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UniProtKB - Q5TA89 (HES5_HUMAN)
Protein
Transcription factor HES-5
Gene
HES5
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).
By similarityGO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: UniProtKB
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- anterior/posterior pattern specification Source: GO_Central
- astrocyte differentiation Source: UniProtKB
- brain development Source: UniProtKB
- camera-type eye development Source: UniProtKB
- cartilage development Source: UniProtKB
- cell adhesion Source: UniProtKB
- cell maturation Source: UniProtKB
- central nervous system myelination Source: UniProtKB
- comma-shaped body morphogenesis Source: Ensembl
- establishment of epithelial cell polarity Source: Ensembl
- forebrain radial glial cell differentiation Source: Ensembl
- glial cell fate commitment Source: UniProtKB
- inner ear receptor cell stereocilium organization Source: Ensembl
- metanephric nephron tubule morphogenesis Source: Ensembl
- negative regulation of astrocyte differentiation Source: UniProtKB
- negative regulation of forebrain neuron differentiation Source: Ensembl
- negative regulation of inner ear auditory receptor cell differentiation Source: Ensembl
- negative regulation of neuron differentiation Source: UniProtKB
- negative regulation of oligodendrocyte differentiation Source: UniProtKB
- negative regulation of pro-B cell differentiation Source: UniProtKB
- negative regulation of stem cell differentiation Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- neural tube development Source: UniProtKB
- neuronal stem cell population maintenance Source: UniProtKB
- Notch signaling pathway Source: UniProtKB
- oligodendrocyte development Source: UniProtKB
- positive regulation of BMP signaling pathway Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of Notch signaling pathway Source: Ensembl
- positive regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
- positive regulation of smooth muscle cell proliferation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
- protein-containing complex assembly Source: UniProtKB
- regulation of cell differentiation Source: UniProtKB
- regulation of epithelial cell proliferation Source: Ensembl
- regulation of myelination Source: UniProtKB
- regulation of neurogenesis Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- smoothened signaling pathway Source: UniProtKB
- specification of loop of Henle identity Source: Ensembl
- S-shaped body morphogenesis Source: Ensembl
- telencephalon development Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, DNA-binding, Repressor |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q5TA89 |
Reactomei | R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2197563, NOTCH2 intracellular domain regulates transcription R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-9013508, NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013695, NOTCH4 Intracellular Domain Regulates Transcription |
SignaLinki | Q5TA89 |
SIGNORi | Q5TA89 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor HES-5Alternative name(s): Class B basic helix-loop-helix protein 38 Short name: bHLHb38 Hairy and enhancer of split 5 |
Gene namesi | Name:HES5 Synonyms:BHLHB38 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19764, HES5 |
MIMi | 607348, gene |
neXtProti | NX_Q5TA89 |
VEuPathDBi | HostDB:ENSG00000197921 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 388585 |
OpenTargetsi | ENSG00000197921 |
PharmGKBi | PA134967985 |
Miscellaneous databases
Pharosi | Q5TA89, Tbio |
Genetic variation databases
BioMutai | HES5 |
DMDMi | 74745795 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000269175 | 1 – 166 | Transcription factor HES-5Add BLAST | 166 |
Proteomic databases
PaxDbi | Q5TA89 |
PeptideAtlasi | Q5TA89 |
PRIDEi | Q5TA89 |
ProteomicsDBi | 64837 |
PTM databases
iPTMneti | Q5TA89 |
PhosphoSitePlusi | Q5TA89 |
Expressioni
Tissue specificityi
Expressed in fetal heart and brain tumors.1 Publication
Gene expression databases
Bgeei | ENSG00000197921, Expressed in ventricular zone and 97 other tissues |
Genevisiblei | Q5TA89, HS |
Organism-specific databases
HPAi | ENSG00000197921, Group enriched (brain, skin) |
Interactioni
Subunit structurei
Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 132759, 4 interactors |
STRINGi | 9606.ENSP00000367714 |
Miscellaneous databases
RNActi | Q5TA89, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 72 | bHLHPROSITE-ProRule annotationAdd BLAST | 57 | |
Domaini | 88 – 119 | OrangePROSITE-ProRule annotationAdd BLAST | 32 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 125 – 144 | DisorderedSequence analysisAdd BLAST | 20 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 163 – 166 | WRPW motif | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 126 – 140 | Pro residuesSequence analysisAdd BLAST | 15 |
Domaini
Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).By similarity
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity
Phylogenomic databases
eggNOGi | ENOG502S6S1, Eukaryota |
GeneTreei | ENSGT00940000162836 |
HOGENOMi | CLU_068550_3_1_1 |
InParanoidi | Q5TA89 |
OMAi | HSKAFAA |
OrthoDBi | 1378299at2759 |
PhylomeDBi | Q5TA89 |
TreeFami | TF351373 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5TA89-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPSTVAVEL LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH
60 70 80 90 100
QPNSKLEKAD ILEMAVSYLK HSKAFVAAAG PKSLHQDYSE GYSWCLQEAV
110 120 130 140 150
QFLTLHAASD TQMKLLYHFQ RPPAAPAAPA KEPKAPGAAP PPALSAKATA
160
AAAAAHQPAC GLWRPW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ272660 mRNA Translation: ABB83829.1 AL139246 Genomic DNA No translation available. CH471183 Genomic DNA Translation: EAW56096.1 |
CCDSi | CCDS41233.1 |
RefSeqi | NP_001010926.1, NM_001010926.3 |
Genome annotation databases
Ensembli | ENST00000378453; ENSP00000367714; ENSG00000197921 ENST00000612705; ENSP00000482150; ENSG00000273529 |
GeneIDi | 388585 |
KEGGi | hsa:388585 |
MANE-Selecti | ENST00000378453.4; ENSP00000367714.3; NM_001010926.4; NP_001010926.1 |
UCSCi | uc001ajn.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ272660 mRNA Translation: ABB83829.1 AL139246 Genomic DNA No translation available. CH471183 Genomic DNA Translation: EAW56096.1 |
CCDSi | CCDS41233.1 |
RefSeqi | NP_001010926.1, NM_001010926.3 |
3D structure databases
SMRi | Q5TA89 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 132759, 4 interactors |
STRINGi | 9606.ENSP00000367714 |
PTM databases
iPTMneti | Q5TA89 |
PhosphoSitePlusi | Q5TA89 |
Genetic variation databases
BioMutai | HES5 |
DMDMi | 74745795 |
Proteomic databases
PaxDbi | Q5TA89 |
PeptideAtlasi | Q5TA89 |
PRIDEi | Q5TA89 |
ProteomicsDBi | 64837 |
Protocols and materials databases
Antibodypediai | 26785, 217 antibodies from 35 providers |
DNASUi | 388585 |
Genome annotation databases
Ensembli | ENST00000378453; ENSP00000367714; ENSG00000197921 ENST00000612705; ENSP00000482150; ENSG00000273529 |
GeneIDi | 388585 |
KEGGi | hsa:388585 |
MANE-Selecti | ENST00000378453.4; ENSP00000367714.3; NM_001010926.4; NP_001010926.1 |
UCSCi | uc001ajn.3, human |
Organism-specific databases
CTDi | 388585 |
DisGeNETi | 388585 |
GeneCardsi | HES5 |
HGNCi | HGNC:19764, HES5 |
HPAi | ENSG00000197921, Group enriched (brain, skin) |
MIMi | 607348, gene |
neXtProti | NX_Q5TA89 |
OpenTargetsi | ENSG00000197921 |
PharmGKBi | PA134967985 |
VEuPathDBi | HostDB:ENSG00000197921 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S6S1, Eukaryota |
GeneTreei | ENSGT00940000162836 |
HOGENOMi | CLU_068550_3_1_1 |
InParanoidi | Q5TA89 |
OMAi | HSKAFAA |
OrthoDBi | 1378299at2759 |
PhylomeDBi | Q5TA89 |
TreeFami | TF351373 |
Enzyme and pathway databases
PathwayCommonsi | Q5TA89 |
Reactomei | R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2197563, NOTCH2 intracellular domain regulates transcription R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-9013508, NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013695, NOTCH4 Intracellular Domain Regulates Transcription |
SignaLinki | Q5TA89 |
SIGNORi | Q5TA89 |
Miscellaneous databases
BioGRID-ORCSi | 388585, 9 hits in 1055 CRISPR screens |
GeneWikii | HES5 |
GenomeRNAii | 388585 |
Pharosi | Q5TA89, Tbio |
PROi | PR:Q5TA89 |
RNActi | Q5TA89, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197921, Expressed in ventricular zone and 97 other tissues |
Genevisiblei | Q5TA89, HS |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HES5_HUMAN | |
Accessioni | Q5TA89Primary (citable) accession number: Q5TA89 Secondary accession number(s): B9DI85 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 23, 2022 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot