UniProtKB - Q5T9Z0 (TEDM1_HUMAN)
Protein
Transmembrane epididymal protein 1
Gene
TEDDM1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane epididymal protein 1Alternative name(s): Human epididymis-specific protein 9 Short name: He9 |
Gene namesi | Name:TEDDM1 Synonyms:HE9 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30233, TEDDM1 |
neXtProti | NX_Q5T9Z0 |
VEuPathDBi | HostDB:ENSG00000203730.2 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 72 – 92 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 96 – 116 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 195 – 215 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000203730 |
PharmGKBi | PA142670818 |
Miscellaneous databases
Pharosi | Q5T9Z0, Tdark |
Genetic variation databases
BioMutai | TEDDM1 |
DMDMi | 74745756 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307129 | 1 – 273 | Transmembrane epididymal protein 1Add BLAST | 273 |
Proteomic databases
PaxDbi | Q5T9Z0 |
PRIDEi | Q5T9Z0 |
ProteomicsDBi | 64817 |
Expressioni
Gene expression databases
Bgeei | ENSG00000203730, Expressed in caput epididymis and 25 other tissues |
Genevisiblei | Q5T9Z0, HS |
Organism-specific databases
HPAi | ENSG00000203730, Tissue enriched (epididymis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 126075, 1 interactor |
STRINGi | 9606.ENSP00000356536 |
Miscellaneous databases
RNActi | Q5T9Z0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM45 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QS1R, Eukaryota |
GeneTreei | ENSGT00940000161715 |
HOGENOMi | CLU_059568_1_0_1 |
InParanoidi | Q5T9Z0 |
OMAi | MGKFIGH |
OrthoDBi | 1297629at2759 |
PhylomeDBi | Q5T9Z0 |
TreeFami | TF328673 |
Family and domain databases
InterProi | View protein in InterPro IPR006904, DUF716 |
Pfami | View protein in Pfam PF04819, DUF716, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5T9Z0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MILKGCLLYP LCSPRNKQRC ARLWKIAYGG LLKIVTGSLL TFYVVLCLDG
60 70 80 90 100
GMVLMRKQVP SRFMYPKEWQ HLTMFILLTL NGCVDFMSKN VLPQRCVGLE
110 120 130 140 150
KGTLVLIIYE LLLLMVSHVK DSEGVELHVY SLLILVVFLL LLVLTAELWA
160 170 180 190 200
PNMCHLQLME TFLILMMGSW LMQAGFILYR PVSGYPWQDD DISDIMFVTT
210 220 230 240 250
FFCWHVMINA SFLLGIYGFS SFWYHCFRPS LKLTGPKEAP YYASTPGPLY
260 270
KLLQEVEQSE KEDQALLLPK SSP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | L → V in CAD56348 (Ref. 1) Curated | 1 | |
Sequence conflicti | 21 | A → S in CAD56348 (Ref. 1) Curated | 1 | |
Sequence conflicti | 27 | A → S in CAD56348 (Ref. 1) Curated | 1 | |
Sequence conflicti | 43 | Y → N in CAD56348 (Ref. 1) Curated | 1 | |
Sequence conflicti | 50 | G → S in CAD56348 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035356 | 130 | Y → H. Corresponds to variant dbSNP:rs6674281Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ515384 mRNA Translation: CAD56348.2 AL139344 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91123.1 |
CCDSi | CCDS30953.1 |
RefSeqi | NP_741997.3, NM_172000.3 |
Genome annotation databases
Ensembli | ENST00000367565; ENSP00000356536; ENSG00000203730 |
GeneIDi | 127670 |
KEGGi | hsa:127670 |
UCSCi | uc001gpe.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ515384 mRNA Translation: CAD56348.2 AL139344 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91123.1 |
CCDSi | CCDS30953.1 |
RefSeqi | NP_741997.3, NM_172000.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126075, 1 interactor |
STRINGi | 9606.ENSP00000356536 |
Genetic variation databases
BioMutai | TEDDM1 |
DMDMi | 74745756 |
Proteomic databases
PaxDbi | Q5T9Z0 |
PRIDEi | Q5T9Z0 |
ProteomicsDBi | 64817 |
Genome annotation databases
Ensembli | ENST00000367565; ENSP00000356536; ENSG00000203730 |
GeneIDi | 127670 |
KEGGi | hsa:127670 |
UCSCi | uc001gpe.3, human |
Organism-specific databases
CTDi | 127670 |
GeneCardsi | TEDDM1 |
HGNCi | HGNC:30233, TEDDM1 |
HPAi | ENSG00000203730, Tissue enriched (epididymis) |
neXtProti | NX_Q5T9Z0 |
OpenTargetsi | ENSG00000203730 |
PharmGKBi | PA142670818 |
VEuPathDBi | HostDB:ENSG00000203730.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QS1R, Eukaryota |
GeneTreei | ENSGT00940000161715 |
HOGENOMi | CLU_059568_1_0_1 |
InParanoidi | Q5T9Z0 |
OMAi | MGKFIGH |
OrthoDBi | 1297629at2759 |
PhylomeDBi | Q5T9Z0 |
TreeFami | TF328673 |
Enzyme and pathway databases
PathwayCommonsi | Q5T9Z0 |
Miscellaneous databases
BioGRID-ORCSi | 127670, 2 hits in 865 CRISPR screens |
GenomeRNAii | 127670 |
Pharosi | Q5T9Z0, Tdark |
PROi | PR:Q5T9Z0 |
RNActi | Q5T9Z0, protein |
Gene expression databases
Bgeei | ENSG00000203730, Expressed in caput epididymis and 25 other tissues |
Genevisiblei | Q5T9Z0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006904, DUF716 |
Pfami | View protein in Pfam PF04819, DUF716, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TEDM1_HUMAN | |
Accessioni | Q5T9Z0Primary (citable) accession number: Q5T9Z0 Secondary accession number(s): Q8IVJ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 10, 2021 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families