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Protein

DEP domain-containing protein 1A

Gene

DEPDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DEP domain-containing protein 1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DEPDC1
Synonyms:DEPDC1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000024526.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22949 DEPDC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612002 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TB30

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55635

Open Targets

More...
OpenTargetsi
ENSG00000024526

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134974825

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
300669641

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002847861 – 811DEP domain-containing protein 1AAdd BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei512PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5TB30

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5TB30

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TB30

PeptideAtlas

More...
PeptideAtlasi
Q5TB30

PRoteomics IDEntifications database

More...
PRIDEi
Q5TB30

ProteomicsDB human proteome resource

More...
ProteomicsDBi
64887
64888 [Q5TB30-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TB30

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TB30

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis. Up-regulated in bladder cancer cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000024526 Expressed in 111 organ(s), highest expression level in heart

CleanEx database of gene expression profiles

More...
CleanExi
HS_DEPDC1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5TB30 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TB30 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017845

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 2 and isoform 5 can form homodimers and heterodimers. Interacts with ZNF224.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120774, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q5TB30, 6 interactors

Molecular INTeraction database

More...
MINTi
Q5TB30

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000412292

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1811
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5TB30

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5TB30

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q5TB30

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 108DEPPROSITE-ProRule annotationAdd BLAST85
Domaini281 – 321Rho-GAPAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni598 – 653Interaction with ZNF2241 PublicationAdd BLAST56

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEI5 Eukaryota
ENOG410YMM7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153589

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG059792

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TB30

Identification of Orthologs from Complete Genome Data

More...
OMAi
IKPRCYS

Database of Orthologous Groups

More...
OrthoDBi
EOG091G04WW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TB30

TreeFam database of animal gene trees

More...
TreeFami
TF328365

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000591 DEP_dom
IPR008936 Rho_GTPase_activation_prot
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00610 DEP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00049 DEP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50186 DEP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5TB30-5) [UniParc]FASTAAdd to basket
Also known as: DEPDC1-V1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESQGVPPGP YRATKLWNEV TTSFRAGMPL RKHRQHFKKY GNCFTAGEAV
60 70 80 90 100
DWLYDLLRNN SNFGPEVTRQ QTIQLLRKFL KNHVIEDIKG RWGSENVDDN
110 120 130 140 150
NQLFRFPATS PLKTLPRRYP ELRKNNIENF SKDKDSIFKL RNLSRRTPKR
160 170 180 190 200
HGLHLSQENG EKIKHEIINE DQENAIDNRE LSQEDVEEVW RYVILIYLQT
210 220 230 240 250
ILGVPSLEEV INPKQVIPQY IMYNMANTSK RGVVILQNKS DDLPHWVLSA
260 270 280 290 300
MKCLANWPRS NDMNNPTYVG FERDVFRTIA DYFLDLPEPL LTFEYYELFV
310 320 330 340 350
NILVVCGYIT VSDRSSGIHK IQDDPQSSKF LHLNNLNSFK STECLLLSLL
360 370 380 390 400
HREKNKEESD STERLQISNP GFQERCAKKM QLVNLRNRRV SANDIMGGSC
410 420 430 440 450
HNLIGLSNMH DLSSNSKPRC CSLEGIVDVP GNSSKEASSV FHQSFPNIEG
460 470 480 490 500
QNNKLFLESK PKQEFLLNLH SEENIQKPFS AGFKRTSTLT VQDQEELCNG
510 520 530 540 550
KCKSKQLCRS QSLLLRSSTR RNSYINTPVA EIIMKPNVGQ GSTSVQTAME
560 570 580 590 600
SELGESSATI NKRLCKSTIE LSENSLLPAS SMLTGTQSLL QPHLERVAID
610 620 630 640 650
ALQLCCLLLP PPNRRKLQLL MRMISRMSQN VDMPKLHDAM GTRSLMIHTF
660 670 680 690 700
SRCVLCCAEE VDLDELLAGR LVSFLMDHHQ EILQVPSYLQ TAVEKHLDYL
710 720 730 740 750
KKGHIENPGD GLFAPLPTYS YCKQISAQEF DEQKVSTSQA AIAELLENII
760 770 780 790 800
KNRSLPLKEK RKKLKQFQKE YPLIYQKRFP TTESEAALFG DKPTIKQPML
810
ILRKPKFRSL R
Length:811
Mass (Da):92,960
Last modified:July 13, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF694E10FB79AF3B0
GO
Isoform 2 (identifier: Q5TB30-2) [UniParc]FASTAAdd to basket
Also known as: DEPDC1-V2

The sequence of this isoform differs from the canonical sequence as follows:
     304-304: V → G
     305-588: Missing.

Show »
Length:527
Mass (Da):61,493
Checksum:i8DFCF1DC7F13AFD7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YES2H0YES2_HUMAN
DEP domain-containing protein 1A
DEPDC1
308Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL61E9PL61_HUMAN
DEP domain-containing protein 1A
DEPDC1
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH03511 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91201 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14246 differs from that shown. Probable cloning artifact.Curated
The sequence BAB14246 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti720S → P in BAA91201 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059798404I → R. Corresponds to variant dbSNP:rs3790479Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024652304V → G in isoform 2. 3 Publications1
Alternative sequenceiVSP_024653305 – 588Missing in isoform 2. 3 PublicationsAdd BLAST284

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ278112 mRNA Translation: CAB92444.1
AB281187 mRNA Translation: BAF91373.1
AB281274 mRNA Translation: BAF91374.1
AL138789 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06475.1
CH471059 Genomic DNA Translation: EAX06476.1
BC003511 mRNA Translation: AAH03511.1 Sequence problems.
BC065304 mRNA Translation: AAH65304.1
AK000490 mRNA Translation: BAA91201.1 Different initiation.
AK022792 mRNA Translation: BAB14246.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44159.1 [Q5TB30-5]
CCDS644.1 [Q5TB30-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001107592.1, NM_001114120.2 [Q5TB30-5]
NP_060249.2, NM_017779.5 [Q5TB30-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.445098

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370966; ENSP00000360005; ENSG00000024526 [Q5TB30-2]
ENST00000456315; ENSP00000412292; ENSG00000024526 [Q5TB30-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55635

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55635

UCSC genome browser

More...
UCSCi
uc001del.5 human [Q5TB30-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278112 mRNA Translation: CAB92444.1
AB281187 mRNA Translation: BAF91373.1
AB281274 mRNA Translation: BAF91374.1
AL138789 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06475.1
CH471059 Genomic DNA Translation: EAX06476.1
BC003511 mRNA Translation: AAH03511.1 Sequence problems.
BC065304 mRNA Translation: AAH65304.1
AK000490 mRNA Translation: BAA91201.1 Different initiation.
AK022792 mRNA Translation: BAB14246.1 Sequence problems.
CCDSiCCDS44159.1 [Q5TB30-5]
CCDS644.1 [Q5TB30-2]
RefSeqiNP_001107592.1, NM_001114120.2 [Q5TB30-5]
NP_060249.2, NM_017779.5 [Q5TB30-2]
UniGeneiHs.445098

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YSRNMR-A11-108[»]
ProteinModelPortaliQ5TB30
SMRiQ5TB30
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120774, 19 interactors
IntActiQ5TB30, 6 interactors
MINTiQ5TB30
STRINGi9606.ENSP00000412292

PTM databases

iPTMnetiQ5TB30
PhosphoSitePlusiQ5TB30

Polymorphism and mutation databases

DMDMi300669641

Proteomic databases

EPDiQ5TB30
MaxQBiQ5TB30
PaxDbiQ5TB30
PeptideAtlasiQ5TB30
PRIDEiQ5TB30
ProteomicsDBi64887
64888 [Q5TB30-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55635
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370966; ENSP00000360005; ENSG00000024526 [Q5TB30-2]
ENST00000456315; ENSP00000412292; ENSG00000024526 [Q5TB30-5]
GeneIDi55635
KEGGihsa:55635
UCSCiuc001del.5 human [Q5TB30-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55635
DisGeNETi55635
EuPathDBiHostDB:ENSG00000024526.16

GeneCards: human genes, protein and diseases

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GeneCardsi
DEPDC1
HGNCiHGNC:22949 DEPDC1
HPAiCAB017845
MIMi612002 gene
neXtProtiNX_Q5TB30
OpenTargetsiENSG00000024526
PharmGKBiPA134974825

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IEI5 Eukaryota
ENOG410YMM7 LUCA
GeneTreeiENSGT00940000153589
HOVERGENiHBG059792
InParanoidiQ5TB30
OMAiIKPRCYS
OrthoDBiEOG091G04WW
PhylomeDBiQ5TB30
TreeFamiTF328365

Miscellaneous databases

EvolutionaryTraceiQ5TB30

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55635

Protein Ontology

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PROi
PR:Q5TB30

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000024526 Expressed in 111 organ(s), highest expression level in heart
CleanExiHS_DEPDC1
ExpressionAtlasiQ5TB30 baseline and differential
GenevisibleiQ5TB30 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR008936 Rho_GTPase_activation_prot
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEP1A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TB30
Secondary accession number(s): A8QXE0
, A8QXE1, Q05DU3, Q5TB28, Q9H9I3, Q9NX21, Q9NXZ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 13, 2010
Last modified: December 5, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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