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UniProtKB - Q5T9S5 (CCD18_HUMAN)

Protein

Coiled-coil domain-containing protein 18

Gene

CCDC18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 18
Alternative name(s):
Sarcoma antigen NY-SAR-24
Gene namesi
Name:CCDC18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000122483.17
HGNCiHGNC:30370 CCDC18
neXtProtiNX_Q5T9S5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000122483
PharmGKBiPA142672178

Polymorphism and mutation databases

BioMutaiCCDC18
DMDMi74745727

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002847751 – 1454Coiled-coil domain-containing protein 18Add BLAST1454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineBy similarity1
Modified residuei1355PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T9S5
MaxQBiQ5T9S5
PaxDbiQ5T9S5
PeptideAtlasiQ5T9S5
PRIDEiQ5T9S5
ProteomicsDBi64812
64813 [Q5T9S5-2]

PTM databases

iPTMnetiQ5T9S5
PhosphoSitePlusiQ5T9S5

Expressioni

Gene expression databases

BgeeiENSG00000122483 Expressed in 121 organ(s), highest expression level in testis
CleanExiHS_CCDC18
ExpressionAtlasiQ5T9S5 baseline and differential
GenevisibleiQ5T9S5 HS

Organism-specific databases

HPAiHPA028035

Interactioni

Protein-protein interaction databases

BioGridi131230, 36 interactors
IntActiQ5T9S5, 25 interactors
STRINGi9606.ENSP00000359299

Structurei

3D structure databases

ProteinModelPortaliQ5T9S5
SMRiQ5T9S5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili107 – 138Sequence analysisAdd BLAST32
Coiled coili170 – 402Sequence analysisAdd BLAST233
Coiled coili438 – 464Sequence analysisAdd BLAST27
Coiled coili508 – 1309Sequence analysisAdd BLAST802

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJJN Eukaryota
ENOG4111YKF LUCA
GeneTreeiENSGT00710000106794
HOGENOMiHOG000111405
HOVERGENiHBG095601
InParanoidiQ5T9S5
PhylomeDBiQ5T9S5

Family and domain databases

InterProiView protein in InterPro
IPR029613 Ccdc18/Sojo
PANTHERiPTHR18875:SF8 PTHR18875:SF8, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T9S5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESSSSDYYN KDNEEESLLA NVASLRHELK ITEWSLQSLG EELSSVSPSE 
        60         70         80         90        100
NSDYAPNPSR SEKLILDVQP SHPGLLNYSP YENVCKISGS STDFQKKPRD 
       110        120        130        140        150
KMFSSSAPVD QEIKSLREKL NKLRQQNACL VTQNHSLMTK FESIHFELTQ 
       160        170        180        190        200
SRAKVSMLES AQQQAASVPI LEEQIINLEA EVSAQDKVLR EAENKLEQSQ 
       210        220        230        240        250
KMVIEKEQSL QESKEECIKL KVDLLEQTKQ GKRAERQRNE ALYNAEELSK 
       260        270        280        290        300
AFQQYKKKVA EKLEKVQAEE EILERNLTNC EKENKRLQER CGLYKSELEI 
       310        320        330        340        350
LKEKLRQLKE ENNNGKEKLR IMAVKNSEVM AQLTESRQSI LKLESELENK 
       360        370        380        390        400
DEILRDKFSL MNENRELKVR VAAQNERLDL CQQEIESSRV ELRSLEKIIS 
       410        420        430        440        450
QLPLKRELFG FKSYLSKYQM SSFSNKEDRC IGCCEANKLV ISELRIKLAI 
       460        470        480        490        500
KEAEIQKLHA NLTANQLSQS LITCNDSQES SKLSSLETEP VKLGGHQVES 
       510        520        530        540        550
VKDQNQHTMN KQYEKERQRL VTGIEELRTK LIQIEAENSD LKVNMAHRTS 
       560        570        580        590        600
QFQLIQEELL EKASNSSKLE SEMTKKCSQL LTLEKQLEEK IVAYSSIAAK 
       610        620        630        640        650
NAELEQELME KNEKIRSLET NINTEHEKIC LAFEKAKKIH LEQHKEMEKQ 
       660        670        680        690        700
IERLEAQLEK KDQQFKEQEK TMSMLQQDII CKQHHLESLD RLLTESKGEM 
       710        720        730        740        750
KKENMKKDEA LKALQNQVSE ETIKVRQLDS ALEICKEELV LHLNQLEGNK 
       760        770        780        790        800
EKFEKQLKKK SEEVYCLQKE LKIKNHSLQE TSEQNVILQH TLQQQQQMLQ 
       810        820        830        840        850
QETIRNGELE DTQTKLEKQV SKLEQELQKQ RESSAEKLRK MEEKCESAAH 
       860        870        880        890        900
EADLKRQKVI ELTGTARQVK IEMDQYKEEL SKMEKEIMHL KRDGENKAMH 
       910        920        930        940        950
LSQLDMILDQ TKTELEKKTN AVKELEKLQH STETELTEAL QKREVLETEL 
       960        970        980        990       1000
QNAHGELKST LRQLQELRDV LQKAQLSLEE KYTTIKDLTA ELRECKMEIE 
      1010       1020       1030       1040       1050
DKKQELLEMD QALKERNWEL KQRAAQVTHL DMTIREHRGE MEQKIIKLEG 
      1060       1070       1080       1090       1100
TLEKSELELK ECNKQIESLN DKLQNAKEQL REKEFIMLQN EQEISQLKKE 
      1110       1120       1130       1140       1150
IERTQQRMKE MESVMKEQEQ YIATQYKEAI DLGQELRLTR EQVQNSHTEL 
      1160       1170       1180       1190       1200
AEARHQQVQA QREIERLSSE LEDMKQLSKE KDAHGNHLAE ELGASKVREA 
      1210       1220       1230       1240       1250
HLEARMQAEI KKLSAEVESL KEAYHMEMIS HQENHAKWKI SADSQKSSVQ 
      1260       1270       1280       1290       1300
QLNEQLEKAK LELEEAQDTV SNLHQQVQDR NEVIEAANEA LLTKESELTR 
      1310       1320       1330       1340       1350
LQAKISGHEK AEDIKFLPAP FTSPTEIMPD VQDPKFAKCF HTSFSKCTKL 
      1360       1370       1380       1390       1400
RRSISASDLT FKIHGDEDLS EELLQDLKKM QLEQPSTLEE SHKNLTYTQP 
      1410       1420       1430       1440       1450
DSFKPLTYNL EADSSENNDF NTLSGMLRYI NKEVRLLKKS SMQTGAGLNQ 

GENV
Note: Gene prediction based on EST data.
Length:1,454
Mass (Da):168,962
Last modified:December 21, 2004 - v1
Checksum:i1F2FB01956059DD1
GO
Isoform 2 (identifier: Q5T9S5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1295-1450: Missing.

Note: No experimental confirmation available.
Show »
Length:1,298
Mass (Da):151,249
Checksum:iEC2B08A1D2934319
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PFB9E9PFB9_HUMAN
Coiled-coil domain-containing prote...
CCDC18
1,299Annotation score:
J3KP97J3KP97_HUMAN
Coiled-coil domain-containing prote...
CCDC18
1,508Annotation score:
Q5T9S2Q5T9S2_HUMAN
Coiled-coil domain-containing prote...
CCDC18
720Annotation score:
H0YCD6H0YCD6_HUMAN
Coiled-coil domain-containing prote...
CCDC18
443Annotation score:
H7C0C9H7C0C9_HUMAN
Coiled-coil domain-containing prote...
CCDC18
166Annotation score:
H0YDP2H0YDP2_HUMAN
Coiled-coil domain-containing prote...
CCDC18
95Annotation score:

Sequence cautioni

The sequence BAC86410 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti326N → T in BAC86410 (PubMed:16710414).Curated1
Sequence conflicti498V → VA in BAC86410 (PubMed:16710414).Curated1
Sequence conflicti901L → F in BAC86410 (PubMed:16710414).Curated1
Sequence conflicti1002K → E in BAC86410 (PubMed:16710414).Curated1
Sequence conflicti1126Y → C in BAC86410 (PubMed:16710414).Curated1
Sequence conflicti1135E → K in BAC86410 (PubMed:16710414).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0246361295 – 1450Missing in isoform 2. 1 PublicationAdd BLAST156

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126045 mRNA Translation: BAC86410.1 Different initiation.
AC126124 Genomic DNA No translation available.
AL139421 Genomic DNA No translation available.
CCDSiCCDS76180.1 [Q5T9S5-1]
RefSeqiNP_001293005.1, NM_001306076.1 [Q5T9S5-1]
NP_996769.3, NM_206886.4
UniGeneiHs.482873
Hs.745125

Genome annotation databases

EnsembliENST00000343253; ENSP00000343377; ENSG00000122483 [Q5T9S5-1]
GeneIDi343099
KEGGihsa:343099
UCSCiuc057iix.1 human [Q5T9S5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126045 mRNA Translation: BAC86410.1 Different initiation.
AC126124 Genomic DNA No translation available.
AL139421 Genomic DNA No translation available.
CCDSiCCDS76180.1 [Q5T9S5-1]
RefSeqiNP_001293005.1, NM_001306076.1 [Q5T9S5-1]
NP_996769.3, NM_206886.4
UniGeneiHs.482873
Hs.745125

3D structure databases

ProteinModelPortaliQ5T9S5
SMRiQ5T9S5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131230, 36 interactors
IntActiQ5T9S5, 25 interactors
STRINGi9606.ENSP00000359299

PTM databases

iPTMnetiQ5T9S5
PhosphoSitePlusiQ5T9S5

Polymorphism and mutation databases

BioMutaiCCDC18
DMDMi74745727

Proteomic databases

EPDiQ5T9S5
MaxQBiQ5T9S5
PaxDbiQ5T9S5
PeptideAtlasiQ5T9S5
PRIDEiQ5T9S5
ProteomicsDBi64812
64813 [Q5T9S5-2]

Protocols and materials databases

DNASUi343099
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343253; ENSP00000343377; ENSG00000122483 [Q5T9S5-1]
GeneIDi343099
KEGGihsa:343099
UCSCiuc057iix.1 human [Q5T9S5-1]

Organism-specific databases

CTDi343099
EuPathDBiHostDB:ENSG00000122483.17
GeneCardsiCCDC18
HGNCiHGNC:30370 CCDC18
HPAiHPA028035
neXtProtiNX_Q5T9S5
OpenTargetsiENSG00000122483
PharmGKBiPA142672178
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJJN Eukaryota
ENOG4111YKF LUCA
GeneTreeiENSGT00710000106794
HOGENOMiHOG000111405
HOVERGENiHBG095601
InParanoidiQ5T9S5
PhylomeDBiQ5T9S5

Miscellaneous databases

ChiTaRSiCCDC18 human
GenomeRNAii343099
PROiPR:Q5T9S5

Gene expression databases

BgeeiENSG00000122483 Expressed in 121 organ(s), highest expression level in testis
CleanExiHS_CCDC18
ExpressionAtlasiQ5T9S5 baseline and differential
GenevisibleiQ5T9S5 HS

Family and domain databases

InterProiView protein in InterPro
IPR029613 Ccdc18/Sojo
PANTHERiPTHR18875:SF8 PTHR18875:SF8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCD18_HUMAN
AccessioniPrimary (citable) accession number: Q5T9S5
Secondary accession number(s): Q6ZU17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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