UniProtKB - Q5T9C2 (F102A_HUMAN)
Protein
Protein FAM102A
Gene
FAM102A
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in estrogen action.1 Publication
Enzyme and pathway databases
PathwayCommonsi | Q5T9C2 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM102AAlternative name(s): Early estrogen-induced gene 1 protein |
Gene namesi | Name:FAM102A Synonyms:C9orf132, EEIG1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:31419, FAM102A |
MIMi | 610891, gene |
neXtProti | NX_Q5T9C2 |
VEuPathDBi | HostDB:ENSG00000167106.11 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 399665 |
OpenTargetsi | ENSG00000167106 |
PharmGKBi | PA142671784 |
Miscellaneous databases
Pharosi | Q5T9C2, Tdark |
Genetic variation databases
BioMutai | FAM102A |
DMDMi | 118572304 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000261634 | 1 – 384 | Protein FAM102AAdd BLAST | 384 |
Proteomic databases
jPOSTi | Q5T9C2 |
MassIVEi | Q5T9C2 |
MaxQBi | Q5T9C2 |
PaxDbi | Q5T9C2 |
PeptideAtlasi | Q5T9C2 |
PRIDEi | Q5T9C2 |
ProteomicsDBi | 64787 [Q5T9C2-1] 64788 [Q5T9C2-2] 64789 [Q5T9C2-3] |
PTM databases
iPTMneti | Q5T9C2 |
PhosphoSitePlusi | Q5T9C2 |
Expressioni
Inductioni
By 17-beta-estradiol but also by a group of natural and synthetic estrogens as well as by estrogenic environmental compounds. Repressed by the antiestrogen 4-hydroxy-tamoxifen.
Gene expression databases
Bgeei | ENSG00000167106, Expressed in stomach and 237 other tissues |
Genevisiblei | Q5T9C2, HS |
Organism-specific databases
HPAi | ENSG00000167106, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ5T9C2
With | #Exp. | IntAct |
---|---|---|
ENKD1 [Q9H0I2] | 3 | EBI-10246318,EBI-744099 |
SH3GL1 [Q6FGM0] | 3 | EBI-10246318,EBI-10173690 |
SKAP1 [Q86WV1] | 4 | EBI-10246318,EBI-2477305 |
Isoform 3 [Q5T9C2-3]
Protein-protein interaction databases
BioGRIDi | 134377, 12 interactors |
IntActi | Q5T9C2, 10 interactors |
STRINGi | 9606.ENSP00000362187 |
Miscellaneous databases
RNActi | Q5T9C2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 145 | C2 NT-typePROSITE-ProRule annotationAdd BLAST | 144 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 157 – 268 | Ser-richAdd BLAST | 112 |
Sequence similaritiesi
Belongs to the FAM102 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QRRN, Eukaryota |
GeneTreei | ENSGT00940000156811 |
HOGENOMi | CLU_024948_1_1_1 |
InParanoidi | Q5T9C2 |
OMAi | WRKKFTF |
OrthoDBi | 725501at2759 |
PhylomeDBi | Q5T9C2 |
TreeFami | TF320966 |
Family and domain databases
InterProi | View protein in InterPro IPR039931, FAM102-like IPR019448, NT-C2 |
PANTHERi | PTHR21456, PTHR21456, 1 hit |
Pfami | View protein in Pfam PF10358, NT-C2, 1 hit |
PROSITEi | View protein in PROSITE PS51840, C2_NT, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q5T9C2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAFLMKKKKF KFQTTFTLEE LTAVPFVNGV LFCKVRLLDG GDFVSLSSRE
60 70 80 90 100
EVQENCVRWR KRFTFVCKMS ANPATGLLDP CVFRVSVRKE LKGGKAYSKL
110 120 130 140 150
GFADLNLAEF AGSGSTVRCC LLEGYDTKNT RQDNSILKVT IGMFLLSGDP
160 170 180 190 200
CFKTPPSTAK SISIPGQDSS LQLTCKGGGT SSGGSSTNSL TGSRPPKARP
210 220 230 240 250
TILSSGLPEE PDQNLSSPEE VFHSGHSRNS SYASQQSKIS GYSTEHSRSS
260 270 280 290 300
SLSDLTHRRN TSTSSSASGG LGMTVEGPEG SEREHRPPEK PPRPPRPLHL
310 320 330 340 350
SDRSFRRKKD SVESHPTWVD DTRIDADAIV EKIVQSQDFT DGSNTEDSNL
360 370 380
RLFVSRDGSA TLSGIQLATR VSSGVYEPVV IESH
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043857 | 1 – 142 | Missing in isoform 3. 1 PublicationAdd BLAST | 142 | |
Alternative sequenceiVSP_021744 | 371 – 384 | Missing in isoform 2. 1 PublicationAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL157935 Genomic DNA No translation available. BC137087 mRNA Translation: AAI37088.1 BC137088 mRNA Translation: AAI37089.1 AK074108 mRNA Translation: BAB84934.1 |
CCDSi | CCDS35150.1 [Q5T9C2-1] CCDS6888.1 [Q5T9C2-3] |
RefSeqi | NP_001030331.1, NM_001035254.2 [Q5T9C2-1] NP_976050.1, NM_203305.2 [Q5T9C2-3] |
Genome annotation databases
Ensembli | ENST00000373084; ENSP00000362176; ENSG00000167106 [Q5T9C2-3] ENST00000373095; ENSP00000362187; ENSG00000167106 [Q5T9C2-1] |
GeneIDi | 399665 |
KEGGi | hsa:399665 |
UCSCi | uc004bsw.2, human [Q5T9C2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL157935 Genomic DNA No translation available. BC137087 mRNA Translation: AAI37088.1 BC137088 mRNA Translation: AAI37089.1 AK074108 mRNA Translation: BAB84934.1 |
CCDSi | CCDS35150.1 [Q5T9C2-1] CCDS6888.1 [Q5T9C2-3] |
RefSeqi | NP_001030331.1, NM_001035254.2 [Q5T9C2-1] NP_976050.1, NM_203305.2 [Q5T9C2-3] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 134377, 12 interactors |
IntActi | Q5T9C2, 10 interactors |
STRINGi | 9606.ENSP00000362187 |
PTM databases
iPTMneti | Q5T9C2 |
PhosphoSitePlusi | Q5T9C2 |
Genetic variation databases
BioMutai | FAM102A |
DMDMi | 118572304 |
Proteomic databases
jPOSTi | Q5T9C2 |
MassIVEi | Q5T9C2 |
MaxQBi | Q5T9C2 |
PaxDbi | Q5T9C2 |
PeptideAtlasi | Q5T9C2 |
PRIDEi | Q5T9C2 |
ProteomicsDBi | 64787 [Q5T9C2-1] 64788 [Q5T9C2-2] 64789 [Q5T9C2-3] |
Protocols and materials databases
Antibodypediai | 51717, 11 antibodies |
Genome annotation databases
Ensembli | ENST00000373084; ENSP00000362176; ENSG00000167106 [Q5T9C2-3] ENST00000373095; ENSP00000362187; ENSG00000167106 [Q5T9C2-1] |
GeneIDi | 399665 |
KEGGi | hsa:399665 |
UCSCi | uc004bsw.2, human [Q5T9C2-1] |
Organism-specific databases
CTDi | 399665 |
DisGeNETi | 399665 |
GeneCardsi | FAM102A |
HGNCi | HGNC:31419, FAM102A |
HPAi | ENSG00000167106, Low tissue specificity |
MIMi | 610891, gene |
neXtProti | NX_Q5T9C2 |
OpenTargetsi | ENSG00000167106 |
PharmGKBi | PA142671784 |
VEuPathDBi | HostDB:ENSG00000167106.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRRN, Eukaryota |
GeneTreei | ENSGT00940000156811 |
HOGENOMi | CLU_024948_1_1_1 |
InParanoidi | Q5T9C2 |
OMAi | WRKKFTF |
OrthoDBi | 725501at2759 |
PhylomeDBi | Q5T9C2 |
TreeFami | TF320966 |
Enzyme and pathway databases
PathwayCommonsi | Q5T9C2 |
Miscellaneous databases
BioGRID-ORCSi | 399665, 10 hits in 997 CRISPR screens |
ChiTaRSi | FAM102A, human |
GenomeRNAii | 399665 |
Pharosi | Q5T9C2, Tdark |
PROi | PR:Q5T9C2 |
RNActi | Q5T9C2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167106, Expressed in stomach and 237 other tissues |
Genevisiblei | Q5T9C2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039931, FAM102-like IPR019448, NT-C2 |
PANTHERi | PTHR21456, PTHR21456, 1 hit |
Pfami | View protein in Pfam PF10358, NT-C2, 1 hit |
PROSITEi | View protein in PROSITE PS51840, C2_NT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F102A_HUMAN | |
Accessioni | Q5T9C2Primary (citable) accession number: Q5T9C2 Secondary accession number(s): A2A329, Q8TEL4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | November 28, 2006 | |
Last modified: | April 7, 2021 | |
This is version 125 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families