UniProtKB - Q5T8R4 (Q5T8R4_HUMAN)
Monocarboxylate transporter 1
SLC16A1
Functioni
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.
ARBA annotationGO - Molecular functioni
- lactate transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | TransportARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Monocarboxylate transporter 1ARBA annotationAlternative name(s): Solute carrier family 16 member 1ARBA annotation |
Gene namesi | Name:SLC16A1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10922, SLC16A1 |
VEuPathDBi | HostDB:ENSG00000155380 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 17 – 36 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 87 – 105 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 111 – 132 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 144 – 164 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 176 – 195 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000155380, Expressed in pigmented layer of retina and 246 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 215 | MFSInterPro annotationAdd BLAST | 197 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000154955 |
HOGENOMi | CLU_001265_59_3_1 |
OMAi | MFMGSAI |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR030757, MCT1 IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
PANTHERi | PTHR11360:SF24, PTHR11360:SF24, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MPPAVGGPVG YTPPDGGWGW AVVIGAFISI GFSYAFPKSI TVFFKEIEGI
60 70 80 90 100
FHATTSEVSW ISSIMLAVMY GGGPISSILV NKYGSRIVMI VGGCLSGCGL
110 120 130 140 150
IAASFCNTVQ QLYVCIGVIG GLGLAFNLNP ALTMIGKYFY KRRPLANGLA
160 170 180 190 200
MAGSPVFLCT LAPLNQVFFG IFGWRGSFLI LGGLLLNCCV AGALMRPIGP
210
KPTKAGKDKS KASLE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP53985 | MOT1_HUMAN | Monocarboxylate transporter 1 | SLC16A1 MCT1 | 500 | Annotation score: | ||
Q5T8R5 | Q5T8R5_HUMAN | Monocarboxylate transporter 1 | SLC16A1 hCG_37455 | 456 | Annotation score: | ||
Q5T8R3 | Q5T8R3_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | 296 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 215 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL158844 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000429288; ENSP00000397106; ENSG00000155380 ENST00000626371; ENSP00000485854; ENSG00000281917 |
UCSCi | uc057jmz.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL158844 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 64753 |
Protocols and materials databases
Antibodypediai | 4301, 330 antibodies from 36 providers |
Genome annotation databases
Ensembli | ENST00000429288; ENSP00000397106; ENSG00000155380 ENST00000626371; ENSP00000485854; ENSG00000281917 |
UCSCi | uc057jmz.1, human |
Organism-specific databases
HGNCi | HGNC:10922, SLC16A1 |
OpenTargetsi | ENSG00000155380 |
VEuPathDBi | HostDB:ENSG00000155380 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154955 |
HOGENOMi | CLU_001265_59_3_1 |
OMAi | MFMGSAI |
Miscellaneous databases
ChiTaRSi | SLC16A1, human |
Gene expression databases
Bgeei | ENSG00000155380, Expressed in pigmented layer of retina and 246 other tissues |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR030757, MCT1 IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
PANTHERi | PTHR11360:SF24, PTHR11360:SF24, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5T8R4_HUMAN | |
Accessioni | Q5T8R4Primary (citable) accession number: Q5T8R4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 21, 2004 |
Last sequence update: | December 21, 2004 | |
Last modified: | January 19, 2022 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |