CAB92444.1
AB281187 mRNA Translation: BAF91373.1
AB281274 mRNA Translation: BAF91374.1
AL138789 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06475.1
CH471059 Genomic DNA Translation: EAX06476.1
BC003511 mRNA Translation: AAH03511.1 Sequence problems.
BC065304 mRNA Translation: AAH65304.1
AK000490 mRNA Translation: BAA91201.1 Different initiation.
AK022792 mRNA Translation: BAB14246.1 Sequence problems.
CCDSiCCDS44159.1 [Q5TB30-5]
CCDS644.1 [Q5TB30-2]
RefSeqiNP_001107592.1, NM_001114120.2 [Q5TB30-5]
NP_060249.2, NM_017779.5 [Q5TB30-2]
UniGeneiHs.445098

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YSRNMR-A11-108[»]
ProteinModelPortaliQ5TB30
SMRiQ5TB30
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120774, 19 interactors
IntActiQ5TB30, 6 interactors
MINTiQ5TB30
STRINGi9606.ENSP00000412292

PTM databases

iPTMnetiQ5TB30
PhosphoSitePlusiQ5TB30

Polymorphism and mutation databases

DMDMi300669641

Proteomic databases

EPDiQ5TB30
MaxQBiQ5TB30
PaxDbiQ5TB30
PeptideAtlasiQ5TB30
PRIDEiQ5TB30
ProteomicsDBi64887
64888 [Q5TB30-2]

Protocols and materials databases

DNASUi55635
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370966; ENSP00000360005; ENSG00000024526 [Q5TB30-2]
ENST00000456315; ENSP00000412292; ENSG00000024526 [Q5TB30-5]
GeneIDi55635
KEGGihsa:55635
UCSCiuc001del.5 human [Q5TB30-5]

Organism-specific databases

CTDi55635
DisGeNETi55635
EuPathDBiHostDB:ENSG00000024526.16
GeneCardsiDEPDC1
HGNCiHGNC:22949 DEPDC1
HPAiCAB017845
MIMi612002 gene
neXtProtiNX_Q5TB30
OpenTargetsiENSG00000024526
PharmGKBiPA134974825
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEI5 Eukaryota
ENOG410YMM7 LUCA
GeneTreeiENSGT00530000063030
HOVERGENiHBG059792
InParanoidiQ5TB30
OMAiIKPRCYS
OrthoDBiEOG091G04WW
PhylomeDBiQ5TB30
TreeFamiTF328365

Miscellaneous databases

EvolutionaryTraceiQ5TB30
GenomeRNAii55635
PROiPR:Q5TB30
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000024526 Expressed in 111 organ(s), highest expression level in heart
CleanExiHS_DEPDC1
ExpressionAtlasiQ5TB30 baseline and differential
GenevisibleiQ5TB30 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR008936 Rho_GTPase_activation_prot
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEP1A_HUMAN
AccessioniPrimary (citable) accession number: Q5TB30
Secondary accession number(s): A8QXE0
, A8QXE1, Q05DU3, Q5TB28, Q9H9I3, Q9NX21, Q9NXZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again