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UniProtKB - Q5TA45 (INT11_HUMAN)

Entry version 145 (25 May 2022)
Sequence version 2 (31 Oct 2006)
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Protein

Integrator complex subunit 11

Gene

INTS11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • endoribonuclease activity Source: FlyBase
Complete GO annotation on QuickGO ...

GO - Biological processi

  • snRNA processing Source: BHF-UCL
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5TA45

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6807505, RNA polymerase II transcribes snRNA genes

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q5TA45

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q5TA45

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrator complex subunit 11 (EC:3.1.27.-)
Short name:
Int11
Alternative name(s):
Cleavage and polyadenylation-specific factor 3-like protein
Short name:
CPSF3-like protein
Protein related to CPSF subunits of 68 kDa
Short name:
RC-68
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INTS11Imported
Synonyms:CPSF3L, RC68
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26052, INTS11

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611354, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5TA45

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000127054

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi203E → Q: Abolishes the ability of the Integrator complex to process U1 and U2 snRNA genes. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		54973

Open Targets

More...OpenTargetsi		ENSG00000127054

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672080

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5TA45, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		INTS11

Domain mapping of disease mutations (DMDM)

More...DMDMi		118572557

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595631 – 600Integrator complex subunit 11Add BLAST600

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5TA45

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5TA45

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5TA45

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5TA45

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5TA45

PeptideAtlas

More...PeptideAtlasi		Q5TA45

PRoteomics IDEntifications database

More...PRIDEi		Q5TA45

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		32426
4590
64825 [Q5TA45-1]
64826 [Q5TA45-2]
64827 [Q5TA45-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5TA45

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5TA45

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000127054, Expressed in cerebellum and 121 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5TA45, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5TA45, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000127054, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120310, 90 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q5TA45

Protein interaction database and analysis system

More...IntActi		Q5TA45, 64 interactors

Molecular INTeraction database

More...MINTi		Q5TA45

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000445001

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5TA45, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1600
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q5TA45

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5TA45

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi68 – 73HXHXDH motif6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1136, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157644

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009673_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5TA45

Identification of Orthologs from Complete Genome Data

More...OMAi		YLDGMIW

Database of Orthologous Groups

More...OrthoDBi		218195at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5TA45

TreeFam database of animal gene trees

More...TreeFami		TF105878

Family and domain databases

Conserved Domains Database

More...CDDi		cd16291, INTS11-like_MBL-fold, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.15.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022712, Beta_Casp
IPR041897, INTS11-like_MBL-fold
IPR001279, Metallo-B-lactamas
IPR036866, RibonucZ/Hydroxyglut_hydro
IPR011108, RMMBL

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10996, Beta-Casp, 1 hit
PF16661, Lactamase_B_6, 1 hit
PF07521, RMMBL, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01027, Beta-Casp, 1 hit
SM00849, Lactamase_B, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56281, SSF56281, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5TA45-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEIRVTPLG AGQDVGRSCI LVSIAGKNVM LDCGMHMGFN DDRRFPDFSY 
        60         70         80         90        100
ITQNGRLTDF LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC 
       110        120        130        140        150
PILLEDYRKI AVDKKGEANF FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI 
       160        170        180        190        200
KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN MTPDRHLGAA WIDKCRPNLL 
       210        220        230        240        250
ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF ALGRAQELCI 
       260        270        280        290        300
LLETFWERMN LKVPIYFSTG LTEKANHYYK LFIPWTNQKI RKTFVQRNMF 
       310        320        330        340        350
EFKHIKAFDR AFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM 
       360        370        380        390        400
PGYCVQGTVG HKILSGQRKL EMEGRQVLEV KMQVEYMSFS AHADAKGIMQ 
       410        420        430        440        450
LVGQAEPESV LLVHGEAKKM EFLKQKIEQE LRVNCYMPAN GETVTLPTSP 
       460        470        480        490        500
SIPVGISLGL LKREMAQGLL PEAKKPRLLH GTLIMKDSNF RLVSSEQALK 
       510        520        530        540        550
ELGLAEHQLR FTCRVHLHDT RKEQETALRV YSHLKSVLKD HCVQHLPDGS 
       560        570        580        590        600
VTVESVLLQA AAPSEDPGTK VLLVSWTYQD EELGSFLTSL LKKGLPQAPS
Length:600
Mass (Da):67,663
Last modified:October 31, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47C4E2E16202B130
GO
Isoform 2 (identifier: Q5TA45-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-143: Missing.

Show »
Length:499
Mass (Da):56,013
Checksum:i91F01E586DDC4FD1
GO
Isoform 3 (identifier: Q5TA45-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-164: Missing.

Show »
Length:578
Mass (Da):65,240
Checksum:iAD63044D90F3D6A2
GO
Isoform 4 (identifier: Q5TA45-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:571
Mass (Da):64,699
Checksum:i4F3056C3490955F1
GO
Isoform 5 (identifier: Q5TA45-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MPEIRVTPL → MCGAGFGHFEWLAGG

Show »
Length:606
Mass (Da):68,147
Checksum:iE943195A6FBB41C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNS4E9PNS4_HUMAN
Integrator complex subunit 11
INTS11
278Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYS7C9IYS7_HUMAN
Cleavage and polyadenylation specif...
INTS11 CPSF3L, hCG_20422
502Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRY6J3QRY6_HUMAN
Cleavage and polyadenylation specif...
INTS11 CPSF3L, hCG_20422
342Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYI0A0A087WYI0_HUMAN
Integrator complex subunit 11
INTS11
502Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J979C9J979_HUMAN
Integrator complex subunit 11
INTS11
344Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI75E9PI75_HUMAN
Integrator complex subunit 11
INTS11
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIG1E9PIG1_HUMAN
Integrator complex subunit 11
INTS11
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXT8A0A087WXT8_HUMAN
Integrator complex subunit 11
INTS11
289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEQ9H0YEQ9_HUMAN
Integrator complex subunit 11
INTS11
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIS0E9PIS0_HUMAN
Integrator complex subunit 11
INTS11
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91246 differs from that shown. Reason: Frameshift.Curated
The sequence BAB14541 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti95P → S in CAB66747 (PubMed:11230166).Curated1
Sequence conflicti95P → S in CAG38588 (Ref. 3) Curated1
Sequence conflicti253E → K in BAB13943 (PubMed:14702039).Curated1
Sequence conflicti434N → D in BAF84076 (PubMed:14702039).Curated1
Sequence conflicti439A → V in BAG51775 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0454281 – 29Missing in isoform 4. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_0466431 – 9MPEIRVTPL → MCGAGFGHFEWLAGG in isoform 5. 1 Publication9
Alternative sequenceiVSP_02147243 – 143Missing in isoform 2. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_021473143 – 164Missing in isoform 3. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL136813 mRNA Translation: CAB66747.1
AK000549 mRNA Translation: BAA91246.1 Sequence problems.
AK021939 mRNA Translation: BAB13943.1
AK023356 mRNA Translation: BAB14541.1 Frameshift.
AK056652 mRNA Translation: BAG51775.1
AK291387 mRNA Translation: BAF84076.1
AK297350 mRNA Translation: BAG59799.1
CR533557 mRNA Translation: CAG38588.1
AL139287 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56238.1
BC000675 mRNA Translation: AAH00675.2
BC007978 mRNA Translation: AAH07978.1
BC013904 mRNA Translation: AAH13904.2
BK005728 mRNA Translation: DAA05728.1
BK005673 mRNA Translation: DAA05669.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS21.1 [Q5TA45-1]
CCDS57959.1 [Q5TA45-4]
CCDS57960.1 [Q5TA45-5]
CCDS57961.1 [Q5TA45-2]

NCBI Reference Sequences

More...RefSeqi		NP_001243385.1, NM_001256456.1 [Q5TA45-5]
NP_001243389.1, NM_001256460.1 [Q5TA45-4]
NP_001243391.1, NM_001256462.1
NP_001243392.1, NM_001256463.1 [Q5TA45-2]
NP_060341.2, NM_017871.5 [Q5TA45-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000419704.5; ENSP00000404886.1; ENSG00000127054.22 [Q5TA45-2]
ENST00000435064.6; ENSP00000413493.2; ENSG00000127054.22
ENST00000450926.6; ENSP00000392848.2; ENSG00000127054.22 [Q5TA45-3]
ENST00000540437.5; ENSP00000445001.1; ENSG00000127054.22 [Q5TA45-5]
ENST00000545578.5; ENSP00000444672.1; ENSG00000127054.22 [Q5TA45-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54973

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54973

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000435064.6; ENSP00000413493.2; NM_017871.6; NP_060341.2

UCSC genome browser

More...UCSCi		uc001aee.3, human [Q5TA45-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136813 mRNA Translation: CAB66747.1
AK000549 mRNA Translation: BAA91246.1 Sequence problems.
AK021939 mRNA Translation: BAB13943.1
AK023356 mRNA Translation: BAB14541.1 Frameshift.
AK056652 mRNA Translation: BAG51775.1
AK291387 mRNA Translation: BAF84076.1
AK297350 mRNA Translation: BAG59799.1
CR533557 mRNA Translation: CAG38588.1
AL139287 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56238.1
BC000675 mRNA Translation: AAH00675.2
BC007978 mRNA Translation: AAH07978.1
BC013904 mRNA Translation: AAH13904.2
BK005728 mRNA Translation: DAA05728.1
BK005673 mRNA Translation: DAA05669.1
CCDSiCCDS21.1 [Q5TA45-1]
CCDS57959.1 [Q5TA45-4]
CCDS57960.1 [Q5TA45-5]
CCDS57961.1 [Q5TA45-2]
RefSeqiNP_001243385.1, NM_001256456.1 [Q5TA45-5]
NP_001243389.1, NM_001256460.1 [Q5TA45-4]
NP_001243391.1, NM_001256462.1
NP_001243392.1, NM_001256463.1 [Q5TA45-2]
NP_060341.2, NM_017871.5 [Q5TA45-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5V8WX-ray2.10B/D/F/H491-600[»]
7BFPelectron microscopy3.50B1-600[»]
7BFQelectron microscopy3.50B1-600[»]
7CUNelectron microscopy3.50K1-600[»]
7PKSelectron microscopy3.60k1-600[»]
AlphaFoldDBiQ5TA45
SMRiQ5TA45
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120310, 90 interactors
CORUMiQ5TA45
IntActiQ5TA45, 64 interactors
MINTiQ5TA45
STRINGi9606.ENSP00000445001

PTM databases

iPTMnetiQ5TA45
PhosphoSitePlusiQ5TA45

Genetic variation databases

BioMutaiINTS11
DMDMi118572557

Proteomic databases

EPDiQ5TA45
jPOSTiQ5TA45
MassIVEiQ5TA45
MaxQBiQ5TA45
PaxDbiQ5TA45
PeptideAtlasiQ5TA45
PRIDEiQ5TA45
ProteomicsDBi32426
4590
64825 [Q5TA45-1]
64826 [Q5TA45-2]
64827 [Q5TA45-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26257, 192 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		54973

Genome annotation databases

EnsembliENST00000419704.5; ENSP00000404886.1; ENSG00000127054.22 [Q5TA45-2]
ENST00000435064.6; ENSP00000413493.2; ENSG00000127054.22
ENST00000450926.6; ENSP00000392848.2; ENSG00000127054.22 [Q5TA45-3]
ENST00000540437.5; ENSP00000445001.1; ENSG00000127054.22 [Q5TA45-5]
ENST00000545578.5; ENSP00000444672.1; ENSG00000127054.22 [Q5TA45-4]
GeneIDi54973
KEGGihsa:54973
MANE-SelectiENST00000435064.6; ENSP00000413493.2; NM_017871.6; NP_060341.2
UCSCiuc001aee.3, human [Q5TA45-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54973
DisGeNETi54973

GeneCards: human genes, protein and diseases

More...GeneCardsi		INTS11
HGNCiHGNC:26052, INTS11
HPAiENSG00000127054, Low tissue specificity
MIMi611354, gene
neXtProtiNX_Q5TA45
OpenTargetsiENSG00000127054
PharmGKBiPA142672080
VEuPathDBiHostDB:ENSG00000127054

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1136, Eukaryota
GeneTreeiENSGT00940000157644
HOGENOMiCLU_009673_3_0_1
InParanoidiQ5TA45
OMAiYLDGMIW
OrthoDBi218195at2759
PhylomeDBiQ5TA45
TreeFamiTF105878

Enzyme and pathway databases

PathwayCommonsiQ5TA45
ReactomeiR-HSA-6807505, RNA polymerase II transcribes snRNA genes
SignaLinkiQ5TA45
SIGNORiQ5TA45

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54973, 763 hits in 1078 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CPSF3L, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CPSF3L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54973
PharosiQ5TA45, Tbio

Protein Ontology

More...PROi		PR:Q5TA45
RNActiQ5TA45, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000127054, Expressed in cerebellum and 121 other tissues
ExpressionAtlasiQ5TA45, baseline and differential
GenevisibleiQ5TA45, HS

Family and domain databases

CDDicd16291, INTS11-like_MBL-fold, 1 hit
Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR022712, Beta_Casp
IPR041897, INTS11-like_MBL-fold
IPR001279, Metallo-B-lactamas
IPR036866, RibonucZ/Hydroxyglut_hydro
IPR011108, RMMBL
PfamiView protein in Pfam
PF10996, Beta-Casp, 1 hit
PF16661, Lactamase_B_6, 1 hit
PF07521, RMMBL, 1 hit
SMARTiView protein in SMART
SM01027, Beta-Casp, 1 hit
SM00849, Lactamase_B, 1 hit
SUPFAMiSSF56281, SSF56281, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINT11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TA45
Secondary accession number(s): A8K5S2
, B3KPR3, B4DM87, G3V1S5, Q5TA46, Q5TA48, Q5TA52, Q5TA53, Q5TA54, Q7L3D7, Q96HY1, Q9BW36, Q9H0F9, Q9H8R5, Q9HAA6, Q9NWX9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: May 25, 2022
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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