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Protein

Coiled-coil domain-containing protein 18

Gene

CCDC18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 18
Alternative name(s):
Sarcoma antigen NY-SAR-24
Gene namesi
Name:CCDC18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000122483.17
HGNCiHGNC:30370 CCDC18
neXtProtiNX_Q5T9S5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000122483
PharmGKBiPA142672178

Polymorphism and mutation databases

BioMutaiCCDC18
DMDMi74745727

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002847751 – 1454Coiled-coil domain-containing protein 18Add BLAST1454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineBy similarity1
Modified residuei1355PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T9S5
MaxQBiQ5T9S5
PaxDbiQ5T9S5
PeptideAtlasiQ5T9S5
PRIDEiQ5T9S5
ProteomicsDBi64812
64813 [Q5T9S5-2]

PTM databases

iPTMnetiQ5T9S5
PhosphoSitePlusiQ5T9S5

Expressioni

Gene expression databases

BgeeiENSG00000122483 Expressed in 121 organ(s), highest expression level in testis
CleanExiHS_CCDC18
ExpressionAtlasiQ5T9S5 baseline and differential
GenevisibleiQ5T9S5 HS

Organism-specific databases

HPAiHPA028035

Interactioni

Protein-protein interaction databases

BioGridi131230, 36 interactors
IntActiQ5T9S5, 25 interactors
STRINGi9606.ENSP00000359299

Structurei

3D structure databases

ProteinModelPortaliQ5T9S5
SMRiQ5T9S5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili107 – 138Sequence analysisAdd BLAST32
Coiled coili170 – 402Sequence analysisAdd BLAST233
Coiled coili438 – 464Sequence analysisAdd BLAST27
Coiled coili508 – 1309Sequence analysisAdd BLAST802

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJJN Eukaryota
ENOG4111YKF LUCA
GeneTreeiENSGT00710000106794
HOGENOMiHOG000111405
HOVERGENiHBG095601
InParanoidiQ5T9S5
PhylomeDBiQ5T9S5

Family and domain databases

InterProiView protein in InterPro
IPR029613 Ccdc18/Sojo
PANTHERiPTHR18875:SF8 PTHR18875:SF8, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T9S5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESSSSDYYN KDNEEESLLA NVASLRHELK ITEWSLQSLG EELSSVSPSE
60 70 80 90 100
NSDYAPNPSR SEKLILDVQP SHPGLLNYSP YENVCKISGS STDFQKKPRD
110 120 130 140 150
KMFSSSAPVD QEIKSLREKL NKLRQQNACL VTQNHSLMTK FESIHFELTQ
160 170 180 190 200
SRAKVSMLES AQQQAASVPI LEEQIINLEA EVSAQDKVLR EAENKLEQSQ
210 220 230 240 250
KMVIEKEQSL QESKEECIKL KVDLLEQTKQ GKRAERQRNE ALYNAEELSK
260 270 280 290 300
AFQQYKKKVA EKLEKVQAEE EILERNLTNC EKENKRLQER CGLYKSELEI
310 320 330 340 350
LKEKLRQLKE ENNNGKEKLR IMAVKNSEVM AQLTESRQSI LKLESELENK
360 370 380 390 400
DEILRDKFSL MNENRELKVR VAAQNERLDL CQQEIESSRV ELRSLEKIIS
410 420 430 440 450
QLPLKRELFG FKSYLSKYQM SSFSNKEDRC IGCCEANKLV ISELRIKLAI
460 470 480 490 500
KEAEIQKLHA NLTANQLSQS LITCNDSQES SKLSSLETEP VKLGGHQVES
510 520 530 540 550
VKDQNQHTMN KQYEKERQRL VTGIEELRTK LIQIEAENSD LKVNMAHRTS
560 570 580 590 600
QFQLIQEELL EKASNSSKLE SEMTKKCSQL LTLEKQLEEK IVAYSSIAAK
610 620 630 640 650
NAELEQELME KNEKIRSLET NINTEHEKIC LAFEKAKKIH LEQHKEMEKQ
660 670 680 690 700
IERLEAQLEK KDQQFKEQEK TMSMLQQDII CKQHHLESLD RLLTESKGEM
710 720 730 740 750
KKENMKKDEA LKALQNQVSE ETIKVRQLDS ALEICKEELV LHLNQLEGNK
760 770 780 790 800
EKFEKQLKKK SEEVYCLQKE LKIKNHSLQE TSEQNVILQH TLQQQQQMLQ
810 820 830 840 850
QETIRNGELE DTQTKLEKQV SKLEQELQKQ RESSAEKLRK MEEKCESAAH
860 870 880 890 900
EADLKRQKVI ELTGTARQVK IEMDQYKEEL SKMEKEIMHL KRDGENKAMH
910 920 930 940 950
LSQLDMILDQ TKTELEKKTN AVKELEKLQH STETELTEAL QKREVLETEL
960 970 980 990 1000
QNAHGELKST LRQLQELRDV LQKAQLSLEE KYTTIKDLTA ELRECKMEIE
1010 1020 1030 1040 1050
DKKQELLEMD QALKERNWEL KQRAAQVTHL DMTIREHRGE MEQKIIKLEG
1060 1070 1080 1090 1100
TLEKSELELK ECNKQIESLN DKLQNAKEQL REKEFIMLQN EQEISQLKKE
1110 1120 1130 1140 1150
IERTQQRMKE MESVMKEQEQ YIATQYKEAI DLGQELRLTR EQVQNSHTEL
1160 1170 1180 1190 1200
AEARHQQVQA QREIERLSSE LEDMKQLSKE KDAHGNHLAE ELGASKVREA
1210 1220 1230 1240 1250
HLEARMQAEI KKLSAEVESL KEAYHMEMIS HQENHAKWKI SADSQKSSVQ
1260 1270 1280 1290 1300
QLNEQLEKAK LELEEAQDTV SNLHQQVQDR NEVIEAANEA LLTKESELTR
1310 1320 1330 1340 1350
LQAKISGHEK AEDIKFLPAP FTSPTEIMPD VQDPKFAKCF HTSFSKCTKL
1360 1370 1380 1390 1400
RRSISASDLT FKIHGDEDLS EELLQDLKKM QLEQPSTLEE SHKNLTYTQP
1410 1420 1430 1440 1450
DSFKPLTYNL EADSSENNDF NTLSGMLRYI NKEVRLLKKS SMQTGAGLNQ

GENV
Note: Gene prediction based on EST data.
Length:1,454
Mass (Da):168,962
Last modified:December 21, 2004 - v1
Checksum:i1F2FB01956059DD1
GO
Isoform 2 (identifier: Q5T9S5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1295-1450: Missing.

Note: No experimental confirmation available.
Show »
Length:1,298
Mass (Da):151,249
Checksum:iEC2B08A1D2934319
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PFB9E9PFB9_HUMAN
Coiled-coil domain-containing prote...
CCDC18
1,299Annotation score:
J3KP97J3KP97_HUMAN
Coiled-coil domain-containing prote...
CCDC18
1,508Annotation score:
Q5T9S2Q5T9S2_HUMAN
Coiled-coil domain-containing prote...
CCDC18
720Annotation score:
H0YCD6H0YCD6_HUMAN
Coiled-coil domain-containing prote...
CCDC18
443Annotation score:
H7C0C9H7C0C9_HUMAN
Coiled-coil domain-containing prote...
CCDC18
166Annotation score:
H0YDP2H0YDP2_HUMAN
Coiled-coil domain-containing prote...
CCDC18
95Annotation score:

Sequence cautioni

The sequence BAC86410 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti326N → T in BAC86410 (PubMed:16710414).Curated1
Sequence conflicti498V → VA in BAC86410 (PubMed:16710414).Curated1
Sequence conflicti901L → F in BAC86410 (PubMed:16710414).Curated1
Sequence conflicti1002K → E in BAC86410 (PubMed:16710414).Curated1
Sequence conflicti1126Y → C in BAC86410 (PubMed:16710414).Curated1
Sequence conflicti1135E → K in BAC86410 (PubMed:16710414).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0246361295 – 1450Missing in isoform 2. 1 PublicationAdd BLAST156

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126045 mRNA Translation: BAC86410.1 Different initiation.
AC126124 Genomic DNA No translation available.
AL139421 Genomic DNA No translation available.
CCDSiCCDS76180.1 [Q5T9S5-1]
RefSeqiNP_001293005.1, NM_001306076.1 [Q5T9S5-1]
NP_996769.3, NM_206886.4
UniGeneiHs.482873
Hs.745125

Genome annotation databases

EnsembliENST00000343253; ENSP00000343377; ENSG00000122483 [Q5T9S5-1]
GeneIDi343099
KEGGihsa:343099
UCSCiuc057iix.1 human [Q5T9S5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126045 mRNA Translation: BAC86410.1 Different initiation.
AC126124 Genomic DNA No translation available.
AL139421 Genomic DNA No translation available.
CCDSiCCDS76180.1 [Q5T9S5-1]
RefSeqiNP_001293005.1, NM_001306076.1 [Q5T9S5-1]
NP_996769.3, NM_206886.4
UniGeneiHs.482873
Hs.745125

3D structure databases

ProteinModelPortaliQ5T9S5
SMRiQ5T9S5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131230, 36 interactors
IntActiQ5T9S5, 25 interactors
STRINGi9606.ENSP00000359299

PTM databases

iPTMnetiQ5T9S5
PhosphoSitePlusiQ5T9S5

Polymorphism and mutation databases

BioMutaiCCDC18
DMDMi74745727

Proteomic databases

EPDiQ5T9S5
MaxQBiQ5T9S5
PaxDbiQ5T9S5
PeptideAtlasiQ5T9S5
PRIDEiQ5T9S5
ProteomicsDBi64812
64813 [Q5T9S5-2]

Protocols and materials databases

DNASUi343099
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343253; ENSP00000343377; ENSG00000122483 [Q5T9S5-1]
GeneIDi343099
KEGGihsa:343099
UCSCiuc057iix.1 human [Q5T9S5-1]

Organism-specific databases

CTDi343099
EuPathDBiHostDB:ENSG00000122483.17
GeneCardsiCCDC18
HGNCiHGNC:30370 CCDC18
HPAiHPA028035
neXtProtiNX_Q5T9S5
OpenTargetsiENSG00000122483
PharmGKBiPA142672178
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJJN Eukaryota
ENOG4111YKF LUCA
GeneTreeiENSGT00710000106794
HOGENOMiHOG000111405
HOVERGENiHBG095601
InParanoidiQ5T9S5
PhylomeDBiQ5T9S5

Miscellaneous databases

ChiTaRSiCCDC18 human
GenomeRNAii343099
PROiPR:Q5T9S5

Gene expression databases

BgeeiENSG00000122483 Expressed in 121 organ(s), highest expression level in testis
CleanExiHS_CCDC18
ExpressionAtlasiQ5T9S5 baseline and differential
GenevisibleiQ5T9S5 HS

Family and domain databases

InterProiView protein in InterPro
IPR029613 Ccdc18/Sojo
PANTHERiPTHR18875:SF8 PTHR18875:SF8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCD18_HUMAN
AccessioniPrimary (citable) accession number: Q5T9S5
Secondary accession number(s): Q6ZU17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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