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Protein

Collagen alpha-1(XIII) chain

Gene

COL13A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • extracellular matrix structural constituent Source: GO_Central
  • extracellular matrix structural constituent conferring tensile strength Source: BHF-UCL
  • heparin binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Heparin-binding
Biological processCell adhesion, Differentiation, Osteogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1442490 Collagen degradation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-216083 Integrin cell surface interactions
R-HSA-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(XIII) chain
Alternative name(s):
COLXIIIA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL13A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197467.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2190 COL13A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
120350 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TAT6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 44CytoplasmicSequence analysisAdd BLAST44
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei45 – 61Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini62 – 717ExtracellularSequence analysisAdd BLAST656

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myasthenic syndrome, congenital, 19 (CMS19)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort.
See also OMIM:616720

Keywords - Diseasei

Congenital myasthenic syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
1305

MalaCards human disease database

More...
MalaCardsi
COL13A1
MIMi616720 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000197467

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98913 Postsynaptic congenital myasthenic syndromes
98914 Presynaptic congenital myasthenic syndromes

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26706

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COL13A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74745860

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002846791 – 717Collagen alpha-1(XIII) chainAdd BLAST717

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5TAT6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TAT6

PeptideAtlas

More...
PeptideAtlasi
Q5TAT6

PRoteomics IDEntifications database

More...
PRIDEi
Q5TAT6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
64863
64864 [Q5TAT6-10]
64865 [Q5TAT6-2]
64866 [Q5TAT6-3]
64867 [Q5TAT6-4]
64868 [Q5TAT6-5]
64869 [Q5TAT6-6]
64870 [Q5TAT6-7]
64871 [Q5TAT6-8]
64872 [Q5TAT6-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TAT6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TAT6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in both fetal and adult ocular tissues (at protein level). In the eye, expression is accentuated in the ciliary muscle, optic nerve and the neural retina. In early placenta, localized to fibroblastoid stromal cells of the placental villi, to endothelial cells of developing capillaries and to cells of the cytotrophoblastic columns. Also detected in large decidual cells of the decidual membrane and to stromal cells of the gestational endometrium, but not in the epithelial cells in the endometrial glands. Isoform 10: Expressed in muscle (PubMed:26626625).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197467 Expressed in 176 organ(s), highest expression level in tibia

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5TAT6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TAT6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050392

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; disulfide-linked. Nucleation of the type XIII collagen triple helix is likely to occur at the N-terminal region with triple helix formation proceeding from the N- to the C-terminus. Interacts with FN1, perlecan/HSPG2 and NID2.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107701, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1754 Collagen type XIII trimer

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381949

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5TAT6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 121Nonhelical region 1 (NC1)Sequence analysisAdd BLAST121
Regioni122 – 216Triple-helical region 1 (COL1)Sequence analysisAdd BLAST95
Regioni217 – 269Nonhelical region 2 (NC2)Sequence analysisAdd BLAST53
Regioni270 – 441Triple-helical region 2 (COL2)Sequence analysisAdd BLAST172
Regioni442 – 463Nonhelical region 3 (NC3)Sequence analysisAdd BLAST22
Regioni464 – 699Triple-helical region 3 (COL3)Sequence analysisAdd BLAST236
Regioni700 – 717Nonhelical region 4 (NC4)Sequence analysisAdd BLAST18

Keywords - Domaini

Collagen, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IS74 Eukaryota
ENOG410YPXK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154865

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000085653

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004933

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TAT6

KEGG Orthology (KO)

More...
KOi
K16617

Identification of Orthologs from Complete Genome Data

More...
OMAi
SPGCHCP

Database of Orthologous Groups

More...
OrthoDBi
669310at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TAT6

TreeFam database of animal gene trees

More...
TreeFami
TF338175

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 11 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.Curated

This entry has 11 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q5TAT6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVAERTHKAA ATGARGPGEL GAPGTVALVA ARAERGARLP SPGSCGLLTL
60 70 80 90 100
ALCSLALSLL AHFRTAELQA RVLRLEAERG EQQMETAILG RVNQLLDEKW
110 120 130 140 150
KLHSRRRREA PKTSPGCNCP PGPPGPTGRP GLPGDKGAIG MPGRVGSPGD
160 170 180 190 200
AGLSIIGPRG PPGQPGTRGF PGFPGPIGLD GKPGHPGPKG DMGLTGPPGQ
210 220 230 240 250
PGPQGQKGEK GQCGEYPHRE CLSSMPAALR SSQIIALKLL PLLNSVRLAP
260 270 280 290 300
PPVIKRRTFQ GEQSQASIQG PPGPPGPPGP SGPLGHPGLP GPMGPPGLPG
310 320 330 340 350
PPGPKGDPGI QGYHGRKGER GMPGMPGKHG AKGAPGIAVA GMKGEPGIPG
360 370 380 390 400
TKGEKGAEGS PGLPGLLGQK GEKGDAGNSI GGGRGEPGPP GLPGPPGPKG
410 420 430 440 450
EAGVDGQVGP PGQPGDKGER GAAGEQGPDG PKGSKGEPGK GEMVDYNGNI
460 470 480 490 500
NEALQEIRTL ALMGPPGLPG QIGPPGAPGI PGQKGEIGLP GPPGHDGEKG
510 520 530 540 550
PRGKPGDMGP PGPQGPPGKD GPPGVKGENG HPGSPGEKGE KGETGQAGSP
560 570 580 590 600
GEKGEAGEKG NPGAEVPGLP GPEGPPGPPG LQGVPGPKGE AGLDGAKGEK
610 620 630 640 650
GFQGEKGDRG PLGLPGASGL DGRPGPPGTP GPIGVPGPAG PKGERGSKGD
660 670 680 690 700
PGMTGPTGAA GLPGLHGPPG DKGNRGERGK KGSRGPKGDK GDQGAPGLDA
710
PCPLGEDGLP VQGCWNK
Length:717
Mass (Da):69,950
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD12CA80CC93540F
GO
Isoform 21 Publication (identifier: Q5TAT6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-260: Missing.

Note: Gene prediction based on EST data.Curated
Show »
Length:695
Mass (Da):67,439
Checksum:i9816F7BCDD8C108B
GO
Isoform 31 Publication (identifier: Q5TAT6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-260: Missing.
     617-628: Missing.

Note: Gene prediction based on EST data.Curated
Show »
Length:683
Mass (Da):66,377
Checksum:i3BB550FD03062C30
GO
Isoform 41 Publication (identifier: Q5TAT6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-260: Missing.
     551-565: Missing.
     617-628: Missing.

Show »
Length:668
Mass (Da):64,965
Checksum:iAAC18C9E4B45DA4E
GO
Isoform 51 Publication (identifier: Q5TAT6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-565: Missing.

Show »
Length:702
Mass (Da):68,538
Checksum:i66FC08083E0D4A91
GO
Isoform 61 Publication (identifier: Q5TAT6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     566-579: Missing.

Show »
Length:703
Mass (Da):68,700
Checksum:i62947B1FEEBF6268
GO
Isoform 71 Publication (identifier: Q5TAT6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     566-579: Missing.
     617-628: Missing.

Show »
Length:691
Mass (Da):67,638
Checksum:iEEC688B6A5364877
GO
Isoform 81 Publication (identifier: Q5TAT6-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-238: Missing.
     617-628: Missing.

Show »
Length:686
Mass (Da):66,887
Checksum:i0256074DDF33E752
GO
Isoform 91 Publication (identifier: Q5TAT6-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-260: Missing.
     551-565: Missing.
     617-628: Missing.
     676-705: Missing.

Show »
Length:638
Mass (Da):62,077
Checksum:iE172A8ADA30B84DC
GO
Isoform 10 (identifier: Q5TAT6-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-159: Missing.
     220-238: Missing.
     551-565: Missing.

Note: No experimental confirmation available.
Show »
Length:645
Mass (Da):63,036
Checksum:i2BD4AF1794648BDA
GO
Isoform 11 (identifier: Q5TAT6-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-163: Missing.
     239-260: Missing.
     551-565: Missing.
     617-628: Missing.
     678-706: Missing.

Note: Gene prediction based on EST data.
Show »
Length:610
Mass (Da):59,465
Checksum:iDDDD4D432DD45849
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EX21E7EX21_HUMAN
Collagen alpha-1(XIII) chain
COL13A1
582Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ES50E7ES50_HUMAN
Collagen alpha-1(XIII) chain
COL13A1
642Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YGI3A0A2R8YGI3_HUMAN
Collagen alpha-1(XIII) chain
COL13A1
728Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYT9H7BYT9_HUMAN
Collagen alpha-1(XIII) chain
COL13A1
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZB6H7BZB6_HUMAN
Collagen alpha-1(XIII) chain
COL13A1
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA51685 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182K → F in AAA51685 (PubMed:1698771).Curated1
Sequence conflicti394G → A in CAC00688 (PubMed:11013208).Curated1
Sequence conflicti394G → A in AAA51685 (PubMed:1698771).Curated1
Sequence conflicti466P → L in AAA51685 (PubMed:1698771).Curated1
Sequence conflicti466P → L in AAA52047 (PubMed:3547403).Curated1
Sequence conflicti469P → L in AAA51685 (PubMed:1698771).Curated1
Sequence conflicti469P → L in AAA52047 (PubMed:3547403).Curated1
Sequence conflicti475P → L in AAA51685 (PubMed:1698771).Curated1
Sequence conflicti475P → L in AAA52047 (PubMed:3547403).Curated1
Sequence conflicti478P → L in AAA51685 (PubMed:1698771).Curated1
Sequence conflicti478P → L in AAA52047 (PubMed:3547403).Curated1
Sequence conflicti480 – 481IP → ML in AAA51685 (PubMed:1698771).Curated2
Sequence conflicti480 – 481IP → ML in AAA52047 (PubMed:3547403).Curated2
Sequence conflicti490P → L in AAA51685 (PubMed:1698771).Curated1
Sequence conflicti490P → L in AAA52047 (PubMed:3547403).Curated1
Sequence conflicti493P → L in AAA51685 (PubMed:1698771).Curated1
Sequence conflicti493P → L in AAA52047 (PubMed:3547403).Curated1
Sequence conflicti498Missing in AAA51685 (PubMed:1698771).Curated1
Sequence conflicti498Missing in AAA52047 (PubMed:3547403).Curated1
Sequence conflicti505P → L in AAA51685 (PubMed:1698771).Curated1
Sequence conflicti505P → L in AAA52047 (PubMed:3547403).Curated1
Sequence conflicti511P → L in AAA51685 (PubMed:1698771).Curated1
Sequence conflicti511P → L in AAA52047 (PubMed:3547403).Curated1
Sequence conflicti517P → L in AAA51685 (PubMed:1698771).Curated1
Sequence conflicti517P → L in AAA52047 (PubMed:3547403).Curated1
Sequence conflicti570P → L in AAA52047 (PubMed:3547403).Curated1
Sequence conflicti570P → L in AAA51987 (PubMed:2459707).Curated1
Sequence conflicti570P → L in AAA51990 (PubMed:2459707).Curated1
Sequence conflicti570P → L in AAA51991 (PubMed:2459707).Curated1
Sequence conflicti706E → Q in AAA52047 (PubMed:3547403).Curated1
Sequence conflicti706E → Q in AAA52048 (PubMed:3547403).Curated1
Sequence conflicti706E → Q in AAA51987 (PubMed:2459707).Curated1
Sequence conflicti706E → Q in AAA51988 (PubMed:2459707).Curated1
Sequence conflicti706E → Q in AAA51989 (PubMed:2459707).Curated1
Sequence conflicti706E → Q in AAA51990 (PubMed:2459707).Curated1
Sequence conflicti706E → Q in AAA51991 (PubMed:2459707).Curated1
Sequence conflicti709L → Y in AAA51987 (PubMed:2459707).Curated1
Sequence conflicti709L → Y in AAA51988 (PubMed:2459707).Curated1
Sequence conflicti709L → Y in AAA51989 (PubMed:2459707).Curated1
Sequence conflicti709L → Y in AAA51990 (PubMed:2459707).Curated1
Sequence conflicti709L → Y in AAA51991 (PubMed:2459707).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055670531H → Q. Corresponds to variant dbSNP:rs1061954Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043361122 – 159Missing in isoform 10. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_047230135 – 163Missing in isoform 11. CuratedAdd BLAST29
Alternative sequenceiVSP_052382220 – 238Missing in isoform 8 and isoform 10. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_052383239 – 260Missing in isoform 2, isoform 3, isoform 4, isoform 9 and isoform 11. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_052384551 – 565Missing in isoform 4, isoform 5, isoform 9, isoform 10 and isoform 11. 3 PublicationsAdd BLAST15
Alternative sequenceiVSP_052385566 – 579Missing in isoform 6 and isoform 7. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_052386617 – 628Missing in isoform 3, isoform 4, isoform 7, isoform 8, isoform 9 and isoform 11. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_052387676 – 705Missing in isoform 9. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_047231678 – 706Missing in isoform 11. CuratedAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ293624 mRNA Translation: CAC00688.1
AC024601 Genomic DNA No translation available.
AC025426 Genomic DNA No translation available.
AL138925 Genomic DNA No translation available.
BC136385 mRNA Translation: AAI36386.1
M59217 mRNA Translation: AAA51685.1 Different initiation.
M33653 mRNA Translation: AAA52047.1
M15524 mRNA Translation: AAA52048.1
M20803
, M20795, M20796, M20797, M20798, M20799, M20800, M20801, M20802, M20804, M20805 Genomic DNA Translation: AAA51987.1
M20803
, M20795, M20796, M20797, M20798, M20799, M20800, M20801, M20802, M20804 Genomic DNA Translation: AAA51988.1
M20803
, M20795, M20796, M20797, M20798, M20799, M20801, M20802, M20804 Genomic DNA Translation: AAA51989.1
M20803
, M20796, M20797, M20798, M20799, M20800, M20801, M20802, M20804, M20805 Genomic DNA Translation: AAA51990.1
M20803
, M20796, M20797, M20798, M20799, M20801, M20802, M20804, M20805 Genomic DNA Translation: AAA51991.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44419.1 [Q5TAT6-1]
CCDS44423.2 [Q5TAT6-4]
CCDS44424.2 [Q5TAT6-2]
CCDS44425.2 [Q5TAT6-8]
CCDS44427.2 [Q5TAT6-10]
CCDS44428.2 [Q5TAT6-11]

Protein sequence database of the Protein Information Resource

More...
PIRi
B40983

NCBI Reference Sequences

More...
RefSeqi
NP_001123575.1, NM_001130103.1 [Q5TAT6-1]
NP_542988.3, NM_080798.3 [Q5TAT6-10]
NP_542990.3, NM_080800.3 [Q5TAT6-8]
NP_542991.3, NM_080801.3 [Q5TAT6-2]
NP_542992.3, NM_080802.3 [Q5TAT6-4]
NP_542995.3, NM_080805.3 [Q5TAT6-11]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.695934

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354547; ENSP00000346553; ENSG00000197467 [Q5TAT6-2]
ENST00000357811; ENSP00000350463; ENSG00000197467 [Q5TAT6-3]
ENST00000398978; ENSP00000381949; ENSG00000197467 [Q5TAT6-1]
ENST00000517713; ENSP00000430061; ENSG00000197467 [Q5TAT6-4]
ENST00000520133; ENSP00000430173; ENSG00000197467 [Q5TAT6-11]
ENST00000520267; ENSP00000428057; ENSG00000197467 [Q5TAT6-10]
ENST00000522165; ENSP00000428342; ENSG00000197467 [Q5TAT6-8]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1305

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1305

UCSC genome browser

More...
UCSCi
uc057tuj.1 human [Q5TAT6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293624 mRNA Translation: CAC00688.1
AC024601 Genomic DNA No translation available.
AC025426 Genomic DNA No translation available.
AL138925 Genomic DNA No translation available.
BC136385 mRNA Translation: AAI36386.1
M59217 mRNA Translation: AAA51685.1 Different initiation.
M33653 mRNA Translation: AAA52047.1
M15524 mRNA Translation: AAA52048.1
M20803
, M20795, M20796, M20797, M20798, M20799, M20800, M20801, M20802, M20804, M20805 Genomic DNA Translation: AAA51987.1
M20803
, M20795, M20796, M20797, M20798, M20799, M20800, M20801, M20802, M20804 Genomic DNA Translation: AAA51988.1
M20803
, M20795, M20796, M20797, M20798, M20799, M20801, M20802, M20804 Genomic DNA Translation: AAA51989.1
M20803
, M20796, M20797, M20798, M20799, M20800, M20801, M20802, M20804, M20805 Genomic DNA Translation: AAA51990.1
M20803
, M20796, M20797, M20798, M20799, M20801, M20802, M20804, M20805 Genomic DNA Translation: AAA51991.1
CCDSiCCDS44419.1 [Q5TAT6-1]
CCDS44423.2 [Q5TAT6-4]
CCDS44424.2 [Q5TAT6-2]
CCDS44425.2 [Q5TAT6-8]
CCDS44427.2 [Q5TAT6-10]
CCDS44428.2 [Q5TAT6-11]
PIRiB40983
RefSeqiNP_001123575.1, NM_001130103.1 [Q5TAT6-1]
NP_542988.3, NM_080798.3 [Q5TAT6-10]
NP_542990.3, NM_080800.3 [Q5TAT6-8]
NP_542991.3, NM_080801.3 [Q5TAT6-2]
NP_542992.3, NM_080802.3 [Q5TAT6-4]
NP_542995.3, NM_080805.3 [Q5TAT6-11]
UniGeneiHs.695934

