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Protein

Transcription factor HES-5

Gene

HES5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-5
Alternative name(s):
Class B basic helix-loop-helix protein 38
Short name:
bHLHb38
Hairy and enhancer of split 5
Gene namesi
Name:HES5
Synonyms:BHLHB38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197921.5
HGNCiHGNC:19764 HES5
MIMi607348 gene
neXtProtiNX_Q5TA89

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi388585
OpenTargetsiENSG00000197921
PharmGKBiPA134967985

Polymorphism and mutation databases

BioMutaiHES5
DMDMi74745795

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002691751 – 166Transcription factor HES-5Add BLAST166

Proteomic databases

PaxDbiQ5TA89
PRIDEiQ5TA89
ProteomicsDBi64837

PTM databases

iPTMnetiQ5TA89
PhosphoSitePlusiQ5TA89

Expressioni

Tissue specificityi

Expressed in fetal heart and brain tumors.1 Publication

Gene expression databases

BgeeiENSG00000197921 Expressed in 84 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_HES5
GenevisibleiQ5TA89 HS

Organism-specific databases

HPAiHPA065458
HPA076164

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi132759, 4 interactors
STRINGi9606.ENSP00000367714

Structurei

3D structure databases

ProteinModelPortaliQ5TA89
SMRiQ5TA89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 72bHLHPROSITE-ProRule annotationAdd BLAST57
Domaini88 – 119OrangePROSITE-ProRule annotationAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi163 – 166WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 31Arg/Lys-rich (basic)Add BLAST18
Compositional biasi122 – 142Pro-richAdd BLAST21
Compositional biasi147 – 153Poly-Ala7

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).By similarity
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Phylogenomic databases

eggNOGiENOG410IWTV Eukaryota
ENOG41120DD LUCA
GeneTreeiENSGT00910000144201
HOGENOMiHOG000236346
HOVERGENiHBG005960
InParanoidiQ5TA89
KOiK06055
OMAiHKLRKPM
OrthoDBiEOG091G0V3D
PhylomeDBiQ5TA89
TreeFamiTF351373

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5TA89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPSTVAVEL LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH
60 70 80 90 100
QPNSKLEKAD ILEMAVSYLK HSKAFVAAAG PKSLHQDYSE GYSWCLQEAV
110 120 130 140 150
QFLTLHAASD TQMKLLYHFQ RPPAAPAAPA KEPKAPGAAP PPALSAKATA
160
AAAAAHQPAC GLWRPW
Length:166
Mass (Da):18,226
Last modified:December 21, 2004 - v1
Checksum:i6B0ECF2482EBE43B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ272660 mRNA Translation: ABB83829.1
AL139246 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56096.1
CCDSiCCDS41233.1
RefSeqiNP_001010926.1, NM_001010926.3
UniGeneiHs.57971

Genome annotation databases

EnsembliENST00000378453; ENSP00000367714; ENSG00000197921
ENST00000612705; ENSP00000482150; ENSG00000273529
GeneIDi388585
KEGGihsa:388585
UCSCiuc001ajn.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ272660 mRNA Translation: ABB83829.1
AL139246 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56096.1
CCDSiCCDS41233.1
RefSeqiNP_001010926.1, NM_001010926.3
UniGeneiHs.57971

3D structure databases

ProteinModelPortaliQ5TA89
SMRiQ5TA89
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132759, 4 interactors
STRINGi9606.ENSP00000367714

PTM databases

iPTMnetiQ5TA89
PhosphoSitePlusiQ5TA89

Polymorphism and mutation databases

BioMutaiHES5
DMDMi74745795

Proteomic databases

PaxDbiQ5TA89
PRIDEiQ5TA89
ProteomicsDBi64837

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378453; ENSP00000367714; ENSG00000197921
ENST00000612705; ENSP00000482150; ENSG00000273529
GeneIDi388585
KEGGihsa:388585
UCSCiuc001ajn.3 human

Organism-specific databases

CTDi388585
DisGeNETi388585
EuPathDBiHostDB:ENSG00000197921.5
GeneCardsiHES5
HGNCiHGNC:19764 HES5
HPAiHPA065458
HPA076164
MIMi607348 gene
neXtProtiNX_Q5TA89
OpenTargetsiENSG00000197921
PharmGKBiPA134967985
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWTV Eukaryota
ENOG41120DD LUCA
GeneTreeiENSGT00910000144201
HOGENOMiHOG000236346
HOVERGENiHBG005960
InParanoidiQ5TA89
KOiK06055
OMAiHKLRKPM
OrthoDBiEOG091G0V3D
PhylomeDBiQ5TA89
TreeFamiTF351373

Enzyme and pathway databases

ReactomeiR-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription

Miscellaneous databases

GeneWikiiHES5
GenomeRNAii388585
PROiPR:Q5TA89
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197921 Expressed in 84 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_HES5
GenevisibleiQ5TA89 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHES5_HUMAN
AccessioniPrimary (citable) accession number: Q5TA89
Secondary accession number(s): B9DI85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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