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UniProtKB - Q5T9C9 (PI5L1_HUMAN)
Protein
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
Gene
PIP5KL1
Organism
Homo sapiens (Human)
Status
Functioni
May act as a scaffold to localize and regulate type I PI4P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.
By similarityCaution
It is unsure if the enzyme has intrinsic kinase activity.Curated
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H+EC:2.7.1.68
GO - Molecular functioni
- 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- negative regulation of cell migration Source: ARUK-UCL
- negative regulation of mitochondrial membrane potential Source: UniProtKB
- negative regulation of protein phosphorylation Source: ARUK-UCL
- positive regulation of apoptotic process Source: UniProtKB
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q5T9C9 |
SignaLinki | Q5T9C9 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (EC:2.7.1.68)Short name: PI(4)P 5-kinase-like protein 1 Short name: PtdIns(4)P-5-kinase-like protein 1 |
Gene namesi | Name:PIP5KL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28711, PIP5KL1 |
MIMi | 612865, gene |
neXtProti | NX_Q5T9C9 |
VEuPathDBi | HostDB:ENSG00000167103 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Other locations
- cell projection Source: Ensembl
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 138429 |
OpenTargetsi | ENSG00000167103 |
PharmGKBi | PA134926015 |
Miscellaneous databases
Pharosi | Q5T9C9, Tbio |
Genetic variation databases
BioMutai | PIP5KL1 |
DMDMi | 146325056 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000285758 | 1 – 394 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1Add BLAST | 394 |
Proteomic databases
MassIVEi | Q5T9C9 |
PaxDbi | Q5T9C9 |
PeptideAtlasi | Q5T9C9 |
PRIDEi | Q5T9C9 |
ProteomicsDBi | 64791 [Q5T9C9-1] 64792 [Q5T9C9-2] |
PTM databases
iPTMneti | Q5T9C9 |
PhosphoSitePlusi | Q5T9C9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167103, Expressed in muscle tissue and 119 other tissues |
Genevisiblei | Q5T9C9, HS |
Organism-specific databases
HPAi | ENSG00000167103, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimerizes with other type I phosphatidylinositol 4-phosphate 5-kinase.
By similarityProtein-protein interaction databases
BioGRIDi | 126513, 5 interactors |
IntActi | Q5T9C9, 1 interactor |
STRINGi | 9606.ENSP00000373399 |
Miscellaneous databases
RNActi | Q5T9C9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 393 | PIPKPROSITE-ProRule annotationAdd BLAST | 358 |
Phylogenomic databases
eggNOGi | KOG0229, Eukaryota |
GeneTreei | ENSGT00940000158633 |
HOGENOMi | CLU_043959_0_0_1 |
InParanoidi | Q5T9C9 |
OMAi | FAWLRHS |
OrthoDBi | 1562683at2759 |
PhylomeDBi | Q5T9C9 |
TreeFami | TF354315 |
Family and domain databases
Gene3Di | 3.30.800.10, 1 hit |
InterProi | View protein in InterPro IPR023610, PInositol-4-P-5-kinase IPR002498, PInositol-4-P-5-kinase_core IPR027484, PInositol-4-P-5-kinase_N |
PANTHERi | PTHR23086, PTHR23086, 1 hit |
Pfami | View protein in Pfam PF01504, PIP5K, 1 hit |
SMARTi | View protein in SMART SM00330, PIPKc, 1 hit |
PROSITEi | View protein in PROSITE PS51455, PIPK, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q5T9C9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAPSPGPRE VLAPSPEAGC RAVTSSRRGL LWRLRDKQSR LGLFEISPGH
60 70 80 90 100
ELHGMTCMMQ AGLWAATQVS MDHPPTGPPS RDDFSEVLTQ VHEGFELGTL
110 120 130 140 150
AGPAFAWLRR SLGLAEEDYQ AALGPGGPYL QFLSTSKSKA SFFLSHDQRF
160 170 180 190 200
FLKTQGRREV QALLAHLPRY VQHLQRHPHS LLARLLGVHS LRVDRGKKTY
210 220 230 240 250
FIVMQSVFYP AGRISERYDI KGCEVSRWVD PAPEGSPLVL VLKDLNFQGK
260 270 280 290 300
TINLGPQRSW FLRQMELDTT FLRELNVLDY SLLIAFQRLH EDERGPGSSL
310 320 330 340 350
IFRTARSVQG AQSPEESRAQ NRRLLPDAPN ALHILDGPEQ RYFLGVVDLA
360 370 380 390
TVYGLRKRLE HLWKTLRYPG RTFSTVSPAR YARRLCQWVE AHTE
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024904 | 1 – 203 | Missing in isoform 2. 1 PublicationAdd BLAST | 203 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL157935 Genomic DNA No translation available. BC042184 mRNA Translation: AAH42184.1 |
CCDSi | CCDS48030.1 [Q5T9C9-1] CCDS6885.1 [Q5T9C9-2] |
RefSeqi | NP_001128691.1, NM_001135219.1 [Q5T9C9-1] NP_775763.1, NM_173492.1 [Q5T9C9-2] |
Genome annotation databases
Ensembli | ENST00000300432; ENSP00000300432; ENSG00000167103 [Q5T9C9-2] ENST00000388747; ENSP00000373399; ENSG00000167103 |
GeneIDi | 138429 |
KEGGi | hsa:138429 |
MANE-Selecti | ENST00000388747.9; ENSP00000373399.4; NM_001135219.2; NP_001128691.1 |
UCSCi | uc004bsu.3, human [Q5T9C9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL157935 Genomic DNA No translation available. BC042184 mRNA Translation: AAH42184.1 |
CCDSi | CCDS48030.1 [Q5T9C9-1] CCDS6885.1 [Q5T9C9-2] |
RefSeqi | NP_001128691.1, NM_001135219.1 [Q5T9C9-1] NP_775763.1, NM_173492.1 [Q5T9C9-2] |
3D structure databases
SMRi | Q5T9C9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126513, 5 interactors |
IntActi | Q5T9C9, 1 interactor |
STRINGi | 9606.ENSP00000373399 |
PTM databases
iPTMneti | Q5T9C9 |
PhosphoSitePlusi | Q5T9C9 |
Genetic variation databases
BioMutai | PIP5KL1 |
DMDMi | 146325056 |
Proteomic databases
MassIVEi | Q5T9C9 |
PaxDbi | Q5T9C9 |
PeptideAtlasi | Q5T9C9 |
PRIDEi | Q5T9C9 |
ProteomicsDBi | 64791 [Q5T9C9-1] 64792 [Q5T9C9-2] |
Protocols and materials databases
Antibodypediai | 30919, 143 antibodies from 27 providers |
DNASUi | 138429 |
Genome annotation databases
Ensembli | ENST00000300432; ENSP00000300432; ENSG00000167103 [Q5T9C9-2] ENST00000388747; ENSP00000373399; ENSG00000167103 |
GeneIDi | 138429 |
KEGGi | hsa:138429 |
MANE-Selecti | ENST00000388747.9; ENSP00000373399.4; NM_001135219.2; NP_001128691.1 |
UCSCi | uc004bsu.3, human [Q5T9C9-1] |
Organism-specific databases
CTDi | 138429 |
DisGeNETi | 138429 |
GeneCardsi | PIP5KL1 |
HGNCi | HGNC:28711, PIP5KL1 |
HPAi | ENSG00000167103, Low tissue specificity |
MIMi | 612865, gene |
neXtProti | NX_Q5T9C9 |
OpenTargetsi | ENSG00000167103 |
PharmGKBi | PA134926015 |
VEuPathDBi | HostDB:ENSG00000167103 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0229, Eukaryota |
GeneTreei | ENSGT00940000158633 |
HOGENOMi | CLU_043959_0_0_1 |
InParanoidi | Q5T9C9 |
OMAi | FAWLRHS |
OrthoDBi | 1562683at2759 |
PhylomeDBi | Q5T9C9 |
TreeFami | TF354315 |
Enzyme and pathway databases
PathwayCommonsi | Q5T9C9 |
SignaLinki | Q5T9C9 |
Miscellaneous databases
BioGRID-ORCSi | 138429, 9 hits in 1037 CRISPR screens |
ChiTaRSi | PIP5KL1, human |
GenomeRNAii | 138429 |
Pharosi | Q5T9C9, Tbio |
PROi | PR:Q5T9C9 |
RNActi | Q5T9C9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167103, Expressed in muscle tissue and 119 other tissues |
Genevisiblei | Q5T9C9, HS |
Family and domain databases
Gene3Di | 3.30.800.10, 1 hit |
InterProi | View protein in InterPro IPR023610, PInositol-4-P-5-kinase IPR002498, PInositol-4-P-5-kinase_core IPR027484, PInositol-4-P-5-kinase_N |
PANTHERi | PTHR23086, PTHR23086, 1 hit |
Pfami | View protein in Pfam PF01504, PIP5K, 1 hit |
SMARTi | View protein in SMART SM00330, PIPKc, 1 hit |
PROSITEi | View protein in PROSITE PS51455, PIPK, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PI5L1_HUMAN | |
Accessioni | Q5T9C9Primary (citable) accession number: Q5T9C9 Secondary accession number(s): Q8IVS3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | February 23, 2022 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot