Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrator complex subunit 11

Gene

INTS11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).2 Publications

GO - Molecular functioni

GO - Biological processi

  • snRNA 3'-end processing Source: GO_Central
  • snRNA processing Source: BHF-UCL
  • snRNA transcription by RNA polymerase II Source: Reactome

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 11 (EC:3.1.27.-)
Short name:
Int11
Alternative name(s):
Cleavage and polyadenylation-specific factor 3-like protein
Short name:
CPSF3-like protein
Protein related to CPSF subunits of 68 kDa
Short name:
RC-68
Gene namesi
Name:INTS11Imported
Synonyms:CPSF3L, RC68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000127054.18
HGNCiHGNC:26052 INTS11
MIMi611354 gene
neXtProtiNX_Q5TA45

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi203E → Q: Abolishes the ability of the Integrator complex to process U1 and U2 snRNA genes. 1 Publication1

Organism-specific databases

DisGeNETi54973
OpenTargetsiENSG00000127054
PharmGKBiPA142672080

Polymorphism and mutation databases

BioMutaiCPSF3L
DMDMi118572557

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595631 – 600Integrator complex subunit 11Add BLAST600

Proteomic databases

EPDiQ5TA45
MaxQBiQ5TA45
PaxDbiQ5TA45
PeptideAtlasiQ5TA45
PRIDEiQ5TA45
ProteomicsDBi64825
64826 [Q5TA45-2]
64827 [Q5TA45-3]

PTM databases

iPTMnetiQ5TA45
PhosphoSitePlusiQ5TA45

Expressioni

Gene expression databases

BgeeiENSG00000127054 Expressed in 101 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ5TA45 baseline and differential
GenevisibleiQ5TA45 HS

Organism-specific databases

HPAiHPA028379
HPA029025

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.1 Publication

Protein-protein interaction databases

BioGridi120310, 33 interactors
CORUMiQ5TA45
IntActiQ5TA45, 48 interactors
MINTiQ5TA45
STRINGi9606.ENSP00000413493

Structurei

Secondary structure

1600
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ5TA45
SMRiQ5TA45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi68 – 73HXHXDH motif6

Domaini

The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1137 Eukaryota
COG1236 LUCA
GeneTreeiENSGT00910000144162
HOGENOMiHOG000231294
HOVERGENiHBG080215
InParanoidiQ5TA45
KOiK13148
OMAiYLDGMIW
OrthoDBiEOG091G03RH
PhylomeDBiQ5TA45
TreeFamiTF105878

Family and domain databases

Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR022712 Beta_Casp
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR011108 RMMBL
PfamiView protein in Pfam
PF10996 Beta-Casp, 1 hit
PF16661 Lactamase_B_6, 1 hit
PF07521 RMMBL, 1 hit
SMARTiView protein in SMART
SM01027 Beta-Casp, 1 hit
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 22 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5TA45-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEIRVTPLG AGQDVGRSCI LVSIAGKNVM LDCGMHMGFN DDRRFPDFSY
60 70 80 90 100
ITQNGRLTDF LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC
110 120 130 140 150
PILLEDYRKI AVDKKGEANF FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI
160 170 180 190 200
KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN MTPDRHLGAA WIDKCRPNLL
210 220 230 240 250
ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF ALGRAQELCI
260 270 280 290 300
LLETFWERMN LKVPIYFSTG LTEKANHYYK LFIPWTNQKI RKTFVQRNMF
310 320 330 340 350
EFKHIKAFDR AFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM
360 370 380 390 400
PGYCVQGTVG HKILSGQRKL EMEGRQVLEV KMQVEYMSFS AHADAKGIMQ
410 420 430 440 450
LVGQAEPESV LLVHGEAKKM EFLKQKIEQE LRVNCYMPAN GETVTLPTSP
460 470 480 490 500
SIPVGISLGL LKREMAQGLL PEAKKPRLLH GTLIMKDSNF RLVSSEQALK
510 520 530 540 550
ELGLAEHQLR FTCRVHLHDT RKEQETALRV YSHLKSVLKD HCVQHLPDGS
560 570 580 590 600
VTVESVLLQA AAPSEDPGTK VLLVSWTYQD EELGSFLTSL LKKGLPQAPS
Length:600
Mass (Da):67,663
Last modified:October 31, 2006 - v2
Checksum:i47C4E2E16202B130
GO
Isoform 2 (identifier: Q5TA45-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-143: Missing.

Note: No experimental confirmation available.
Show »
Length:499
Mass (Da):56,013
Checksum:i91F01E586DDC4FD1
GO
Isoform 3 (identifier: Q5TA45-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-164: Missing.

Note: No experimental confirmation available.
Show »
Length:578
Mass (Da):65,240
Checksum:iAD63044D90F3D6A2
GO
Isoform 4 (identifier: Q5TA45-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:571
Mass (Da):64,699
Checksum:i4F3056C3490955F1
GO
Isoform 5 (identifier: Q5TA45-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MPEIRVTPL → MCGAGFGHFEWLAGG

Show »
Length:606
Mass (Da):68,147
Checksum:iE943195A6FBB41C5
GO

Computationally mapped potential isoform sequencesi

There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IYS7C9IYS7_HUMAN
Cleavage and polyadenylation specif...
INTS11 CPSF3L, hCG_20422
502Annotation score:
J3QRY6J3QRY6_HUMAN
Cleavage and polyadenylation specif...
INTS11 CPSF3L, hCG_20422
342Annotation score:
Q96HV7Q96HV7_HUMAN
CPSF3L protein
INTS11 CPSF3L
389Annotation score:
A0A087WYI0A0A087WYI0_HUMAN
Integrator complex subunit 11
INTS11
502Annotation score:
E9PIG1E9PIG1_HUMAN
Integrator complex subunit 11
INTS11
249Annotation score:
E9PI75E9PI75_HUMAN
Integrator complex subunit 11
INTS11
209Annotation score:
E9PNS4E9PNS4_HUMAN
Integrator complex subunit 11
INTS11
278Annotation score:
C9J979C9J979_HUMAN
Integrator complex subunit 11
INTS11
344Annotation score:
E9PQF0E9PQF0_HUMAN
Integrator complex subunit 11
INTS11
167Annotation score:
E9PIL7E9PIL7_HUMAN
Integrator complex subunit 11
INTS11
140Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence BAA91246 differs from that shown. Reason: Frameshift at position 587.Curated
The sequence BAB14541 differs from that shown. Reason: Frameshift at position 248.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95P → S in CAB66747 (PubMed:11230166).Curated1
Sequence conflicti95P → S in CAG38588 (Ref. 3) Curated1
Sequence conflicti253E → K in BAB13943 (PubMed:14702039).Curated1
Sequence conflicti434N → D in BAF84076 (PubMed:14702039).Curated1
Sequence conflicti439A → V in BAG51775 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0454281 – 29Missing in isoform 4. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_0466431 – 9MPEIRVTPL → MCGAGFGHFEWLAGG in isoform 5. 1 Publication9
Alternative sequenceiVSP_02147243 – 143Missing in isoform 2. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_021473143 – 164Missing in isoform 3. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136813 mRNA Translation: CAB66747.1
AK000549 mRNA Translation: BAA91246.1 Sequence problems.
AK021939 mRNA Translation: BAB13943.1
AK023356 mRNA Translation: BAB14541.1 Frameshift.
AK056652 mRNA Translation: BAG51775.1
AK291387 mRNA Translation: BAF84076.1
AK297350 mRNA Translation: BAG59799.1
CR533557 mRNA Translation: CAG38588.1
AL139287 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56238.1
BC000675 mRNA Translation: AAH00675.2
BC007978 mRNA Translation: AAH07978.1
BC013904 mRNA Translation: AAH13904.2
BK005728 mRNA Translation: DAA05728.1
BK005673 mRNA Translation: DAA05669.1
CCDSiCCDS21.1 [Q5TA45-1]
CCDS57959.1 [Q5TA45-4]
CCDS57960.1 [Q5TA45-5]
CCDS57961.1 [Q5TA45-2]
RefSeqiNP_001243385.1, NM_001256456.1 [Q5TA45-5]
NP_001243389.1, NM_001256460.1 [Q5TA45-4]
NP_001243391.1, NM_001256462.1
NP_001243392.1, NM_001256463.1 [Q5TA45-2]
NP_060341.2, NM_017871.5 [Q5TA45-1]
UniGeneiHs.6449

Genome annotation databases

EnsembliENST00000419704; ENSP00000404886; ENSG00000127054 [Q5TA45-2]
ENST00000435064; ENSP00000413493; ENSG00000127054 [Q5TA45-1]
ENST00000450926; ENSP00000392848; ENSG00000127054 [Q5TA45-3]
ENST00000540437; ENSP00000445001; ENSG00000127054 [Q5TA45-5]
ENST00000545578; ENSP00000444672; ENSG00000127054 [Q5TA45-4]
GeneIDi54973
KEGGihsa:54973
UCSCiuc001aee.3 human [Q5TA45-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136813 mRNA Translation: CAB66747.1
AK000549 mRNA Translation: BAA91246.1 Sequence problems.
AK021939 mRNA Translation: BAB13943.1
AK023356 mRNA Translation: BAB14541.1 Frameshift.
AK056652 mRNA Translation: BAG51775.1
AK291387 mRNA Translation: BAF84076.1
AK297350 mRNA Translation: BAG59799.1
CR533557 mRNA Translation: CAG38588.1
AL139287 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56238.1
BC000675 mRNA Translation: AAH00675.2
BC007978 mRNA Translation: AAH07978.1
BC013904 mRNA Translation: AAH13904.2
BK005728 mRNA Translation: DAA05728.1
BK005673 mRNA Translation: DAA05669.1
CCDSiCCDS21.1 [Q5TA45-1]
CCDS57959.1 [Q5TA45-4]
CCDS57960.1 [Q5TA45-5]
CCDS57961.1 [Q5TA45-2]
RefSeqiNP_001243385.1, NM_001256456.1 [Q5TA45-5]
NP_001243389.1, NM_001256460.1 [Q5TA45-4]
NP_001243391.1, NM_001256462.1
NP_001243392.1, NM_001256463.1 [Q5TA45-2]
NP_060341.2, NM_017871.5 [Q5TA45-1]
UniGeneiHs.6449

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5V8WX-ray2.10B/D/F/H491-600[»]
ProteinModelPortaliQ5TA45
SMRiQ5TA45
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120310, 33 interactors
CORUMiQ5TA45
IntActiQ5TA45, 48 interactors
MINTiQ5TA45
STRINGi9606.ENSP00000413493

PTM databases

iPTMnetiQ5TA45
PhosphoSitePlusiQ5TA45

Polymorphism and mutation databases

BioMutaiCPSF3L
DMDMi118572557

Proteomic databases

EPDiQ5TA45
MaxQBiQ5TA45
PaxDbiQ5TA45
PeptideAtlasiQ5TA45
PRIDEiQ5TA45
ProteomicsDBi64825
64826 [Q5TA45-2]
64827 [Q5TA45-3]

Protocols and materials databases

DNASUi54973
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000419704; ENSP00000404886; ENSG00000127054 [Q5TA45-2]
ENST00000435064; ENSP00000413493; ENSG00000127054 [Q5TA45-1]
ENST00000450926; ENSP00000392848; ENSG00000127054 [Q5TA45-3]
ENST00000540437; ENSP00000445001; ENSG00000127054 [Q5TA45-5]
ENST00000545578; ENSP00000444672; ENSG00000127054 [Q5TA45-4]
GeneIDi54973
KEGGihsa:54973
UCSCiuc001aee.3 human [Q5TA45-1]

Organism-specific databases

CTDi54973
DisGeNETi54973
EuPathDBiHostDB:ENSG00000127054.18
GeneCardsiINTS11
HGNCiHGNC:26052 INTS11
HPAiHPA028379
HPA029025
MIMi611354 gene
neXtProtiNX_Q5TA45
OpenTargetsiENSG00000127054
PharmGKBiPA142672080
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1137 Eukaryota
COG1236 LUCA
GeneTreeiENSGT00910000144162
HOGENOMiHOG000231294
HOVERGENiHBG080215
InParanoidiQ5TA45
KOiK13148
OMAiYLDGMIW
OrthoDBiEOG091G03RH
PhylomeDBiQ5TA45
TreeFamiTF105878

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes

Miscellaneous databases

ChiTaRSiCPSF3L human
GeneWikiiCPSF3L
GenomeRNAii54973
PROiPR:Q5TA45
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127054 Expressed in 101 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ5TA45 baseline and differential
GenevisibleiQ5TA45 HS

Family and domain databases

Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR022712 Beta_Casp
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR011108 RMMBL
PfamiView protein in Pfam
PF10996 Beta-Casp, 1 hit
PF16661 Lactamase_B_6, 1 hit
PF07521 RMMBL, 1 hit
SMARTiView protein in SMART
SM01027 Beta-Casp, 1 hit
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINT11_HUMAN
AccessioniPrimary (citable) accession number: Q5TA45
Secondary accession number(s): A8K5S2
, B3KPR3, B4DM87, G3V1S5, Q5TA46, Q5TA48, Q5TA52, Q5TA53, Q5TA54, Q7L3D7, Q96HY1, Q9BW36, Q9H0F9, Q9H8R5, Q9HAA6, Q9NWX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again