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Entry version 159 (12 Aug 2020)
Sequence version 3 (23 Jan 2007)
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Protein

RNA-binding protein 26

Gene

RBM26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri288 – 316C3H1-typePROSITE-ProRule annotationAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5T8P6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding protein 26
Alternative name(s):
CTCL tumor antigen se70-2
RNA-binding motif protein 26
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBM26
Synonyms:C13orf10
ORF Names:PRO1777
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000139746.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20327, RBM26

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T8P6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64062

Open Targets

More...
OpenTargetsi
ENSG00000139746

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134982324

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5T8P6, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RBM26

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124021002

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002733761 – 1007RNA-binding protein 26Add BLAST1007

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei127PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei510N6-acetyllysineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei616PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T8P6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5T8P6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5T8P6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T8P6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T8P6

PeptideAtlas

More...
PeptideAtlasi
Q5T8P6

PRoteomics IDEntifications database

More...
PRIDEi
Q5T8P6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64744 [Q5T8P6-1]
64745 [Q5T8P6-2]
64746 [Q5T8P6-3]
64747 [Q5T8P6-4]
64748 [Q5T8P6-5]
64749 [Q5T8P6-6]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q5T8P6, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T8P6

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q5T8P6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T8P6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139746, Expressed in nasal cavity mucosa and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5T8P6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T8P6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000139746, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122035, 76 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T8P6, 51 interactors

Molecular INTeraction database

More...
MINTi
Q5T8P6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000483408

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5T8P6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5T8P6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini532 – 606RRM 1PROSITE-ProRule annotationAdd BLAST75
Domaini891 – 960RRM 2PROSITE-ProRule annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili719 – 795Sequence analysisAdd BLAST77
Coiled coili823 – 847Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi134 – 213Arg-richAdd BLAST80
Compositional biasi326 – 420Pro-richAdd BLAST95

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri288 – 316C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2135, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000046929

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006190_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T8P6

KEGG Orthology (KO)

More...
KOi
K13192

Database of Orthologous Groups

More...
OrthoDBi
741871at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T8P6

TreeFam database of animal gene trees

More...
TreeFami
TF319253

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12516, RRM1_RBM26, 1 hit
cd12258, RRM2_RBM26_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR002483, PWI_dom
IPR035979, RBD_domain_sf
IPR034861, RBM26
IPR039511, RBM26-like_RRM2
IPR034859, RBM26_RRM1
IPR000504, RRM_dom
IPR000571, Znf_CCCH

The PANTHER Classification System

More...
PANTHERi
PTHR14398:SF2, PTHR14398:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01480, PWI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360, RRM, 2 hits
SM00356, ZnF_C3H1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 2 hits
PS50103, ZF_C3H1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T8P6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSKMIIENF EALKSWLSKT LEPICDADPS ALAKYVLALV KKDKSEKELK
60 70 80 90 100
ALCIDQLDVF LQKETQIFVE KLFDAVNTKS YLPPPEQPSS GSLKVEFFPH
110 120 130 140 150
QEKDIKKEEI TKEEEREKKF SRRLNHSPPQ SSSRYRENRS RDERKKDDRS
160 170 180 190 200
RKRDYDRNPP RRDSYRDRYN RRRGRSRSYS RSRSRSWSKE RLRERDRDRS
210 220 230 240 250
RTRSRSRTRS RERDLVKPKY DLDRTDPLEN NYTPVSSVPS ISSGHYPVPT
260 270 280 290 300
LSSTITVIAP THHGNNTTES WSEFHEDQVD HNSYVRPPMP KKRCRDYDEK
310 320 330 340 350
GFCMRGDMCP FDHGSDPVVV EDVNLPGMLP FPAQPPVVEG PPPPGLPPPP
360 370 380 390 400
PILTPPPVNL RPPVPPPGPL PPSLPPVTGP PPPLPPLQPS GMDAPPNSAT
410 420 430 440 450
SSVPTVVTTG IHHQPPPAPP SLFTADTYDT DGYNPEAPSI TNTSRPMYRH
460 470 480 490 500
RVHAQRPNLI GLTSGDMDLP PREKPPNKSS MRIVVDSESR KRTIGSGEPG
510 520 530 540 550
VPTKKTWFDK PNFNRTNSPG FQKKVQFGNE NTKLELRKVP PELNNISKLN
560 570 580 590 600
EHFSRFGTLV NLQVAYNGDP EGALIQFATY EEAKKAISST EAVLNNRFIK
610 620 630 640 650
VYWHREGSTQ QLQTTSPKVM QPLVQQPILP VVKQSVKERL GPVPSSTIEP
660 670 680 690 700
AEAQSASSDL PQNVTKLSVK DRLGFVSKPS VSATEKVLST STGLTKTVYN
710 720 730 740 750
PAALKAAQKT LLVSTSAVDN NEAQKKKQEA LKLQQDVRKR KQEILEKHIE
760 770 780 790 800
TQKMLISKLE KNKTMKSEDK AEIMKTLEVL TKNITKLKDE VKAASPGRCL
810 820 830 840 850
PKSIKTKTQM QKELLDTELD LYKKMQAGEE VTELRRKYTE LQLEAAKRGI
860 870 880 890 900
LSSGRGRGIH SRGRGAVHGR GRGRGRGRGV PGHAVVDHRP RALEISAFTE
910 920 930 940 950
SDREDLLPHF AQYGEIEDCQ IDDSSLHAVI TFKTRAEAEA AAVHGARFKG
960 970 980 990 1000
QDLKLAWNKP VTNISAVETE EVEPDEEEFQ EESLVDDSLL QDDDEEEEDN

ESRSWRR
Length:1,007
Mass (Da):113,597
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDCA34DF4A9A42045
GO
Isoform 2 (identifier: Q5T8P6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     663-686: Missing.

Show »
Length:983
Mass (Da):111,024
Checksum:iDB5E498EF00A14E9
GO
Isoform 3 (identifier: Q5T8P6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     619-621: Missing.
     663-686: Missing.

Show »
Length:980
Mass (Da):110,666
Checksum:i6810866351CFDEF0
GO
Isoform 4 (identifier: Q5T8P6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-446: Missing.
     619-621: Missing.

Show »
Length:558
Mass (Da):62,580
Checksum:iC408F59C293D82EB
GO
Isoform 5 (identifier: Q5T8P6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-446: Missing.
     619-621: Missing.
     663-686: Missing.

Show »
Length:534
Mass (Da):60,007
Checksum:i26F03191A469E43E
GO
Isoform 6 (identifier: Q5T8P6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-120: ITKEEEREKKF → VTICVNTLQVI
     121-1007: Missing.

Show »
Length:120
Mass (Da):13,644
Checksum:i5E074B43B4BF4D65
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0H9A0A087X0H9_HUMAN
RNA-binding protein 26
RBM26
1,009Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E2PSN0E2PSN0_HUMAN
RNA-binding protein 26
RBM26
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG34912 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14933 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55125 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12A → T in CAI56708 (PubMed:17974005).Curated1
Sequence conflicti66Q → H in CAI56708 (PubMed:17974005).Curated1
Sequence conflicti426D → A in CAI56708 (PubMed:17974005).Curated1
Sequence conflicti709K → E in BAB55046 (PubMed:14702039).Curated1
Sequence conflicti900E → G in BAB55046 (PubMed:14702039).Curated1
Sequence conflicti900E → G in BAB55125 (PubMed:14702039).Curated1
Sequence conflicti959K → E in BAB14933 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030137718V → D. Corresponds to variant dbSNP:rs10767Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0225281 – 446Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST446
Alternative sequenceiVSP_022529110 – 120ITKEEEREKKF → VTICVNTLQVI in isoform 6. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_022530121 – 1007Missing in isoform 6. 1 PublicationAdd BLAST887
Alternative sequenceiVSP_022531619 – 621Missing in isoform 3, isoform 4 and isoform 5. 2 Publications3
Alternative sequenceiVSP_022532663 – 686Missing in isoform 2, isoform 3 and isoform 5. 3 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK024610 mRNA Translation: BAB14933.1 Different initiation.
AK027339 mRNA Translation: BAB55046.1
AK027456 mRNA Translation: BAB55125.1 Different initiation.
AK302871 mRNA Translation: BAG64052.1
AF116667 mRNA Translation: AAF71087.1
AL139006 Genomic DNA No translation available.
AL159974 Genomic DNA No translation available.
BC041655 mRNA Translation: AAH41655.1
BC111697 mRNA Translation: AAI11698.1
BC111739 mRNA Translation: AAI11740.1
AL834343 mRNA Translation: CAD39009.3
BX648672 mRNA Translation: CAI56708.1
AF273052 mRNA Translation: AAG34912.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS66566.1 [Q5T8P6-2]
CCDS9462.1 [Q5T8P6-3]

NCBI Reference Sequences

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RefSeqi
NP_001273560.1, NM_001286631.1
NP_001273561.1, NM_001286632.1 [Q5T8P6-2]
NP_071401.3, NM_022118.4 [Q5T8P6-3]
XP_011533490.1, XM_011535188.2 [Q5T8P6-1]
XP_011533494.1, XM_011535192.2 [Q5T8P6-2]
XP_011533495.1, XM_011535193.2 [Q5T8P6-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000267229; ENSP00000267229; ENSG00000139746 [Q5T8P6-3]
ENST00000438724; ENSP00000390222; ENSG00000139746 [Q5T8P6-2]
ENST00000438737; ENSP00000387531; ENSG00000139746 [Q5T8P6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64062

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64062

UCSC genome browser

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UCSCi
uc001vky.4, human [Q5T8P6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024610 mRNA Translation: BAB14933.1 Different initiation.
AK027339 mRNA Translation: BAB55046.1
AK027456 mRNA Translation: BAB55125.1 Different initiation.
AK302871 mRNA Translation: BAG64052.1
AF116667 mRNA Translation: AAF71087.1
AL139006 Genomic DNA No translation available.
AL159974 Genomic DNA No translation available.
BC041655 mRNA Translation: AAH41655.1
BC111697 mRNA Translation: AAI11698.1
BC111739 mRNA Translation: AAI11740.1
AL834343 mRNA Translation: CAD39009.3
BX648672 mRNA Translation: CAI56708.1
AF273052 mRNA Translation: AAG34912.1 Different initiation.
CCDSiCCDS66566.1 [Q5T8P6-2]
CCDS9462.1 [Q5T8P6-3]
RefSeqiNP_001273560.1, NM_001286631.1
NP_001273561.1, NM_001286632.1 [Q5T8P6-2]
NP_071401.3, NM_022118.4 [Q5T8P6-3]
XP_011533490.1, XM_011535188.2 [Q5T8P6-1]
XP_011533494.1, XM_011535192.2 [Q5T8P6-2]
XP_011533495.1, XM_011535193.2 [Q5T8P6-3]

3D structure databases

SMRiQ5T8P6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122035, 76 interactors
IntActiQ5T8P6, 51 interactors
MINTiQ5T8P6
STRINGi9606.ENSP00000483408

PTM databases

GlyGeniQ5T8P6, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ5T8P6
MetOSiteiQ5T8P6
PhosphoSitePlusiQ5T8P6

Polymorphism and mutation databases

BioMutaiRBM26
DMDMi124021002

Proteomic databases

EPDiQ5T8P6
jPOSTiQ5T8P6
MassIVEiQ5T8P6
MaxQBiQ5T8P6
PaxDbiQ5T8P6
PeptideAtlasiQ5T8P6
PRIDEiQ5T8P6
ProteomicsDBi64744 [Q5T8P6-1]
64745 [Q5T8P6-2]
64746 [Q5T8P6-3]
64747 [Q5T8P6-4]
64748 [Q5T8P6-5]
64749 [Q5T8P6-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
24703, 223 antibodies

Genome annotation databases

EnsembliENST00000267229; ENSP00000267229; ENSG00000139746 [Q5T8P6-3]
ENST00000438724; ENSP00000390222; ENSG00000139746 [Q5T8P6-2]
ENST00000438737; ENSP00000387531; ENSG00000139746 [Q5T8P6-1]
GeneIDi64062
KEGGihsa:64062
UCSCiuc001vky.4, human [Q5T8P6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64062
DisGeNETi64062
EuPathDBiHostDB:ENSG00000139746.15

GeneCards: human genes, protein and diseases

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GeneCardsi
RBM26
HGNCiHGNC:20327, RBM26
HPAiENSG00000139746, Low tissue specificity
neXtProtiNX_Q5T8P6
OpenTargetsiENSG00000139746
PharmGKBiPA134982324

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2135, Eukaryota
GeneTreeiENSGT00510000046929
HOGENOMiCLU_006190_0_0_1
InParanoidiQ5T8P6
KOiK13192
OrthoDBi741871at2759
PhylomeDBiQ5T8P6
TreeFamiTF319253

Enzyme and pathway databases

PathwayCommonsiQ5T8P6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
64062, 15 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RBM26, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RBM26

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64062
PharosiQ5T8P6, Tdark

Protein Ontology

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PROi
PR:Q5T8P6
RNActiQ5T8P6, protein

Gene expression databases

BgeeiENSG00000139746, Expressed in nasal cavity mucosa and 252 other tissues
ExpressionAtlasiQ5T8P6, baseline and differential
GenevisibleiQ5T8P6, HS

Family and domain databases

CDDicd12516, RRM1_RBM26, 1 hit
cd12258, RRM2_RBM26_like, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR002483, PWI_dom
IPR035979, RBD_domain_sf
IPR034861, RBM26
IPR039511, RBM26-like_RRM2
IPR034859, RBM26_RRM1
IPR000504, RRM_dom
IPR000571, Znf_CCCH
PANTHERiPTHR14398:SF2, PTHR14398:SF2, 1 hit
PfamiView protein in Pfam
PF01480, PWI, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 2 hits
SM00356, ZnF_C3H1, 1 hit
SUPFAMiSSF54928, SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 2 hits
PS50103, ZF_C3H1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBM26_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T8P6
Secondary accession number(s): B4DZE0
, Q2NKM2, Q2NKQ2, Q5CZH8, Q5T8P5, Q5T8P8, Q5U5P5, Q5W0G7, Q8N3H5, Q96K92, Q96SZ3, Q9H2F8, Q9H7F9, Q9P1G7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: August 12, 2020
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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