UniProtKB - Q5TAP6 (UT14C_HUMAN)
Protein
U3 small nucleolar RNA-associated protein 14 homolog C
Gene
UTP14C
Organism
Homo sapiens (Human)
Status
Functioni
Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity).By similarity1 Publication
Miscellaneous
Encoded by an autosomal retrotransposed copy of the X-linked gene UTP14A. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- meiotic cell cycle Source: UniProtKB-KW
- multicellular organism development Source: UniProtKB-KW
- rRNA processing Source: InterPro
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Meiosis, Ribosome biogenesis, Spermatogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q5TAP6 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: U3 small nucleolar RNA-associated protein 14 homolog C |
Gene namesi | Name:UTP14C Synonyms:KIAA0266 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20321, UTP14C |
MIMi | 608969, gene |
neXtProti | NX_Q5TAP6 |
VEuPathDBi | HostDB:ENSG00000253797.2 |
Subcellular locationi
Nucleus
- nucleolus By similarity
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: HPA
Other locations
- small-subunit processome Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9724 |
OpenTargetsi | ENSG00000253797 |
PharmGKBi | PA134944828 |
Miscellaneous databases
Pharosi | Q5TAP6, Tdark |
Genetic variation databases
BioMutai | UTP14C |
DMDMi | 68566167 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000065736 | 1 – 766 | U3 small nucleolar RNA-associated protein 14 homolog CAdd BLAST | 766 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 28 | PhosphoserineBy similarity | 1 | |
Modified residuei | 51 | PhosphoserineBy similarity | 1 | |
Modified residuei | 76 | PhosphoserineBy similarity | 1 | |
Modified residuei | 80 | PhosphoserineBy similarity | 1 | |
Cross-linki | 121 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 204 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 403 | PhosphoserineBy similarity | 1 | |
Modified residuei | 405 | PhosphoserineBy similarity | 1 | |
Modified residuei | 443 | PhosphoserineBy similarity | 1 | |
Cross-linki | 447 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 451 | PhosphoserineBy similarity | 1 | |
Cross-linki | 517 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 567 | PhosphoserineBy similarity | 1 | |
Cross-linki | 732 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q5TAP6 |
jPOSTi | Q5TAP6 |
MassIVEi | Q5TAP6 |
MaxQBi | Q5TAP6 |
PaxDbi | Q5TAP6 |
PeptideAtlasi | Q5TAP6 |
PRIDEi | Q5TAP6 |
ProteomicsDBi | 64855 |
PTM databases
iPTMneti | Q5TAP6 |
PhosphoSitePlusi | Q5TAP6 |
Expressioni
Tissue specificityi
Expressed in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000253797, Expressed in tibia and 245 other tissues |
ExpressionAtlasi | Q5TAP6, baseline and differential |
Genevisiblei | Q5TAP6, HS |
Organism-specific databases
HPAi | ENSG00000253797, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ5TAP6
Protein-protein interaction databases
BioGRIDi | 115073, 43 interactors |
IntActi | Q5TAP6, 31 interactors |
MINTi | Q5TAP6 |
STRINGi | 9606.ENSP00000428619 |
Miscellaneous databases
RNActi | Q5TAP6, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 216 – 245 | Sequence analysisAdd BLAST | 30 | |
Coiled coili | 316 – 346 | Sequence analysisAdd BLAST | 31 | |
Coiled coili | 452 – 470 | Sequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the UTP14 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2172, Eukaryota |
GeneTreei | ENSGT00390000008142 |
HOGENOMi | CLU_012635_1_0_1 |
InParanoidi | Q5TAP6 |
OMAi | NARMMER |
OrthoDBi | 370022at2759 |
PhylomeDBi | Q5TAP6 |
TreeFami | TF314531 |
Family and domain databases
InterProi | View protein in InterPro IPR006709, SSU_processome_Utp14 |
PANTHERi | PTHR14150, PTHR14150, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5TAP6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNVNQVAENL ALSHQEELVD LPKNYPLSEN EDEGDSDGER KHQKLLEAII
60 70 80 90 100
SLDGKNRRKL AERSEASLKV SEFSVSSEGS GEKLGLADLL EPVKTSSSLA
110 120 130 140 150
TVKKQLNRVK SKKVVELPLN KEKIEQIHRE VAFSKTSQVL SKWDPIILKN
160 170 180 190 200
QQAEQLVFPL GKEQPAIAPI EHALSGWKAR TPLEQEIFNL LHKNKQPVTD
210 220 230 240 250
PLLTPMEKAS LQAMSLEEAK MHRAELQRAR ALQSYYEAKA RKEKKIKSKK
260 270 280 290 300
YHKVVKKGKA KKALKEFEQL QKVNPTVALE EMEKIENARM MERMSLKHQN
310 320 330 340 350
SGKWAKSKAI MAKYDLEARQ AMQEQLAKNK ELTQKLQVAS ESEEEEGGTE
360 370 380 390 400
VEELLVPHVA NEVQMNVDGP NPWMFRSCTS DTKEAATQED PEQVPELAAH
410 420 430 440 450
EVSASEAEER PVAEEEILLR EFEERQSLRK RSELNQDAEP ASSQETKDSS
460 470 480 490 500
SQEVLSELRA LSQKLKEKHQ SRKQKASSEG TVPQVQREEP APEEAEPLLL
510 520 530 540 550
QRSERVQTLE ELEELGKEDC FQNKELPRPV LEGQQSERTP NNRPDAPKEK
560 570 580 590 600
KEKEQLINLQ NFLTTQSPSV RSLAVPTIIE ELEDEEERDQ RQMIKEAFAG
610 620 630 640 650
DDVIRDFLKE KREAVEASKP KDVDLTLPGW GEWGGVGLKP SAKKRRQFLI
660 670 680 690 700
KAPEGPPRKD KNLPNVIISE KRNIHAAAHQ VQVLPYPFTH HRQFERTIQT
710 720 730 740 750
PIGSTWNTQR AFQKLTTPKV VTKPGHIIKP IKAEDVGYQS SSRSDLPVIQ
760
RNPKRITTRH NKEEKL
Sequence cautioni
The sequence BAA13396 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022812 | 85 | G → V1 PublicationCorresponds to variant dbSNP:rs3742289Ensembl. | 1 | |
Natural variantiVAR_022813 | 101 | T → A. Corresponds to variant dbSNP:rs3742290Ensembl. | 1 | |
Natural variantiVAR_051482 | 319 | R → H. Corresponds to variant dbSNP:rs17402034Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87455 mRNA Translation: BAA13396.2 Different initiation. AL139082 Genomic DNA No translation available. BC089407 mRNA Translation: AAH89407.1 |
CCDSi | CCDS31978.1 |
RefSeqi | NP_067677.4, NM_021645.5 |
Genome annotation databases
Ensembli | ENST00000521776; ENSP00000428619; ENSG00000253797 |
GeneIDi | 9724 |
KEGGi | hsa:9724 |
UCSCi | uc058xgb.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87455 mRNA Translation: BAA13396.2 Different initiation. AL139082 Genomic DNA No translation available. BC089407 mRNA Translation: AAH89407.1 |
CCDSi | CCDS31978.1 |
RefSeqi | NP_067677.4, NM_021645.5 |
3D structure databases
SMRi | Q5TAP6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115073, 43 interactors |
IntActi | Q5TAP6, 31 interactors |
MINTi | Q5TAP6 |
STRINGi | 9606.ENSP00000428619 |
PTM databases
iPTMneti | Q5TAP6 |
PhosphoSitePlusi | Q5TAP6 |
Genetic variation databases
BioMutai | UTP14C |
DMDMi | 68566167 |
Proteomic databases
EPDi | Q5TAP6 |
jPOSTi | Q5TAP6 |
MassIVEi | Q5TAP6 |
MaxQBi | Q5TAP6 |
PaxDbi | Q5TAP6 |
PeptideAtlasi | Q5TAP6 |
PRIDEi | Q5TAP6 |
ProteomicsDBi | 64855 |
Protocols and materials databases
Antibodypediai | 49851, 20 antibodies |
DNASUi | 9724 |
Genome annotation databases
Ensembli | ENST00000521776; ENSP00000428619; ENSG00000253797 |
GeneIDi | 9724 |
KEGGi | hsa:9724 |
UCSCi | uc058xgb.1, human |
Organism-specific databases
CTDi | 9724 |
DisGeNETi | 9724 |
GeneCardsi | UTP14C |
HGNCi | HGNC:20321, UTP14C |
HPAi | ENSG00000253797, Low tissue specificity |
MIMi | 608969, gene |
neXtProti | NX_Q5TAP6 |
OpenTargetsi | ENSG00000253797 |
PharmGKBi | PA134944828 |
VEuPathDBi | HostDB:ENSG00000253797.2 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2172, Eukaryota |
GeneTreei | ENSGT00390000008142 |
HOGENOMi | CLU_012635_1_0_1 |
InParanoidi | Q5TAP6 |
OMAi | NARMMER |
OrthoDBi | 370022at2759 |
PhylomeDBi | Q5TAP6 |
TreeFami | TF314531 |
Enzyme and pathway databases
PathwayCommonsi | Q5TAP6 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 9724, 2 hits in 994 CRISPR screens |
ChiTaRSi | UTP14C, human |
GenomeRNAii | 9724 |
Pharosi | Q5TAP6, Tdark |
PROi | PR:Q5TAP6 |
RNActi | Q5TAP6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000253797, Expressed in tibia and 245 other tissues |
ExpressionAtlasi | Q5TAP6, baseline and differential |
Genevisiblei | Q5TAP6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006709, SSU_processome_Utp14 |
PANTHERi | PTHR14150, PTHR14150, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UT14C_HUMAN | |
Accessioni | Q5TAP6Primary (citable) accession number: Q5TAP6 Secondary accession number(s): Q5FWG3, Q92555 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | December 21, 2004 | |
Last modified: | April 7, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families