Transcription factor HES-5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: Ensembl
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: UniProtKB
• protein dimerization activity Source: InterPro
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: ARUK-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Impact of cytosine methylation on DNA binding specificities of human transcription factors."
    Yin Y., Morgunova E., Jolma A., Kaasinen E., Sahu B., Khund-Sayeed S., Das P.K., Kivioja T., Dave K., Zhong F., Nitta K.R., Taipale M., Popov A., Ginno P.A., Domcke S., Yan J., Schubeler D., Vinson C., Taipale J.
    Science 356:0-0(2017) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer."
    Katoh M., Katoh M.
    Int J Oncol 31:461-466(2007) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• anterior/posterior pattern specification Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• astrocyte differentiation Source: UniProtKB
• brain development Source: UniProtKB
• camera-type eye development Source: UniProtKB
• cartilage development Source: UniProtKBInferred from direct assayⁱ
  • "Notch and HES5 are regulated during human cartilage differentiation."
    Karlsson C., Jonsson M., Asp J., Brantsing C., Kageyama R., Lindahl A.
    Cell Tissue Res 327:539-551(2007) [PubMed] [Europe PMC] [Abstract]
• cell adhesion Source: UniProtKB
• cell maturation Source: UniProtKB
• central nervous system myelination Source: UniProtKB
• comma-shaped body morphogenesis Source: Ensembl
• establishment of epithelial cell polarity Source: Ensembl
• forebrain radial glial cell differentiation Source: Ensembl
• glial cell fate commitment Source: UniProtKB
• inner ear receptor cell stereocilium organization Source: Ensembl
• metanephric nephron tubule morphogenesis Source: Ensembl
• negative regulation of astrocyte differentiation Source: UniProtKB
• negative regulation of forebrain neuron differentiation Source: Ensembl
• negative regulation of inner ear auditory receptor cell differentiation Source: Ensembl
• negative regulation of neuron differentiation Source: UniProtKB
• negative regulation of oligodendrocyte differentiation Source: UniProtKB
• negative regulation of pro-B cell differentiation Source: UniProtKB
• negative regulation of stem cell differentiation Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells."
    Woo S.M., Kim J., Han H.W., Chae J.I., Son M.Y., Cho S., Chung H.M., Han Y.M., Kang Y.K.
    BMC Neurosci 10:97-97(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: UniProtKB
• neural tube development Source: UniProtKB
• neuronal stem cell population maintenance Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells."
    Woo S.M., Kim J., Han H.W., Chae J.I., Son M.Y., Cho S., Chung H.M., Han Y.M., Kang Y.K.
    BMC Neurosci 10:97-97(2009) [PubMed] [Europe PMC] [Abstract]
• Notch signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells."
    Woo S.M., Kim J., Han H.W., Chae J.I., Son M.Y., Cho S., Chung H.M., Han Y.M., Kang Y.K.
    BMC Neurosci 10:97-97(2009) [PubMed] [Europe PMC] [Abstract]
  • "Notch3 signaling promotes the development of pulmonary arterial hypertension."
    Li X., Zhang X., Leathers R., Makino A., Huang C., Parsa P., Macias J., Yuan J.X., Jamieson S.W., Thistlethwaite P.A.
    Nat Med 15:1289-1297(2009) [PubMed] [Europe PMC] [Abstract]
• oligodendrocyte development Source: UniProtKB
• positive regulation of BMP signaling pathway Source: UniProtKB
• positive regulation of cell population proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells."
    Zhang X.P., Zheng G., Zou L., Liu H.L., Hou L.H., Zhou P., Yin D.D., Zheng Q.J., Liang L., Zhang S.Z., Feng L., Yao L.B., Yang A.G., Han H., Chen J.Y.
    Mol Cell Biochem 307:101-108(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of Notch signaling pathway Source: Ensembl
• positive regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
• positive regulation of smooth muscle cell proliferation Source: UniProtKB <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Notch3 signaling promotes the development of pulmonary arterial hypertension."
    Li X., Zhang X., Leathers R., Makino A., Huang C., Parsa P., Macias J., Yuan J.X., Jamieson S.W., Thistlethwaite P.A.
    Nat Med 15:1289-1297(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
• protein-containing complex assembly Source: UniProtKB
• regulation of cell differentiation Source: UniProtKB
• regulation of epithelial cell proliferation Source: Ensembl
• regulation of myelination Source: UniProtKB
• regulation of neurogenesis Source: UniProtKB
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• smoothened signaling pathway Source: UniProtKB
• specification of loop of Henle identity Source: Ensembl
• S-shaped body morphogenesis Source: Ensembl
• telencephalon development Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protein dimerization activity Source: InterPro
• transcription factor binding Source: UniProtKBNon-traceable author statementⁱ
  • "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer."
    Katoh M., Katoh M.
    Int J Oncol 31:461-466(2007) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAPSTVAVEL LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH 
        60         70         80         90        100
QPNSKLEKAD ILEMAVSYLK HSKAFVAAAG PKSLHQDYSE GYSWCLQEAV 
       110        120        130        140        150
QFLTLHAASD TQMKLLYHFQ RPPAAPAAPA KEPKAPGAAP PPALSAKATA 
       160 
AAAAAHQPAC GLWRPW                                      

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot