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Protein

Sodium/hydrogen exchanger 11

Gene

SLC9C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in pH regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi867 – 999cNMPAdd BLAST133

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels

Protein family/group databases

TCDBi2.A.36.7.4 the monovalent cation:proton antiporter-1 (cpa1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchanger 11
Alternative name(s):
Na(+)/H(+) exchanger 11
Short name:
NHE-11
Solute carrier family 9 member 11
Solute carrier family 9 member C2
Gene namesi
Name:SLC9C2
Synonyms:SLC9A11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162753.11
HGNCiHGNC:28664 SLC9C2
neXtProtiNX_Q5TAH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Transmembranei612 – 632HelicalSequence analysisAdd BLAST21
Transmembranei641 – 661HelicalSequence analysisAdd BLAST21
Transmembranei674 – 694HelicalSequence analysisAdd BLAST21
Transmembranei706 – 726HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi284525
OpenTargetsiENSG00000162753
PharmGKBiPA134865165

Polymorphism and mutation databases

BioMutaiSLC9C2
DMDMi74745831

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002957061 – 1124Sodium/hydrogen exchanger 11Add BLAST1124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi447N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi473N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5TAH2
PeptideAtlasiQ5TAH2
PRIDEiQ5TAH2
ProteomicsDBi64851

PTM databases

iPTMnetiQ5TAH2
PhosphoSitePlusiQ5TAH2

Expressioni

Gene expression databases

BgeeiENSG00000162753 Expressed in 81 organ(s), highest expression level in testis
CleanExiHS_SLC9A11
GenevisibleiQ5TAH2 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356687

Structurei

3D structure databases

ProteinModelPortaliQ5TAH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni642 – 723Ion transport-likeBy similarityAdd BLAST82

Domaini

Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0100 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00530000063840
HOGENOMiHOG000154241
HOVERGENiHBG102046
InParanoidiQ5TAH2
KOiK14726
OMAiWPSLEYK
OrthoDBiEOG091G031U
PhylomeDBiQ5TAH2
TreeFamiTF328865

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di1.20.120.350, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR014710 RmlC-like_jellyroll
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10110 PTHR10110, 1 hit
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00999 Na_H_Exchanger, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5TAH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYFWAQNE SNRPDLLCGQ PADYLVEEKH FTTLVCFIVV LGGLLKMCLK
60 70 80 90 100
NCEVIVLTIL SLSGFVIGHM AYNSVEVHQI VYPLLRTSSF SLYSYFSPLI
110 120 130 140 150
IFMVALDVEF YTLKKMFWQV LLTGLISFST ASIIIGYVVI KFNKDSWDLQ
160 170 180 190 200
SCLLFSITLG IIDPLRSVNS LKTIGISKIY IDLIRGESLI ICSIASIFFG
210 220 230 240 250
NFRGNRIHFS IFRDLHVGIE LSYDILGSII FGYWCAKIIQ CILADVFSNM
260 270 280 290 300
LTNIILCFSM VYMTFYIVEF LGMSGTLALA AVGLNLDSLT FKPKIELVIT
310 320 330 340 350
KFLRIFSSVY EHLIYAFFGI VIGCGELSHY EFHTIPFIFI LFTTVNLVRL
360 370 380 390 400
LTILLVSPIL MHSNYEYNWR WGVVITWSGI KGVFNLLWAP DVYNLAERKV
410 420 430 440 450
EVPQMFILYV QVISLLTMGI NSYVMTQSAR KLDLCVLSLP RQMILQNATQ
460 470 480 490 500
HIQEIVQNTI TLFKTEKILT NVNWTLVEDK TRIEYIPFSH VSHNDMKTES
510 520 530 540 550
TTDEALMEEA RLHVAAIQMS SFEKQRNNGI LEIEAARILI GAAKCYYSIQ
560 570 580 590 600
GKFMSIYDVS TYMRTRSWLI KFKNVLTFLE YCIEKIHFIP PESNTFLTFI
610 620 630 640 650
FHIVFSEEFE YTGQIINLIY IYPMIIHLWP MARGLNVSAL ISINYYFMFL
660 670 680 690 700
YVLESTLKII ILKRKYFQQC WNTLEFFILV IGIIDIFCVY FVKLRPDNLA
710 720 730 740 750
LIQLTVIMGY LRIIRFLPLF KIIVPILIRI ADVQIKKRLS LMYSITKGYI
760 770 780 790 800
KSQEDAKLLI KQIAVCESIY QKLCEILETN KQDAVKELVL MEHEGRDVVI
810 820 830 840 850
ALKTKQAIRN VIAKALKNLT FLCSRGIIDK HEVIEINKVL LKKLKALNNF
860 870 880 890 900
PKAIPPPTPD IYLHNIIWLE GKDVLIDFFK ERAKLACFDS GDTICKGGEM
910 920 930 940 950
PQGIYLIISG MAILHSLSPT FGIESNQRCD RGSRDMFTEF CTTGDIIGEL
960 970 980 990 1000
SCLLKREIEY TVICETSLQA CFISLEDLYE GFDAFWPSLE YKIWLKLALS
1010 1020 1030 1040 1050
TAYQYFESSL IDEDLRFQNC VMFNQAYVET LSSYSDMIID NMTMKFVIIV
1060 1070 1080 1090 1100
YGSVIDTKTE EPYFAPCIIP TTCEQVQGTS DLSKLLIIQA SELTQRNSNT
1110 1120
NVMASVNTVF EQPGKNINGR QKMS
Length:1,124
Mass (Da):129,053
Last modified:December 21, 2004 - v1
Checksum:i5D1E20BB33AEDD65
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033331481T → M. Corresponds to variant dbSNP:rs7551131Ensembl.1
Natural variantiVAR_033332505A → G. Corresponds to variant dbSNP:rs16846206Ensembl.1
Natural variantiVAR_033333934R → S1 PublicationCorresponds to variant dbSNP:rs17854214Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139142 Genomic DNA No translation available.
BC042592 mRNA Translation: AAH42592.1
CCDSiCCDS1308.1
RefSeqiNP_848622.2, NM_178527.3
UniGeneiHs.494981

Genome annotation databases

EnsembliENST00000367714; ENSP00000356687; ENSG00000162753
GeneIDi284525
KEGGihsa:284525
UCSCiuc001giz.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139142 Genomic DNA No translation available.
BC042592 mRNA Translation: AAH42592.1
CCDSiCCDS1308.1
RefSeqiNP_848622.2, NM_178527.3
UniGeneiHs.494981

3D structure databases

ProteinModelPortaliQ5TAH2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000356687

Protein family/group databases

TCDBi2.A.36.7.4 the monovalent cation:proton antiporter-1 (cpa1) family

PTM databases

iPTMnetiQ5TAH2
PhosphoSitePlusiQ5TAH2

Polymorphism and mutation databases

BioMutaiSLC9C2
DMDMi74745831

Proteomic databases

PaxDbiQ5TAH2
PeptideAtlasiQ5TAH2
PRIDEiQ5TAH2
ProteomicsDBi64851

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367714; ENSP00000356687; ENSG00000162753
GeneIDi284525
KEGGihsa:284525
UCSCiuc001giz.3 human

Organism-specific databases

CTDi284525
DisGeNETi284525
EuPathDBiHostDB:ENSG00000162753.11
GeneCardsiSLC9C2
HGNCiHGNC:28664 SLC9C2
neXtProtiNX_Q5TAH2
OpenTargetsiENSG00000162753
PharmGKBiPA134865165
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0100 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00530000063840
HOGENOMiHOG000154241
HOVERGENiHBG102046
InParanoidiQ5TAH2
KOiK14726
OMAiWPSLEYK
OrthoDBiEOG091G031U
PhylomeDBiQ5TAH2
TreeFamiTF328865

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels

Miscellaneous databases

ChiTaRSiSLC9C2 human
GeneWikiiSLC9A11
GenomeRNAii284525
PROiPR:Q5TAH2

Gene expression databases

BgeeiENSG00000162753 Expressed in 81 organ(s), highest expression level in testis
CleanExiHS_SLC9A11
GenevisibleiQ5TAH2 HS

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di1.20.120.350, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR014710 RmlC-like_jellyroll
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10110 PTHR10110, 1 hit
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00999 Na_H_Exchanger, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSL9C2_HUMAN
AccessioniPrimary (citable) accession number: Q5TAH2
Secondary accession number(s): Q86UF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 21, 2004
Last modified: October 10, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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