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Protein

RNA-binding protein 26

Gene

RBM26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri288 – 316C3H1-typePROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • mRNA binding Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 26
Alternative name(s):
CTCL tumor antigen se70-2
RNA-binding motif protein 26
Gene namesi
Name:RBM26
Synonyms:C13orf10
ORF Names:PRO1777
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000139746.15
HGNCiHGNC:20327 RBM26
neXtProtiNX_Q5T8P6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi64062
OpenTargetsiENSG00000139746
PharmGKBiPA134982324

Polymorphism and mutation databases

DMDMi124021002

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002733761 – 1007RNA-binding protein 26Add BLAST1007

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei127PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei510N6-acetyllysineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei616PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5T8P6
MaxQBiQ5T8P6
PaxDbiQ5T8P6
PeptideAtlasiQ5T8P6
PRIDEiQ5T8P6
ProteomicsDBi64744
64745 [Q5T8P6-2]
64746 [Q5T8P6-3]
64747 [Q5T8P6-4]
64748 [Q5T8P6-5]
64749 [Q5T8P6-6]

PTM databases

iPTMnetiQ5T8P6
PhosphoSitePlusiQ5T8P6

Miscellaneous databases

PMAP-CutDBiQ5T8P6

Expressioni

Gene expression databases

BgeeiENSG00000139746 Expressed in 242 organ(s), highest expression level in nasal cavity mucosa
CleanExiHS_RBM26
ExpressionAtlasiQ5T8P6 baseline and differential
GenevisibleiQ5T8P6 HS

Organism-specific databases

HPAiHPA040252

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK2O436393EBI-3232077,EBI-713635

Protein-protein interaction databases

BioGridi122035, 65 interactors
IntActiQ5T8P6, 40 interactors
MINTiQ5T8P6
STRINGi9606.ENSP00000267229

Structurei

3D structure databases

ProteinModelPortaliQ5T8P6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini532 – 606RRM 1PROSITE-ProRule annotationAdd BLAST75
Domaini891 – 960RRM 2PROSITE-ProRule annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili719 – 795Sequence analysisAdd BLAST77
Coiled coili823 – 847Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi134 – 213Arg-richAdd BLAST80
Compositional biasi326 – 420Pro-richAdd BLAST95

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri288 – 316C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2135 Eukaryota
ENOG41119BA LUCA
GeneTreeiENSGT00510000046929
HOVERGENiHBG057372
InParanoidiQ5T8P6
KOiK13192
PhylomeDBiQ5T8P6
TreeFamiTF319253

Family and domain databases

CDDicd12516 RRM1_RBM26, 1 hit
cd12258 RRM2_RBM26_like, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR002483 PWI_dom
IPR035979 RBD_domain_sf
IPR034861 RBM26
IPR039511 RBM26-like_RRM2
IPR034859 RBM26_RRM1
IPR000504 RRM_dom
IPR000571 Znf_CCCH
PANTHERiPTHR14398:SF2 PTHR14398:SF2, 1 hit
PfamiView protein in Pfam
PF01480 PWI, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
PS50103 ZF_C3H1, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T8P6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSKMIIENF EALKSWLSKT LEPICDADPS ALAKYVLALV KKDKSEKELK
60 70 80 90 100
ALCIDQLDVF LQKETQIFVE KLFDAVNTKS YLPPPEQPSS GSLKVEFFPH
110 120 130 140 150
QEKDIKKEEI TKEEEREKKF SRRLNHSPPQ SSSRYRENRS RDERKKDDRS
160 170 180 190 200
RKRDYDRNPP RRDSYRDRYN RRRGRSRSYS RSRSRSWSKE RLRERDRDRS
210 220 230 240 250
RTRSRSRTRS RERDLVKPKY DLDRTDPLEN NYTPVSSVPS ISSGHYPVPT
260 270 280 290 300
LSSTITVIAP THHGNNTTES WSEFHEDQVD HNSYVRPPMP KKRCRDYDEK
310 320 330 340 350
GFCMRGDMCP FDHGSDPVVV EDVNLPGMLP FPAQPPVVEG PPPPGLPPPP
360 370 380 390 400
PILTPPPVNL RPPVPPPGPL PPSLPPVTGP PPPLPPLQPS GMDAPPNSAT
410 420 430 440 450
SSVPTVVTTG IHHQPPPAPP SLFTADTYDT DGYNPEAPSI TNTSRPMYRH
460 470 480 490 500
RVHAQRPNLI GLTSGDMDLP PREKPPNKSS MRIVVDSESR KRTIGSGEPG
510 520 530 540 550
VPTKKTWFDK PNFNRTNSPG FQKKVQFGNE NTKLELRKVP PELNNISKLN
560 570 580 590 600
EHFSRFGTLV NLQVAYNGDP EGALIQFATY EEAKKAISST EAVLNNRFIK
610 620 630 640 650
VYWHREGSTQ QLQTTSPKVM QPLVQQPILP VVKQSVKERL GPVPSSTIEP
660 670 680 690 700
AEAQSASSDL PQNVTKLSVK DRLGFVSKPS VSATEKVLST STGLTKTVYN
710 720 730 740 750
PAALKAAQKT LLVSTSAVDN NEAQKKKQEA LKLQQDVRKR KQEILEKHIE
760 770 780 790 800
TQKMLISKLE KNKTMKSEDK AEIMKTLEVL TKNITKLKDE VKAASPGRCL
810 820 830 840 850
PKSIKTKTQM QKELLDTELD LYKKMQAGEE VTELRRKYTE LQLEAAKRGI
860 870 880 890 900
LSSGRGRGIH SRGRGAVHGR GRGRGRGRGV PGHAVVDHRP RALEISAFTE
910 920 930 940 950
SDREDLLPHF AQYGEIEDCQ IDDSSLHAVI TFKTRAEAEA AAVHGARFKG
960 970 980 990 1000
QDLKLAWNKP VTNISAVETE EVEPDEEEFQ EESLVDDSLL QDDDEEEEDN

ESRSWRR
Length:1,007
Mass (Da):113,597
Last modified:January 23, 2007 - v3
Checksum:iDCA34DF4A9A42045
GO
Isoform 2 (identifier: Q5T8P6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     663-686: Missing.

Show »
Length:983
Mass (Da):111,024
Checksum:iDB5E498EF00A14E9
GO
Isoform 3 (identifier: Q5T8P6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     619-621: Missing.
     663-686: Missing.

Note: No experimental confirmation available.
Show »
Length:980
Mass (Da):110,666
Checksum:i6810866351CFDEF0
GO
Isoform 4 (identifier: Q5T8P6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-446: Missing.
     619-621: Missing.

Note: No experimental confirmation available.
Show »
Length:558
Mass (Da):62,580
Checksum:iC408F59C293D82EB
GO
Isoform 5 (identifier: Q5T8P6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-446: Missing.
     619-621: Missing.
     663-686: Missing.

Note: No experimental confirmation available.
Show »
Length:534
Mass (Da):60,007
Checksum:i26F03191A469E43E
GO
Isoform 6 (identifier: Q5T8P6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-120: ITKEEEREKKF → VTICVNTLQVI
     121-1007: Missing.

Note: No experimental confirmation available.
Show »
Length:120
Mass (Da):13,644
Checksum:i5E074B43B4BF4D65
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0H9A0A087X0H9_HUMAN
RNA-binding protein 26
RBM26
1,009Annotation score:
E2PSN0E2PSN0_HUMAN
RNA-binding protein 26
RBM26
171Annotation score:

Sequence cautioni

The sequence AAG34912 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14933 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55125 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12A → T in CAI56708 (PubMed:17974005).Curated1
Sequence conflicti66Q → H in CAI56708 (PubMed:17974005).Curated1
Sequence conflicti426D → A in CAI56708 (PubMed:17974005).Curated1
Sequence conflicti709K → E in BAB55046 (PubMed:14702039).Curated1
Sequence conflicti900E → G in BAB55046 (PubMed:14702039).Curated1
Sequence conflicti900E → G in BAB55125 (PubMed:14702039).Curated1
Sequence conflicti959K → E in BAB14933 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030137718V → D. Corresponds to variant dbSNP:rs10767Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0225281 – 446Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST446
Alternative sequenceiVSP_022529110 – 120ITKEEEREKKF → VTICVNTLQVI in isoform 6. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_022530121 – 1007Missing in isoform 6. 1 PublicationAdd BLAST887
Alternative sequenceiVSP_022531619 – 621Missing in isoform 3, isoform 4 and isoform 5. 2 Publications3
Alternative sequenceiVSP_022532663 – 686Missing in isoform 2, isoform 3 and isoform 5. 3 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024610 mRNA Translation: BAB14933.1 Different initiation.
AK027339 mRNA Translation: BAB55046.1
AK027456 mRNA Translation: BAB55125.1 Different initiation.
AK302871 mRNA Translation: BAG64052.1
AF116667 mRNA Translation: AAF71087.1
AL139006 Genomic DNA No translation available.
AL159974 Genomic DNA No translation available.
BC041655 mRNA Translation: AAH41655.1
BC111697 mRNA Translation: AAI11698.1
BC111739 mRNA Translation: AAI11740.1
AL834343 mRNA Translation: CAD39009.3
BX648672 mRNA Translation: CAI56708.1
AF273052 mRNA Translation: AAG34912.1 Different initiation.
CCDSiCCDS66566.1 [Q5T8P6-2]
CCDS9462.1 [Q5T8P6-3]
RefSeqiNP_001273560.1, NM_001286631.1
NP_001273561.1, NM_001286632.1 [Q5T8P6-2]
NP_071401.3, NM_022118.4 [Q5T8P6-3]
XP_011533490.1, XM_011535188.2 [Q5T8P6-1]
XP_011533494.1, XM_011535192.2 [Q5T8P6-2]
XP_011533495.1, XM_011535193.2 [Q5T8P6-3]
UniGeneiHs.558528
Hs.596629
Hs.732265

Genome annotation databases

EnsembliENST00000267229; ENSP00000267229; ENSG00000139746 [Q5T8P6-3]
ENST00000438724; ENSP00000390222; ENSG00000139746 [Q5T8P6-2]
ENST00000438737; ENSP00000387531; ENSG00000139746 [Q5T8P6-1]
GeneIDi64062
KEGGihsa:64062
UCSCiuc001vky.4 human [Q5T8P6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024610 mRNA Translation: BAB14933.1 Different initiation.
AK027339 mRNA Translation: BAB55046.1
AK027456 mRNA Translation: BAB55125.1 Different initiation.
AK302871 mRNA Translation: BAG64052.1
AF116667 mRNA Translation: AAF71087.1
AL139006 Genomic DNA No translation available.
AL159974 Genomic DNA No translation available.
BC041655 mRNA Translation: AAH41655.1
BC111697 mRNA Translation: AAI11698.1
BC111739 mRNA Translation: AAI11740.1
AL834343 mRNA Translation: CAD39009.3
BX648672 mRNA Translation: CAI56708.1
AF273052 mRNA Translation: AAG34912.1 Different initiation.
CCDSiCCDS66566.1 [Q5T8P6-2]
CCDS9462.1 [Q5T8P6-3]
RefSeqiNP_001273560.1, NM_001286631.1
NP_001273561.1, NM_001286632.1 [Q5T8P6-2]
NP_071401.3, NM_022118.4 [Q5T8P6-3]
XP_011533490.1, XM_011535188.2 [Q5T8P6-1]
XP_011533494.1, XM_011535192.2 [Q5T8P6-2]
XP_011533495.1, XM_011535193.2 [Q5T8P6-3]
UniGeneiHs.558528
Hs.596629
Hs.732265

3D structure databases

ProteinModelPortaliQ5T8P6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122035, 65 interactors
IntActiQ5T8P6, 40 interactors
MINTiQ5T8P6
STRINGi9606.ENSP00000267229

PTM databases

iPTMnetiQ5T8P6
PhosphoSitePlusiQ5T8P6

Polymorphism and mutation databases

DMDMi124021002

Proteomic databases

EPDiQ5T8P6
MaxQBiQ5T8P6
PaxDbiQ5T8P6
PeptideAtlasiQ5T8P6
PRIDEiQ5T8P6
ProteomicsDBi64744
64745 [Q5T8P6-2]
64746 [Q5T8P6-3]
64747 [Q5T8P6-4]
64748 [Q5T8P6-5]
64749 [Q5T8P6-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267229; ENSP00000267229; ENSG00000139746 [Q5T8P6-3]
ENST00000438724; ENSP00000390222; ENSG00000139746 [Q5T8P6-2]
ENST00000438737; ENSP00000387531; ENSG00000139746 [Q5T8P6-1]
GeneIDi64062
KEGGihsa:64062
UCSCiuc001vky.4 human [Q5T8P6-1]

Organism-specific databases

CTDi64062
DisGeNETi64062
EuPathDBiHostDB:ENSG00000139746.15
GeneCardsiRBM26
HGNCiHGNC:20327 RBM26
HPAiHPA040252
neXtProtiNX_Q5T8P6
OpenTargetsiENSG00000139746
PharmGKBiPA134982324
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2135 Eukaryota
ENOG41119BA LUCA
GeneTreeiENSGT00510000046929
HOVERGENiHBG057372
InParanoidiQ5T8P6
KOiK13192
PhylomeDBiQ5T8P6
TreeFamiTF319253

Miscellaneous databases

ChiTaRSiRBM26 human
GeneWikiiRBM26
GenomeRNAii64062
PMAP-CutDBiQ5T8P6
PROiPR:Q5T8P6

Gene expression databases

BgeeiENSG00000139746 Expressed in 242 organ(s), highest expression level in nasal cavity mucosa
CleanExiHS_RBM26
ExpressionAtlasiQ5T8P6 baseline and differential
GenevisibleiQ5T8P6 HS

Family and domain databases

CDDicd12516 RRM1_RBM26, 1 hit
cd12258 RRM2_RBM26_like, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR002483 PWI_dom
IPR035979 RBD_domain_sf
IPR034861 RBM26
IPR039511 RBM26-like_RRM2
IPR034859 RBM26_RRM1
IPR000504 RRM_dom
IPR000571 Znf_CCCH
PANTHERiPTHR14398:SF2 PTHR14398:SF2, 1 hit
PfamiView protein in Pfam
PF01480 PWI, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
PS50103 ZF_C3H1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBM26_HUMAN
AccessioniPrimary (citable) accession number: Q5T8P6
Secondary accession number(s): B4DZE0
, Q2NKM2, Q2NKQ2, Q5CZH8, Q5T8P5, Q5T8P8, Q5U5P5, Q5W0G7, Q8N3H5, Q96K92, Q96SZ3, Q9H2F8, Q9H7F9, Q9P1G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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