3D structure databases

ProteinModelPortaliQ5TAT6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107701, 1 interactor
ComplexPortaliCPX-1754 Collagen type XIII trimer
STRINGi9606.ENSP00000381949

PTM databases

iPTMnetiQ5TAT6
PhosphoSitePlusiQ5TAT6

Polymorphism and mutation databases

BioMutaiCOL13A1
DMDMi74745860

Proteomic databases

jPOSTiQ5TAT6
PaxDbiQ5TAT6
PeptideAtlasiQ5TAT6
PRIDEiQ5TAT6
ProteomicsDBi64863
64864 [Q5TAT6-10]
64865 [Q5TAT6-2]
64866 [Q5TAT6-3]
64867 [Q5TAT6-4]
64868 [Q5TAT6-5]
64869 [Q5TAT6-6]
64870 [Q5TAT6-7]
64871 [Q5TAT6-8]
64872 [Q5TAT6-9]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354547; ENSP00000346553; ENSG00000197467 [Q5TAT6-2]
ENST00000357811; ENSP00000350463; ENSG00000197467 [Q5TAT6-3]
ENST00000398978; ENSP00000381949; ENSG00000197467 [Q5TAT6-1]
ENST00000517713; ENSP00000430061; ENSG00000197467 [Q5TAT6-4]
ENST00000520133; ENSP00000430173; ENSG00000197467 [Q5TAT6-11]
ENST00000520267; ENSP00000428057; ENSG00000197467 [Q5TAT6-10]
ENST00000522165; ENSP00000428342; ENSG00000197467 [Q5TAT6-8]
GeneIDi1305
KEGGihsa:1305
UCSCiuc057tuj.1 human [Q5TAT6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1305
DisGeNETi1305
EuPathDBiHostDB:ENSG00000197467.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
COL13A1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0025928
HGNCiHGNC:2190 COL13A1
HPAiHPA050392
MalaCardsiCOL13A1
MIMi120350 gene
616720 phenotype
neXtProtiNX_Q5TAT6
OpenTargetsiENSG00000197467
Orphaneti98913 Postsynaptic congenital myasthenic syndromes
98914 Presynaptic congenital myasthenic syndromes
PharmGKBiPA26706

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IS74 Eukaryota
ENOG410YPXK LUCA
GeneTreeiENSGT00940000154865
HOGENOMiHOG000085653
HOVERGENiHBG004933
InParanoidiQ5TAT6
KOiK16617
OMAiSPGCHCP
OrthoDBi669310at2759
PhylomeDBiQ5TAT6
TreeFamiTF338175

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-216083 Integrin cell surface interactions
R-HSA-8948216 Collagen chain trimerization

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Collagen,_type_XIII,_alpha_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1305

Protein Ontology

More...
PROi
PR:Q5TAT6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197467 Expressed in 176 organ(s), highest expression level in tibia
ExpressionAtlasiQ5TAT6 baseline and differential
GenevisibleiQ5TAT6 HS

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
PfamiView protein in Pfam
PF01391 Collagen, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCODA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TAT6
Secondary accession number(s): A6NFR5
, B9EGD2, E7EWL8, Q13992, Q13993, Q13994, Q13995, Q13996, Q5TAT4, Q5TAT5, Q7KZ33, Q7KZ49, Q99228, Q9NQ52
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 21, 2004
Last modified: January 16, 2019
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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