UniProtKB - Q5T9B9 (Q5T9B9_HUMAN)
Protein
Submitted name:
Endoglin (Osler-Rendu-Weber syndrome 1)
Gene
ENG
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Endoglin (Osler-Rendu-Weber syndrome 1)ImportedSubmitted name: Endoglin (Osler-Rendu-Weber syndrome 1), isoform CRA_bImported |
Gene namesi | Name:ENGImported ORF Names:hCG_18549Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000106991.13 |
Subcellular locationi
Nucleus
- nuclear body Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 587 – 614 | HelicalSequence analysisAdd BLAST | 28 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_5010140462 | 26 – 625 | Sequence analysisAdd BLAST | 600 |
Proteomic databases
MaxQBi | Q5T9B9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000106991, Expressed in right lung and 224 other tissues |
ExpressionAtlasi | Q5T9B9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 363 – 500 | ZPInterPro annotationAdd BLAST | 138 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OMAi | VQTTPPK |
Family and domain databases
InterProi | View protein in InterPro IPR001507, ZP_dom |
Pfami | View protein in Pfam PF00100, Zona_pellucida, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5T9B9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRGTLPLAV ALLLASCSLS PTSLAETVHC DLQPVGPERG EVTYTTSQVS
60 70 80 90 100
KGCVAQAPNA ILEVHVLFLE FPTGPSQLEL TLQASKQNGT WPREVLLVLS
110 120 130 140 150
VNSSVFLHLQ ALGIPLHLAY NSSLVTFQEP PGVNTTELPS FPKTQILEWA
160 170 180 190 200
AERGPITSAA ELNDPQSILL RLGQAQGSLS FCMLEASQDM GRTLEWRPRT
210 220 230 240 250
PALVRGCHLE GVAGHKEAHI LRVLPGHSAG PRTVTVKVEL SCAPGDLDAV
260 270 280 290 300
LILQGPPYVS WLIDANHNMQ IWTTGEYSFK IFPEKNIRGF KLPDTPQGLL
310 320 330 340 350
GEARMLNASI VASFVELPLA SIVSLHASSC GGRLQTSPAP IQTTPPKDTC
360 370 380 390 400
SPELLMSLIQ TKCADDAMTL VLKKELVAHL KCTITGLTFW DPSCEAEDRG
410 420 430 440 450
DKFVLRSAYS SCGMQVSASM ISNEAVVNIL SSSSPQRKKV HCLNMDSLSF
460 470 480 490 500
QLGLYLSPHF LQASNTIEPG QQSFVQVRVS PSVSEFLLQL DSCHLDLGPE
510 520 530 540 550
GGTVELIQGR AAKGNCVSLL SPSPEGDPRF SFLLHFYTVP IPKTGTLSCT
560 570 580 590 600
VALRPKTGSQ DQEVHRTVFM RLNIISPDLS GCTSKGLVLP AVLGITFGAF
610 620
LIGALLTAAL WYIYSHTREY PRPPQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ866809 Genomic DNA Translation: ABI75346.1 CH471090 Genomic DNA Translation: EAW87704.1 |
RefSeqi | NP_000109.1, NM_000118.3 |
Genome annotation databases
GeneIDi | 2022 |
UCSCi | uc004bsk.6, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ866809 Genomic DNA Translation: ABI75346.1 CH471090 Genomic DNA Translation: EAW87704.1 |
RefSeqi | NP_000109.1, NM_000118.3 |
3D structure databases
SMRi | Q5T9B9 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q5T9B9 |
Protocols and materials databases
Antibodypediai | 2321, 2425 antibodies |
DNASUi | 2022 |
Genome annotation databases
GeneIDi | 2022 |
UCSCi | uc004bsk.6, human |
Organism-specific databases
CTDi | 2022 |
PharmGKBi | PA27785 |
VEuPathDBi | HostDB:ENSG00000106991.13 |
Phylogenomic databases
OMAi | VQTTPPK |
Miscellaneous databases
BioGRID-ORCSi | 2022, 7 hits in 995 CRISPR screens |
ChiTaRSi | ENG, human |
GenomeRNAii | 2022 |
Gene expression databases
Bgeei | ENSG00000106991, Expressed in right lung and 224 other tissues |
ExpressionAtlasi | Q5T9B9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001507, ZP_dom |
Pfami | View protein in Pfam PF00100, Zona_pellucida, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5T9B9_HUMAN | |
Accessioni | Q5T9B9Primary (citable) accession number: Q5T9B9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |