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UniProtKB - Q5T9S5 (CCD18_HUMAN)
Protein
Coiled-coil domain-containing protein 18
Gene
CCDC18
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 18Alternative name(s): Sarcoma antigen NY-SAR-24 |
Gene namesi | Name:CCDC18 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30370, CCDC18 |
neXtProti | NX_Q5T9S5 |
VEuPathDBi | HostDB:ENSG00000122483 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 343099 |
OpenTargetsi | ENSG00000122483 |
PharmGKBi | PA142672178 |
Miscellaneous databases
Pharosi | Q5T9S5, Tdark |
Genetic variation databases
BioMutai | CCDC18 |
DMDMi | 74745727 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284775 | 1 – 1454 | Coiled-coil domain-containing protein 18Add BLAST | 1454 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 45 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1355 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q5T9S5 |
jPOSTi | Q5T9S5 |
MassIVEi | Q5T9S5 |
MaxQBi | Q5T9S5 |
PaxDbi | Q5T9S5 |
PeptideAtlasi | Q5T9S5 |
PRIDEi | Q5T9S5 |
ProteomicsDBi | 64812 [Q5T9S5-1] 64813 [Q5T9S5-2] |
PTM databases
iPTMneti | Q5T9S5 |
PhosphoSitePlusi | Q5T9S5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000122483, Expressed in testis and 143 other tissues |
ExpressionAtlasi | Q5T9S5, baseline and differential |
Genevisiblei | Q5T9S5, HS |
Organism-specific databases
HPAi | ENSG00000122483, Tissue enhanced (bone marrow, lymphoid tissue, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 131230, 62 interactors |
IntActi | Q5T9S5, 35 interactors |
MINTi | Q5T9S5 |
STRINGi | 9606.ENSP00000383808 |
Miscellaneous databases
RNActi | Q5T9S5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 828 – 851 | DisorderedSequence analysisAdd BLAST | 24 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 107 – 138 | Sequence analysisAdd BLAST | 32 | |
Coiled coili | 170 – 402 | Sequence analysisAdd BLAST | 233 | |
Coiled coili | 438 – 464 | Sequence analysisAdd BLAST | 27 | |
Coiled coili | 508 – 1309 | Sequence analysisAdd BLAST | 802 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QTZW, Eukaryota |
GeneTreei | ENSGT00940000153190 |
InParanoidi | Q5T9S5 |
OMAi | TDRNMKE |
OrthoDBi | 130835at2759 |
PhylomeDBi | Q5T9S5 |
Family and domain databases
InterProi | View protein in InterPro IPR029613, Ccdc18/Sojo |
PANTHERi | PTHR18875:SF8, PTHR18875:SF8, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5T9S5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESSSSDYYN KDNEEESLLA NVASLRHELK ITEWSLQSLG EELSSVSPSE
60 70 80 90 100
NSDYAPNPSR SEKLILDVQP SHPGLLNYSP YENVCKISGS STDFQKKPRD
110 120 130 140 150
KMFSSSAPVD QEIKSLREKL NKLRQQNACL VTQNHSLMTK FESIHFELTQ
160 170 180 190 200
SRAKVSMLES AQQQAASVPI LEEQIINLEA EVSAQDKVLR EAENKLEQSQ
210 220 230 240 250
KMVIEKEQSL QESKEECIKL KVDLLEQTKQ GKRAERQRNE ALYNAEELSK
260 270 280 290 300
AFQQYKKKVA EKLEKVQAEE EILERNLTNC EKENKRLQER CGLYKSELEI
310 320 330 340 350
LKEKLRQLKE ENNNGKEKLR IMAVKNSEVM AQLTESRQSI LKLESELENK
360 370 380 390 400
DEILRDKFSL MNENRELKVR VAAQNERLDL CQQEIESSRV ELRSLEKIIS
410 420 430 440 450
QLPLKRELFG FKSYLSKYQM SSFSNKEDRC IGCCEANKLV ISELRIKLAI
460 470 480 490 500
KEAEIQKLHA NLTANQLSQS LITCNDSQES SKLSSLETEP VKLGGHQVES
510 520 530 540 550
VKDQNQHTMN KQYEKERQRL VTGIEELRTK LIQIEAENSD LKVNMAHRTS
560 570 580 590 600
QFQLIQEELL EKASNSSKLE SEMTKKCSQL LTLEKQLEEK IVAYSSIAAK
610 620 630 640 650
NAELEQELME KNEKIRSLET NINTEHEKIC LAFEKAKKIH LEQHKEMEKQ
660 670 680 690 700
IERLEAQLEK KDQQFKEQEK TMSMLQQDII CKQHHLESLD RLLTESKGEM
710 720 730 740 750
KKENMKKDEA LKALQNQVSE ETIKVRQLDS ALEICKEELV LHLNQLEGNK
760 770 780 790 800
EKFEKQLKKK SEEVYCLQKE LKIKNHSLQE TSEQNVILQH TLQQQQQMLQ
810 820 830 840 850
QETIRNGELE DTQTKLEKQV SKLEQELQKQ RESSAEKLRK MEEKCESAAH
860 870 880 890 900
EADLKRQKVI ELTGTARQVK IEMDQYKEEL SKMEKEIMHL KRDGENKAMH
910 920 930 940 950
LSQLDMILDQ TKTELEKKTN AVKELEKLQH STETELTEAL QKREVLETEL
960 970 980 990 1000
QNAHGELKST LRQLQELRDV LQKAQLSLEE KYTTIKDLTA ELRECKMEIE
1010 1020 1030 1040 1050
DKKQELLEMD QALKERNWEL KQRAAQVTHL DMTIREHRGE MEQKIIKLEG
1060 1070 1080 1090 1100
TLEKSELELK ECNKQIESLN DKLQNAKEQL REKEFIMLQN EQEISQLKKE
1110 1120 1130 1140 1150
IERTQQRMKE MESVMKEQEQ YIATQYKEAI DLGQELRLTR EQVQNSHTEL
1160 1170 1180 1190 1200
AEARHQQVQA QREIERLSSE LEDMKQLSKE KDAHGNHLAE ELGASKVREA
1210 1220 1230 1240 1250
HLEARMQAEI KKLSAEVESL KEAYHMEMIS HQENHAKWKI SADSQKSSVQ
1260 1270 1280 1290 1300
QLNEQLEKAK LELEEAQDTV SNLHQQVQDR NEVIEAANEA LLTKESELTR
1310 1320 1330 1340 1350
LQAKISGHEK AEDIKFLPAP FTSPTEIMPD VQDPKFAKCF HTSFSKCTKL
1360 1370 1380 1390 1400
RRSISASDLT FKIHGDEDLS EELLQDLKKM QLEQPSTLEE SHKNLTYTQP
1410 1420 1430 1440 1450
DSFKPLTYNL EADSSENNDF NTLSGMLRYI NKEVRLLKKS SMQTGAGLNQ
GENV
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KP97 | J3KP97_HUMAN | Coiled-coil domain-containing prote... | CCDC18 | 1,508 | Annotation score: | ||
E9PFB9 | E9PFB9_HUMAN | Coiled-coil domain-containing prote... | CCDC18 | 1,299 | Annotation score: | ||
Q5T9S2 | Q5T9S2_HUMAN | Coiled-coil domain-containing prote... | CCDC18 | 720 | Annotation score: | ||
H7C0C9 | H7C0C9_HUMAN | Coiled-coil domain-containing prote... | CCDC18 | 119 | Annotation score: | ||
H0YCD6 | H0YCD6_HUMAN | Coiled-coil domain-containing prote... | CCDC18 | 404 | Annotation score: | ||
H0YDP2 | H0YDP2_HUMAN | Coiled-coil domain-containing prote... | CCDC18 | 63 | Annotation score: | ||
A0A8I5KNM5 | A0A8I5KNM5_HUMAN | Coiled-coil domain-containing prote... | CCDC18 | 158 | Annotation score: | ||
A0A8I5KRA2 | A0A8I5KRA2_HUMAN | Coiled-coil domain-containing prote... | CCDC18 | 212 | Annotation score: | ||
A0A8I5KUE1 | A0A8I5KUE1_HUMAN | Coiled-coil domain-containing prote... | CCDC18 | 210 | Annotation score: | ||
A0A8I5KWA2 | A0A8I5KWA2_HUMAN | Coiled-coil domain-containing prote... | CCDC18 | 1,455 | Annotation score: |
Sequence cautioni
The sequence BAC86410 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 326 | N → T in BAC86410 (PubMed:16710414).Curated | 1 | |
Sequence conflicti | 498 | V → VA in BAC86410 (PubMed:16710414).Curated | 1 | |
Sequence conflicti | 901 | L → F in BAC86410 (PubMed:16710414).Curated | 1 | |
Sequence conflicti | 1002 | K → E in BAC86410 (PubMed:16710414).Curated | 1 | |
Sequence conflicti | 1126 | Y → C in BAC86410 (PubMed:16710414).Curated | 1 | |
Sequence conflicti | 1135 | E → K in BAC86410 (PubMed:16710414).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024636 | 1295 – 1450 | Missing in isoform 2. 1 PublicationAdd BLAST | 156 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126045 mRNA Translation: BAC86410.1 Different initiation. AC126124 Genomic DNA No translation available. AL139421 Genomic DNA No translation available. |
CCDSi | CCDS76180.1 [Q5T9S5-1] |
RefSeqi | NP_001293005.1, NM_001306076.1 [Q5T9S5-1] NP_996769.3, NM_206886.4 |
Genome annotation databases
Ensembli | ENST00000343253.11; ENSP00000343377.7; ENSG00000122483.18 ENST00000370276.6; ENSP00000359299.2; ENSG00000122483.18 |
GeneIDi | 343099 |
KEGGi | hsa:343099 |
UCSCi | uc057iix.1, human [Q5T9S5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126045 mRNA Translation: BAC86410.1 Different initiation. AC126124 Genomic DNA No translation available. AL139421 Genomic DNA No translation available. |
CCDSi | CCDS76180.1 [Q5T9S5-1] |
RefSeqi | NP_001293005.1, NM_001306076.1 [Q5T9S5-1] NP_996769.3, NM_206886.4 |
3D structure databases
AlphaFoldDBi | Q5T9S5 |
SMRi | Q5T9S5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131230, 62 interactors |
IntActi | Q5T9S5, 35 interactors |
MINTi | Q5T9S5 |
STRINGi | 9606.ENSP00000383808 |
PTM databases
iPTMneti | Q5T9S5 |
PhosphoSitePlusi | Q5T9S5 |
Genetic variation databases
BioMutai | CCDC18 |
DMDMi | 74745727 |
Proteomic databases
EPDi | Q5T9S5 |
jPOSTi | Q5T9S5 |
MassIVEi | Q5T9S5 |
MaxQBi | Q5T9S5 |
PaxDbi | Q5T9S5 |
PeptideAtlasi | Q5T9S5 |
PRIDEi | Q5T9S5 |
ProteomicsDBi | 64812 [Q5T9S5-1] 64813 [Q5T9S5-2] |
Protocols and materials databases
Antibodypediai | 33656, 46 antibodies from 11 providers |
DNASUi | 343099 |
Genome annotation databases
Ensembli | ENST00000343253.11; ENSP00000343377.7; ENSG00000122483.18 ENST00000370276.6; ENSP00000359299.2; ENSG00000122483.18 |
GeneIDi | 343099 |
KEGGi | hsa:343099 |
UCSCi | uc057iix.1, human [Q5T9S5-1] |
Organism-specific databases
CTDi | 343099 |
DisGeNETi | 343099 |
GeneCardsi | CCDC18 |
HGNCi | HGNC:30370, CCDC18 |
HPAi | ENSG00000122483, Tissue enhanced (bone marrow, lymphoid tissue, testis) |
neXtProti | NX_Q5T9S5 |
OpenTargetsi | ENSG00000122483 |
PharmGKBi | PA142672178 |
VEuPathDBi | HostDB:ENSG00000122483 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTZW, Eukaryota |
GeneTreei | ENSGT00940000153190 |
InParanoidi | Q5T9S5 |
OMAi | TDRNMKE |
OrthoDBi | 130835at2759 |
PhylomeDBi | Q5T9S5 |
Enzyme and pathway databases
PathwayCommonsi | Q5T9S5 |
SignaLinki | Q5T9S5 |
Miscellaneous databases
BioGRID-ORCSi | 343099, 1 hit in 257 CRISPR screens |
ChiTaRSi | CCDC18, human |
GenomeRNAii | 343099 |
Pharosi | Q5T9S5, Tdark |
PROi | PR:Q5T9S5 |
RNActi | Q5T9S5, protein |
Gene expression databases
Bgeei | ENSG00000122483, Expressed in testis and 143 other tissues |
ExpressionAtlasi | Q5T9S5, baseline and differential |
Genevisiblei | Q5T9S5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029613, Ccdc18/Sojo |
PANTHERi | PTHR18875:SF8, PTHR18875:SF8, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCD18_HUMAN | |
Accessioni | Q5T9S5Primary (citable) accession number: Q5T9S5 Secondary accession number(s): Q6ZU17 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | May 25, 2022 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM