UniProtKB - Q5TAX3 (TUT4_HUMAN)
Protein
Terminal uridylyltransferase 4
Gene
TUT4
Organism
Homo sapiens (Human)
Status
Functioni
Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:25979828, PubMed:25480299, PubMed:16643855, PubMed:19703396, PubMed:18172165) (By similarity). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351).By similarity7 Publications
Catalytic activityi
- EC:2.7.7.522 Publications
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 306 | Zinc 11 Publication | 1 | |
Metal bindingi | 309 | Zinc 11 Publication | 1 | |
Metal bindingi | 322 | Zinc 11 Publication | 1 | |
Metal bindingi | 328 | Zinc 11 Publication | 1 | |
Metal bindingi | 1009 | Magnesium or manganese; catalyticBy similarity | 1 | |
Metal bindingi | 1011 | Magnesium or manganese; catalyticBy similarity | 1 | |
Binding sitei | 1081 | UTPBy similarity | 1 | |
Binding sitei | 1103 | UTPBy similarity | 1 | |
Binding sitei | 1237 | UTPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 304 – 334 | Matrin-typePROSITE-ProRule annotationAdd BLAST | 31 | |
Zinc fingeri | 913 – 930 | CCHC-type 1PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 1293 – 1310 | CCHC-type 2PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 1357 – 1374 | CCHC-type 3PROSITE-ProRule annotationAdd BLAST | 18 |
GO - Molecular functioni
- miRNA binding Source: UniProtKB
- nucleotidyltransferase activity Source: GO_Central
- polynucleotide adenylyltransferase activity Source: GO_Central
- RNA binding Source: UniProtKB
- RNA uridylyltransferase activity Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- miRNA catabolic process Source: UniProtKB
- miRNA metabolic process Source: UniProtKB
- mRNA polyadenylation Source: GO_Central
- mRNA processing Source: GO_Central
- negative regulation of transposition, RNA-mediated Source: UniProtKB
- nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
- oocyte maturation Source: UniProtKB
- polyuridylation-dependent mRNA catabolic process Source: UniProtKB
- pre-miRNA processing Source: UniProtKB
- RNA 3'-end processing Source: UniProtKB
- RNA 3' uridylation Source: UniProtKB
- stem cell population maintenance Source: UniProtKB
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | RNA-mediated gene silencing |
Ligand | Magnesium, Manganese, Metal-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 2.7.7.52, 2681 |
PathwayCommonsi | Q5TAX3 |
Reactomei | R-HSA-429947, Deadenylation of mRNA |
Names & Taxonomyi
Protein namesi | Recommended name: Terminal uridylyltransferase 4Curated (EC:2.7.7.522 Publications)Short name: TUTase 4 Alternative name(s): Zinc finger CCHC domain-containing protein 11 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000134744.13 |
HGNCi | HGNC:28981, TUT4 |
MIMi | 613692, gene |
neXtProti | NX_Q5TAX3 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm 3 Publications
- Cytoplasmic ribonucleoprotein granule 1 Publication
Note: Mainly cytoplasmic (PubMed:19703396, PubMed:25480299). Translocates into the cytoplasm following treatment of the cell with LPS (PubMed:16643855). Co-enriched in cytoplasmic foci with MOV10 (PubMed:30122351).1 Publication
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
Nucleus
Other locations
- cytoplasm Source: UniProtKB
- cytoplasmic ribonucleoprotein granule Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 253 – 333 | Missing : Loss of interaction with LIN28A and pre-let-7 RNA. 1 PublicationAdd BLAST | 81 | |
Mutagenesisi | 306 | C → A: Loss of LIN28A and pre-let-7 RNA binding and loss of pre-let-7 RNA uridylylation; when associated with A-309. 1 Publication | 1 | |
Mutagenesisi | 309 | C → A: Loss of LIN28A and pre-let-7 RNA binding and loss of pre-let-7 RNA uridylylation; when associated with A-306. 1 Publication | 1 | |
Mutagenesisi | 321 | K → A: Strongly decreased LIN28A and pre-let-7 RNA binding and pre-let-7 RNA uridylylation; when associated with A-324. 1 Publication | 1 | |
Mutagenesisi | 324 | K → A: Strongly decreased LIN28A and pre-let-7 RNA binding and pre-let-7 RNA uridylylation; when associated with A-321. 1 Publication | 1 | |
Mutagenesisi | 326 – 327 | KR → AA: Strongly decreased LIN28A and pre-let-7 RNA binding and pre-let-7 RNA uridylylation. 1 Publication | 2 | |
Mutagenesisi | 329 – 330 | KK → AA: Decreased LIN28A and pre-let-7 RNA binding and pre-let-7 RNA uridylylation. 1 Publication | 2 | |
Mutagenesisi | 450 | H → A: Decreased LIN28A and pre-let-7 RNA binding and pre-let-7 RNA uridylylation; when associated with A-452. 1 Publication | 1 | |
Mutagenesisi | 452 | K → A: Decreased LIN28A and pre-let-7 RNA binding and pre-let-7 RNA uridylylation; when associated with A-450. 1 Publication | 1 | |
Mutagenesisi | 669 – 670 | RR → AA: Decreased LIN28A and pre-let-7 RNA binding and pre-let-7 RNA uridylylation. 1 Publication | 2 | |
Mutagenesisi | 1011 | D → A: Loss of nucleotidyltransferase activity and stabilization of pre-let-7 miRNAs. Abolishes inhibition of LIRE1 retrotransposition. 3 Publications | 1 |
Organism-specific databases
DisGeNETi | 23318 |
OpenTargetsi | ENSG00000134744 |
PharmGKBi | PA134918178 |
Miscellaneous databases
Pharosi | Q5TAX3, Tbio |
Polymorphism and mutation databases
BioMutai | ZCCHC11 |
DMDMi | 116242850 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150970 | 1 – 1644 | Terminal uridylyltransferase 4Add BLAST | 1644 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 104 | PhosphoserineCombined sources | 1 | |
Modified residuei | 134 | PhosphoserineBy similarity | 1 | |
Modified residuei | 156 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1624 | Omega-N-methylarginineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q5TAX3 |
jPOSTi | Q5TAX3 |
MassIVEi | Q5TAX3 |
MaxQBi | Q5TAX3 |
PaxDbi | Q5TAX3 |
PeptideAtlasi | Q5TAX3 |
PRIDEi | Q5TAX3 |
ProteomicsDBi | 64876 [Q5TAX3-1] 64877 [Q5TAX3-2] |
PTM databases
iPTMneti | Q5TAX3 |
PhosphoSitePlusi | Q5TAX3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000134744, Expressed in kidney and 231 other tissues |
ExpressionAtlasi | Q5TAX3, baseline and differential |
Genevisiblei | Q5TAX3, HS |
Organism-specific databases
HPAi | ENSG00000134744, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Isoform 1 [Q5TAX3-1]
With | #Exp. | IntAct |
---|---|---|
TIFA [Q96CG3] | 2 | EBI-1606425,EBI-740711 |
Protein-protein interaction databases
BioGRIDi | 116909, 27 interactors |
IntActi | Q5TAX3, 14 interactors |
STRINGi | 9606.ENSP00000257177 |
Miscellaneous databases
RNActi | Q5TAX3, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q5TAX3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 628 – 678 | PAP-associated 1Add BLAST | 51 | |
Domaini | 1184 – 1237 | PAP-associated 2Add BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 253 – 333 | Required for interaction with LIN28A and pre-let-7 RNA1 PublicationAdd BLAST | 81 | |
Regioni | 901 – 1634 | Sufficient for monouridylation activityBy similarityAdd BLAST | 734 | |
Regioni | 998 – 1001 | UTP bindingBy similarity | 4 | |
Regioni | 1008 – 1011 | UTP bindingBy similarity | 4 | |
Regioni | 1121 – 1125 | UTP bindingBy similarity | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1398 – 1483 | Gln-richAdd BLAST | 86 | |
Compositional biasi | 1424 – 1598 | Pro-richAdd BLAST | 175 |
Domaini
Utilizes two multidomain functional modules during the switch from monouridylation to oligouridylation. The catalytic module (containing the 3 CCHC-type Zinc finger domains) is essential for both activities while the Lin28-interacting module (LIM) at the N-termail part is indispensable for oligouridylation.By similarity
Sequence similaritiesi
Belongs to the DNA polymerase type-B-like family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 304 – 334 | Matrin-typePROSITE-ProRule annotationAdd BLAST | 31 | |
Zinc fingeri | 913 – 930 | CCHC-type 1PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 1293 – 1310 | CCHC-type 2PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 1357 – 1374 | CCHC-type 3PROSITE-ProRule annotationAdd BLAST | 18 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2277, Eukaryota |
GeneTreei | ENSGT00940000156988 |
InParanoidi | Q5TAX3 |
OrthoDBi | 803033at2759 |
PhylomeDBi | Q5TAX3 |
TreeFami | TF315661 |
Family and domain databases
Gene3Di | 3.30.460.10, 1 hit |
InterProi | View protein in InterPro IPR043519, NT_sf IPR002058, PAP_assoc IPR001878, Znf_CCHC IPR036875, Znf_CCHC_sf |
Pfami | View protein in Pfam PF03828, PAP_assoc, 2 hits PF00098, zf-CCHC, 2 hits |
SMARTi | View protein in SMART SM00343, ZnF_C2HC, 3 hits |
SUPFAMi | SSF57756, SSF57756, 2 hits SSF81301, SSF81301, 2 hits |
PROSITEi | View protein in PROSITE PS50158, ZF_CCHC, 3 hits PS00028, ZINC_FINGER_C2H2_1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5TAX3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEESKTLKSE NHEPKKNVIC EESKAVQVIG NQTLKARNDK SVKEIENSSP
60 70 80 90 100
NRNSSKKNKQ NDICIEKTEV KSCKVNAANL PGPKDLGLVL RDQSHCKAKK
110 120 130 140 150
FPNSPVKAEK ATISQAKSEK ATSLQAKAEK SPKSPNSVKA EKASSYQMKS
160 170 180 190 200
EKVPSSPAEA EKGPSLLLKD MRQKTELQQI GKKIPSSFTS VDKVNIEAVG
210 220 230 240 250
GEKCALQNSP RSQKQQTCTD NTGDSDDSAS GIEDVSDDLS KMKNDESNKE
260 270 280 290 300
NSSEMDYLEN ATVIDESALT PEQRLGLKQA EERLERDHIF RLEKRSPEYT
310 320 330 340 350
NCRYLCKLCL IHIENIQGAH KHIKEKRHKK NILEKQEESE LRSLPPPSPA
360 370 380 390 400
HLAALSVAVI ELAKEHGITD DDLRVRQEIV EEMSKVITTF LPECSLRLYG
410 420 430 440 450
SSLTRFALKS SDVNIDIKFP PKMNHPDLLI KVLGILKKNV LYVDVESDFH
460 470 480 490 500
AKVPVVVCRD RKSGLLCRVS AGNDMACLTT DLLTALGKIE PVFIPLVLAF
510 520 530 540 550
RYWAKLCYID SQTDGGIPSY CFALMVMFFL QQRKPPLLPC LLGSWIEGFD
560 570 580 590 600
PKRMDDFQLK GIVEEKFVKW ECNSSSATEK NSIAEENKAK ADQPKDDTKK
610 620 630 640 650
TETDNQSNAM KEKHGKSPLA LETPNRVSLG QLWLELLKFY TLDFALEEYV
660 670 680 690 700
ICVRIQDILT RENKNWPKRR IAIEDPFSVK RNVARSLNSQ LVYEYVVERF
710 720 730 740 750
RAAYRYFACP QTKGGNKSTV DFKKREKGKI SNKKPVKSNN MATNGCILLG
760 770 780 790 800
ETTEKINAER EQPVQCDEMD CTSQRCIIDN NNLLVNELDF ADHGQDSSSL
810 820 830 840 850
STSKSSEIEP KLDKKQDDLA PSETCLKKEL SQCNCIDLSK SPDPDKSTGT
860 870 880 890 900
DCRSNLETES SHQSVCTDTS ATSCNCKATE DASDLNDDDN LPTQELYYVF
910 920 930 940 950
DKFILTSGKP PTIVCSICKK DGHSKNDCPE DFRKIDLKPL PPMTNRFREI
960 970 980 990 1000
LDLVCKRCFD ELSPPCSEQH NREQILIGLE KFIQKEYDEK ARLCLFGSSK
1010 1020 1030 1040 1050
NGFGFRDSDL DICMTLEGHE NAEKLNCKEI IENLAKILKR HPGLRNILPI
1060 1070 1080 1090 1100
TTAKVPIVKF EHRRSGLEGD ISLYNTLAQH NTRMLATYAA IDPRVQYLGY
1110 1120 1130 1140 1150
TMKVFAKRCD IGDASRGSLS SYAYILMVLY FLQQRKPPVI PVLQEIFDGK
1160 1170 1180 1190 1200
QIPQRMVDGW NAFFFDKTEE LKKRLPSLGK NTESLGELWL GLLRFYTEEF
1210 1220 1230 1240 1250
DFKEYVISIR QKKLLTTFEK QWTSKCIAIE DPFDLNHNLG AGVSRKMTNF
1260 1270 1280 1290 1300
IMKAFINGRK LFGTPFYPLI GREAEYFFDS RVLTDGELAP NDRCCRVCGK
1310 1320 1330 1340 1350
IGHYMKDCPK RKSLLFRLKK KDSEEEKEGN EEEKDSRDVL DPRDLHDTRD
1360 1370 1380 1390 1400
FRDPRDLRCF ICGDAGHVRR ECPEVKLARQ RNSSVAAAQL VRNLVNAQQV
1410 1420 1430 1440 1450
AGSAQQQGDQ SIRTRQSSEC SESPSYSPQP QPFPQNSSQS AAITQPSSQP
1460 1470 1480 1490 1500
GSQPKLGPPQ QGAQPPHQVQ MPLYNFPQSP PAQYSPMHNM GLLPMHPLQI
1510 1520 1530 1540 1550
PAPSWPIHGP VIHSAPGSAP SNIGLNDPSI IFAQPAARPV AIPNTSHDGH
1560 1570 1580 1590 1600
WPRTVAPNSL VNSGAVGNSE PGFRGLTPPI PWEHAPRPHF PLVPASWPYG
1610 1620 1630 1640
LHQNFMHQGN ARFQPNKPFY TQDRCATRRC RERCPHPPRG NVSE
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DFM7 | A0A0C4DFM7_HUMAN | Terminal uridylyltransferase 4 | TUT4 | 1,645 | Annotation score: | ||
E9PKX1 | E9PKX1_HUMAN | Terminal uridylyltransferase 4 | TUT4 | 906 | Annotation score: | ||
E9PKY2 | E9PKY2_HUMAN | Terminal uridylyltransferase 4 | TUT4 | 1,203 | Annotation score: | ||
H0YEE8 | H0YEE8_HUMAN | Terminal uridylyltransferase 4 | TUT4 | 338 | Annotation score: | ||
H0YDJ1 | H0YDJ1_HUMAN | Terminal uridylyltransferase 4 | TUT4 | 337 | Annotation score: | ||
E9PRG2 | E9PRG2_HUMAN | Terminal uridylyltransferase 4 | TUT4 | 343 | Annotation score: | ||
H0YF28 | H0YF28_HUMAN | Terminal uridylyltransferase 4 | TUT4 | 151 | Annotation score: | ||
X6R5G7 | X6R5G7_HUMAN | Terminal uridylyltransferase 4 | TUT4 | 309 | Annotation score: | ||
E9PJN7 | E9PJN7_HUMAN | Terminal uridylyltransferase 4 | TUT4 | 77 | Annotation score: | ||
H0YCX5 | H0YCX5_HUMAN | Terminal uridylyltransferase 4 | TUT4 | 164 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1313 | S → SS in AAI31735 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028402 | 796 | D → Y. Corresponds to variant dbSNP:rs12127732EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038135 | 685 – 719 | RSLNS…GNKST → LQPGRQEWKLCLKKKKKNSV KYTFIYEIQVSLFVI in isoform 2. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_038136 | 720 – 1644 | Missing in isoform 2. 1 PublicationAdd BLAST | 925 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK303532 mRNA Translation: BAH13981.1 AL138849 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06778.1 CH471059 Genomic DNA Translation: EAX06780.1 BC131734 mRNA Translation: AAI31735.1 D83776 mRNA Translation: BAA12105.1 |
CCDSi | CCDS30716.1 [Q5TAX3-1] |
RefSeqi | NP_001009881.1, NM_001009881.2 NP_056084.1, NM_015269.2 [Q5TAX3-1] |
Genome annotation databases
Ensembli | ENST00000371544; ENSP00000360599; ENSG00000134744 [Q5TAX3-1] |
GeneIDi | 23318 |
KEGGi | hsa:23318 |
UCSCi | uc001ctx.3, human [Q5TAX3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK303532 mRNA Translation: BAH13981.1 AL138849 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06778.1 CH471059 Genomic DNA Translation: EAX06780.1 BC131734 mRNA Translation: AAI31735.1 D83776 mRNA Translation: BAA12105.1 |
CCDSi | CCDS30716.1 [Q5TAX3-1] |
RefSeqi | NP_001009881.1, NM_001009881.2 NP_056084.1, NM_015269.2 [Q5TAX3-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6IW6 | X-ray | 2.40 | A/B | 253-723 | [»] | |
SMRi | Q5TAX3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116909, 27 interactors |
IntActi | Q5TAX3, 14 interactors |
STRINGi | 9606.ENSP00000257177 |
PTM databases
iPTMneti | Q5TAX3 |
PhosphoSitePlusi | Q5TAX3 |
Polymorphism and mutation databases
BioMutai | ZCCHC11 |
DMDMi | 116242850 |
Proteomic databases
EPDi | Q5TAX3 |
jPOSTi | Q5TAX3 |
MassIVEi | Q5TAX3 |
MaxQBi | Q5TAX3 |
PaxDbi | Q5TAX3 |
PeptideAtlasi | Q5TAX3 |
PRIDEi | Q5TAX3 |
ProteomicsDBi | 64876 [Q5TAX3-1] 64877 [Q5TAX3-2] |
Protocols and materials databases
Antibodypediai | 19117, 194 antibodies |
DNASUi | 23318 |
Genome annotation databases
Ensembli | ENST00000371544; ENSP00000360599; ENSG00000134744 [Q5TAX3-1] |
GeneIDi | 23318 |
KEGGi | hsa:23318 |
UCSCi | uc001ctx.3, human [Q5TAX3-1] |
Organism-specific databases
CTDi | 23318 |
DisGeNETi | 23318 |
EuPathDBi | HostDB:ENSG00000134744.13 |
GeneCardsi | TUT4 |
HGNCi | HGNC:28981, TUT4 |
HPAi | ENSG00000134744, Low tissue specificity |
MIMi | 613692, gene |
neXtProti | NX_Q5TAX3 |
OpenTargetsi | ENSG00000134744 |
PharmGKBi | PA134918178 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2277, Eukaryota |
GeneTreei | ENSGT00940000156988 |
InParanoidi | Q5TAX3 |
OrthoDBi | 803033at2759 |
PhylomeDBi | Q5TAX3 |
TreeFami | TF315661 |
Enzyme and pathway databases
BRENDAi | 2.7.7.52, 2681 |
PathwayCommonsi | Q5TAX3 |
Reactomei | R-HSA-429947, Deadenylation of mRNA |
Miscellaneous databases
BioGRID-ORCSi | 23318, 6 hits in 848 CRISPR screens |
ChiTaRSi | ZCCHC11, human |
GenomeRNAii | 23318 |
Pharosi | Q5TAX3, Tbio |
PROi | PR:Q5TAX3 |
RNActi | Q5TAX3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134744, Expressed in kidney and 231 other tissues |
ExpressionAtlasi | Q5TAX3, baseline and differential |
Genevisiblei | Q5TAX3, HS |
Family and domain databases
Gene3Di | 3.30.460.10, 1 hit |
InterProi | View protein in InterPro IPR043519, NT_sf IPR002058, PAP_assoc IPR001878, Znf_CCHC IPR036875, Znf_CCHC_sf |
Pfami | View protein in Pfam PF03828, PAP_assoc, 2 hits PF00098, zf-CCHC, 2 hits |
SMARTi | View protein in SMART SM00343, ZnF_C2HC, 3 hits |
SUPFAMi | SSF57756, SSF57756, 2 hits SSF81301, SSF81301, 2 hits |
PROSITEi | View protein in PROSITE PS50158, ZF_CCHC, 3 hits PS00028, ZINC_FINGER_C2H2_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TUT4_HUMAN | |
Accessioni | Q5TAX3Primary (citable) accession number: Q5TAX3 Secondary accession number(s): A2RRP0 Q86XZ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations